Candida auris in US Correctional Facilities.

Candida auris is an emerging fungal pathogen that typically affects patients in healthcare settings. Data on C. auris cases in correctional facilities are limited but are needed to guide public health recommendations. We describe cases and challenges of providing care for 13 patients who were transferred to correctional facilities during January 2020-December 2022 after having a positive C. auris specimen. All patients had positive specimens identified while receiving inpatient care at healthcare facilities in geographic areas with high C. auris prevalence. Correctional facilities reported challenges managing patients and implementing prevention measures; those challenges varied by whether patients were housed in prison medical units or general population units. Although rarely reported, C. auris cases in persons who are incarcerated may occur, particularly in persons with known risk factors. Measures to manage cases and prevent C. auris spread in correctional facilities should address setting-specific challenges in healthcare and nonhealthcare correctional environments.

Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration.

The pathophysiological mechanisms driving disease progression of frontotemporal lobar degeneration (FTLD) and corresponding biomarkers are not fully understood. We leveraged aptamer-based proteomics (> 4,000 proteins) to identify dysregulated communities of co-expressed cerebrospinal fluid proteins in 116 adults carrying autosomal dominant FTLD mutations (C9orf72, GRN, MAPT) compared to 39 noncarrier controls. Network analysis identified 31 protein co-expression modules. Proteomic signatures of genetic FTLD clinical severity included increased abundance of RNA splicing (particularly in C9orf72 and GRN) and extracellular matrix (particularly in MAPT) modules, as well as decreased abundance of synaptic/neuronal and autophagy modules. The generalizability of genetic FTLD proteomic signatures was tested and confirmed in independent cohorts of 1) sporadic progressive supranuclear palsy-Richardson syndrome and 2) frontotemporal dementia spectrum syndromes. Network-based proteomics hold promise for identifying replicable molecular pathways in adults living with FTLD. 'Hub' proteins driving co-expression of affected modules warrant further attention as candidate biomarkers and therapeutic targets.

Sensitivity of the African neuropsychology battery memory subtests and learning slopes in discriminating APOE 4 and amyloid pathology in adult individuals in the Democratic Republic of Congo.

Background: The current study examined the sensitivity of two memory subtests and their corresponding learning slope metrics derived from the African Neuropsychology Battery (ANB) to detect amyloid pathology and APOEε4 status in adults from Kinshasa, the Democratic Republic of the Congo. Methods: 85 participants were classified for the presence of ß-amyloid pathology and based on allelic presence of APOEε4 using Simoa. All participants were screened using CSID and AQ, underwent verbal and visuospatial memory testing from ANB, and provided blood samples for plasma Aß42, Aß40, and APOE proteotype. Pearson correlation, linear and logistic regression were conducted to compare amyloid pathology and APOEε4 status with derived learning scores, including initial learning, raw learning score, learning over trials, and learning ratio. Results: Our sample included 35 amyloid positive and 44 amyloid negative individuals as well as 42 without and 39 with APOEε4. All ROC AUC ranges for the prediction of amyloid pathology based on learning scores were low, ranging between 0.56-0.70 (95% CI ranging from 0.44-0.82). The sensitivity of all the scores ranged between 54.3-88.6, with some learning metrics demonstrating good sensitivity. Regarding APOEε4 prediction, all AUC values ranged between 0.60-0.69, with all sensitivity measures ranging between 53.8-89.7. There were minimal differences in the AUC values across learning slope metrics, largely due to the lack of ceiling effects in this sample. Discussion: This study demonstrates that some ANB memory subtests and learning slope metrics can discriminate those that are normal from those with amyloid pathology and those with and without APOEε4, consistent with findings reported in Western populations.

PKC Inhibition Improves Human Penile Vascular Function and the NO/cGMP Pathway in Diabetic Erectile Dysfunction: The Role of NADPH Oxidase.

Erectile dysfunction (ED) is a frequent and difficult-to-treat condition in diabetic men. Protein kinase C (PKC) is involved in diabetes-related vascular and cavernosal alterations. We aimed to evaluate the role of PKC in endothelial dysfunction and NO/cGMP impairment associated with diabetic ED in the human corpus cavernosum (CC) and penile resistance arteries (PRAs) and the potential mechanisms involved. Functional responses were determined in the CC and PRAs in patients with non-diabetic ED and diabetic ED undergoing penile prosthesis insertion. PKC activator 12,13-phorbol-dibutyrate (PDBu) impaired endothelial relaxations and cGMP generation in response to acetylcholine in the CC from non-diabetic ED. PDBu also impaired responses to a PDE5 inhibitor, sildenafil, in non-diabetic ED patients. Conversely, a PKC inhibitor, GF109203X, improved endothelial, neurogenic, and PDE5-inhibitor-induced relaxations and cGMP generation only in the CC in diabetic ED patients. Endothelial and PDE5-inhibitor-induced vasodilations of PRAs were potentiated only in diabetes. Improvements in endothelial function in diabetes were also achieved with a specific inhibitor of the PKCß2 isoform or an NADPH-oxidase inhibitor, apocynin, which prevented PDBu-induced impairment in non-diabetic patients. PKC inhibition counteracted NO/cGMP impairment and endothelial dysfunction in diabetes-related ED, potentially improving response to PDE5 inhibition.

