[Age differences in topic concentrations and activity of H2- and B2-receptors in the larynx and trachea]. / Vozrastnye razlichiia topicheskoi kontsentratsii i aktivnosti H2- i B2-retseptorov v gortani i trakhee.

H2- and B2-receptors concentrations and activity were measured in 12 adult (6-7-month-old) and 12 young (1.5-2-month-old) rabbits by vascular reactions to histamine and bradykinin with and without prior usage of relevant specific receptor blocker. The findings suggest that concentration and activity of H2- and B2-receptors in young animals are the highest in the larynx. In mature animals-partially in trachea. With aging these concentrations and activity diminish in the larynx and rise in the trachea, the changes of B2-receptors are more significant.

[Kinin antagonists in the treatment of acute stenosing laryngotracheitis in children]. / Protivokininnye lekarstvennye sredstva v lechenii ostrykh stenoziruiushchikh laringotrakheitov i detei.

The treatment of 97 infants aged from 3 months to 2 years included: nasotracheal intubation (56 patients); i. v. injection, drops (77 patients) or aerosol inhalations (20 cases) of trasylol, kontrikal or gordox; inhalations of epsilon aminocaproic acid (12 cases); glucocorticoids (locally, inhalations, laryngeal drop infusions); local and oral bioantioxidants; noradrenaline for local vasoconstriction. The addition of antikinin medication to the complex of pathogenetically differentiated means which are also proteolytic enzyme inhibitors reduced the frequency and duration of tracheal intubation, duration of laryngeal stenosis by half. Systemic and local administration of antikinin drugs is advocated starting on the first post-diagnosis days, except cases of advanced acute inflammation in the presence of infiltrates in the cavum infraglotticum when antikinin, antihistamine and vasoconstrictors proved ineffective.

[Acute herpetic stenosing laryngitis in children]. / Gerpeticheskii ostryi stenoziruiushchii laringit u detei.

Herpetic acute stenosing laryngitis (ASL) in 6 infants was compared clinically to catarrhal ASL and latent herpetic infection in 6 infants with acute respiratory disease. Labial, oral and nasal herpes was observed only in 2 patients with herpetic ASC which in the other 4 patients was diagnosed only at laryngoscopy, thus laryngoscopic picture is a key prompting in diagnosis of herpetic ASL.

[Cellular histamine and bradykinin receptors in the larynx and trachea. I]. / Kletochnye retseptory dlia gistamina i bradikinina v gortani i trakhee. Soobshchenie 1.

Classic physiological and pharmacological experiments were made on 33 rabbits under hexenal anesthesia to determine the presence, topical concentration and activity of H2 and B2-receptors. These parameters were inferred by edema and other vascular responses of the mucosa to local application of histamine and bradykinin prior to and after usage of specific blocker of each receptor type. Both mediators and receptor blockers were applied to laryngeal and tracheal mucosa for 10 min (histamine 10(-4) and 10(-3) g/ml, H2-receptor blocker metiamide 0.1 and 1 mmol, bradykinin 10(-5) and 10(-4) g/ml, B2-receptor blocker pyridinolcarbamate 10(-2) and 10(-1) g/ml). The larynx and trachea were found to contain H2- and B2-receptors the concentrations of which were greater in the subvocal part of the larynx than in the vestibular part and trachea. B2-receptor activity and concentrations in the subvocal part of the larynx were 10 times while in the trachea 1.5-2 times greater than those of H2-receptors. These regularities were not influenced by individual varieties of receptor topical concentrations. The blocker density in the receptors and the duration of their binding were not universally proportional. This is also true for the relations mediator-receptor. Concentrations and activity of H2- and B2-receptors are thought important in pathogenesis and location of acute inflammatory and allergic conditions in the upper respiratory tract.

[Allergy and acute stenosing laryngotracheitis in children]. / Allergiia i ostrye stenoziruiushchie laringotrakheity u detei.

An allergological examination of 144 patients suffering from acute stenosing laryngotracheitis revealed food, drug, bacterial allergy of exudative diathesis in 62.5% of the cases. Allergic children had laryngostenosis of degree II and more advanced two times more frequently, whereas recurrences (12 cases) occurred primarily in children in premorbid condition. Allergy of shown to contribute to the onset of acute stenosing laryndotracheitis as allergic subjects are more susceptible to respiratory bacterial and viral infection. Local factors are mostly responsible for this. The author offers recommendations on more advanced treatment of acute stenosing laryngotracheitis with consideration of allergic aspects.