Management of pediatric aural foreign bodies: Towards a universal Otolaryngology referral algorithm.

OBJECTIVES: Children with aural foreign bodies (AFB) frequently present to the Emergency Department (ED). Our objective was to analyze patterns of pediatric AFB management at our center to characterize children who are commonly referred to Otolaryngology. METHODS: A retrospective chart review of all children (ages 0-18 years) presenting with AFB to the tertiary care Pediatric ED over a three-year period was performed. Demographics, symptoms, type of AFB, retrieval strategy, complications, need for Otolaryngology referral, and, use of sedation, were evaluated with respect to outcomes. Univariable logistic regression models were conducted to determine which patient characteristics were predictive of AFB removal success. RESULTS: One hundred and fifty-nine patients seen at the Pediatric ED met the inclusion criteria. Average age at presentation was 6 years (2-18 years). Otalgia was the most common presenting symptom (18.0%). However, only 27.0% of children were symptomatic. ED physicians primarily flushed AFBs out of the external auditory canal with water, whereas Otolaryngologists exclusively used direct visualization. Otolaryngology-Head & Neck Surgery (OHNS) was consulted for 29.6% of children. Of these, 68.1% had complications associated with prior retrieval attempts. Sedation was administered in 40.4% of referred children, with 21.2% in an operative setting. Patients experiencing multiple retrieval methods by ED, and, age less than 3 years, were more likely to be referred to OHNS. CONCLUSION: Patient's age should be strongly considered as a factor for early OHNS referral. By synthesizing our conclusions with previously published results, we propose a referral algorithm.

Achondroplasia and severe sensorineural hearing loss: The role of active bone conduction implants.

The BONEBRIDGE is a partially implantable, transcutaneous bone conduction device that can be used to treat conductive or mixed mild-to-moderate hearing loss in patients who do not attain sufficient improvement from conventional hearing aids. The following case report describes sequential bilateral BONEBRIDGE implantation in a 25-year-old patient with achondroplasia and bilateral mixed-hearing loss with a significant sensorineural component in the setting of chronic suppurative otitis media. Although the patient did not meet the approved BONEBRIDGE criteria, implantation was successful with improvements in audiological outcomes and self-reported quality of life. There were no reported complications at 5-years post-implantation.

Skin Necrosis Following Rhinoplasty: A Review and Proposed Strategy on Identifying High-Risk Patients.

Vascular compromise leading to cutaneous loss following surgical rhinoplasty is a devastating complication. The objective of this review is to identify all reported cases in literature published in English and summarize the current evidence to identify the patients at risk of this complication following surgery. A comprehensive literature review using Medline and Embase databases was performed to capture all reported cases of cutaneous vascular compromise following rhinoplasty from database inception through September 2020. Nonsurgical rhinoplasty cases were excluded. We identified eight studies that featured vascular cutaneous compromise following surgical rhinoplasty. A total of 18 patients were included in the analysis. The majority of the patients were females with a mean age of 30.9. Risk factors included smoking in 23.5% patients and revision setting. Extensive tip thinning, tight splinting and taping with dorsal onlay grafting, or combining extended alar base excision with revision open rhinoplasty were among surgical techniques associated with vascular compromise. The most commonly affected aesthetic nasal subunit in our review was the dorsum followed by the nasal tip. Conservative management primarily was utilized in 72.2% of patients, allowing the defect to heal by secondary intention. Studies reporting on cutaneous vascular compromise following surgical rhinoplasty are of low level of evidence. This review is the largest summary reporting on this complication to date, aiming to caution surgeons about associated techniques and management options. We also share an expert opinion on preoperative assessment of nasal skin to guide surgeons to potentially avoid rhinoplasty surgery in this subset of patients.

Cartilage-Sparing Otoplasty: A Systematic Review.

