RESUMO
The study involved 100 patients with chronic heart failure of ischemic origin II-III functional class (NYNA) and diabetes mellitus type 2. The concentration of serum markers of inflammation was determined by enzyme immunoassay. Сardiac dyssynchrony was detected echocardiographic and electrocardiographic methods. The study showed that the presence of cardiac dyssynchrony is accompanied by significant increase concentrations of inflammatory markers (CRP (p=2â¢10-9), TNF-α (p=4â¢10-6), IL-1ß (p=0,01596), IL-6 (Ñ=2â¢10-6) in patients. Ðlso revealed statistically significant direct correlations between levels: Ts and CRP (r=0,604; p<0,001) and Ts-SD (r=0,611; p<0,001); TNF-α and Ts (r=0,585; p<0,001) and Ts-SD (r=0,561; p<0,001); IL-1ß with the QRS (r=0,257; p<0,05), Ts (r=0,365; p<0,001), Ts-SD (r=0,350; p<0,001) and IVMD (r=0,272; p<0,05); IL-6 and Ts (r=0,744, p<0,001) and Ts-SD (r=0,744; p<0,001), which implies that the amplification of inflammation contributes to the further progression of myocardial dyssynchrony in patients with chronic heart failure of ischemic origin and type 2 diabetes.
