RESUMO
The distribution of polymorphic variants of innate immunity genes TLR9 (+2848G>A) and DEFB1(-20G>A; -44C>G; -52G>A) was evaluated in long-living individuals. No significant differences were found in the distribution of genotypes and alleles of the TLR9 gene. The following features were revealed: increase in the frequency of AA and GG genotypes and decrease in the frequency of the AG genotype of the DEFB1(-20G>A) gene; increase in the frequency of the CC genotype and C allele and decrease in the frequency of CG and GG genotypes and G allele of the DEFB1(44C>G) gene; and increase in the frequency of AA and AG genotypes and A allele and decrease in the frequency of the GG genotypes and G allele of the DEFB1(-52G>A) gene. Genotypes and alleles of the DEFB1 gene found in long-living individuals can be considered as the factors that increase the probability of longevity and favorable course of age-related diseases.
Assuntos
Longevidade/genética , Receptor Toll-Like 9/genética , beta-Defensinas/genética , Adulto , Idoso de 80 Anos ou mais , Envelhecimento , Alelos , DNA/genética , Frequência do Gene/genética , Humanos , Imunidade Inata/genética , Pessoa de Meia-Idade , Polimorfismo de Nucleotídeo Único/genética , Transdução de Sinais/genética , Transdução de Sinais/imunologia , Adulto JovemRESUMO
Studies on etiology and pathogenesis of proliferative vitreoretinopathy are necessitated by the absence of a unified theory, which would provide a clear understanding of causes and mechanisms of the disease. The results of recent investigations allow to consider proliferative vitreoretinopathy as an uncontrollable plastic process caused by certain changes in the retina aimed at survival of its cells under oxidative stress. This approach enables preclinical indication of the process and development of new therapies.
Assuntos
Terapias em Estudo/métodos , Vitreorretinopatia Proliferativa , Gerenciamento Clínico , Humanos , Modelos Biológicos , Estresse Oxidativo , Retina/patologia , Retina/fisiopatologia , Vitreorretinopatia Proliferativa/diagnóstico , Vitreorretinopatia Proliferativa/etiologia , Vitreorretinopatia Proliferativa/fisiopatologia , Vitreorretinopatia Proliferativa/terapiaRESUMO
In Moscow region long-livers we have studied distribution of LPL, CETP, APOE, F2, F5, F7, F13, FGB, ITGA2, ITGB3, PAI-1, MTHFR, MTRR, HLA-DRB1, HLA-DQA1, HLA-DQB1 genes polymorphisms, associated with predisposition to age pathology. Long-livers are characterized by favorable course of cardiovascular diseases accompanied by certain genetic factors. We have established that genotype H-H- of LPL, allele epsilon2 of APOE, genotype CC of MTHFR (677C > T), genotype TC of ITGB3, genotype GA of FGB, HLA-DRB1*11 positively correlate with longevity.
Assuntos
Doenças Cardiovasculares/genética , Marcadores Genéticos/genética , Predisposição Genética para Doença , Longevidade/genética , Polimorfismo Genético , População Urbana , Idoso , Idoso de 80 Anos ou mais , Alelos , Doenças Cardiovasculares/epidemiologia , Doenças Cardiovasculares/metabolismo , Feminino , Frequência do Gene , Genótipo , Humanos , Masculino , Moscou/epidemiologia , PrevalênciaRESUMO
We haven't found or identified individual risk factors of cardiovascular diseases (smoking, drinking habit) and a later accession of other risk factors (arterial hypertension, left ventricular hypertrophy, anemia, hyperfibrinogenemia) in nonagenarians with different age-related diseases. This age group was characterized by comorbidity, delayed onset of the disease with fewer complications and some features of metabolism as compared to other age groups. These results enable us to consider longevity as possible model of successful aging.
Assuntos
Envelhecimento , Doenças Cardiovasculares , Predisposição Genética para Doença/epidemiologia , Expectativa de Vida , Longevidade/genética , Adaptação Fisiológica , Idoso de 80 Anos ou mais , Envelhecimento/genética , Envelhecimento/metabolismo , Consumo de Bebidas Alcoólicas/efeitos adversos , Índice de Massa Corporal , Doenças Cardiovasculares/epidemiologia , Doenças Cardiovasculares/etiologia , Doenças Cardiovasculares/metabolismo , Doenças Cardiovasculares/fisiopatologia , Comorbidade , Feminino , Indicadores Básicos de Saúde , Humanos , Masculino , Fatores de Risco , Fumar/efeitos adversos , Fatores SocioeconômicosRESUMO
The antiarrhythmic activity of lidocaine on the models of early arrhythmias induced by occlusion and reperfusion was studied in rats with background derangements of lipidic and carbohydrate metabolisms. It was established that lidocaine in a dose of 100 mg/kg did not produce reliable antiarrhythmic action under these conditions. In addition, changes in the development of early occlusional and reperfusional arrhythmias against the background violation of lipid and carbohydrate metabolisms were found.
