Occurrence and distribution of persistent organic pollutants (POPs) in the atmosphere of the Andean city of Medellin, Colombia.

Passive air sampling (PAS) was used to evaluate organochlorine pesticides, polychlorinated biphenyls, polybrominated diphenyl ethers, polybrominated biphenyl, hexabromocyclododecane, polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and perfluoroalkane substances in the atmosphere of Medellin, Colombia. PAS was carried out for three months (four quarters per year) over two consecutive years (2017 and 2018). This study allowed establishing the baseline of some pollutants in the city against which future temporal trends can be assessed. Furthermore, monitoring results suggested releases of DDT in the city or surrounding areas despite this pollutant was banned many years ago in the country. Moreover, this study evidenced the limited scope of the national laboratories to analyze persistent organic pollutants, specially brominated and fluorinated contaminants. However, there is an installed capacity to analyze organochlorine pesticide and indicator PCB in future national monitoring plans. Therefore, it is essential to realize efforts to improve the analytical capacity and increase the scope of the national laboratories. Furthermore, the PAS strategy was valuable for monitoring these pollutants in air. Finally, the results provide an overall view of persistent organic pollutants levels and represent an initial attempt to monitor and surveillance the releases of these pollutants in the city.

Human Biomonitoring of Polychlorinated Biphenyls (PCBs) in the Breast Milk of Colombian Mothers.

Polychlorinated biphenyls (PCBs) are persistent in the environment, bioaccumulate and biomagnify throughout the food chain, and may have adverse effects on human health and wildlife. PCB indicator (PCB 28, PCB 52, PCB 101, PCB 118, PCB 138, PCB 153, and PCB 180) were monitored in human milk using 68 samples from healthy and primiparous mothers from seven cities in Colombia, and the estimated daily intake (EDI) of infants was calculated. The PCB indicator with the highest concentration was PCB 153 with a value of 7.30 ng g-1 lipids. The maximum EDI was calculated as 0.257 µg kg-1 bw-1 day-1. In general, the PCB levels found in the 68 samples were low and did not represent a risk to breastfed infants. Additionally, these results could strengthen Colombia's efforts to increase the practice of breastfeeding. Finally, the results establish a general overview of population exposure and can be a scientific tool to improve environmental health policies in the country.

Occupational exposure to polychlorinated biphenyls (PCBs) in workers at companies in the Colombian electricity sector.

Polychlorinated biphenyls (PCBs) comprise a family of 209 congeners that have low electrical conductivity and high thermal resistance due to their physicochemical properties and are thus widely used as dielectric oils, among other applications. Although PCBs are no longer used in dielectric oils in Colombia as of several years ago, electric transformers in Colombia might still contain PCBs, and workers might carry PCBs due to exposure from when they were still used in dielectric fluid. Thus, occupational exposure in Colombia to PCBs was evaluated by determining their concentrations in the blood plasma samples of 115 workers in the electricity sector . The sum of the six PCB indicators was between

Validación de una metodología analítica para determinar bifenilos policlorados en muestras de plasma sanguíneo / Validation of an analytical methodology to determine polychlorinated biphenyls in samples from blood plasma