Objective: Cartilage-sparing techniques have continued to play a large role in modern otoplasty. Without invasion of the cartilage, the approach has been associated with less risk of skin necrosis, cartilage irregularities, hematoma, and infection. However, refinements are often needed to decrease the incidence of recurrence and suture extrusion. The objective of this systematic review is to assess the current evidence for cartilage-sparing otoplasty. Data Sources: PubMed and EMBASE databases. Study Selection: Search terms utilized were "cartilage" and "sparing" and "otoplasty." Exclusion criteria include book chapters, technical reviews, and non-English language articles. Data Extraction: On August 1, 2019, two independent authors performed a literature query with the aforementioned key words and databases. Data Synthesis: The initial search yielded 80 results, of which 20 final articles remained for final analysis. Sample sizes ranged from 17 to 565 patients, with 14 (70%) of the studies being case series with and without adjunctive techniques. Four (20%) studies compared outcomes between cartilage-invasive and cartilage-sparing techniques. Five (25%) studies were retrospective cohort studies and only one (5%) study was prospective in nature. However, according to the Oxford Centre for Evidence-Based Medicine scale, all of the studies were of low quality. Conclusions: Since the inception of cartilage-sparing otoplasty, various modifications of the approach have been described. Recent studies demonstrated superior outcomes compared with cartilage-invasive techniques; however, a personalized approach to each patient remains necessary and often may require a combination of both to achieve the most satisfying aesthetic result. Question: Is there a preferred method for otoplasty based on outcomes? Findings: Studies on otoplasty have low quality. Cartilage-sparing otoplasty outcomes seem to be superior to cartilage-scoring otoplasty. Meaning: Provide systematic review to surgeons who perform otoplasty with outcomes in order for a personalized approach to be implemented.

Estimating Survival After Salvage Surgery for Recurrent Oral Cavity Cancer.

Importance: Locoregional recurrence of oral cavity squamous cell carcinoma (OCSCC) continues to be a life-threatening and difficult clinical situation. Salvage surgery can result in significant morbidities, and survival following recurrence is poor. Objective: To outline prognostic factors influencing overall survival (OS) following salvage surgery for OCSCC to guide management of treatment for patients with locoregionally recurrent disease. Design, Setting, and Participants: The medical records of 293 patients presenting to the London Health Sciences Center with locoregionally recurrent OCSCC between October 5, 1999, and May 2, 2011, were retrospectively reviewed. The primary outcome was OS from salvage treatment to last follow-up or death. Univariate analyses were carried out using the Cox proportional hazards regression model. A recursive partitioning analysis was used to create risk groups based on prognosis. Analysis was conducted from December 8, 2015, to February 26, 2016. Results: Of the 293 patients evaluated, 59 (20%) had recurrence identified after their initial OCSCC treatment; 39 (66%) were men, and the mean (SD) age at diagnosis was 62.2 (11.8) years. Thirty-nine (66%) of these patients underwent salvage surgery for locoregional recurrence with curative intent. Five-year OS from the time of salvage surgery was 43%. Recursive partitioning analysis identified 3 risk groups: (1) high risk (patients who received adjuvant chemoradiotherapy or radiotherapy after initial surgery) with 5-year OS rate of 10% (hazard ratio [HR], 9.41; 95% CI, 2.68-33.04), (2) intermediate risk (previous surgery alone, age ≥62 years) with a 5-year OS rate of 39% (HR, 2.95; 95% CI, 0.86-10.09), and (3) low risk (previous surgery alone, age <62 years) with 5-year OS rate of 74%. Conclusions and Relevance: This recursive partitioning analysis identified 3 prognostic groups in patients undergoing salvage surgery for recurrent OCSCC. The marked differences in survival between these groups should be taken into consideration when counselling and managing treatment for patients with locoregionally recurrent disease.

Silent sinus syndrome after facial trauma: A case report and literature review.