Clinicopathological correlation of cerebrospinal fluid alpha-synuclein seed amplification assay in a behavioral neurology autopsy cohort.

INTRODUCTION: Lewy body disease (LBD) is a common primary or co-pathology in neurodegenerative syndromes. An alpha-synuclein seed amplification assay (αSyn-SAA) is clinically available, but clinical performance, especially lower sensitivity in amygdala-predominant cases, is not well understood. METHODS: Antemortem CSF from neuropathology-confirmed LBD cases was tested with αSyn-SAA (N = 56). Diagnostic performance and clinicopathological correlations were examined. RESULTS: Similar to prior reports, sensitivity was 100% for diffuse and transitional LBD (9/9), and overall specificity was 96.3% (26/27). Sensitivity was lower in amygdala-predominant (6/14, 42.8%) and brainstem-predominant LBD (1/6, 16.7%), but early spread outside these regions (without meeting criteria for higher stage) was more common in αSyn-SAA-positive cases (6/7, 85.7%) than negative (2/13, 15.4%). DISCUSSION: In this behavioral neurology cohort, αSyn-SAA had excellent diagnostic performance for cortical LBD. In amygdala- and brainstem-predominant cases, sensitivity was lower, but positivity was associated with anatomical spread, suggesting αSyn-SAA detects early LBD progression in these cohorts. HIGHLIGHTS: A cerebrospinal fluid alpha-synuclein assay detects cortical LBD with high sensitivity/specificity. Positivity in prodromal stages of LBD was associated with early cortical spread. The assay provides precision diagnosis of LBD that could support clinical trials. The assay can also identify LBD co-pathology, which may impact treatment responses.

TRITRIAL: The Impact of Fixed Triple Therapy with Beclometasone/Formoterol/Glycopyrronium on Health Status and Adherence in Chronic Obstructive Pulmonary Disease in an Italian Context of Real Life.

Purpose: The TRITRIAL study assessed the effects of beclometasone dipropionate/formoterol fumarate/glycopyrronium (BDP/FF/G) fixed combination in patients with chronic obstructive pulmonary disease (COPD) in a real-world setting, focusing on patient's experience and perspective through the use of patients reported outcomes. Patients and Methods: TRITRIAL was a multicenter, prospective, observational study conducted on patients with moderate-severe COPD treated with BDP/FF/G fixed therapy for 12 months. The main objective was to evaluate the impact of BDP/FF/G on health status through the COPD Assessment Test (CAT) score. Additional assessments included adherence and satisfaction, measured by the TAI-10/12 questionnaire and a specifically designed eight-item questionnaire, quality of life through the EQ-5D-5L test, sleep quality through the COPD and Asthma Sleep Impact Scale (CASIS), as well as safety and disease-related outcomes. Results: Data from 655 patients were analyzed in the study. The mean total CAT score significantly improved (from 22.8 at baseline to 18.1 at 6 months and 16.5 at 12 months; p < 0.0001), as well as all the eight CAT sub-items, which decreased on average by 0.5-0.9 points during the study. Adherence and usability of the inhaler also improved during the study, with a decrease in poor compliance (from 30.1% to 18.3%) and an increase in good compliance (from 51.8% to 58.3%) according to the TAI score. Patients also benefited from significantly improved quality of life (EQ Index from 0.70 to 0.80; EQ-5D VAS score from 55.1 to 63.1) and sleep quality (CASIS score from 41.1 to 31.8). Finally, patients reported a significant reduction in exacerbation during the study. Conclusion: TRITRIAL showed that the BDP/FF/G fixed combination is effective and safe in patients with moderate-severe COPD and poorly controlled disease, improving patients' HRQoL, sleep quality, adherence and inhaler usability and reducing COPD symptoms and the risk of exacerbation in a real-life setting.

Study protocol: Project 2VIDA! SARS-CoV-2 vaccine intervention delivery for adults in Southern California.

