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Mol Biosyst ; 9(6): 1401-10, 2013 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-23483086

RESUMO

Owing to the large panel of biological functions of peptides and their high specificity and potency, the development of peptide-based therapeutic and diagnostic tools has received increasing interest. Peptide amphiphiles (PAs) are an emerging class of molecules in which a bioactive peptide is covalently conjugated to a hydrophobic moiety. Due to the coexistence in the molecule of a hydrophilic peptide sequence and a hydrophobic group, PAs are able to self-assemble spontaneously into a variety of nanostructures, such as monolayers, bilayers, and vesicles. In this work we have synthesized a disordered peptide, henceforth called R11, and two lipophilic derivatives of R11 bearing two alkyl chains, connected or not to R11 by an ethoxylic-based linker. The structural properties in solution of these new PAs were investigated using CD and NMR. R11 lipophilic derivatives display typical features of PAs, such as the formation of micelles and unilamellar vesicles. In addition, their surface properties were studied using Langmuir monomolecular films and the results obtained support the formation of molecular aggregates upon compression of the PA films. The presence of the alkyl chains induces not only the self-assembly of these new PAs into supramolecular aggregates but also a gain of structure within the disordered peptide.


Assuntos
Proteínas Intrinsicamente Desordenadas/química , Nanoestruturas/química , Peptídeos/química , Tensoativos/química , Dicroísmo Circular , Interações Hidrofóbicas e Hidrofílicas , Lipossomos , Micelas , Ressonância Magnética Nuclear Biomolecular , Peptídeos/análise , Peptídeos/síntese química , Ligação Proteica , Conformação Proteica , Propriedades de Superfície
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