Fluorescein and indocyanine green videoangiography of choroidal melanomas.

PURPOSE: This study was performed to determine what role indocyanine green video angiography might play in the evaluation of choroidal melanomas, and to compare this role with that of fluorescein angiography. METHODS: Six patients with posterior segment uveal melanoma underwent digital fluorescein and indocyanine green videoangiography. All patients were women and their mean age was 50.7 years. RESULTS: In all eyes with melanoma, fluorescein angiography revealed irregular hyperfluorescence in the early phase and staining of the tumor in the late phase. A double circulation pattern was obvious in 1 eye with a mushroom-shaped melanoma. The patterns of indocyanine green videoangiography varied, depending on the degree of tumor pigmentation, thickness, and vascularity. Early frames of indocyanine green video angiography demonstrated hypofluorescence in all eyes, and the intrinsic choroidal vasculature was obvious in 3 eyes. In the late phase of indocyanine green videoangiograms, different patterns (hyperfluorescence, three-ring pattern) were observed. CONCLUSION: Indocyanine green videoangiography may be a useful adjunct to fluorescein angiography in the evaluation of choroidal melanomas.

ICG videoangiography of occult choroidal neovascularization in age-related macular degeneration.

Digital indocyanine green videoangiography has recently been reported to improve the imaging of occult choroidal neovascularization. In this study, 44 eyes with occult choroidal neovascularization in age-related macular degeneration were studied with fluorescein and indocyanine green videoangiography. On indocyanine green videoangiographic examination, 6 of the 44 eyes (13.6%) with occult choroidal neovascularization had vascularized pigment epithelial detachment and 27 (61.4%) had vascularized retinal pigment epithelium. In the remaining 11 (25%) eyes which had previous laser photocoagulation, indocyanine green videoangiography confirmed the presence of recurrence while fluorescein revealed no demonstrable neovascularization. The findings in our study indicate that patients with occult choroidal neovascularization have manifestations that are more clearly demonstrated with indocyanine green videoangiography and improved imaging of these abnormal vessels could potentially increase the number of patients eligible for photocoagulation treatment.

[Detection of subretinal neovessels with indocyanine green videoangiography]. / La détection des néovaisseaux sous-rétiniens au moyen de la vidéo-angiographie au vert d'indocyanine.

PURPOSE: To evaluate the ability of indocyanine green videoangiography to delineate the subretinal neovascular membranes and to compare with fluorescein angiography. METHODS: Between August 1993 and November 1994, digital fluorescein and indocyanine green videoangiography was performed in 214 eyes of 108 cases. Of the 108 cases, 96 had age-related macular degeneration, 6 had angioid streaks and 3 had degenerative myopia. RESULTS: On fluorescein angiography, 47 of the 214 eyes had well-defined and 42 had occult subretinal neovascular membrane. Occult membranes were clearly delineated with indocyanine green angiography. Using these two angiographies, we could detect subretinal neovascular membrane in 89 eyes. These membranes were in 79 of the 181 eyes with age-related macular degeneration, 5 of the 12 eyes with angioid streaks and 2 of the 6 eyes with degenerative myopia. In addition, 3 eyes of the 3 cases had idiopathic subretinal neovascular membranes. CONCLUSION: The results of this study indicate that ICG videoangiography is an adjunctive diagnostic tool to fluorescein angiography in the detection of subretinal neovascular membranes in age-related macular degeneration and in other chorioretinal pathologies.

Indocyanine green videoangiography of angioid streaks.

PURPOSE: This study was performed to define the indocyanine green angiographic features of angioid streaks and associated posterior pole lesions and to compare them with fluorescein angiography. METHODS: Digital fluorescein and indocyanine green videoangiography was performed on 16 eyes of 8 patients with angioid streaks. RESULTS: Streaks were hyperfluorescent in 15, hypo- and hyperfluorescent in 1 of the 16 eyes with fluorescein angiography. Indocyanine green angiography showed hyperfluorescent streaks in 10 and hypofluorescent streaks in 6 eyes. Of the hyperfluorescent streaks, 6 had a hypofluorescent line between fluorescent edges and 4 were made up of numerous hyperfluorescent spots. Peau d'orange appearance was more evident in indocyanine green angiography as dark, round spots throughout the posterior pole. Fluorescein angiography confirmed the presence of well-defined choroidal neovascularization in 5 eyes. In one eye, occult choroidal neovascularization which was not evident on fluorescein angiography, became well-demarcated on indocyanine green angiography. CONCLUSION: Indocyanine green angiographic features of angioid streaks are different from fluorescein angiography. Angioid streaks and peau d'orange are more evident with indocyanine green angiography.

Evaluation of choroidal neovascularization in age-related macular degeneration with fluorescein and indocyanine green videoangiography.

This study is performed to evaluate the fluorescein and indocyanine green (ICG) characteristics of choroidal neovascularization (CNV) in age-related macular degeneration (ARMD). 200 eyes of 101 patients were examined with digital ICG videoangiography (ICGV). 190 of the 200 eyes had macular lesions of ARMD, and CNVs were detected in 84 (44.2%) of them. Angiographies confirmed the presence of well-defined CNV in 40 (47.6%) eyes and occult CNV in 44 (52.4%) eyes. On ICG-videoangiographic examination, 6 (13.6%) of the 44 eyes with occult CNV had vascularized pigment epithelial detachment. 27 (61.4%) had a vascularized retinal pigment epithelium. Laser photocoagulation had been performed on the remaining 11 (25%) eyes. The results of this study suggest that ICGV is a valuable technique in the diagnosis and evaluation of occult CNVs and may be suggested as an additional diagnostic tool in cases with choroidal neovascular membranes.