1.
Bioorg Med Chem Lett
; 13(19): 3191-5, 2003 Oct 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12951091
RESUMO
Fluorinated trienoic acid analogues of the RXR selective modulator 1 (LG101506) were synthesized, and tested for their ability to bind RXRalpha and activate RXR homo and heterodimers. Potency and efficacy were observed to be dependent upon the position of fluorination, and improvement in pharmacological profile was demonstrated in some cases.