Roles of the Taql and Bsml vitamin D receptor gene polymorphisms in hospital mortality of burn patients.

OBJECTIVE: The aim of this study was to evaluate the roles of the Taql and Bsml vitamin D receptor gene polymorphisms in hospital mortality of burn patients. METHODS: In total, 105 consecutive burn injury patients over 18 years in age who were admitted to the Burn Unit of Bauru State Hospital from January to December 2013 were prospectively evaluated. Upon admission, patient demographic information was recorded and a blood sample was taken for biochemical analysis to identify the presence of the Taql(rs731236) and Bsml(rs1544410) polymorphisms. All of the patients were followed over their hospital stay and mortality was recorded. RESULTS: Eighteen of the patients did not sign the informed consent form, and there were technical problems with genotype analysis for 7 of the patients. Thus, 80 patients (mean age, 42.5±16.1 years) were included in the final analysis. In total, 60% of the patients were male, and 16.3% died during the hospital stay. The genotype frequencies for the Taql polymorphism were 51.25% TT, 41.25% TC and 7.50% CC; for the Bsml polymorphism, they were 51.25% GG, 42.50% GA and 6.25% AA. In logistic regression analysis, after adjustments for age, gender and total body surface burn area, there were no associations between the Taql (OR: 1.575; CI95%: 0.148-16.745; p=0.706) or Bsml (OR: 1.309; CI95%: 0.128-13.430; p=0.821) polymorphisms and mortality for the burn patients. CONCLUSIONS: Our results suggest that the Taql and Bsml vitamin D receptor gene polymorphisms are not associated with hospital mortality of burn patients.

Roles of the Taql and Bsml vitamin D receptor gene polymorphisms in hospital mortality of burn patients

OBJECTIVE: The aim of this study was to evaluate the roles of the Taql and Bsml vitamin D receptor gene polymorphisms in hospital mortality of burn patients. METHODS: In total, 105 consecutive burn injury patients over 18 years in age who were admitted to the Burn Unit of Bauru State Hospital from January to December 2013 were prospectively evaluated. Upon admission, patient demographic information was recorded and a blood sample was taken for biochemical analysis to identify the presence of the Taql(rs731236) and Bsml(rs1544410) polymorphisms. All of the patients were followed over their hospital stay and mortality was recorded. RESULTS: Eighteen of the patients did not sign the informed consent form, and there were technical problems with genotype analysis for 7 of the patients. Thus, 80 patients (mean age, 42.5±16.1 years) were included in the final analysis. In total, 60% of the patients were male, and 16.3% died during the hospital stay. The genotype frequencies for the Taql polymorphism were 51.25% TT, 41.25% TC and 7.50% CC; for the Bsml polymorphism, they were 51.25% GG, 42.50% GA and 6.25% AA. In logistic regression analysis, after adjustments for age, gender and total body surface burn area, there were no associations between the Taql (OR: 1.575; CI95%: 0.148-16.745; p=0.706) or Bsml (OR: 1.309; CI95%: 0.128-13.430; p=0.821) polymorphisms and mortality for the burn patients. CONCLUSIONS: Our results suggest that the Taql and Bsml vitamin D receptor gene polymorphisms are not associated with hospital mortality of burn patients.

A formação do enfermeiro para a Estratégia Saúde da Família / The training of nurses for the Family Health Strategy / La formación de los enfermeros para la Estrategia de Salud de la Familia