Resumen Introducción. Los bifenilos policlorados se encuentran entre los cinco contaminantes orgánicos persistentes más tóxicos para los organismos vivos, según la Agency for Toxic Substances and Disease Registry (ATSDR) de los Estados Unidos. Objetivo. Estandarizar y validar un método analítico para la determinación y cuantificación de los bifenilos policlorados indicadores en muestras de plasma sanguíneo, mediante cromatografía de gases acoplada a espectrometría de masas. Materiales y métodos. Se fortificó un pool de plasma para hacer los ensayos en la matriz. Además, se utilizó el material de referencia NIST SRM ® 1958 (Organic Contaminants in Fortified Human Serum, Freeze-Dried) para los ensayos de veracidad y precisión intermedia. Resultados. Los porcentajes de recuperación obtenidos con la metodología estuvieron entre 88,4 y 97,5 %, y el sesgo fue menor del 20 %. Los límites de detección y cuantificación de los bifenilos policlorados indicadores policlorados fueron de 0,04 µg/L y 0,10 µg/L, respectivamente. La linealidad representada por el coeficiente de determinación (R2) varió entre 0,9866 y 0,9886. La precisión expresada como desviación estándar relativa fue menor del 20 % en todo el rango lineal de trabajo (0,5-500 µg/L). Por último, se analizaron 115 muestras de población colombiana de diferentes zonas del país y se encontraron 65 muestras positivas, de las cuales dos estuvieron por encima de los valores de control biológico en humanos (Human Biomonitoring Values, HBM- II): 7,0 µg/L, 2XΣPCB 138, 153, 180 , y otras dos, por encima del HBM-I: 3,5 µg/L, 2XΣPCB 138, 153, 180. Conclusión. El método desarrollado resultó ser preciso para el análisis de los bifenilos policlorados en muestras de plasma sanguíneo y se puede utilizar para el control biológico de estos contaminantes en población colombiana.

Abstract Introduction: Polychlorinated biphenyls are among the five most toxic persistent contaminants for living organisms according to the Agency for Toxic Substances and Disease Registry (ATSDR). Objective: To standardize and validate an analytical method to determine and quantify polychlorinated biphenyl indicators in samples from blood plasma by means of gas chromatography-mass spectrometry. Materials and methods: We fortified a plasma pool to do the matrix assays. Additionally, we used the NIST SRM® 1958 reference material for the veracity and intermediate accuracy assays. Results: Methodology recovery percentages ranged between 88.4 and 97.5%, and the bias was less than 20%. Detection and quantification limits were 0.04 µg/L and 0.10 µg/L, respectively, for all polychlorinated biphenyl indicators. The linearity represented by the determination coefficient (R2 ) varied between 0.9866 and 0.9886. Accuracy, expressed as relative standard deviation was less than 20% in all the linear work range (0.5-500 µg/L). Finally, we analyzed 115 samples from Colombian population in various zones of the country and we found 65 positive samples, from which two samples were above HBM-II (7.0 µg/L, 2XΣPCB 138, 153, 180), and two, above HBM-I (3.5 µg/L, 2XΣPCB 138, 153, 180 ). Conclusion: The method we developed is accurate for PCB analysis in blood plasma samples and could be used for biological surveillance of these contaminants in the Colombian population.

[Validation of an analytical methodology to determine polychlorinated biphenyls in samples from blood plasma].

INTRODUCTION: Polychlorinated biphenyls are among the five most toxic persistent contaminants for living organisms according to the Agency for Toxic Substances and Disease Registry (ATSDR). OBJECTIVE: To standardize and validate an analytical method to determine and quantify polychlorinated biphenyl indicators in samples from blood plasma by means of gas chromatography-mass spectrometry. MATERIALS AND METHODS: We fortified a plasma pool to do the matrix assays. Additionally, we used the NIST SRM® 1958 reference material for the veracity and intermediate accuracy assays. RESULTS: Methodology recovery percentages ranged between 88.4 and 97.5%, and the bias was less than 20%. Detection and quantification limits were 0.04 µg/L and 0.10 µg/L, respectively, for all polychlorinated biphenyl indicators. The linearity represented by the determination coefficient (R2) varied between 0.9866 and 0.9886. Accuracy, expressed as relative standard deviation was less than 20% in all the linear work range (0.5-500 µg/L). Finally, we analyzed 115 samples from Colombian population in various zones of the country and we found 65 positive samples, from which two samples were above HBM-II (7.0 µg/L, 2XΣPCB 138, 153, 180), and two, above HBM-I (3.5 µg/L, 2XΣPCB 138, 153, 180). CONCLUSION: The method we developed is accurate for PCB analysis in blood plasma samples and could be used for biological surveillance of these contaminants in the Colombian population.