RESUMO
The authors evaluated the performance characteristics of the Abbott AxSYM Vancomycin II immunoassay in sera of patients with (n = 93 samples) and without (n = 327 patients) renal dysfunction. Correlation of vancomycin measurements with the Abbott AxSYM Vancomycin, Abbott TDx/TDxFLx, Syva enzyme-multiplied immunoassay technique (EMIT), DuPont automated chemistry analyzer (ACA), and high-performance liquid chromatography methods showed acceptable correlation as indicated by: slope values >0.95, r-values >0.97, y-intercepts <1.7 microg/ml, and S(y/x) ranging from 9% to 15% of the average vancomycin value. The AxSYM Vancomycin II assay showed acceptable correlation with AxSYM vancomycin, TDx/TDxFLx, and high-performance liquid chromatography methods in 93 samples from patients with renal dysfunction. This monoclonal antibody-based assay showed no apparent interference from the presence of human antimouse antibody (HAMA) or the microbiologically inactive vancomycin crystalline degradation product (CDP). The authors conclude that the AxSYM Vancomycin II assay showed satisfactory agreement with other methods tested in this study.
Assuntos
Antibacterianos/sangue , Monitoramento de Medicamentos/normas , Imunoensaio de Fluorescência por Polarização/normas , Vancomicina/sangue , Antibacterianos/química , Calibragem , Cromatografia Líquida de Alta Pressão/normas , Contaminação de Medicamentos/prevenção & controle , Monitoramento de Medicamentos/métodos , Técnica de Imunoensaio Enzimático de Multiplicação/normas , Imunoensaio de Fluorescência por Polarização/métodos , Humanos , Técnicas In Vitro , Infecções/sangue , Infecções/tratamento farmacológico , Infecções/etiologia , Nefropatias/sangue , Nefropatias/complicações , Transplante de Rim/fisiologia , Modelos Lineares , Valores de Referência , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Vancomicina/químicaRESUMO
This article describes the placement, success rate, and evaluation of an experimental alumina (Al2O3) ceramic dental implant at a mean placement time of 5 years. The study compared the longevity of a submerged implant of the same root design and a refined surgical technique with previously reported studies of the implant exposed to the human oral environment during initial healing. A 54% success rate was achieved for 29 implants placed in the maxillae and mandible, all restored with cast gold dental crowns. A significant difference (p = 0.05) appeared between success and failures at 7.8 months following placement. Crown/root ratio slopes were an earlier and more sensitive indicator of potential success or failure than the bone height slopes. Computer analysis revealed no apparent correlation between implant mobility and/or pocket depths and implant longevity. Delayed implant root fractures and a cast post fracture occurred in 20% of the implants that survived.