Development of Rogowski probe for internal plasma current measurement in the collisional merging process of field-reversed configurations.

To directly detect the spatial distribution of a plasma current during the collisional merging of two field-reversed configurations (FRCs) in the FAT-CM (FRC Amplification via Translation-Collisional Merging) device, an internal current probe using Rogowski coils has been developed. An FRC is a type of magnetically confined plasma maintained by a diamagnetic plasma current flowing in the toroidal direction. Self-organized FRC formation and increased poloidal flux have been observed following the destructive perturbation during the collision in collisional merging FRC formation when two initial-plasmoids collide at a relative speed of 300-400 km/s to form one FRC. It is indicated that the toroidal plasma current is driven in those processes. In this research, an internal Rogowski probe was designed and developed to have a high-frequency response to capture a rapid change of the plasma current in a few microseconds during the collision/merging process. The FRC plasma in FAT-CM has relatively high temperature (∼100 to 200 eV) and high density (∼1020 to 1021 m-3). As a result, the probe was built to be as compact as possible to minimize disruption to the plasma. Because of its high melting point and low Z property, a machinable boron nitride ceramic was chosen to shield the Rogowski coils thermally and electrically from the plasma. All connections and seams were constructed such that the epoxy glue used for the probe assembly was not exposed to the plasma.

Tumor-selective mitochondrial network collapse induced by atmospheric gas plasma-activated medium.

Non-thermal atmospheric gas plasma (AGP) exhibits cytotoxicity against malignant cells with minimal cytotoxicity toward normal cells. However, the mechanisms of its tumor-selective cytotoxicity remain unclear. Here we report that AGP-activated medium increases caspase-independent cell death and mitochondrial network collapse in a panel of human cancer cells, but not in non-transformed cells. AGP irradiation stimulated reactive oxygen species (ROS) generation in AGP-activated medium, and in turn the resulting stable ROS, most likely hydrogen peroxide (H2O2), activated intracellular ROS generation and mitochondrial ROS (mROS) accumulation. Culture in AGP-activated medium resulted in cell death and excessive mitochondrial fragmentation and clustering, and these responses were inhibited by ROS scavengers. AGP-activated medium also increased dynamin-related protein 1-dependent mitochondrial fission in a tumor-specific manner, and H2O2 administration showed similar effects. Moreover, the vulnerability of tumor cells to mitochondrial network collapse appeared to result from their higher sensitivity to mROS accumulation induced by AGP-activated medium or H2O2. The present findings expand our previous observations on death receptor-mediated tumor-selective cell killing and reinforce the importance of mitochondrial network remodeling as a powerful target for tumor-selective cancer treatment.

Development of a low-energy and high-current pulsed neutral beam injector with a washer-gun plasma source for high-beta plasma experiments.

We have developed a novel and economical neutral-beam injection system by employing a washer-gun plasma source. It provides a low-cost and maintenance-free ion beam, thus eliminating the need for the filaments and water-cooling systems employed conventionally. In our primary experiments, the washer gun produced a source plasma with an electron temperature of approximately 5 eV and an electron density of 5 × 10(17) m(-3), i.e., conditions suitable for ion-beam extraction. The dependence of the extracted beam current on the acceleration voltage is consistent with space-charge current limitation, because the observed current density is almost proportional to the 3/2 power of the acceleration voltage below approximately 8 kV. By optimizing plasma formation, we successfully achieved beam extraction of up to 40 A at 15 kV and a pulse length in excess of 0.25 ms. Its low-voltage and high-current pulsed-beam properties enable us to apply this high-power neutral beam injection into a high-beta compact torus plasma characterized by a low magnetic field.

Magnetic probe array with high sensitivity for fluctuating field.

A magnetic probe array is constructed to measure precisely the spatial structure of a small fluctuating field included in a strong confinement field that varies with time. To exclude the effect of the confinement field, the magnetic probes consisting of figure-eight-wound coils are prepared. The spatial structure of the fluctuating field is obtained from a Fourier analysis of the probe signal. It is found that the probe array is more sensitive to the fluctuating field with a high mode number than that with a low mode number. An experimental demonstration of the present method is attempted using a field-reversed configuration plasma, where the fluctuating field with 0.1% of the confinement field is successfully detected.