Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 43
Filtrar
1.
J Pediatr Surg ; 2023 Sep 26.
Artigo em Inglês | MEDLINE | ID: mdl-37845125

RESUMO

BACKGROUND: The worldwide accepted repair for indirect inguinal hernia in children is high ligation of the hernia sac with open herniotomy. However, laparoscopic pediatric inguinal hernia repair (IHR) has been gaining popularity in the last two decades. An experimental study was conducted to investigate the effects of different intraperitoneal IHR suture techniques on the collagen formation at the hernia sac neck. METHODS: Present study was conducted on thirty-five male adult (3-6 months old) Wistar-Albino rats (260-300 g). Intraperitoneal IHR with different hernia sac neck suturing techniques (purse string suture only, transfixation suture only and purse string suture plus transfixation suture) were performed through median laparotomy using open operative techniques. Non-absorbable 2/0 braided polyester suture with 16 mm 1/2 curved round needle (Ti-cron, Covidien, MN) was used as suture material. RESULTS: The highest collagen thickness around the suture was detected in intraperitoneal IHR with purse-string plus transfixation suture group. The collagen thickness of the intraperitoneal IHR with purse string suture only and IHR with tranfixation suture only groups were not statistically significantly different. The collagen thickness of the intraperitoneal IHR with purse string suture plus transfixation suture group was statistically significantly higher compared with the intraperitoneal IHR with purse string suture only and intraperitoneal IHR with transfixation suture only groups. CONCLUSIONS: The combined usage of purse string suture and transfixation suture during laparoscopic intraperitoneal inguinal hernia repair further stimulates mesothelial fibrosis at the hernia sac neck compared with mesothelial fibrosis induced by purse string suture only or transfixation suture only.

2.
J Pediatr Hematol Oncol ; 45(7): 423-426, 2023 10 01.
Artigo em Inglês | MEDLINE | ID: mdl-37490638

RESUMO

BACKGROUND: Respiratory system involvement is common in congenital plasminogen deficiency. Although many treatment approaches have been tried, there is still no definitive treatment for respiratory system involvement. OBSERVATIONS: We report 2 congenital plasminogen deficiency cases, who presented with severe respiratory symptoms, for whom a novel treatment modality was tried. After intravenous administration of FFP (fresh frozen plasma), tissue plasminogen activator and FFP were administered intratracheally, and respiratory system findings improved. CONCLUSIONS: Intratracheal administration of tissue plasminogen activator and FFP is an available treatment modality for patients with lung involvement. Fibrin plaques should be carefully removed and new lesion formation should be prevented.


Assuntos
Transtornos de Proteínas de Coagulação , Ativador de Plasminogênio Tecidual , Humanos , Ativador de Plasminogênio Tecidual/uso terapêutico , Plasminogênio , Plasma
3.
J Pediatr Urol ; 19(2): 197.e1-197.e7, 2023 04.
Artigo em Inglês | MEDLINE | ID: mdl-36464563

RESUMO

INTRODUCTION: Diagnosing real urinary obstruction and surgical decision making for the operative correction of urinary obstruction, are still problematic in congenital hydronephrosis (CH). Compliance of the renal pelvis is one of the important defense mechanisms of renal parenchyma against urinary obstruction. We observed early loss of function in some cases of CH with low and moderate anteroposterior diameter of the renal pelvis (APDRP). OBJECTIVE: To evaluate structural properties of the renal pelvic tissue of patients with CH and the relation of these structural properties with renal function and Anteroposterior diameter of the renal pelvis. STUDY DESIGN: Ureteropelvic junction (UPJ) excised during UPJ obstruction operations from 2013 to 2019 were evaluated histopathologically. The patients were divided into the two groups according to initial renal function, i.e. group with initial preoperative differential renal function (DRF) less than 35% and group with initial DRF greater than 35%. The percentage of collagen to whole tissue area were analyzed using image processing program. The relationship between DRF and tissue collagen ratio, SFU and APDRP was evaluated. RESULTS: There were 5 patients in the DRF <35% group and 16 patients in the DRF >35% group. However, APDRP's of the DRF <35% group were also significantly lower than the DRF >35% group. The collagen distribution in the muscle layer was more prominent in the DRF <35% group. Proportionally, percentage of collagen stained surface was significantly higher in DRF <35% group. DISCUSSION: There are numerous histopathological studies evaluating the cause of UPJ obstruction. Besides these studies that are oriented to etiology, there are many studies comparing the histopathological changes at UPJ with surgical outcome and prognosis. In the present study, we found that renal pelvis collagen ratio was significantly increased in patients with lower APDRP and with severe renal function loss. This increase in the collagen content in the renal pelvis have been shown to affect the compliance negatively and decrease APDRP, which leads to a faster loss of renal function. Thus, pelvic structural changes accompanying UPJ obstruction may aggravate urinary obstructive process. CONCLUSION: Increased renal pelvis collagen ratio negatively affects the expansion of the renal pelvis, which is one of the protective mechanisms of the renal parenchyma, and may be one of the triggering mechanisms of early loss of renal function.