Assuntos
Antiarrítmicos/uso terapêutico , Arritmias Cardíacas/tratamento farmacológico , Dislipidemias/complicações , Hiperglicemia/complicações , Lidocaína/uso terapêutico , Aloxano/toxicidade , Animais , Arritmias Cardíacas/complicações , Metabolismo dos Carboidratos , Modelos Animais de Doenças , Dislipidemias/induzido quimicamente , Hiperglicemia/induzido quimicamente , Metabolismo dos Lipídeos , Reperfusão Miocárdica , Ratos , Ratos EndogâmicosRESUMO
Antiarrhythmic activity of lidocaine during early occlusion and reperfusion arrhythmias decreased in rats with experimental disturbances in lipid and carbohydrate metabolism. The course of additional treatment with compound LBK-149 potentiated antiarrhythmic activity of lidocaine.
Assuntos
Antiarrítmicos/administração & dosagem , Antioxidantes/administração & dosagem , Arritmias Cardíacas/tratamento farmacológico , Lidocaína/administração & dosagem , Animais , Arritmias Cardíacas/metabolismo , Metabolismo dos Carboidratos/efeitos dos fármacos , Sinergismo Farmacológico , Feminino , Metabolismo dos Lipídeos/efeitos dos fármacos , Peroxidação de Lipídeos/efeitos dos fármacos , Masculino , RatosRESUMO
In rats with dyslipidemia epinephrine decreased HR and suppressed automaticity of the sinus node. This effect was not eliminated by LBK-149, dibunol, and glutabiance despite normalization of the plasma lipid spectrum. LBK-149 prevented the development of heart rhythm disturbances during epinephrine administration.
Assuntos
Antiarrítmicos/farmacologia , Arritmias Cardíacas/induzido quimicamente , Hidroxitolueno Butilado/farmacologia , Epinefrina/farmacologia , Hiperlipidemias/tratamento farmacológico , Animais , Arritmias Cardíacas/fisiopatologia , Colesterol , Eletrocardiografia , Feminino , Sistema de Condução Cardíaco/efeitos dos fármacos , Frequência Cardíaca/efeitos dos fármacos , Hiperlipidemias/induzido quimicamente , Masculino , Ratos , Nó Sinoatrial/efeitos dos fármacos , Vitamina DRESUMO
We studied the levels of acute inflammation phase proteins (AIPP), production of alpha, gamma and serum interferons, the activity of epsilon-receptors of T-lymphocytes in 39 patients with bronchial asthma (BA). Correlations were made with the process severity and basic therapy. We discovered imbalance of immunoregulatory mechanisms: enhanced AIPP synthesis, low production of induced alpha and gamma interferons, elevated concentrations of poor-differentiated T-lymphocytes. This confirms persisting inflammation in BA.
Assuntos
Asma/imunologia , Asma/metabolismo , Imunoglobulinas/imunologia , Interferons/sangue , Linfócitos T/imunologia , Proteínas de Bactérias/metabolismo , HumanosRESUMO
Experiments were conducted on models of early occlusion and reperfusion arrhythmias in cats to study the antiarrhythmic activity of trimecain, its morpholine analogue (MPT), and MPT derivatives containing glycine, magnesium salt of aspartic acid, and N-acetylglutaminic acid. All the compounds were injected in doses of 5% of LD50. A 22.5 mg/kg dose of trimecain prevented cardiac rhythm disorders after occlusion of the coronary arteries as well as after restoration of the coronary blood flow. Replacement of the diethyl group in the structure of trimecain by the morpholine ring led to diminution of antiarrhythmic activity, and MPT in a dose of 28.0 mg/kg, in distinction from the former, had no effect on the frequency of the occurrence of early occlusion arrhythmias and the duration of reperfusion arrhythmias. Introduction of amino acids as an anion into the MPT structure raised the antiarrhythmic activity of the last named.
