Application of non-uniform film thickness concept in predicting deviated gas wells liquid loading.

Liquid loading causes undesirable occurrences such as premature death of wells, as well as significant reduction in production. However, most available models consider vertical wells and only a few focus on deviated gas wells. In order to reduce the impact of liquid loading on gas production, gas well load-up should be diagnosed at its early stage so as to proffer adequate solution. Unfortunately, most gas wells will experience liquid loading at some stage or point in their production life. Therefore, it is of utmost importance to predict liquid loading at the early life of such wells in order to develop apt liquid management strategies as corrective measures. Liquid film flow reversal concept has been identified as one of the major concepts responsible for the occurrence of liquid loading in deviated gas wells. This study develops an improvement on Chen's liquid loading model. The model specifically introduces the concept of non-uniform film thickness around the pipe wall, as against previous works which considered uniform film thickness. A modified friction factor is also introduced to account for large film thicknesses around the pipe wall. Results from the model were compared with those of previous models, and data from published literature was used to validate the new model. The new model gave accurate predictions for 11 of 12 unloaded wells while for the loaded wells, the estimated data gave accuracies for 29 out of 30 loaded wells. This then implies that the new model is accurate for predicting liquid loading in deviated gas wells. •Predictions from the new model show a good improvement over existing models.•The uniform film assumption made in Chen liquid loading model was modified, and a different interfacial friction factor was applied.•The method proposed in this study introduces the concept of non-uniform film thickness around the pipe wall as against previous works which considered uniform film thickness.

Facile Microemulsion Synthesis of Vanadium-Doped ZnO Nanoparticles to Analyze the Compositional, Optical, and Electronic Properties.

In this work, microemulsion method has been followed to synthesize vanadium-doped Zn1-xVxO (with x = 0.0, 0.02, 0.04, 0.06, 0.08, and 0.10) nanoparticles. The prepared samples are characterized by several techniques to investigate the structural, morphology, electronic, functional bonding, and optical properties. X-ray diffractometer (XRD) analysis confirms the wurtzite phase of the undoped and V-doped ZnO nanoparticles. Variation in the lattice parameters ensures the incorporation of vanadium in the lattice of ZnO. Scanning electron microscopy (SEM) shows that by increasing contents of V ions, the average particle size increases gradually. X-ray Absorption Near Edge Spectroscopy (XANES) at the V L3,2 edge, oxygen K-edge, and Zn L3,2 edge reveals the presence and effect of vanadium contents in the Zn host lattice. Furthermore, the existence of chemical bonding and functional groups are also asserted by attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR). UV⁻Visible analysis shows that by increasing V⁺ contents, a reduction up to 2.92 eV in the energy band gap is observed, which is probably due to an increase in the free electron concentration and change in the lattice parameters.

Breast cancer therapy by laser-induced Coulomb explosion of gold nanoparticles.

OBJECTIVE: Laser-induced Coulomb explosion of gold nanoparticles for breast cancer has been studied by nanophotolysis technique. This study aimed to investigate whether laser-induced bubble formation due to Coulomb explosion can provide an effective approach for selective damage of breast cancer with gold nanoparticles. METHOD: Numerical method involves laser-induced Coulomb explosion of gold nanoparticles. Different parameters related to nanophotolysis such as laser fluence, tumor depth, cluster radius, laser pulse duration, and bubble formation is studied numerically. Numerical simulation was performed using Mat lab. RESULTS: The gold nanoparticles of 10, 20, 30, 40, and 50 nm in radius could penetrate into tumor 1.14, 1.155, 1.189, 1.20 and 1.22 cm in depth respectively. The maximum penetration depth in tumor could be obtained with nanoparticles of 50 nm radius. Short laser pulse of 40 ns with nanoparticles of 10 nm radius could penetrate into tumor 1.14 cm in depth. Bubbles with a radius of 9 µm could effectively kill breast cancer cells without damaging healthy ones. The bubble radius increased from 4 to 9 µm with an increase in pulse duration in the range of 10 to 30 ns. CONCLUSIONS: Gold nanoparticles with increasing radius and bubble formation for selective damage of breast cancer cells are successfully probed. The present calculated results are compared with other experimental findings, and good correlation is found between the present work and previous experimental values. It was demonstrated that bubble formation in tumor may further increase the efficacy of breast cancer treatment.