Assuntos
Hidronefrose , Obstrução Ureteral , Humanos , Lactente , Renografia por Radioisótopo/métodos , Pelve Renal/patologia , Hidronefrose/diagnóstico por imagem , Hidronefrose/etiologia , Rim/diagnóstico por imagem , Rim/fisiologia , Rim/patologia , Obstrução Ureteral/diagnóstico , Obstrução Ureteral/diagnóstico por imagem , Diurese , Estudos Retrospectivos
4.
J Child Health Care ; 27(4): 667-679, 2023 12.
Artigo em Inglês | MEDLINE | ID: mdl-36349442

RESUMO

Aim of this study was to develop a patient satisfaction scale for needs and expectations of pediatric surgery patients and to propose a new measurement tool in this field. Population of study consisted of all patients between May 2018 and February 2020 at a pediatric surgery service of a university hospital in Turkey. A pool of 70 items was prepared for scale. Two items were removed in line with expert opinions and suggestions. As a result of content validity and test application, 36 items were removed, and scale was revised. Data were transferred to SPSS Statistics 23 and AMOS 22 program. After evaluating scope validity of scale, Content Validity, Structural Validity, Exploratory Factor Analysis, and finally Reliability Analysis were examined. As a result of the analyses, 32 items with eight sub-dimensions were obtained from scale. Eight-factor scale explained 60.42% of total variance. Cronbach Alpha internal consistency of scale was found to be 0.88. Item factor loads of scale were created and the reliability of scale were obtained at desired level. The scale is suitable for patients aged 6 to 18 years old.


Assuntos
Satisfação do Paciente , Criança , Humanos , Adolescente , Reprodutibilidade dos Testes , Turquia , Inquéritos e Questionários , Psicometria/métodos
6.
Pol J Radiol ; 86: e372-e379, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34322187

RESUMO

PURPOSE: To evaluate the mean lung density in children with pectus excavatum (PE) and to assess the correlation between the cardiac rotation angle, Haller index, pulmonary function test, and lung density. MATERIAL AND METHODS: This retrospective study included 33 children with PE and 31 healthy controls. The densities of lung parenchyma were evaluated by quantitative computed tomography (CT). Three lung levels were determined: T4 vertebra level, T10 vertebra level, and the level of the measurement of the cardiac rotation angle. The cardiac rotation angle and the Haller index were calculated. All measurements were done by 2 radiologists, independently. Student's t-test or the Mann-Whitney U test, intraclass correlation coefficients, Pearson or Spearman's rank correlation coefficient, and Kruskal-Wallis test were used for statistical analysis. A p-value less than 0.05 was considered as statistically significant. RESULTS: All the lung levels in the PE group had lower mean densities than healthy children, with statistical significance in the right lung at the T10 vertebra level (-818.60 ± 33.49 HU, -798.45 ± 40.24 HU; p = 0.028). There was a correlation between the cardiac rotation angle and the Haller index (r = 0.593; p < 0.001). There were no correlations between mean lung density and cardiac rotation angle, Haller index, and pulmonary function tests. CONCLUSIONS: The lower mean lung densities were found in PE, especially in the right lower lobe. The parenchymal aeration should be considered independently from the severity of PE.

