A GATE Monte Carlo framework for dosimetric evaluation in mammography in an Algerian hospital.

A framework has been developed for dosimetric evaluation in mammography, using the GATE Monte Carlo (MC) platform, to simulate a MAMMOMAT 3000 Nova mammograph (Siemens) available at the University Hospital Center "1st November 1954" of Oran (EHU Oran 1er Novembre, 1954), Algeria. Calculated quantities such half-value layer (HVL), Entrance Surface Dose (ESD) and Mean Glandular Dose (MGD) have been compared to experimental data in order to validate the modeling of mammography examinations. Results are consistent with previous studies and show a good agreement between measurements and Monte Carlo calculations. By varying the tube voltage from 25 to 35 kV, we have estimated an increasing of a factor of 2.4 in ESD, and a factor of 2.75 for the MGD in a breast phantom. Furthermore, the current intensity of 100 mAs used for a beam quality combination (Mo/Mo) Anode/filter was found suitable for the tube voltages of 25-29 keV since the MGD does not exceed the limits set by the different quality insurance protocols. This GATE dose calculation framework thus provides a very useful tool for the optimization of mammography examinations at Oran hospital by allowing a better estimation of the dose delivered to patients according to the parameters of the examination.

The OpenGATE ecosystem for Monte Carlo simulation in medical physics.

This paper reviews the ecosystem of GATE, an open-source Monte Carlo toolkit for medical physics. Based on the shoulders of Geant4, the principal modules (geometry, physics, scorers) are described with brief descriptions of some key concepts (Volume, Actors, Digitizer). The main source code repositories are detailed together with the automated compilation and tests processes (Continuous Integration). We then described how the OpenGATE collaboration managed the collaborative development of about one hundred developers during almost 20 years. The impact of GATE on medical physics and cancer research is then summarized, and examples of a few key applications are given. Finally, future development perspectives are indicated.

A GATE/Geant4 Monte Carlo toolkit for surface dose calculation in VMAT breast cancer radiotherapy.

The accuracy of superficial dose calculations for breast cancer treatments with Volumetric Modulated Arc Therapy (VMAT) is of major importance. For target volumes close to the surface, the inverse dosimetric planning can lead to very high fluences in the build-up region to properly cover the volume to be treated. Various radiotherapy modalities are currently used in parallel with additional protocols to enable a better control on the dose delivery (bolus, target volume margins). One of the difficulties currently facing medical physicists is the lack of available tools to test the impact of these different solutions on the superficial dose distribution. We present a new open source toolkit to assist medical physicists in evaluating the 3D distributions of superficial dose in VMAT breast cancer treatments. This tool is based on the GATE Monte Carlo software, a Geant4 application dedicated to medical physics. A set of macros has been developed to simulate in an easy way a full VMAT plan from the information available in the DICOM-RT files (image, plan, structure and dose). The toolkit has been tested on a 6 MV Varian NovalisTx™ accelerator. The paper presents a precise comparison of 3D surface dose distributions from experimental measurements (EBT3 films), TPS (Varian Eclipse) and Monte Carlo simulation (GATE). The comparison made it possible to highlight both the TPS biases for the surface dose calculation and the good performances of the developed toolkit. The simulation of surface dose distributions on a real patient has also been performed to illustrate the potential clinical applications.

Real-time detection of fast and thermal neutrons in radiotherapy with CMOS sensors.

The peripheral dose distribution is a growing concern for the improvement of new external radiation modalities. Secondary particles, especially photo-neutrons produced by the accelerator, irradiate the patient more than tens of centimeters away from the tumor volume. However the out-of-field dose is still not estimated accurately by the treatment planning softwares. This study demonstrates the possibility of using a specially designed CMOS sensor for fast and thermal neutron monitoring in radiotherapy. The 14 microns-thick sensitive layer and the integrated electronic chain of the CMOS are particularly suitable for real-time measurements in γ/n mixed fields. An experimental field size dependency of the fast neutron production rate, supported by Monte Carlo simulations and CR-39 data, has been observed. This dependency points out the potential benefits of a real-time monitoring of fast and thermal neutron during beam intensity modulated radiation therapies.

A method for determining Am-241 activity for large area contamination.

Airborne gamma-ray spectrometry system HELINUC™ is used for different missions. Although well-developed for estimation of high energy emitters' activity, it is rarely used for low energy emitters. A new method for the determination of Am-241 activity over extended sites based both on statistical analysis of spectra and deconvolution of Am-241 signal with a reference library is presented. Results show a lowering of the detection threshold and a good agreement with ground level measurements.

Study of different filtering techniques applied to spectra from airborne gamma spectrometry.

One of the features of the spectra obtained by airborne gamma spectrometry is the low counting statistics due to a short acquisition time (1 s) and a large source-detector distance (40 m) which leads to large statistical fluctuations. These fluctuations bring large uncertainty in radionuclide identification and determination of their respective activities from the window method recommended by the IAEA, especially for low-level radioactivity. Different types of filter could be used on spectra in order to remove these statistical fluctuations. The present work compares the results obtained with filters in terms of errors over the whole gamma energy range of the filtered spectra with the window method. These results are used to determine which filtering technique is the most suitable in combination with some method for total stripping of the spectrum.