Background: To date, the United States (US) leads the world in the number of infections and deaths due to the Coronavirus Disease 2019 (COVID-19). Racial and ethnic disparities in COVID-19 morbidity and mortality are staggering. Age-adjusted data show that AA and Latino individuals have had higher rates of death over most of the pandemic and during surges. Project 2VIDA! is community-based participatory research (CBPR) that was developed to address individual, social, and contextual factors related to access and acceptance of the COVID-19 vaccine among African American and Latino communities in Southern California. This paper describes the study protocol and overarching objectives. Methods and design: Project 2VIDA! is a multilevel intervention that builds on the principals of CBPR and is designed to increase uptake of the COVID-19 vaccine among African American and Latino individuals (≥16 years and older) in San Diego County. The intervention was developed with a working group comprised of representatives from community and academia and centers on targeted COVID-19 individual awareness and education, linkage to medical and supportive services, COVID-19 community outreach and health promotion and offering the COVID-19 vaccine through community pop-up clinics. Discussion: Findings from 2VIDA! will provide data on the impact, feasibility, and acceptability of the intervention which are all crucial for the adaptation, refinement, and improvement of vaccine outreach interventions for COVID-19 and other vaccine preventable infectious diseases that severely impact African American and Latino communities. Clinical trial registration: https://clinicaltrials.gov/ct2/show/NCT05022472?term=Project+2VIDA&draw=2&rank=1, NCT05022472.

Community based participatory research as a promising practice for addressing vaccine hesitancy, rebuilding trust and addressing health disparities among racial and ethnic minority communities.

The COVID-19 pandemic disproportionately affected racial and ethnic minority communities across the United States (U.S.). Despite the disproportionate burden of COVID-19 faced by communities of color, Black and Hispanic communities are less likely to be fully vaccinated than White non-Hispanic Persons. Health inequity and vaccine hesitancy are complex phenomena that require multilevel responses tailored to the unique needs of each community, a process that inherently necessitates a high level of community engagement in order to develop the most effective health interventions. Building on the principles of community based participatory research (CBPR) and with the support of the National Institutes of Health (NIH), Project 2VIDA! was born. A multidisciplinary collaborative of academic researchers, community members, and clinicians whose aim is to foster sustainable partnerships to reduce the burden of COVID-19 in Hispanic and Black communities across Southern California. Our model was designed to meet our community members where they were - whether on their lunch break or picking their children from school. This CBPR model has been well received by community members. Future health interventions focused on reducing health disparities should prioritize the role of the community, leverage the voices of key community partners, and be grounded in equitable power sharing.

Alterations in Lysosomal, Glial and Neurodegenerative Biomarkers in Patients with Sporadic and Genetic Forms of Frontotemporal Dementia.

Background: Frontotemporal dementia (FTD) is the most common cause of early-onset dementia with 10-20% of cases caused by mutations in one of three genes: GRN, C9orf72, or MAPT. To effectively develop therapeutics for FTD, the identification and characterization of biomarkers to understand disease pathogenesis and evaluate the impact of specific therapeutic strategies on the target biology as well as the underlying disease pathology are essential. Moreover, tracking the longitudinal changes of these biomarkers throughout disease progression is crucial to discern their correlation with clinical manifestations for potential prognostic usage. Methods: We conducted a comprehensive investigation of biomarkers indicative of lysosomal biology, glial cell activation, synaptic and neuronal health in cerebrospinal fluid (CSF) and plasma from non-carrier controls, sporadic FTD (symptomatic non-carriers) and symptomatic carriers of mutations in GRN, C9orf72, or MAPT, as well as asymptomatic GRN mutation carriers. We also assessed the longitudinal changes of biomarkers in GRN mutation carriers. Furthermore, we examined biomarker levels in disease impacted brain regions including middle temporal gyrus (MTG) and superior frontal gyrus (SFG) and disease-unaffected inferior occipital gyrus (IOG) from sporadic FTD and symptomatic GRN carriers. Results: We confirmed glucosylsphingosine (GlcSph), a lysosomal biomarker regulated by progranulin, was elevated in the plasma from GRN mutation carriers, both symptomatic and asymptomatic. GlcSph and other lysosomal biomarkers such as ganglioside GM2 and globoside GB3 were increased in the disease affected SFG and MTG regions from sporadic FTD and symptomatic GRN mutation carriers, but not in the IOG, compared to the same brain regions from controls. The glial biomarkers GFAP in plasma and YKL40 in CSF were elevated in asymptomatic GRN carriers, and all symptomatic groups, except the symptomatic C9orf72 mutation group. YKL40 was also increased in SFG and MTG regions from sporadic FTD and symptomatic GRN mutation carriers. Neuronal injury and degeneration biomarkers NfL in CSF and plasma, and UCHL1 in CSF were elevated in patients with all forms of FTD. Synaptic biomarkers NPTXR, NPTX1/2, and VGF were reduced in CSF from patients with all forms of FTD, with the most pronounced reductions observed in symptomatic MAPT mutation carriers. Furthermore, we demonstrated plasma NfL was significantly positively correlated with disease severity as measured by CDR+NACC FTLD SB in genetic forms of FTD and CSF NPTXR was significantly negatively correlated with CDR+NACC FTLD SB in symptomatic GRN and MAPT mutation carriers. Conclusions: In conclusion, our comprehensive investigation replicated alterations in biofluid biomarkers indicative of lysosomal function, glial activation, synaptic and neuronal health across sporadic and genetic forms of FTD and unveiled novel insights into the dysregulation of these biomarkers within brain tissues from patients with GRN mutations. The observed correlations between biomarkers and disease severity open promising avenues for prognostic applications and for indicators of drug efficacy in clinical trials. Our data also implicated a complicated relationship between biofluid and tissue biomarker changes and future investigations should delve into the mechanistic underpinnings of these biomarkers, which will serve as a foundation for the development of targeted therapeutics for FTD.