7.
Int Urol Nephrol ; 53(9): 1813-1818, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34037908

RESUMO

PURPOSE: We aimed to present the results of urinary continence assessment objectively with electromyography (EMG)-uroflowmetry after high urogenital sinus (HUGS) repair with posterior prone approach without division of rectum. METHODS: The records of patients who underwent HUGS repair via posterior prone approach between January 2005 and July 2018 were reviewed retrospectively. Incontinence, dysuria, hesitation, and straining during urination were evaluated during the clinical follow-up. Dysfunctional voiding scoring system was used as a questionnaire. Patients were re-evaluated with EMG-uroflowmetry in terms of voiding volume and pattern, voiding time, maximum flow rate, average flow rate, maximum flow time, and post-voiding residual volume. RESULTS: Seven patients with HUGS were treated with a posterior prone approach. The median age of the patients was 18 months (8-21 months). The median UGS length was 4.4 cm (3.6-5.5 cm), urethral length was 1.1 cm (1.0-1.5 cm), and vaginal length was 4.9 cm (4.1-5.1 cm). No urination or defecation problems were described by the patients or their parents. When the results of the dysfunctional voiding scoring systems questionnaire were analyzed, results scored 7 (range 5-8). EMG-uroflowmetric test graphics of the patients showed normal flow curves without plateau, intermittency or irregularity. Pelvic EMG assessment was normal in all patients. CONCLUSION: EMG-uroflowmetry has shown objectively that urinary continence and normal voiding pattern are preserved after HUGS repair with posterior prone approach without division of rectum.


Assuntos
Genitália Feminina/anormalidades , Genitália Feminina/cirurgia , Complicações Pós-Operatórias/diagnóstico , Incontinência Urinária/diagnóstico , Sistema Urinário/anormalidades , Sistema Urinário/cirurgia , Pré-Escolar , Eletromiografia , Feminino , Humanos , Lactente , Posicionamento do Paciente , Complicações Pós-Operatórias/fisiopatologia , Decúbito Ventral , Estudos Retrospectivos , Incontinência Urinária/fisiopatologia , Urodinâmica , Procedimentos Cirúrgicos Urológicos/métodos
8.
J Clin Ultrasound ; 49(5): 451-455, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33782988

RESUMO

PURPOSE: To detect false-positive reduction results after ultrasound (US)-guided hydrostatic intussusception reduction, we have incorporated water-soluble contrast material to the enema fluid and confirmed the reduction with a single abdominal radiograph. We present the results of the combined imaging method for the reduction of intussusception in children. MATERIALS AND METHODS: The records of the patients who were treated for intussusception were analyzed retrospectively. Patients were divided into two groups: a US-guided reduction group and a US-guided reduction plus radiographic control group. The patient characteristics, symptoms, treatment methods, outcomes, and complications and follow-up were analyzed. RESULTS: A total of 164 intussusception episodes were treated in 153 patients. Hydrostatic reduction of intussusception was performed in 59 patients in the US-guided group and in 94 patients in the US-guided plus radiographic control group. Recurrence rate in the US-guided group was 15.7%, vs 3.5% in the US-guided plus radiography group (P = .029). In the US-guided plus radiographic control group, 5 (5.3%) false positive reductions under US guidance were determined by abdominal radiography. CONCLUSION: In order to decrease false positive reduction rate and early recurrence, US-guided intussusception reduction can be performed with saline plus water-soluble contrast material and confirmation of reduction obtained with a single direct abdominal radiograph.


Assuntos
Enema/métodos , Intussuscepção/diagnóstico por imagem , Intussuscepção/terapia , Radiografia Abdominal , Criança , Pré-Escolar , Meios de Contraste , Humanos , Lactente , Masculino , Recidiva , Estudos Retrospectivos , Solução Salina , Ultrassonografia
9.
J Pediatr Surg ; 55(8): 1610-1612, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31378366