OBJECTIVE: The accepted definition of silent sinus syndrome (SSS) excludes posttraumatic cases. To challenge current exclusion criteria of antecedent facial trauma, we have identified all published cases of posttraumatic SSS in English literature, including a new representative case from our institution. DATA SOURCES: MEDLINE, EMBASE, and Scopus databases. REVIEW METHODS: All case reports and case series published in English literature from 1964 through August 2016 were sequentially identified. Authors of cases with missing information were contacted for completion. RESULTS: Thirteen documented cases of posttraumatic SSS were identified through the literature review. An additional case from our institution was presented, bringing the total reported case count to 14. Time from initial trauma to presentation ranged from 2 months to 32 years, with a median duration of 6 months. Endoscopic sinus surgery (ESS) with either concurrent or staged orbital floor implant repair was used to treat posttraumatic SSS in 64% of reported cases. Three patients had ESS alone, with one case showing postoperative improvement in enophthalmos. CONCLUSION: Recent emergence of case reports of SSS postorbital and facial trauma challenge the current exclusion criteria of precedent facial trauma. Posttraumatic SSS is rare, but the availability of cross-sectional imaging pre- and postdevelopment of SSS makes a strong case for a causal relationship. Laryngoscope, 127:1520-1524, 2017.

Evaluating organ preservation outcome as treatment endpoint for T1aN0 glottic cancer.

OBJECTIVES/HYPOTHESIS: Common endpoints in reporting the outcomes for early glottic cancer do not highlight the importance of organ preservation. We evaluated the treatment outcomes among patients with T1aN0 laryngeal cancer with laryngectomy-free disease-specific survival (LFS-DSS), which is defined as time to total laryngectomy or time to death from cancer cause, against all other endpoints. STUDY DESIGN: Outcome research on an institutional database. METHODS: A retrospective review covered all consecutive patients from 2003 to 2013. Patients with T1a laryngeal squamous cell carcinoma (SCC) were offered the options of either radiation treatment (RT) or transoral laser microsurgery (TLM). Tumor control, survival outcomes, standard definition laryngectomy-free survival (LFS), and LFS-DSS were calculated. RESULTS: There were 105 patients, of whom 53 were treated with TLM and 52 were treated with RT. There were 11 recurrences within the TLM group, of which four were successfully salvaged with repeated TLM and two were salvaged with RT. Among the four recurrences within the RT group, all four patients had salvage total laryngectomies. The 5-year overall survival for patients treated with TLM versus RT was 86% versus 85% (P = .887), disease-free survival was 69% versus 78% (P = .151), LFS was 65% versus 77% (P = .198), LFS-DSS was 100% versus 88% (P = .030), and ultimate locoregional control was 100% in both groups. CONCLUSIONS: Patients with T1aN0 glottic SCC treated with RT or TLM have similar survival outcomes. Patients with T1a tumor treated with TLM have better organ preservation compared to RT, when measured with LFS-DSS. LEVEL OF EVIDENCE: 4. Laryngoscope, 127:1322-1327, 2017.

Aldehyde dehydrogenase activity of breast cancer stem cells is primarily due to isoform ALDH1A3 and its expression is predictive of metastasis.

Cancer stem cells (CSCs) are proposed to initiate cancer and propagate metastasis. Breast CSCs identified by aldehyde dehydrogenase (ALDH) activity are highly tumorigenic in xenograft models. However, in patient breast tumor immunohistological studies, where CSCs are identified by expression of ALDH isoform ALDH1A1, CSC prevalence is not correlative with metastasis, raising some doubt as to the role of CSCs in cancer. We characterized the expression of all 19 ALDH isoforms in patient breast tumor CSCs and breast cancer cell lines by total genome microarray expression analysis, immunofluorescence protein expression studies, and quantitative polymerase chain reaction. These studies revealed that ALDH activity of patient breast tumor CSCs and cell lines correlates best with expression of another isoform, ALDH1A3, not ALDH1A1. We performed shRNA knockdown experiments of the various ALDH isoforms and found that only ALDH1A3 knockdown uniformly reduced ALDH activity of breast cancer cells. Immunohistological studies with fixed patient breast tumor samples revealed that ALDH1A3 expression in patient breast tumors correlates significantly with tumor grade, metastasis, and cancer stage. Our results, therefore, identify ALDH1A3 as a novel CSC marker with potential clinical prognostic applicability, and demonstrate a clear correlation between CSC prevalence and the development of metastatic breast cancer.