Extensively Drug-Resistant Pseudomonas aeruginosa Outbreak associated with Artificial Tears.

BACKGROUND: Carbapenemase-producing, carbapenem-resistant Pseudomonas aeruginosa (CP-CRPA) are extensively drug resistant bacteria. We investigated the source of a multistate CP-CRPA outbreak. METHODS: Cases were defined as a U.S. patient's first isolation of P. aeruginosa sequence type 1203 with the carbapenemase gene blaVIM-80 and cephalosporinase gene blaGES-9 from any specimen source collected and reported to CDC between January 1, 2022-May 15, 2023. We conducted a 1:1 matched case-control study at the post-acute care facility with the most cases, assessed exposures associated with case status for all case-patients, and tested products for bacterial contamination. RESULTS: We identified 81 case-patients from 18 states, 27 of whom were identified through surveillance cultures. Four (7%) of 54 case-patients with clinical cultures died within 30 days of culture collection, and four (22%) of 18 with eye infections underwent enucleation. In the case-control study, case-patients had increased odds of receiving artificial tears compared to controls (crude matched OR: 5.0, 95% CI: 1.1, 22.8). Overall, artificial tears use was reported by 61 (87%) of 70 case-patients with information; 43 (77%) of 56 case-patients with brand information reported use of Brand A, an imported, preservative-free, over-the-counter (OTC) product. Bacteria isolated from opened and unopened bottles of Brand A were genetically related to patient isolates. FDA inspection of the manufacturing plant identified likely sources of contamination. CONCLUSIONS: A manufactured medical product serving as the vehicle for carbapenemase-producing organisms is unprecedented in the U.S. The clinical impacts from this outbreak underscore the need for improved requirements for U.S. OTC product importers.

Scalable plasma and digital cognitive markers for diagnosis and prognosis of Alzheimer's disease and related dementias.

INTRODUCTION: With emergence of disease-modifying therapies, efficient diagnostic pathways are critically needed to identify treatment candidates, evaluate disease severity, and support prognosis. A combination of plasma biomarkers and brief digital cognitive assessments could provide a scalable alternative to current diagnostic work-up. METHODS: We examined the accuracy of plasma biomarkers and a 10-minute supervised tablet-based cognitive assessment (Tablet-based Cognitive Assessment Tool Brain Health Assessment [TabCAT-BHA]) in predicting amyloid ß positive (Aß+) status on positron emission tomography (PET), concurrent disease severity, and functional decline in 309 older adults with subjective cognitive impairment (n = 49), mild cognitive impairment (n = 159), and dementia (n = 101). RESULTS: Combination of plasma pTau181, Aß42/40, neurofilament light (NfL), and TabCAT-BHA was optimal for predicting Aß-PET positivity (AUC = 0.962). Whereas NfL and TabCAT-BHA optimally predicted concurrent disease severity, combining these with pTau181 and glial fibrillary acidic protein was most accurate in predicting functional decline. DISCUSSION: Combinations of plasma and digital cognitive markers show promise for scalable diagnosis and prognosis of ADRD. HIGHLIGHTS: The need for cost-efficient diagnostic and prognostic markers of AD is urgent. Plasma and digital cognitive markers provide complementary diagnostic contributions. Combination of these markers holds promise for scalable diagnosis and prognosis. Future validation in community cohorts is needed to inform clinical implementation.

Plasma phosphorylated tau-217 exhibits sex-specific prognostication of cognitive decline and brain atrophy in cognitively unimpaired adults.

INTRODUCTION: Accumulating evidence indicates disproportionate tau burden and tau-related clinical progression in females. However, sex differences in plasma phosphorylated tau (p-tau)217 prediction of subclinical cognitive and brain changes are unknown. METHODS: We measured baseline plasma p-tau217, glial fibrillary acidic protein (GFAP), and neurofilament light (NfL) in 163 participants (85 cognitively unimpaired [CU], 78 mild cognitive impairment [MCI]). In CU, linear mixed effects models examined sex differences in plasma biomarker prediction of longitudinal domain-specific cognitive decline and brain atrophy. Cognitive models were repeated in MCI. RESULTS: In CU females, baseline plasma p-tau217 predicted verbal memory and medial temporal lobe trajectories such that trajectories significantly declined once p-tau217 concentrations surpassed 0.053 pg/ml, a threshold that corresponded to early levels of cortical amyloid aggregation in secondary amyloid positron emission tomography analyses. CU males exhibited similar rates of cognitive decline and brain atrophy, but these trajectories were not dependent on plasma p-tau217. Plasma GFAP and NfL exhibited similar female-specific prediction of medial temporal lobe atrophy in CU. Plasma p-tau217 exhibited comparable prediction of cognitive decline across sex in MCI. DISCUSSION: Plasma p-tau217 may capture earlier Alzheimer's disease (AD)-related cognitive and brain atrophy hallmarks in females compared to males, possibly reflective of increased susceptibility to AD pathophysiology.

