Generating waist area-dependent ground reaction forces for long-duration spaceflight.

Prolonged microgravity exposure greatly weakens the bones and muscles of astronauts. This is a critical biomechanical issue for astronauts as they may be more prone to bone fractures. To combat this issue, lower body negative pressure (LBNP) is a concept that generates artificial gravitational forces that may help strengthen bones and muscles during long-term spaceflight. Negative pressure, defined as below ambient pressure, is applied within a chamber that encompasses the lower half of the body. By increasing the negative pressure, more ground reaction forces (GRFs) are generated beneath the subject's feet. We hypothesize that increasing the cross-sectional area (CSA) of the subject's waist will generate greater GRFs beneath the subject's feet. Six healthy subjects volunteered to participate under two different experimental conditions: 1) original CSA of their waist and 2) larger CSA of their waist. In both conditions the subjects were suspended in a supine position (simulated microgravity) along with a weight scale beneath their feet. Negative pressures ranged from zero to 50 mmHg, increasing in increments of 5 mmHg. At -50 mmHg, original CSAs generated 1.18 ± 0.31 (mean ± SD) of their normal bodyweight. Subjects generated about one bodyweight at -45 mmHg using their original waist CSA. At -50 mmHg, larger CSAs generated 1.46 ± 0.31 of their normal bodyweight. Subjects generated about one bodyweight at -35 mmHg using their larger waist CSA. These data support our hypothesis. This novel technique may apply less stress to the cardiovascular system and conserve power for exercise in the spacecraft.

The Mobile Lower Body Negative Pressure Gravity Suit for Long-Duration Spaceflight.

Spaceflight Associated Neuro-ocular Syndrome, bone decalcification, and muscle atrophy are among the most prevalent risks associated with long-duration spaceflight. Implementing the lower body negative pressure (LBNP) method is a potential countermeasure for these risks. LBNP counteracts head-ward fluid shifts and generates ground-reaction forces (GRFs). GRFs are beneficial for maintaining bones and muscles by producing gravity-like loads experienced on Earth. Currently, LBNP devices are large/bulky, and usually require the subject to maintain a stationary position. However, our new mobile gravity suit is relatively small, untethered, and flexible in order to improve mobility in space. We hypothesized that this novel mobile gravity suit generates greater GRFs than a standard LBNP chamber. While lying supine, GRF data were recorded in both devices using foot sole sensors and a weight scale. At -40 mmHg, the gravity suit generated a mean maximum bodyweight of 125 ± 22% (P < 0.02) whereas the standard LBNP chamber generated 91 ± 24%. The standard LBNP chamber generated a single force on the stationary subject, which was expressed as AW(LBNP) = GRF, where Aw = cross-sectional area (CSA) of subject's waist. However, the mobile gravity suit generated an additional force based on the following equation, (AF + AW)LBNP = GRF, where AF = CSA of subject's feet. The additional force was further expressed as F1 + F2 = AF × LBNP, where F1 = spinal loading force, F2 = waist shear force, and AF × LBNP = the total downward foot force. Thus, the mobile gravity suit produces higher percentages of bodyweight due to the suit's novel design.

Mobile Lower Body Negative Pressure Suit as an Integrative Countermeasure for Spaceflight.

BACKGROUND: Persistent headward fluid shift and mechanical unloading cause neuro-ocular, cardiovascular, and musculoskeletal deconditioning during long-term spaceflight. Lower body negative pressure (LBNP) reintroduces footward fluid shift and mechanical loading.METHODS: We designed, built, and tested a wearable, mobile, and flexible LBNP device (GravitySuit) consisting of pressurized trousers with built-in shoes to support ground reaction forces (GRF) and a thoracic vest to distribute load to the entire axial length of the body. In eight healthy subjects we recorded GRF under the feet and over the shoulders (Tekscan) while assessing cardiovascular response (Nexfin) and footward fluid shift from internal jugular venous cross-sectional area (IJVa) using ultrasound (Terason).RESULTS: Relative to normal bodyweight (BW) when standing upright, increments of 10 mmHg LBNP from 0 to 40 mmHg while supine induced axial loading corresponding to 0%, 13 ± 3%, 41 ± 5%, 75 ± 11%, and 125 ± 22% BW, respectively. Furthermore, LBNP reduced IJVa from 1.12 ± 0.3 cm² to 0.67 ± 0.2, 0.50 ± 0.1, 0.35 ± 0.1, and 0.31 ± 0.1 cm², respectively. LBNP of 30 and 40 mmHg reduced cardiac stroke volume and increased heart rate while cardiac output and mean arterial pressure were unaffected. During 2 h of supine rest at 20 mmHg LBNP, temperature and humidity inside the suit were unchanged (23 ± 1°C; 47 ± 3%, respectively).DISCUSSION: The flexible GravitySuit at 20 mmHg LBNP comfortably induced mechanical loading and desired fluid displacement while maintaining the mobility of hips and knee joints. The GravitySuit may provide a feasible method to apply low-level, long-term LBNP without interfering with daily activity during spaceflight to provide an integrative countermeasure.Petersen LG, Hargens A, Bird EM, Ashari N, Saalfeld J, Petersen JCG. Mobile lower body negative pressure suit as an integrative countermeasure for spaceflight. Aerosp Med Hum Perform. 2019; 90(12):993-999.