RESUMO

PURPOSE: In this study, we aimed to compare the effects of testicular vein ligation level on complications encountered; i.e. high-level ligation cranial to the linea terminalis vs ligation caudal to the linea terminalis. METHODS: A total of 47 unilateral adolescent patients, treated with laparoscopic varicocelectomy between January 2004 and December 2017, were reviewed retrospectively. Patients were divided into two groups in terms of ligation level: caudal to the linea terminalis as group 1 and cranial to the linea terminalis as group 2. Symptoms, varicocele grades, preoperative testicular growth arrest, operative method, hydrocele formation, postoperative recurrence and testicular catch-up growth were recorded. RESULTS: The mean operation time was 38.6 ±â€¯10.2 min (34-53 min) in group 1 and was 33.6 ±â€¯6.4 min (29-42 min) in group 2. Single hydrocele occurred in the laparoscopic nonselective varicocelectomy in group 1 (4.5%) and was successfully treated with open hydrocelectomy. Single varicocele recurrence was observed in the laparoscopic selective varicocelectomy in group 1 (4.5%) and treated with laparoscopic nonselective varicocelectomy cranial to the linea terminalis. CONCLUSIONS: The high-level ligation of the spermatic veins cranial to the linea terminalis during laparoscopic varicocelectomy, independent of the technique applied, may contribute to reasonable low hydrocele and recurrence rates. LEVEL OF EVIDENCE: Level III.


Assuntos
Laparoscopia , Testículo/cirurgia , Varicocele/cirurgia , Procedimentos Cirúrgicos Vasculares , Adolescente , Humanos , Masculino , Duração da Cirurgia , Recidiva , Estudos Retrospectivos , Testículo/irrigação sanguínea , Resultado do Tratamento
10.
J Pediatr Adolesc Gynecol ; 33(3): 318-320, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31874314

RESUMO

BACKGROUND: Herein, we report laparoscopic excision of a retroperitoneal Mullerian cyst, which is uniquely located medial to the left adrenal gland, mimicking adrenal adenoma in an adolescent girl. CASE: A healthy 13-year-old adolescent girl presented with secondary amenorrhea. Ultrasound and magnetic resonance imaging showed a solid-cystic mass medial to the left adrenal gland. Laparoscopic cyst excision was performed. The histopathological findings were consistent with a benign cyst of Mullerian origin. SUMMARY AND CONCLUSION: To the best of our knowledge, this is the first case report of Mullerian cyst located medial to the adrenal gland in all age groups.


Assuntos
Cistos/patologia , Espaço Retroperitoneal/patologia , Adolescente , Cistos/diagnóstico por imagem , Cistos/cirurgia , Feminino , Humanos , Laparoscopia , Imageamento por Ressonância Magnética , Espaço Retroperitoneal/cirurgia , Tomografia Computadorizada por Raios X , Ultrassonografia
11.
J Pediatr Surg ; 52(3): 481-483, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-28029371

RESUMO

OBJECTIVE: Intraamniotic meconium has been responsible for intestinal damage in gastroschisis and meconium-dependent intestinal ischemia has been proposed to induce additional intestinal damage in gastroschisis. This study is aimed to determine the effects of lipid and water-soluble meconium subfractions on the contractility of the superior mesenteric artery (SMA). MATERIALS AND METHODS: The study was conducted on 18-day fertilized chick embryos (Gallus Domesticus). Meconium is fractioned into water and lipid-soluble components. Only one SMA tissue was prepared from each embryo and suspended in the organ bath. Isometric contraction responses (ICR) were created in SMA tissues by one hour of incubation in Krebs-Henseleit solution for each group. Groups consisted of control, meconium, water-soluble meconium subfraction and lipid-soluble meconium subfraction. ICR of the SMA specimens were evaluated with a transducer-amplifier system on a computer. The data were expressed (mean±1SD) as milliNewton (mN). RESULTS: The ICR of the meconium, water-soluble meconium subfraction and lipid-soluble meconium subfraction groups were significantly high when compared to the control group (p<0.01). The meconium and water-soluble meconium subfraction created more contraction response than the lipid-soluble meconium subfraction (p<0.01). The ICR of the meconium group was not different from the ICR of the water-soluble meconium subfraction group (p>0.05). CONCLUSION: Water-soluble meconium subfraction has a profound vasoconstrictor effect on the SMA compared to the lipid-soluble meconium subfraction.


