RESUMO
The mastocytosis form a group of complaints characterized by the accumulation of mast cell. Systemic mastocytosis is diagnoses when there are one or more organ or tissues affected, independent of their localization in the skin. Bone mastocytosis affects between 70-90% of the patients suffering from systemic mastocytosis and lacks common diagnostic criteria. The most characteristic finds of bone mastocytosis, collected from 213 cases published in the universal literature over the last 20 years will be discussed. The results which, were found in relation to clinical, analytical, radiological and anatomophatological variables, aimed at the diagnosis of systemic mastocytosis and indispensable for the diagnosis of bone mastocytosis will be commented upon. Compiling this data the publications about mastocytosis between 1977 and 1997 have been revised, choosing those in which complaints of radiologic bone could be found.
Assuntos
Doenças Ósseas/diagnóstico , Mastocitose/diagnóstico , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
Las mastocitosis constituyen un grupo de afecciones caracterizadas por la acumulación de mastocitos. La mastocitosis sistémica se diagnostica cuando aparece afectación de una o más vísceras o tejidos, con independencia de la localización cutánea. La mastocitosis ósea afecta a un 70-90 por ciento de pacientes con mastocitosis sistémica y carece de criterios diagnósticos consensuados. Se exponen los hallazgos más característicos de la mastocitosis ósea recogidos en 213 casos publicados en los últimos 20 años en la literatura universal. Se comentan los resultados encontrados en relación con variables clínicas, analíticas, radiológicas y anatomopatológicas, orientadas al diagnóstico de la mastocitosis sistémica e imprescindibles para el de mastocitosis ósea. Para conseguir estos datos se han revisado las publicaciones sobre mastocitosis entre 1977-97, seleccionando aquellas en las que aparecía afectación ósea radiológica (AU)
Assuntos
Adulto , Idoso , Feminino , Masculino , Pessoa de Meia-Idade , Idoso de 80 Anos ou mais , Humanos , Doenças Ósseas , Mastocitose , Doenças Ósseas/diagnóstico , Mastocitose/diagnósticoRESUMO
BACKGROUND: To assess the usefulness of an enzyme immuno-assay test for the diagnosis of two familial outbreaks of Fasciola hepatica parasitosis in the Zamora area, where watercress are a normal part of the diet. PATIENTS AND METHODS: The microbiological diagnosis of two familial outbreaks of fascioliasis was analyzed, which included the search for eggs in feces by the Kato technique and two serologic tests, one screening test by indirect hemagglutination, and a confirmatory test by enzyme-immunoassay in 12 patients. RESULTS: Five out of the six seropositive patients had eggs detected in their feces. To note that two of the patients with eosinophilia that excreted eggs--one asymptomatic and the other with abdominal pain--had a positive result in the EIA test only and with high titers. CONCLUSIONS: The EIA test is useful for the diagnosis and study of fascioliasis outbreaks to interpret the significance of low titers in the screening test in patients with eosinophilia.
Assuntos
Fasciolíase/diagnóstico , Adolescente , Adulto , Idoso , Criança , Surtos de Doenças , Saúde da Família , Fasciolíase/epidemiologia , Fezes/parasitologia , Feminino , Humanos , Técnicas Imunoenzimáticas , Masculino , Pessoa de Meia-Idade , Testes SorológicosRESUMO
BACKGROUND: Some paramyxovirus (measles, respiratory syncytial virus, and dog's distemper virus) are currently considered to be responsible for Paget's disease of the bone. A relevant role is also given to inheritance as predisposing factor. Some authors have found an association between HLA antigens with this disease, but without unanimous agreement. Although this hypothesis of an interaction between a genetic factor and a viral infectious agent is the most accepted universally, there is not yet a definitive cause for the disease. The participation of some other environmental factors has not been ruled out. METHODS: One hundred and forty patients in the Zamora province were studied. The geographic distribution in the different areas of the province was analyzed and also whether there was family aggregation all cases. HLA-I was determined in 59 patients and HLA-II in cases with aggregation. The mineral composition (calcium, fluorine, magnesium, nitrates, and chlorine) analysis of public running water was carried out in all population centers in the province. RESULTS: Aggregation was found in four families (four, two, four, and three siblings, respectively). Although HLA-I antigens were determined in 59 patients, no association was found. HLA-II antigens were also determined in the involved patients with family links and no association was found between these antigens and the disease. A much higher aggregation was found in some particular areas in our province and these foci coincided with some characteristics of mineral composition of public running waters. CONCLUSIONS: There is a genetic factor predisposing to the disease, as family aggregation occurs with a higher frequency than would otherwise be expected. Nevertheless, no association with HLA antigens was found. This disease is more common in some particular geographic areas, thus supporting the hypothesis of an environmental factor as trigger. An association was found between mineral composition of public running waters and patient geographic distribution.