RESUMO
AIMS: Chronic primary mitral regurgitation (MR) results in enhanced filling of the left ventricle (LV) during early diastole. Filling is impaired with the onset of LV systolic dysfunction, due to increased myocardial stiffness and reduced restoring forces. We investigated echocardiographic parameters of early diastolic function in relation to LV systolic function. METHODS AND RESULTS: Early diastolic transmitral flow and tissue Doppler velocities, propagation velocity of early filling (V(p)), and early diastolic strain rates (SR-E) were measured in 30 patients with chronic degenerative MR and 30 age-matched controls. MR subjects were further subdivided into group 1 (14 subjects) if they had well compensated LV, and group 2 (16 subjects) if they had one or more of the following: functional limitation (> NYHA class I), LV end-systolic diameter >or=4.0 cm, and LV ejection fraction Assuntos
Ecocardiografia Doppler/instrumentação
, Ventrículos do Coração/patologia
, Insuficiência da Valva Mitral/patologia
, Miocárdio/patologia
, Disfunção Ventricular Esquerda/patologia
, Idoso
, Análise de Variância
, Biomarcadores
, Estudos de Casos e Controles
, Doença Crônica
, Diástole
, Feminino
, Ventrículos do Coração/diagnóstico por imagem
, Humanos
, Masculino
, Insuficiência da Valva Mitral/diagnóstico por imagem
, Estatística como Assunto
, Estatísticas não Paramétricas
, Sístole
, Fatores de Tempo
, Disfunção Ventricular Esquerda/diagnóstico por imagem