RESUMO
To date, hydroxyurea is the only effective and safe drug that significantly reduces morbidity and mortality of individuals with Sickle cell disease. Twenty years of real-life experience has demonstrated that hydroxyurea reduces pain attacks, vaso-occlusive events, including acute chest syndrome, the number and duration of hospitalizations and the need for transfusion. The therapeutic success of hydroxyurea is directly linked to access to the drug, the dose used and adherence to treatment which, in part, is correlated to the availability of hydroxyurea. This consensus aims to reduce the number of mandatory exams needed to access the drug, prioritizing the requesting physician's report, without affecting patient safety.
RESUMO
OBJETIVO: Avaliar o estado nutricional antropométrico de crianças e adolescentes com doença falciforme, atendidas em um hospital de pediatria no município do Rio de Janeiro. MÉTODOS: Trata-se de estudo descritivo transversal, com dados extraídos dos prontuários. Foram coletadas variáveis antropométricas, sociodemográficas, clínicas e hematológicas referentes à última consulta da criança no ano de 2006. RESULTADO: A amostra foi composta por 161 crianças e adolescentes. Dentre elas, 15,5 por cento apresentaram baixa estatura (estatura/idade <-2 escore-Z), e 5,7 por cento, magreza (índice de massa corporal/idade <-2 escore-Z). Crianças de baixo peso ao nascer e cujo responsável não vive com o companheiro apresentaram menor escore-Z para o índice altura/idade do que crianças de peso adequado ao nascimento (p=0,030) e cujo responsável vive com o companheiro (p=0,003). CONCLUSÃO: Crianças e adolescentes com doença falciforme apresentaram maior prevalência de baixa estatura e magreza em relação à população geral. Por outro lado, o baixo peso ao nascer e o fato de o responsável não viver com o companheiro foram fatores associados com a menor estatura da criança.
OBJECTIVE: This study assessed the anthropometric status of children and adolescents with sickle cell disease seen at a pediatric hospital in Rio de Janeiro county, Brazil. METHODS: This cross-sectional study collected data from medical records, which included anthropometric, sociodemographic, clinical, and hematological measurements from the last medical appointment in 2006. RESULTS: The study comprised 161 children and adolescents of which 15.5 percent were stunted (height-for-age <-2 Z-scores) and 5.7 percent were wasted (body mass index-for-age <-2 Z-scores). Children with low birth weight and those whose caregivers did not live with a partner had lower height-for-age Z-scores than children with appropriate birth weight (p=0.030) and those whose caregivers lived with a partner (p=0.003), respectively. CONCLUSION: Children and adolescents with sickle cell disease showed a higher prevalence of stunting and wasting than the general population, and low birth weight and caregivers who did not live with a partner were associated with smaller height.