Structural, Microstructural and Compositional Changes of the AISI 314 Steel Used in the Sintering Furnace Belt Depending on the Operating Time.

The damage due to embrittlement of the sintering furnace belt and its replacement after a certain time of use represents a problem for the manufacturers of sintered parts. Finding out the reason for the damage could help to increase the duration of its operation. This research aimed to investigate the causes of embrittlement, considering both the temperatures and atmosphere of the sintering furnace to which the furnace belt is exposed during its operation. The furnace belt was made of AISI 314 stainless steel. Optical microscopy, scanning electron microscopy, combined with energy-dispersive X-ray analysis, X-ray diffraction and the Vickers hardness tests were used to analyze the microstructural, structural, compositional and hardness changes of the belt used for 45 weeks. Cr and Mn carbides, the oxides of Fe, Cr, Mn and Si were found to form at the edge of the furnace belt. The grains grew after 45 weeks of use, approximately 10 times, due to thermal cycles in an endothermic gas atmosphere to which the belt was exposed. Also, the hardness increased from 226 to 338 HV0.05, due to the formation of carbide and oxide-type compounds. All these results represent a starting point in optimizing the lifetime of the sintering furnace belt.

Emerging Zoonotic Diseases among Pastoral Communities of Caia and Búzi Districts, Sofala, Mozambique: Evidence of Antibodies against Brucella, Leptospira, Rickettsia, and Crimean-Congo Hemorrhagic Fever Virus

Emerging zoonotic diseases are an increasing threat to public health. There is little data on the seroprevalence of zoonotic diseases among pastoralists in the country. We aim to carry out a cross-sectional study on the prevalence of major zoonotic diseases among pastoral communities in the Caia and Búzi districts. Methods: Between January and December 2018, a questionnaire was used to solicit socio-demographic data from consenting pastoralists with the collection of blood samples in the Caia and Búzi districts of the Sofala province. All samples were tested using ELISA commercial reagents for the detection of IgM antibodies against Brucella and Leptospira. Likewise, IgM and IgG antibodies against Rickettsia and CCHFV were determined using ELISA kits. Results: A total of 218 samples were tested, of which 43.5% (95/218) were from the district of Caia and 56.4% (123/218) from the Búzi district. Results from both districts showed that the seroprevalence of IgM antibodies against Brucella and Leptospira was 2.7% (6/218) and 30.3% (67/218), respectively. Positivity rates for IgM and IgG anti-Rickettsia and CCHFV were 8.7% (19/218), 2.7% (6/218), 4.1% (9/218), and 0.9% (2/218), respectively. Conclusions: Results from our study showed evidence of antibodies due to exposure to Brucella, Leptospira, Rickettsia, and CCHFV with antibodies against Leptospira and Rickettsia being the most prevalent. Hence, laboratory diagnosis of zoonotic diseases is essential in the early detection of outbreaks, the identification of silent transmission, and the etiology of non-febrile illness in a pastoral community. There is a need to develop public health interventions that will reduce the risk of transmission.

Emerging Zoonotic Diseases among Pastoral Communities of Caia and Búzi Districts, Sofala, Mozambique: Evidence of Antibodies against Brucella, Leptospira, Rickettsia, and Crimean-Congo Hemorrhagic Fever Virus.

BACKGROUND: Emerging zoonotic diseases are an increasing threat to public health. There is little data on the seroprevalence of zoonotic diseases among pastoralists in the country. We aim to carry out a cross-sectional study on the prevalence of major zoonotic diseases among pastoral communities in the Caia and Búzi districts. METHODS: Between January and December 2018, a questionnaire was used to solicit socio-demographic data from consenting pastoralists with the collection of blood samples in the Caia and Búzi districts of the Sofala province. All samples were tested using ELISA commercial reagents for the detection of IgM antibodies against Brucella and Leptospira. Likewise, IgM and IgG antibodies against Rickettsia and CCHFV were determined using ELISA kits. RESULTS: A total of 218 samples were tested, of which 43.5% (95/218) were from the district of Caia and 56.4% (123/218) from the Búzi district. Results from both districts showed that the seroprevalence of IgM antibodies against Brucella and Leptospira was 2.7% (6/218) and 30.3% (67/218), respectively. Positivity rates for IgM and IgG anti-Rickettsia and CCHFV were 8.7% (19/218), 2.7% (6/218), 4.1% (9/218), and 0.9% (2/218), respectively. CONCLUSIONS: Results from our study showed evidence of antibodies due to exposure to Brucella, Leptospira, Rickettsia, and CCHFV with antibodies against Leptospira and Rickettsia being the most prevalent. Hence, laboratory diagnosis of zoonotic diseases is essential in the early detection of outbreaks, the identification of silent transmission, and the etiology of non-febrile illness in a pastoral community. There is a need to develop public health interventions that will reduce the risk of transmission.

