Ultrasonography-guided botulinum toxin injection for lumbrical muscle spasticity in a hemiplegic patient.

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A case report of a patient with COVID-19 infection and widespread heterotopic ossification.

Since the beginning of the novel coronavirus disease-2019 (COVID-19) pandemic, physical medicine and rehabilitation specialists have played an important role in fighting this disease apart from the pulmonary rehabilitation. As a high number of patients have needed immobilization and intensive care unit (ICU) treatment, many complications have emerged inevitably. Heterotopic ossification (HO) is one of these complications. Herein, we present a case of young male patient who had widespread HO in his shoulders, elbows, and hips. Although he managed to survive, he still has difficulty in ambulation and daily living activities. Given the continuing high prevalence of COVID-19, many patients would need immobilization and ICU treatment. Therefore, causes of HO should be scrutinized, physicians and caregivers need to raise vigilance, and comprehensive protective measures should be put in place. On the other hand, as HO is used to be diagnosed quite frequently in the patients with neurological diseases, diagnosis of HO in the COVID-19 patients should not automatically be linked to the stay in the ICU. Yet, it is a fact that impaired immune response is prevalent both in COVID-19 and HO. The correlation between COVID-19 and HO is remarkable, but further research is needed to establish a causal relationship.

Does Dry Needling Increase the Efficacy of Botulinum Toxin Injection in the Management of Post-Stroke Spasticity: A Randomized Controlled Study.

Introduction: The purpose of the current study was to investigate the antispastic efficacy of dry needling in combination with botulinum toxin-A injections. Methods: Thirty stroke patients with elbow flexor spasticity were randomised into two groups; the patients treated with botulinum toxin-A injections and exercise into the BTX-A group, and patients treated with botulinum toxin-A injections, exercise, and dry needling in the BTX-A+Dry needling group. Spasticity was evaluated using the modified Ashworth scale and modified Tardieu scale before treatment, immediately after treatment, the third day after treatment, second week after treatment and at the third month after treatment. The upper extremity motor function was evaluated using the Fugl-Meyer upper extremity motor function scale. Results: A statistically significant difference in all parameters was found after treatment in both groups compared to before treatment (p<0.05). In all evaluation parameters immediately after treatment, on the third day after treatment, the second week after treatment and the third month after treatment, a statistically significant difference in favour of the BTX-A+Dry needling group was achieved compared to before treatment (p<0.05). Conclusion: Dry needling combined with botulinum toxin-A injections performed over a total of four sessions with three-day intervals, contribute to the antispastic effect. Also combined therapy is more effective and provides longer-lasting results.

Effects of Robot-Assisted Gait Training in Patients With Multiple Sclerosis: A Single-Blinded Randomized Controlled Study.

OBJECTIVE: This study aims to evaluate and compare the effects of conventional and robot-assisted gait training (RAGT) programs on fatigue, mood, and quality of life in patients with multiple sclerosis who have fatigue. METHODS: In this single-blinded, randomized controlled study, 37 patients with multiple sclerosis were randomized into two groups: RAGT ( n = 18) and conventional gait training ( n = 19). The RAGT group had gait training with RoboGait, whereas the conventional gait training group received conventional physiotherapist-assisted gait training. Outcome measures were the Fatigue Severity Scale, Hospital Anxiety Depression Scale, Multiple Sclerosis Quality of Life-54, Extended Disability Status Scale, Functional Ambulation Category, Berg Balance Test, and 6-min walk test. RESULTS: Baseline demographic, clinic, and functional data were similar. Both groups showed improvements in the Fatigue Severity Scale, Hospital Anxiety Depression Scale-Depression, Multiple Sclerosis Quality of Life, Berg Balance Test, and 6-min walk test scores after treatment. Only the RAGT group showed an improvement in Hospital Anxiety Depression Scale-Anxiety score. The RAGT group had better Fatigue Severity Scale, and Hospital Anxiety Depression Scale scores. CONCLUSION: In combination with the standard rehabilitation program, both RAGT and conventional gait training are effective for multiple sclerosis. However, RAGT has superior effects in terms of fatigue, depression, and anxiety. Therefore, it may be preferred in multiple sclerosis patients who exhibit prominent symptoms of fatigue, depression, or anxiety.

Evaluation of Neuropathic Extremity Pain in Patients with Multiple Sclerosis.