Assuntos
Gastrosquise/fisiopatologia , Enteropatias/fisiopatologia , Mecônio/química , Artéria Mesentérica Superior/fisiopatologia , Vasoconstrição , Animais , Embrião de Galinha , Gastrosquise/complicações , Glucose/química , Enteropatias/etiologia , Intestinos/fisiopatologia , Lipídeos/química , Trometamina/química , Água/química
12.
Turk J Urol ; 42(4): 285-289, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-27909623

RESUMO

OBJECTIVE: Myelomeningocele (MMC) is one of the most common reason of neurogenic bladder dysfunction in children. Although neurogenic bladder dysfunction occurrence is related with bladder innervation, also there are some changes seen in the smooth muscle and neural cells of the bladder. Interstitial cells of Cajal (ICC) are the pacemaker cells found in organs with peristaltic activity. Although it has been shown that ICC are diminished in the rat urinary bladder with traumatic spinal cord injury, there is no data about ICC in fetal rat bladders with MMC. This study has been conducted to investigate the ICC in the bladders of fetal rats with retinoic acid induced MMC. MATERIALS AND METHODS: Time dated pregnant Wistar albino rats were divided into 3 groups. In MMC group, dams were fed with gavage solution containing 60 mg/kg all-trans retinoic acid dissolved in olive oil on 10. embryologic day. Sham group animals were fed only olive oil. Control group dams were fed with standard rat chow. Fetuses were delivered by cesarean section and harvested on 22. embryologic day. MMC was identified by observing MMC sacs at the back of the fetuses. Distribution of ICCs were evaluated using immunohistochemical staining. RESULTS: ICCs were found in all groups, which have the same morphological features that had been described earlier in the gastrointestinal tract and the bladder. The density of the ICC in the MMC group was found to be significantly decreased when compared with the control and the sham groups (p<0.05). CONCLUSION: The density of the ICC in the urinary bladder decreased in the neurogenic bladder developed in MMC.

13.
Ann Thorac Med ; 11(3): 214-8, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27512512

RESUMO

BACKGROUND: Modifications defined to ease bending of the support bar and lateral stabilizer placement during minimal invasive repair of pectus excavatum (MIRPE) have not been reported. We herein report our experience with MIRPE including several technical modifications. METHODS: A total of 87 patients who underwent MIRPE were evaluated retrospectively. Technical modifications are (1) a template drawn preoperatively according to the anthropometric measurements, (2) more laterally placed thoracal incisions, (3) single existing incision for multiple support bars, (4) to secure lateral stabilizers to support bar in inverted position. RESULTS: The mean patient age was 11.2 ± 3.8 years. The mean operating time was 63.7 ± 18.7 min. The mean Haller index was 5.4 ± 2.1. Eight patients necessitated two support bars. The support bars were removed in 69 patients after the completion of treatment. Support bars were left in place 26.8 ± 4.3 months. Final chest contours of the 56 patients were evaluated as 12 months passed after support bar removal and excellent repair results were determined in 84.2%. CONCLUSION: Preoperative bending of the support bar according to anthropometric measurements and fixation of the lateral stabilizers to the support bar in inverted position facilitates bar shaping and lateral stabilizer placement.

14.
J Pediatr Surg ; 51(8): 1303-6, 2016 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-27039120

RESUMO

BACKGROUND: It is unclear which substances in meconium are responsible for intestinal damage in gastroschisis. An experimental study was designed to investigate the effects of the lipid or water soluble subfractions of meconium on the intestines of gastroschisis in a chick model. METHODS: Meconium was pooled, homogenated, rota-evaporated dry and diluted. Meconium subfractions were obtained from water soluble and lipid soluble extracts of the meconium. Five days old fertilized chick embryos were used and divided into 5 groups: control, sham, water soluble meconium subfraction, lipid soluble meconium subfraction and whole meconium. All embryos were extirpated on the 18days and the intestines were harvested for histopathological examination. Serosal thickness was measured under light microscopy. RESULTS: Serosal thickness of the meconium (36.36±2.8µm), the water soluble meconium (14.15±0.93µm) and the lipid soluble meconium (23.88±1.69µm) subfractions groups were significantly increased compared with the control (7.47±0.68µm) and the sham (7.48±0.71µm) groups (p<0.001). Serosal thickness of the lipid soluble meconium subfraction group was significantly increased compared with the water soluble meconium subfraction group (p<0.001). Serosal thickness of the meconium group was significantly increased compared to both the water and the lipid soluble meconium subfraction groups (p<0.001). CONCLUSION: Lipid soluble meconium subfraction induces more intestinal damage compared to water soluble meconium subfraction.


