RESUMO
Over the past two decades, immunohistochemical techniques have improved to such a degree that it is now a common adjuvant test to the traditional hematoxylin and eosin-stained histologic sections. It is used in most realms of surgical pathology and can often aid in final diagnosis and, in some cases, prognosis. However, immunohistochemistry (IHC) is not always helpful and many pitfalls to its use exist. Understanding the basics of IHC, its utility and difficulties will aid clinicians in better understanding how diagnoses are rendered. This study reviews the general principles of IHC and demonstrates its utility with several commonly encountered problematic areas in gynecological pathology.
Assuntos
Carcinoma/diagnóstico , Carcinoma/patologia , Neoplasias dos Genitais Femininos/diagnóstico , Neoplasias dos Genitais Femininos/patologia , Imuno-Histoquímica/métodos , Carcinoma/secundário , Análise Custo-Benefício , Inibidor p16 de Quinase Dependente de Ciclina/análise , Feminino , Neoplasias dos Genitais Femininos/secundário , Humanos , Imuno-Histoquímica/economia , Queratina-20/análise , Queratina-7/análise , Neoplasias Primárias Desconhecidas/diagnósticoRESUMO
Liesegang rings are lamellated concretions commonly found in chronic cystic lesions that are inflamed, necrotic, fibrotic, or hemorrhagic. We report on an unusual case of a 14-yr-old girl with an acute, rapidly enlarging solid submental mass in which Liesegang rings were identified on aspirate smears.
Assuntos
Cisto Epidérmico/patologia , Dermatopatias/patologia , Doença Aguda , Adolescente , Biópsia por Agulha , Precipitação Química , Queixo , Cisto Epidérmico/cirurgia , Feminino , Humanos , Dermatopatias/cirurgiaAssuntos
Alveolite Alérgica Extrínseca/induzido quimicamente , Alveolite Alérgica Extrínseca/diagnóstico por imagem , Antineoplásicos Fitogênicos/efeitos adversos , Paclitaxel/efeitos adversos , Tomografia Computadorizada por Raios X , Antineoplásicos Fitogênicos/uso terapêutico , Neoplasias da Mama/tratamento farmacológico , Terapia Combinada , Feminino , Humanos , Pessoa de Meia-Idade , Paclitaxel/uso terapêutico , Fatores de TempoRESUMO
Right ventricular heart involvement of an otherwise unknown hepatocellular carcinoma is presented and the cytologic differential diagnosis is discussed. This tumor displays classic cytologic features of hepatocellular carcinoma, including trabecular arrangements with prominent endothelial cells and numerous intracytoplasmic hyaline bodies. The background contains many "naked nuclei" and extracellular hyaline bodies. The patient is alive with residual disease 4 months after surgical extirpation of the cardiac mass.
Assuntos
Carcinoma Hepatocelular/secundário , Neoplasias Cardíacas/secundário , Neoplasias Hepáticas/patologia , Idoso , Biópsia por Agulha , Carcinoma Hepatocelular/metabolismo , Feminino , Átrios do Coração/patologia , Neoplasias Cardíacas/metabolismo , Neoplasias Cardíacas/cirurgia , Humanos , Hialina/metabolismo , Neoplasias Hepáticas/metabolismo , Imageamento por Ressonância MagnéticaRESUMO
Individuals with more than one defect in natural coagulant/anticoagulant systems have been postulated to be at an increased risk for thrombotic events. We report a case of combined protein S and C deficiency in a young woman, which resulted in fatal arterial mesenteric thrombosis. The role of coagulation defects in arterial thrombosis is discussed.
