1.
Chirality
; 23(9): 779-83, 2011 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22135807
RESUMO
We report an alternative synthesis of the two enantiomers of the floral fragrance Rosaphen®. The key intermediate 2-methyl-5-phenylpentanoic acid 3 is synthesized via asymmetric hydrogenation (ee up to 99%) in the presence of an in situ prepared ruthenium catalyst containing the chiral ferrocenyl phosphine Mandyphos-4.