Lactoferrin as treatment for iron-deficiency anemia in children: a systematic review.

BACKGROUND: Anemia is a common nutritional problem in children, especially those under five. Lactoferrin (Lf) as a supplement in treating iron deficiency anemia (IDA) has been studied, but its results in children have not been reviewed. This review aims to evaluate the effect of lactoferrin on children with IDA. METHODS: PubMed, ProQuest, EBSCO and Ovid databases were searched using a variation of keywords: lactoferrin, anemia, and children. The literature selected must be clinical trial-based in design. The years of the studies published were limited to 2012 and 2022. RESULTS: Eleven studies were included in the final systematic review, consisting of 10 randomized controlled trials (RCTs) and 1 non-randomized trial. Serum ferritin (SF) and hemoglobin (Hb) were found to be increased in groups treated with Lf or a combination of Lf and elemental iron compared to iron only or placebo supplementation. Adverse events such as constipation, vomiting, anorexia, and abdominal pain were found; particularly, a significant decrease in constipation is seen in Lf-treated groups. CONCLUSIONS: This study supports Lf as a superior treatment for IDA in children regarding the improvement in hematological and iron indices and fewer adverse effects.

Impact of trained volunteers' services in caring for older persons with dementia: a systematic review.

Dementia causes a great burden of disease globally. Volunteers' contributions in caring for older persons with dementia (OPD) are growing. This review aims to evaluate the impact of trained volunteers' involvement in providing care and support for OPD. PubMed, ProQuest, EBSCOHost, and Cochrane Library databases were searched using specific keywords. Inclusion criteria were studies of OPD who received interventions delivered by trained volunteers, which were published between 2018 and 2023. Seven studies were included in the final systematic review, comprising studies using quantitative and qualitative approaches. A wide range of outcomes was seen in both acute and home/community-based care settings. Improvements in social interaction, loneliness, mood, ability to recall, and physical activity of OPD were found. Carers and trained volunteers were also found to benefit. Trained volunteers' involvement in OPD care plays a very valuable role for OPD, their caregivers, the volunteers, and in turn to society. This review also emphasizes the importance of person-centred care for OPD.