Salud mental / Repertorios 6. Perspectivas y debates en clave de Derechos Humanos / Mental Health / Repertoires Collection Human Rights Perspectives and Debates

Contiene: Prólogo / Horacio Pietragalla Corti; Introducción /Leonardo Gorbacz y Adelqui Del Do; Eje 1: Consecuencias psicológicas del terrorismo de Estado; Pensar el dispositivo de la crueldad: la encerrona trágica en situaciones de tortura y exclusión social / Fernando Ulloa; El método de desaparición forzada y los juicios de lesa humanidad. Diálogo entre la dimensión jurídica y la dimensión subjetiva. Especificidades del caso argentino / Mariana Wikinski, Mariana Biaggio, Rosa Matilde Díaz Jiménez y Marcelo Marmer; Salud Mental del Centro de Estudios Legales y Sociales (CELS); Las dimensiones del trauma. Reflexiones desde la experiencia argentina / Julieta Calmels; Memoria y verdad. Los juicios como rito restitutivo / Fabiana Rousseaux; Historia, Memoria y Filiación: la apropiación de niños como política del terror de Estado y los procesos actuales de restitución de identidad / Alicia Stolkiner; La práctica psicoanalítica en el "Centro de atención por el derecho a la identidad de Abuelas de Plaza de Mayo" / Alicia Lo Giúdice; Anexo. Protocolo de Intervención para el Tratamiento de Víctimas­Testigos en el marco de procesos judiciales / Secretaría de Derechos Humanos; Eje 2: Salud mental, violencias y derechos humanos; Diagnósticos, fármacos y mujeres internadas en un hospital neuropsiquiátrico / Eugenia Bianchi y Macarena Sabin Paz; El acompañamiento a víctimas durante el proceso de justicia. Reflexiones desde la experiencia / Laura Sobredo; Presentación ante Comité sobre los Derechos de las Personas con Discapacidad. Organización Naciones Unidas / Julieta Calmels (Ministerio de Salud de la provincia de Buenos Aires); Inimputabilidad y medidas de seguridad a la luz de los estándares del Derecho Internacional de los Derechos Humanos / Dirección Nacional de Protección de Grupos en Situación de Vulnerabilidad, Secretaría de Derechos Humanos de la Nación; Anexo I. Derechos de personas usuarias de servicios de salud mental. Preguntas frecuentes / Dirección Nacional de Protección de Grupos en Situación de Vulnerabilidad, Secretaría de Derechos Humanos de la Nación; Anexo II. Protocolo de abordaje integral a víctimas de violencia institucional / Centro de Estudios Legales y Sociales (CELS)