Objetivo: refletir sobre a formação do graduando em Enfermagem, com base no referencial da Estratégia Saúde da Família (ESF). Metodologia: trata-se de uma pesquisa bibliográfica realizada nas bases de dados da Biblioteca Virtual em Saúde (BVS), no portal Scientific Electronic Library Online (SciELO) e Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS). Englobou artigos científicos publicados entre 2002 à 2009 em português. Para a seleção dos artigos foram utilizados os descritores: sistema único de saúde; saúde da família; educação em enfermagem. A seleção foi feita utilizando um instrumento construído para este fim. Após as análises, que foram realizadas de forma independente por três pesquisadores, selecionou-se 13 publicações que apresentavam relação com a temática. Resultados: a estratégia saúde da família exige um perfil diferenciado dos profissionais, os quais devem mudar o pólo indivíduo/doença/cura para uma assistência holística, promovendo saúde de forma integral. Nesta perspectiva, fazem-se necessárias reformulações nos currículos de graduação em enfermagem a partir de Projetos Pedagógicos centrados no aluno, falar teoria/prática e, adaptando-se ao perfil epidemiológico ao qual está inserido. Apesar das mudanças na formação do graduando, ainda persistem lacunas e desafios a serem superados. Conclusão: enfatiza-se a importância da introdução precoce de conteúdos acerca da ESF, a fim de promover a formação do enfermeiro para atuar nesta perspectiva interdisciplinar no âmbito do SUS, correspondendo às exigências deste novo perfil da saúde.(AU)

Objective: to think about the formation of the nursing senior student having family health strategy as a base. Methodology: this paper describes a bibliographic research done based on Virtual Health Library (BVS - Biblioteca Virtual em Saúde) on the site Scientific Electronic Library on-line (Scielo) and Latin-America and Caribbean Literature in Health Science (Lilacs), along the period of 2002 to 2009 in Portuguese. For the selection of the articles were the following keywords: national health care system, family health, education, nursing. The selection was made using an instrument constructed for this purpose. After the analysis, which were performed independently by three researchers were selected from 13 publications that had relation with the theme. Result: the Family Health Strategy demand a special profile from the professionals who must change the individual /illness/ cure approach to a holistic assistance promoting health in a integrated way. Under these perspectives it´s necessary a reformulation in the nursing graduation curriculum having projects centered in the student working together theory and practice and adapting to the epidemiology profile in which it is inserted. Although there have been changes for the graduating students, there are still some gaps and challenges to be overcome. Conclusion: the importance of an early introduction of ESF subject is emphasize in order to promote the nurse formation making him/her able to work bearing this interdisciplinary perspective in mind at SUS matching with this new demand of health profile.(AU)

Objetivo: reflexionar sobre la formación de los estudiantes de Enfermería, tomándose por base referencial la Estrategia Salud de la Familia (ESF). Metodología: se trata de una investigación bibliográfica realizada en las bases de datos de la Biblioteca Virtual en Salud (BVS), en los portales Scientific Electronic Library Online (SciELO) y Literatura LatinoAmericana y del Caribe en Ciencias de la Salud (LILACS), durante el período de 2002 a 2009,em portugués. Envolvió artículos científicos publicados entre 2002 a 2009 en portugués. Para la selección de los artículos fueron las siguientes palabras: sistema nacional de salud, salud familiar, la educación, la enfermería. La selección se hizo mediante un instrumento construido para este propósito. Después del análisis, que se realizaron de forma independiente por tres investigadores fueron seleccionados de 13 publicaciones que habían relación con el tema. Resultados: la Estrategia Salud de la Familia exige un perfil diferenciado de los profesionales, quienes deben cambiar el foco de individuo/enfermedad/cura para una atención holística, que promueva la salud de forma integral. Bajo este enfoque, se hacen necesarias alteraciones en los currículos de graduación en enfermería a partir de Proyectos Pedagógicos centrados en el alumno, proyectos estos que unan teoría y práctica, y que se adapten al perfil epidemiológico en el que están insertados. A pesar de los cambios ya realizados en la formación de los estudiantes, aún existen lagunas y retos por superarse. Conclusion: se hace hincapié en la importancia de la introducción precoz de contenidos acerca de la ESF en la formación de los enfermeros, con la finalidad de promocionarles una actuación dentro de esta perspectiva interdisciplinaria en el ámbito de SUS, consonante con las exigencias de este nuevo perfil de salud.(AU)