Assuntos
Gastrosquise/patologia , Enteropatias/patologia , Intestinos/patologia , Mecônio/química , Animais , Embrião de Galinha , Gastrosquise/complicações , Enteropatias/etiologia , Lipídeos , Solubilidade , Água
15.
J Minim Access Surg ; 12(1): 16-21, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-26917914

RESUMO

BACKGROUND: Laparoscopic appendectomy (LA) is gradually gaining popularity among paediatric surgeons for complicated appendicitis. A retrospective study was conducted to compare conventional single port LA, multiport LA and open appendectomy (OA) for complicated appendicitis in children. PATIENTS AND METHODS: From January 1995 from December 2014, 1,408 patients (604 girls, 804 boys) underwent surgery for uncomplicated and complicated appendicitis. The patient characteristics, operation times, duration of hospitalization, operative costs, and postoperative complications were recorded. A 10-mm 0(°) scope with a parallel eye piece and an integrated 6 mm working channel were inserted through an 11-mm "conventional umbilical port" for single port LA. RESULTS: A total of 314 patients with complicated appendicitis (128 girls, 186 boys) underwent appendectomy. Among these, 102 patients (32.4%) underwent single port LA, 17 patients (5.4%) underwent multiport LA and 195 patients (62.1%) underwent OA. The hospital stay of the single port LA group was significantly less (3.88 ± 1.1) compared with multiport LA (5.41 ± 1.2) and OA groups (6.14 ± 1.1) (P < 0.001). Drain usage, wound infection and adhesive intestinal obstruction rates were significantly high in the OA group. There was no significant difference between the groups in postoperative intraabdominal abscess formation. Single-port LA performed for complicated appendicitis was cheaper compared with the other groups. CONCLUSIONS: The present study has shown that single-port LA for complicated appendicitis can be conducted in a reasonable operative time; it shortens the hospitalization period, markedly reduces postoperative wound infection and adhesive intestinal obstruction rates and does not increase the operative cost.

16.
Dig Dis Sci ; 61(3): 900-4, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-26547756

RESUMO

BACKGROUND AND AIMS: Interstitial cells of Cajal (ICC) have been shown to be present in the extrahepatic biliary tract of animals and humans. However, ICC distribution in choledochal cysts (CC) has not been investigated. A study was conducted to investigate the distribution of ICC in the extrahepatic biliary tract, including CC, in pediatric human specimens. METHOD: The specimens were divided into two main groups as gallbladders and common bile ducts. Gallbladders were obtained from the cholelithiasis, CC operations and autopsies. Common bile ducts were obtained from autopsies. Tissues were stained using c-kit immunohistochemical staining. ICC were assessed semi-quantitatively by applying morphological criteria and were counted as the number of cells/0.24 mm(2) in each area under light microscopy. RESULTS: A total of 35 gallbladders and 14 CC were obtained from operations. Ten gallbladders plus common bile ducts were obtained from autopsies. The mean numbers of ICC in the gallbladders of cholelithiasis and the gallbladders of CC were 12.2 ± 4.9 and 5.3 ± 1.2, respectively (p = 0.003). The mean numbers of ICC in the common bile ducts and CC were 9.8 ± 2.9 and 3.4 ± 1.4, respectively (p = 0.001). CONCLUSION: The scarcity of ICC in the extrahepatic biliary tract may be responsible for the etiopathogenesis of the CC.