INTRODUCTION: Neuropathic extremity pain is one of the most common symptoms of multiple sclerosis (MS). This study was aimed to evaluate and compare the frequency and severity of neuropathic extremity pain in subtypes of MS. METHODS: Patients with the diagnosis of MS were included in the study, consecutively. Patients' demographic and clinical data were recorded. Patients' pain severity was assessed with visual analog scale (VAS). For the evaluation of neuropathic pain Leeds assessment of neuropathic symptoms and signs (LANSS) and douleur neuropathique 4 questions (DN4) were used. Disability was assessed with the Extended Disability Status Scale (EDSS). RESULTS: One hundred and three patients were included and 82.5% of them had relapsing-remitting (RR) MS. According to LANSS and DN4, 47.6% of patients had neuropathic pain. Female patients had significantly higher pain scores. There was no significant difference between the subtypes of MS based on having neuropathic pain. Patients with seconder progressive (SP) MS had significantly higher EDSS. A significant positive correlation was detected between EDSS score and duration of disease. CONCLUSION: Regardless of the MS subtype patients had neuropathic pain. Patients with SP had significantly higher disease duration and EDSS which were correlated with each other. All patients with the diagnosis of MS should be evaluated for neuropathic pain.

The effect of vitamin D and exercise on balance and fall risk in postmenopausal women: A randomised controlled study.

OBJECTIVE: To evaluate the effects of vitamin D and exercise on balance, fall risk and quality of life (QoL) in postmenopausal women. METHODS: In this prospective, randomised, controlled, single-blind study postmenopausal women aged 50-70 years were included. Participants with <25nmol/L 25(OH) vitamin D were randomised to three groups: group-I (vitamin D replacement) (n = 21), group-II (core and balance exercises) (n = 18), and group-III (vitamin D replacement plus core and balance exercises) (n = 20). The participants with >75nmol/L 25(OH) vitamin D (group-IV) (n = 40) were designated as control group and received the core and balance exercises. The participants were evaluated before and after 8 weeks with Berg balance test and Biodex balance system (postural stability and fall risk tests) for balance and Nottingham Health Profile (NHP) for QoL. RESULTS: Group IV had better baseline BBT, NHP pain, NHP emotional reactions, NHP social isolation subdomain and total score. After treatment, all groups showed significant improvement in balance (except group I, mediolateral stability index) and QoL (except group II). There was no significant difference between groups (I, II and III) after intervention. CONCLUSION: Vitamin D replacement therapy has positive effects on balance and QoL. Core strengthening and balance exercises are essential for better balance and fall prevention in postmenopausal women. Any superior effect of vitamin D or exercise on each other was not determined.

Ultrasonographic assessment of femoral cartilage thickness in patients with Helicobacter pylori infection.

OBJECTIVES: Helicobacter pylori is a major cause of gastritis and a potential trigger of inflammatory disease. The effect of H pylori infection on distal femoral cartilage has yet to be evaluated. The aim of this study was to evaluate femoral cartilage thickness in patients with H pylori infection and to find whether this infection affects femoral cartilage thickness. METHODS: This cross-sectional study included 199 patients. To measure the thickness of femoral articular cartilage, 99 patients with H pylori infections and 100 with H pylori-negative controls were enrolled into two groups. The measurements were made using linear probe ultrasonography with the patients in supine positions and their knees in maximum flexion. Demographic, clinical, endoscopic and laboratory data were collected for all patients. RESULTS: Both the right and left femoral condyles had thinner cartilage thickness in the H pylori-positive group than in the H pylori-negative group (P = .016, P = .036). For the intercondylar area and lateral femoral condyles, although the H pylori-positive patients had thinner femoral cartilage thickness than the H pylori-negative individuals for both extremities, this finding was not statistically significant (P > .05). CONCLUSION: Femoral cartilage was thinner in patients with H pylori than patients without H pylori for right and left medial femoral condyles. This study suggests that H pylori infections may affect femoral cartilage thickness and potentially increase the risk of cartilage degeneration.

Ultrasonographic Assessment of Knee Cartilage Thickness in Patients with Ulcerative Colitis: Decreased Femoral Cartilage Thickness May Be an Indicator of Extraintestinal Manifestation in Patients with Mild Activity Ulcerative Colitis.

OBJECTIVES: Ulcerative colitis is a systemic inflammatory disease which primarily involves the gut but presented by numerous extraintestinal manifestations. The effect of ulcerative colitis on knee cartilage has not been evaluated up to the present. In the current study, we aimed to investigate the possible relationship between the presence of ulcerative colitis and femoral cartilage thickness. DESIGN: Sixty-two patients with confirmed diagnosis of ulcerative colitis and 70 healthy controls aged 18 to 50 years referred to the gastroenterology outpatient department between January 2018 and January 2019 participated in this cross-sectional study. The measurements were made by ultrasonography with the patient in a supine position and the knees in complete flexion. Demographic, clinical, endoscopic and laboratory data were collected for all the subjects. RESULTS: The groups of ulcerative colitis and control group were similar with regard to sex, mean age, weight, height, body mass index, extremity dominancy, and existence of knee pain (P > 0.05). Medial femoral condyles, intercondylar areas, and lateral femoral condyles of both right and left knees had thinner cartilage thickness in ulcerative colitis group than control group (P < 0.001). CONCLUSION: Knee cartilage was thinner in subjects with mild activity ulcerative colitis than in healthy controls. Decreased knee cartilage thickness may be an indicator of extraintestinal manifestation in patients with mild activity ulcerative colitis. This association between ulcerative colitis and knee cartilage degeneration may be effective in early detection of possible risk factors and potential treatment strategies for both ulcerative colitis and specific subtypes of knee osteoarthritis.