CONGRESO ARGENTINO DE NUTRICIÓN / ARGENTINE NUTRITION CONGRESS

0006 PERFIL CLÍNICO EN PACIENTES INGRESADOS POR INFARTO AGUDO DE MIOCARDIO. Autor: CABRERA, F. 0008 EFECTO DE LA SUPLEMENTACIÓN CON ACEITE DE AVESTRUZ EN EL PRONÓSTICO DEL COVID-19: ESTUDIO OBSERVACIONAL. Autores: ATAIDE R; CARDOZO L; APARECIDA PEIXOTO FERRO K; GREGÓRIO TROCZINSKI DE SOUZA M; MARQUES MACHADO DO AMARAL A. 0011 - INFOALIMENTOS, UN PROYECTO QUE BUSCA MEJORAR EL DIÁLOGO ENTRE LA COMUNIDAD CIENTÍFICA Y LA SOCIEDAD. Autores: DURAND V F; SCHRAIER S D; RUBINSTEIN C; LEVITUS G. 0013- "ENTORNOS ESCOLARES SALUDABLES". Autores: GARCÍA É; LEIBIKER L; PEREZ, C. 0042 - ESTRATEGIAS PRÁCTICAS PARA MANTENER UNA ALIMENTACIÓN SALUDABLE: EXPERIENCIA DE INTERVENCIÓN COMUNITARIA EN FAMILIAS DE LA COMUNA DE QUILPUÉ, REGIÓN DE VALPARAÍSO. CHILE. Autores: PARRA V; NAVARRO F; JARA G. 0043 - IMPORTANCIA DE LA IDENTIFICACIÓN DE FACTORES MOTIVACIONALES Y EXPECTATIVAS DE LOS PACIENTES QUE OPTAN POR UNA CIRUGÍA BARIÁTRICA EN LA CIUDAD DE SANTIAGO DEL ESTERO, ARGENTINA. Autor: DÍAZ FERNÁNDEZ A N. 0055 - PRÁCTICAS ALIMENTARIAS SOBRE CONSUMO DE SODIO/SAL Y ALIMENTOS ENVASADOS EN LA POBLACIÓN DOCENTE Y NO DOCENTE DE LA UNIVERSIDAD NACIONAL DEL CHACO AUSTRAL. Autores: AMBROGGIO V; VARELA N; POLISCHUK T; PROTASOVICKI P; LLANES I; OSUNA M. 0066 - INGESTA DE AZÚCARES AGREGADOS EN PACIENTES DISPÉPTICOS Y VOLUNTARIOS ASINTOMÁTICOS. Autores: MARCHESI OLID L S; MANTERO P; DRESSL N L; Zubillaga M; JANJETIC M; GOLDMAN CG. 0078 - GUIA NUTRICIONAL MATERNO INFANTIL Y DEL ADOLESCENTE, ADAPATADA POR NUTRICIONISTAS FORMOSEÑOS - ALIMENTACION E INTERCULTURALIDAD. Autores: ROJAS MM; BENITEZ NM. A; DISTEL DM; OLGUIN L; CAÑETE I B; AQUINO THOMPSON M G; TEJADA T; VERA S I; FERCH M O; PALACIOS A. 0087 - PERCEPCIÓN DE LOS ESTUDIANTES DE LA LICENCIATURA EN KINESIOLOGÍA Y FISIATRÍA ACERCA DE LA IMPORTANCIA DE LOS CONTENIDOS DE QUÍMICA BIOLÓGICA I EN LA EVALUACIÓN DE SUS HÁBITOS ALIMENTICIOS Y EN LA FORMACIÓN DE PROFESIONALES RESPONSABLES EN LA PROMOCIÓN DE ESTILOS DE VIDA SALUDABLE. Autores: BARROS N E; LUGANO MC; BIANCARDI ME; RIGO E; COBOS M. 0099 "DETERIORO COGNITIVO Y ASPECTOS NUTRICIONALES. INVESTIGACIÓN E INTERVENCIONES PARA LA PREVENCIÓN Y PROMOCIÓN DE LA SALUD EN PERSONAS MAYORES". Autor: BANFI A. 0107 OBSTÁCULOS Y DIFICULTADES PARA EL DESCENSO DE PESO PERCIBIDOS POR LAS PERSONAS CON OBESIDAD Y DIABETES. Autores: RUSSO M P; ARMENGOL C; BARONE M; BERTOCCHI M; SOTO TUPA P; URBIETA N; WAIJER María C; SY A. 0116 - ÍNDICE DE CINTURA TALLA VERSUS ÍNDICE DE MASA CORPORAL, COMO INDICADOR DE OBESIDAD Y SU POSIBLE UTILIDAD PARA INDICAR CIRUGÍA METABÓLICA. Autor: NACUL S. 0129 -HIPERTRIGLICERIDEMIA SEVERA SECUNDARIA AL TRATAMIENTO CON ASPARAGINASA: CASO CLÍNICO. Autores: GAONA TORRES A M; CAUTIVO FLORES A K; VERA F; CARBAJAL K; JOUBERT B; GHEZZI N; FERNANDEZ S; RIVERA S; QUEVEDO María Del Pilar; FRECHTEL G D.0131 TELEMEDICINA Y ACCESIBILIDAD. Autores: TARTAGIONE J Ig; LEWIS L; DEGENNARO V; VICTORIA PINTOS Y; SCHRAIER S D; LEDESMA SOLAECHE, F M; COPPOLILLO F E. 0136 - PLANES ALIMENTARIOS ADAPTADOS A PATOLOGÍAS EN EL PROGRAMA DE ASISTENCIA INTEGRAL DE CÓRDOBA (P.A.I.COR.).BERNAL M J; BONARDI VILA M J ;BRUNELLO D; FERNANDEZ MV; MONTAÑANA SS; OLIVERA S; TORRES V O. 0140 ANÁLISIS DE LA COMPOSICIÓN NUTRICIONAL DEL ACEITE DE AVESTRUZ Y SU APLICABILIDAD EN EL DEPORTE. Autores: CARDOZO L; SOUZA F H; COUTINHO D. 0146- CAMBIOS DE HÁBITOS ALIMENTARIOS EN EMBARAZADAS CON DIABETES POSTERIOR A INTERVENCIÓN EDUCATIVA. Autores: DE LA VEGA VM; VERA I; OSUNA F; ARIAS V; MONTENEGRO Al; AQUINO A ;RAMIREZ M, GUTIERREZ JP; ELGART J; GORBAN DE LAPERTOSA SB. 0148 -APORTE NUTRICIONAL DE PRODUCTOS DESTINADOS A LA ALIMENTACIÓN VEGETARIANA COMPARADO CON SU REFERENTE EN LA ALIMENTACIÓN OMNÍVORA. Autores: BATISTA M L; RODRIGUEZ V; CASTROMÁN J; DE LA CASA L; BINAGHI M J; GRECO CB; DYNER L. 0150 - EXPOSICIÓN A REDES SOCIALES: ¿FACTOR DE RIESGO PARA TRASTORNOS ALIMENTARIOS?. Autores: MURAWSKI BM ; SALABERRY P; ARMATTA A M.0151- DESARROLLO DE UN COMPLEMENTO ALIMENTARIO PARA LA HIPERTROFIA MUSCULAR A PARTIR DE CARNE DE AVESTRUZ (STRUTHIO CAMELUS) Y TRIBULUS TERRESTRIS. Autores: CARDOZO L; SOUZA F H; GUSTAVO KLEIN CAMARGO D ; CUSTÓDIO FINFA M; FREITAS ARAÚJO M; ZANDONADI MENEGUELLI A.0163 - LA DIETA BAJA EN FÓSFORO EN PACIENTES CON ENFERMEDAD RENAL CRÓNICA: UNO DE LOS PILARES DEL TRATAMIENTO JUNTO AL USO DE QUELANTES DE FÓSFORO. Autor: FRANCO M.0170 - ESTUDIO DE HÁBITOS ALIMENTARIOS EN FAMILIAS TITULARES DE DERECHO CON ASISTENCIA ALIMENTARIA EN EL CHACO SALTEÑO - 2023. Autores: GOMEZ AUGIER M V; CAPPELEN L C; CEJAS REY V C.0172 - ANÁLISIS DEL VALOR NUTRICIONAL, MICROBIOLÓGICO Y SENSORIAL DE LA CARNE DE AVESTRUZ DESHIDRATADA. Autores: CARDOZO L; VENTURI I; COELHO K C.0179 - EVALUACIÓN DEL POTENCIAL NUTRICIONAL, LOS COMPUESTOS BIOACTIVOS Y LA ACTIVIDAD ANTIOXIDANTE DEL ACEITE DE AVESTRUZ (OSTRICH OIL). Autores: CARDOZO L; SOUZA F H; VENTURI I. 0184 - IMPLEMENTACIÓN DE LA CALOSTROTERAPIA EN UNA UCIN DE UN HOSPITAL DEL INTERIOR DE CÓRDOBA. Autor: BONETTO Ivana