Assuntos
Cisto do Colédoco/patologia , Ducto Colédoco/citologia , Vesícula Biliar/citologia , Células Intersticiais de Cajal/citologia , Adolescente , Estudos de Casos e Controles , Contagem de Células , Criança , Pré-Escolar , Colecistectomia , Cisto do Colédoco/metabolismo , Cisto do Colédoco/cirurgia , Colelitíase/cirurgia , Ducto Colédoco/metabolismo , Feminino , Vesícula Biliar/metabolismo , Humanos , Imuno-Histoquímica , Lactente , Células Intersticiais de Cajal/metabolismo , Masculino , Proteínas Proto-Oncogênicas c-kit/metabolismo
17.
Eur J Pediatr Surg ; 25(4): 373-6, 2015 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-24870946

RESUMO

INTRODUCTION: Intestinal damage has been shown to occur when intra-amniotic meconium concentration exceeds threshold level. However, the mechanism of the meconium-induced intestinal damage is still unclear. Intestinal ischemia can cause intestinal damage in gastroschisis. This study was aimed to determine the effects of intra-amniotic meconium on the contractility of superior mesenteric artery (SMA). MATERIALS AND METHODS: Eighteen-day-old fertilized chick embryos (Gallus Domesticus) were extirpated and intestines were harvested. The SMA specimens were prepared as 4 mm segments in the organ bath with Krebs-Henseleit buffer. The isometric contraction responses of the SMA specimens were evaluated with norepinephrine, different meconium concentrations, and clear amniotic fluid. Maximum isometric contractions responses (MICR) of the SMA specimens were recorded with an amplifier system on a computer. RESULTS: In the norepinephrine group, MICR was found as 2.92 ± 0.57 mN. While MICR of the 1/100 meconium group (highest meconium concentration) was found as 1.56 ± 0.40 mN, MICR of the clear amniotic fluid group was 0.41 ± 0.07 mN. The MICR of the norepinephrine group was significantly increased compared with the 1/100 meconium and clear amniotic fluid groups. MICR of the 1/100 meconium group was also found to be significantly increased compared with clear amniotic fluid group. No statistically significant difference was found among the meconium subgroups. CONCLUSION: Intra-amniotic meconium in fetuses with gastroschisis might cause ischemic intestinal damage by reducing the intestinal blood flow. Further studies are needed to show the outcomes of the vasoactive effect of meconium on the SMA blood flow.


Assuntos
Gastrosquise/fisiopatologia , Mecônio/fisiologia , Artéria Mesentérica Superior/fisiopatologia , Vasoconstrição/fisiologia , Animais , Embrião de Galinha , Modelos Animais de Doenças , Humanos , Técnicas In Vitro , Intestinos/irrigação sanguínea , Isquemia/etiologia , Contração Isométrica/fisiologia , Norepinefrina/farmacologia , Vasoconstritores/farmacologia
18.
Eur J Pediatr Surg ; 24(4): 337-40, 2014 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-23737131

RESUMO

PURPOSE: Fetal ovarian cysts' size and nature are considered as the most important factors for determining the treatment modality. When to perform an intervention and to which fetal ovarian cysts has not been clarified yet. We herein present our experience with fetal ovarian cysts. Materials and METHODS: The hospital records of 38 ovarian cysts (27 simple and 11 complex) were evaluated retrospectively. The prenatal and postnatal outcomes of the cysts were investigated. RESULTS: Prenatally at the 37 fetuses, 38 fetal ovarian cysts were evaluated retrospectively. There were 27 simple and 11 complex fetal ovarian cysts followed by prenatally and postnatally. None of the simple fetal ovarian cysts underwent in utero torsion. Postnatally, 23 simple ovarian cysts were regressed within 3 months. Four patients with simple ovarian cysts larger than 4 cm were operated. During follow-up period, seven complex ovarian cysts regressed, one complex ovarian cyst complicated with intestinal obstruction underwent surgery, and three complex ovarian cysts did not regress and they were operated. Three out of seven complex ovarian cysts that were initially regressed presented with intestinal obstruction and oophorectomy plus adhesiolysis were performed. Surgical treatment was required in 7 out of 11 (64%) complex ovarian cysts. CONCLUSION: Complex ovarian cysts lead to problems even after regression in the postnatal period and require operative intervention sooner or later.


