1.
Biomark Med
; 13(1): 27-31, 2019 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30556735
RESUMO
BACKGROUND: Immune thrombocytopenia (ITP) is an acquired disease characterized by various pathogenetic mechanisms. We aimed to evaluate the value of TRAF6 as a biomarker of pathogenesis in ITP. METHODS: 85 newly diagnosed ITP patients and 85 controls were included. RESULTS: In the patient group, mean TRAF6 level was 2348 pg/ml and in the control group, TRAF6 level was 25.57 pg/ml. In corticosteroid-responding patients, TRAF6 levels were lower than nonresponding patients. DISCUSSION: TRAF6 levels were observed to be higher than healthy controls, which suggest a solid relation with ITP pathogenesis. The observation that in patients who present with high TRAF6 levels, there was a significant corticosteroid refractoriness and responsiveness.
Assuntos
Biomarcadores/sangue , Imunoglobulinas Intravenosas/administração & dosagem , Fatores Imunológicos/administração & dosagem , Púrpura Trombocitopênica Idiopática/sangue , Fator 6 Associado a Receptor de TNF/sangue , Adulto , Idoso , Idoso de 80 Anos ou mais , Estudos de Casos e Controles , Feminino , Seguimentos , Humanos , Peptídeos e Proteínas de Sinalização Intracelular , Masculino , Pessoa de Meia-Idade , Prognóstico , Estudos Prospectivos , Púrpura Trombocitopênica Idiopática/diagnóstico , Púrpura Trombocitopênica Idiopática/tratamento farmacológico , Adulto Jovem
2.
J Cancer Res Ther
; 11(4): 1043, 2015.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26881672