[Changes in the lipoprotein metabolism in alcoholism do not recover during of prolonged remission].

Contents of lipoproteins (LP), activity of lipoprotein lipase (LP-lipase) and cholesterol esterification activity of blood serum were examined in patients with alcoholism at the periods of intoxication, alcohol abstinence and under conditions of prolonged remission. During remission a general pattern of apoB-containing LP was similar to the period of intoxication. Processes of transformation of this class LP significantly delayed in isolated blood serum in vitro. The magnitude of these changes almost corresponded to the period of intoxication. However activity of free and membrane-bound forms of LP-lipase. A high level of LPHD2a was characteristic for the conditions of intoxication and alcohol abstinence. In the remission the level of all the apoA-containing LP fractions was significantly lower than in the control. Besides, processes of their transformations in vitro were slowed down. Intensity of these changes resembled the period of intoxication. Thus, disorders of LP metabolism pointed out during the period of intoxication and alcohol abstinence do not recovered under conditions of a prolonged remission.

[Depression of serum esterase and lipoprotein lipase activities in acute and longitudinal actions of ethanol].

Esterase (LCAT) and lipoprotein lipase (LPL) activities of blood serum, and a range of blood serum lipoproteins (LP) in acute and chronic ethanol intoxication were examined in healthy persons and patients with alcohol abuse. Ethanol inhibited LCAT and LPL activities, and increased apoA-containing LP in blood serum. These changes are considered as a basis for depression of a direct and reverse transportation of cholesterol in blood circulation under the action of ethanol.

[Dynamics of redistribution of blood serum lipoproteins in patients with alcoholism during alcohol intoxication and its abolition]. / Dinamika pereraspredeleniia lipoproteinov syvorotki krovi bol'nykh alkogolizmom v periody intoksikatsii i otmeny alkogolia.

In the patients with alcoholism at intoxication and different periods of alcohol abolition the blood serum lipoproteins were investigated by a method of gradient gel-electrophoresis using the computer program for qualitative definition. It was found out that change of the total sum of all lipoprotein fractions was approximated to parabolic dependence with maximum in the 3rd day after alcohol abolition. Under intoxication disturbances the individual apoB-containing fractions were minimal as compared with the control, while at the initial stages of alcohol abolition their redistribution was noticed as reflecting the growth of the processes of cholesterol transportation from liver to peripheral tissues. The 14th day after alcohol abolition was characterized by tendency to normalization of these disturbances, but at the 30th day of soberness a recurrence growing the changes of apoA-containing lipoproteins transformation was observed. In the patients under intoxication period and first 3 days after alcohol abolition a significant increase of quantity of all the apoA-containing lipoprotein populations took place which was restored completely in remission. On the base of both the own results and data from literature sources we suppose that these changes are the results of direct influence of ethanol and but they are not a pathogenic indication of a chronic alcoholism.

[The prevalence of cardiovascular pathology in alcoholism patients]. / Rasprostranennost' serdechno-sosudistoi patologii u bol'nykh alkogolizmom.

ECG was made in 336 patients with alcoholism that were admitted in a special hospital for alcoholic patients during one year. 146 patients were examined in the state of alcohol withdrawal syndrome, after its arrest and in stress. A prevalence of ECG changes well as stability of such alterations, prognostic criteria for a further course of both alcoholism and cardiovascular pathology were determined. A correlation was established between the cardiovascular changes on the one hand the age of the patients and the type of a course of alcoholism on the other hand.

[Outpatient stress psychotherapy of patients with alcoholism]. / Stressopsikhoterapiia bol'nykh alkogolizmom v ambulatornykh usloviiakh.

Trial of the method of stress psychotherapy developed by Dovzhenko has revealed its high efficacy: over 68% of treated patients continue the remission in a year after the treatment. The essence of the technique consists in the reaction of a stable psychological orientation toward a prolonged abstinence from alcohol by employing a complex of sequential psychotherapeutic methods and approaches materialized by means of physiogenic (stress) impacts aimed at activization of emotiogenic mechanisms of the brain.