Ultrasonographic assessment of femoral cartilage thickness in patients with and without uveitis in Behçet's disease.

The objective for this study is to evaluate the femoral cartilage thickness in patients with/without uveitis in Behçet's disease (BD). Patients with BD aged 18-70 years were included. The demographic and clinical characteristics of the patients were recorded. The thickness of femoral articular cartilage was measured with musculoskeletal ultrasound. Cartilage thickness was measured bilaterally from the central points of medial condyle (MFC), lateral condyle (LFC), and intercondylar area (ICA). 20 patients with uveitis [uveitis (+)] and 20 patients without uveitis [uveitis (-)] were included. Both right and left MFC and LFC had statistically significant thinner cartilage in uveitis (+) group (p < 0.05). For the ICA, uveitis (+) patients had thinner femoral cartilage than uveitis (-) patients; however, in the left side, statistically significance could not be detected. Femoral cartilage was thinner in uveitis (+) patients than in uveitis (-) patients in BD. This relationship between uveitis and femoral cartilage thickness may be helpful in the prevention and early treatment of cartilage degeneration.

Does kinesiotaping increase the efficacy of lidocaine injection in myofascial pain syndrome treatment? A randomized controlled study.

BACKGROUND: Myofascial pain syndrome is a common form of musculoskeletal disorder that originates from a painful site in a muscle or related fascia. There are various non-invasive and invasive treatment methods. OBJECTIVE: To investigate the efficacy of myofascial trigger point kinesiotaping with that of local anesthetic injection alone on the degree of pain and quality of life in myofascial pain syndrome. METHODS: Seventy-six patients with myofascial pain syndrome were randomly assigned to three study groups. Group 1 (n= 26) received only local anesthetic (1 ml lidocaine of 0.5% for each trigger point) injection. Group 2 (n= 25) received local anesthetic injection + sham kinesiotaping. Group 3 (n= 25) received local anesthetic injection + kinesiotaping. Pain intensity was measured by visual analog scale (VAS) at baseline, immediately after treatment, and in the 1st and 4th week post-treatment. To evaluate the effect of treatment on quality of life, Short Form-12 (SF-12) was used at baseline and at 4th week post-treatment. RESULTS: Group 3 showed significantly more improvement than other groups at post-treatment VAS, SF-12 physical component evaluations (p< 0.05). No significant difference was found between groups 2 and 3 in the mental component of SF-12 (p> 0.05), but the patients in group 3 performed significantly better than group 1 (p< 0.05). No significant difference was found between groups 1 and 2 in VAS, SF12 Physical Components Summary and SF-12 Mental Components Summary scores at post-treatment evaluations. CONCLUSION: This study indicated that kinesiotaping may be useful to increase the efficacy of myofascial trigger point lidocaine injection in myofascial pain syndrome.

Ultrasonographic Assessment of Femoral Cartilage Thickness in Patients With Cerebral Palsy.

BACKGROUND: Cerebral palsy (CP) is one of the most disabling syndromes in children. To our knowledge, there has not yet been any reported evaluation by ultrasonography of the effect of CP on distal femoral cartilage. The value of understanding this effect on cartilage is that sonographic evaluation of cartilage thickness may help physicians to predict the joint health of these children. OBJECTIVE: To determine whether femoral cartilage thickness in patients with CP is different from that in healthy control subjects. DESIGN: Cross-sectional study. SETTING: National tertiary rehabilitation center. PATIENTS: The study included 40 patients with diplegic CP (23 male and 17 female) and 51 healthy control subjects (29 male and 22 female). METHODS: Demographic and clinical characteristics were recorded. Cartilage thicknesses were measured. MAIN OUTCOME MEASURE: Cartilage thickness measurements were taken from the medial and lateral condyles, and intercondylar areas of both knees. RESULTS: Both groups were similar in terms of age, gender, and weight (P > .05). The mean cartilage thickness measurements of the medial condyle and intercondylar area of knees in the CP group were significantly less than those in the healthy control group (all P < .05). There was moderate negative correlation between age and all femoral cartilage thickness measurements in the CP group. There was no correlation between age and femoral cartilage thickness measurements in the healthy group. There was a negative correlation between Gross Motor Functional Classification System levels and cartilage thickness in the CP group. The highest cartilage thickness measurements were detected in level 1 patients, and the lowest measurements were detected in level 5 patients. CONCLUSION: This study showed that patients with CP have a thinner femoral cartilage than healthy control subjects. Management of patients with CP should include close surveillance. LEVEL OF EVIDENCE: III.