Assuntos
Doenças Fetais/cirurgia , Cistos Ovarianos/cirurgia , Feminino , Doenças Fetais/diagnóstico por imagem , Humanos , Obstrução Intestinal/etiologia , Cistos Ovarianos/complicações , Cistos Ovarianos/diagnóstico por imagem , Remissão Espontânea , Estudos Retrospectivos , Ultrassonografia Pré-Natal
19.
J Laparoendosc Adv Surg Tech A ; 23(8): 728-32, 2013 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-23837513

RESUMO

PURPOSE: As the interest in minimal invasive surgery has turned to single-site access surgery, single-incision laparoscopic surgery (SILS) is becoming popular. Recently limited numbers of pediatric SILS series have been published. SILS needs nonconventional three-lumen ports and articulated working instruments. However, it is possible to perform single-port laparoscopic cholecystectomy using a single conventional port and conventional working instruments. We herein present our preliminary experience with cholecystectomy conducted with single-port incisionless-intracorporeal conventional equipment-endoscopic surgery. SUBJECTS AND METHODS: During December 2009-October 2012, 27 patients (12 boys, 15 girls) underwent single-port incisionless-intracorporeal conventional equipment-endoscopic cholecystectomy. A 10-mm 0° scope with a parallel eye piece and an integrated 6-mm working channel is inserted through an 11-mm "conventional umbilical port." Conventional working instruments were introduced through the integrated working channel. The fundus of the gallbladder is hung with a transabdominal sling suture. The infundibulum is retracted laterally to expose the triangle of Calot with a second transabdominal sling suture. Then the cystic duct and the artery are dissected and clipped separately. The gallbladder is dissected from the liver bed with monopolar cautery and extracted through the umbilicus. RESULTS: The patients were 5-17 years of age (mean, 10.7±4.6 years). Cholecystectomy was performed through a single port in 23 patients. A second port insertion was necessary in 4 patients. No preoperative or postoperative complications were encountered. Mean operating time was 74.3±13 minutes. CONCLUSIONS: Single-port incisionless-intracorporeal conventional equipment-endoscopic cholecystectomy is feasible in pediatric patients with reasonable operating times. It is a safe, cheap, and highly minimal invasive procedure with excellent cosmetic results.


Assuntos
Colecistectomia Laparoscópica/instrumentação , Colecistectomia Laparoscópica/métodos , Doenças da Vesícula Biliar/cirurgia , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Masculino
20.
Eur J Cardiothorac Surg ; 44(3): e228-32, 2013 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-23824936

RESUMO

OBJECTIVES: The treatment of pectus carinatum (PC) deformity has been considered to be operative. Some authors have shown that postoperative pulmonary function is worsened. They have suggested that compromised chest wall expansion secondary to surgery leads to compromised pulmonary function. Several authors have advocated an orthotic brace for the treatment of PC. Pulmonary functions after orthotic brace treatment have not been investigated. METHODS: Between April 2006 and October 2012, 61 patients presented with PC. Orthotic braces allowing gradual compression were prepared according to the anthropometric measurements of individual patients. The brace belt was tightened gradually. The brace was worn 6 h a day during the first week and the bracing time was prolonged for an additional hour per week till 16 h per day has been reached. Pre- and post-treatment echocardiography, pulmonary function tests and thorax computed tomography (CT) were obtained. The pectus severity index (Haller index) and the angle of sternal rotation were measured using CT. Satisfaction from bracing was evaluated by parents or patients at the end of the treatment. RESULTS: While the mean pretreatment Haller index was 1.96 ± 0.24, the mean post-treatment index was 2.26 ± 0.32. The angle of rotation was improved by 47.5%. Forced vital capacity and forced expiratory volume in 1 second were correlated with the predicted values for age. There was no statistically significant difference between pre- and post-treatment values. No skin breakdown or bruising was encountered. The overall average satisfaction score was 3.92 ± 0.27. CONCLUSIONS: We conclude that pulmonary function tests are not affected after brace treatment and gradual progression of bracing increases the patient's compliance.


Assuntos
Braquetes , Anormalidades Musculoesqueléticas/terapia , Cooperação do Paciente , Esterno/anormalidades , Tórax/anormalidades , Adolescente , Criança , Pré-Escolar , Estudos de Coortes , Ecocardiografia , Feminino , Humanos , Masculino , Testes de Função Respiratória , Tomografia Computadorizada por Raios X , Resultado do Tratamento
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...