Emergence of optrA-mediated linezolid resistance in clinical isolates of Enterococcus faecalis from Argentina.

OBJECTIVES: The aim of this study was to characterize the first 14 optrA-carrying linezolid resistant E. faecalis clinical isolates recovered in seven Argentinian hospitals between 2016 and 2021. The epidemiology of optrA-carrying isolates and the optrA genetic context were determined. METHODS: The isolates were phenotypically and genotypically characterized. Susceptibility to 13 antimicrobial agents was performed; clonal relationship was assessed by pulsed field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). Data provided by the whole-genome sequencing were used for identification of sequence types, antimicrobial resistance genes, optrA variants, phylogenetic tree, and mobile genetic elements responsible to the dissemination of these strains. RESULTS: All the optrA-carrying E. faecalis isolates were multidrug-resistant and harboured several antimicrobial resistance genes. They carried three optrA variants and belonged to different lineages; however, three of them belonged to the hyperepidemic CC16. Mobile genetic elements were detected in all the isolates. The analysis of the optrA flanking region suggests the plasmidic localization in most of the isolates. CONCLUSIONS: To the best of our knowledge, this is the first report of optrA-mediated linezolid resistance in Argentina. The emergence and dissemination of the optrA genes in clinical E. faecalis isolates are of concern and highlights the importance of initiating the antimicrobial surveillance of Enterococcus spp. under a One Health strategy.

Impact of COVID-19 on Dental Practices in El Salvador and Mexico: A Comprehensive Survey Analysis.

BACKGROUND AND OBJECTIVES: This study aimed to identify the relationship between prevention measures and protective barriers in dental practice in El Salvador and Mexico during the COVID-19 pandemic in 2020 and 2021. MATERIALS AND METHODS: A longitudinal study was conducted from June 2020 to December 2021, involving 1,719 dentists divided into four groups based on location and year. A 20-question survey in Spanish was utilized and validated with a Cronbach's alpha value of 0.84. RESULTS: The use of phone triage (OR = 1.3), thermometers (OR = 1.4), physical distancing (OR = 1.7), and face shields (OR = 2.6) was significantly associated with dental practice in both countries during the pandemic. CONCLUSIONS: During 2020 and 2021, dental care in El Salvador and Mexico was significantly linked to COVID-19 preventive measures. Phone triage, thermometers, distancing, and face shields positively correlated with dental services. National health agencies should promote the use of minimum preventive measures in dental care, preparing for potential reinfections or new pandemics from emerging virus variants.