Hyaluronic Acid and Platelet-Rich Plasma Mixture Versus Hyaluronic Acid and Corticosteroid in the Treatment of Temporomandibular Joint Internal Derangement: A Comparative Randomized Study.

Objectives: This study aimed to compare the effects of different intra-articular injections using a mixture of hyaluronic acid (HA) and platelet-rich plasma (PRP) versus hyaluronic acid and corticosteroid in the management of TMJ internal derangement with reduction. Materials and Methods: Sixty patients were randomly divided into two equal groups. Group I was injected with hyaluronic acid and PRP, while group II was injected with hyaluronic acid and corticosteroid. Pain intensity according to the visual analogue scale, maximum inter-incisal opening (MIO), lateral movement, and joint sound were measured pre-operatively and at 1 week, 1 month, and 6 months post-operatively. Results: MIO and lateral movements were improved in both groups, with a reduction in the number of patients suffering from clicking sounds along the follow-up periods with no significant difference between the studied groups. However, regarding pain, the group injected with HA and PRP achieved the best results after 6 months, while patients treated with HA and corticosteroids obtained the best results at the end of the 1st week. Conclusion: Hyaluronic acid and platelet-rich plasma mixture performed better than hyaluronic acid and corticosteroid in the treatment of TMJ internal derangement with reduction at the long-term follow-up regarding pain intensity.

Comparison of Clinical Efficacy of Screw-retained Arch Bar vs Conventional Erich's Arch Bar in Maxillomandibular Fixation: A Randomized Clinical Trial.

AIM: This study aimed to compare the clinical outcomes of a conventional Erich's arch bar vs a modified screw-retained arch bar in maxillomandibular fixation of mandibular fracture. MATERIALS AND METHODS: This parallel-arm randomized control trial included patients from the outpatient clinic with single favorable mandibular fractures that are indicated for closed reduction. They were subjected to maxillomandibular fixation using conventional Erich's arch bars in the control group and modified screw-retained arch bars in the study group. The outcome measures included operating time, glove perforations, postoperative pain, oral hygiene, fixation stability, occlusion, and mucosal coverage. RESULTS: A total of 20 patients (12 males and 8 females) with a 1:1 allocation ratio were included. There was a significant statistical difference regarding operation time and number of glove perforations in favor of group B as p < 0.001, p = 0.007, respectively. There was a significant statistical difference regarding pain after 1 day (p < 0.001), 1 week (p < 0.001) in favor of group B, and at 4 weeks (p = 0.015), and 6 weeks (p = 0.002) in favor of group A. Regarding oral hygiene at 1 week (p = 0.021) and at 6 weeks (p < 0.001), there was a significant statistical difference in favor of group B. Regarding mucosal coverage at 6 weeks, there was a significant statistical difference in favor of group A (p = 0.005). CONCLUSION: The modified screw-retained arch bar can be considered an alternative to conventional arch bar as it provided less application time and better operator safety. It also showed better patient satisfaction regarding pain and oral hygiene. CLINICAL SIGNIFICANCE: Maxillomandibular fixation with the conventional technique was modified to screw-retained arch bar which is less time-consuming and provides better patient and operator satisfaction. How to cite this article: Elhadidi MH, Awad S, Elsheikh HAE, et al. Comparison of Clinical Efficacy of Screw-retained Arch Bar vs Conventional Erich's Arch Bar in Maxillomandibular Fixation: A Randomized Clinical Trial. J Contemp Dent Pract 2023;24(12):928-935.

Metal-Ceramic and Polyether Ether Ketone-Composite Maxillary Fixed Prosthesis Supported by Four Implants and Opposed by Removable Distal Extension Partial Dentures: A Comparative Study of Clinical and Prosthetic Outcomes.

PURPOSE: This study aimed to evaluate clinical and prosthetic outcomes of metal-ceramic and polyether ether ketone (PEEK) fixed prostheses supported by four maxillary implants and opposed by distal extension removable partial dentures. MATERIALS AND METHODS: Thirty participants with edentulous maxillary and distal extension mandibular ridges received four implants according to the All-on-4 treatment concept. The implants were immediately loaded by fixed acrylic prostheses. After 6 months, patients received either metal frameworks covered with porcelain teeth (metal group) or PEEK framework veneered with composite teeth (PEEK group). Plaque Index (PI), Gingival Index (GI), pocket depth (PD), implant stability quotient (ISQ), peri-implant marginal bone loss (MBL, using digital periapical radiographs), and implant survival were measured at baseline, 1 year, and 3 years. Prosthetic complications were measured on the patient and implant levels after 3 years. RESULTS: No implant failures occurred after insertion of the definitive prosthesis, and the implant survival rate was 100% in both groups. PI, GI, PD, ISQ, and MBL increased significantly with time. The most frequent complications were veneer fracture for the PEEK group and prosthetic screw loosening for the metal group. The metal group showed significantly higher PI, PD, and MBL than the PEEK group after 3 years. PEEK was associated with significantly higher veneer fracture than metal, while metal was associated with significantly higher prosthetic screw loosening than PEEK. CONCLUSION: Within the limitations of this study, the PEEK framework veneered with composite may be a suitable alternative to a metal porcelain prosthesis for All-on-4 implant rehabilitation in patients with maxillary edentulous arches opposed by distal extension mandibular ridges, as it was associated with favorable clinical and prosthetic outcomes after 3 years. However, it was associated with an increased rate of veneer or artificial gingiva fracture.

Impact of Different Preparations of Tooth Graft vs Xenogeneic Bone Graft on Bone Healing: An Experimental Study.

AIM: This study aims to compare the effect of demineralized xenogeneic tooth graft in its two forms, particulate and block, with bovine xenograft in the healing of a rabbit tibial bone defect model. MATERIALS AND METHODS: Two monocortical bony defects were made in the right tibias of 36 rabbits, and were divided into four groups. Group I defects were left empty, while group II, III, and IV were filled with bovine xenograft, demineralized particulate tooth graft, and demineralized perforated block tooth graft, respectively for evaluation of the bone healing process. Three rabbits from each group were euthanized at 2, 4, and 6 weeks after surgery. The bone specimens were processed and stained with hematoxylin and eosin (H&E) and osteopontin (OPN) immunohistochemical staining. The results were subjected to image analysis and quantitative evaluation. RESULTS: Demineralized particulate tooth graft showed the best bone healing capacity compared to all other groups at all time points tested, as it showed a large amount of the formed bone, rapid closure of the defect with a significant increase in OPN expression, and the least amount of the residual grafted particles. CONCLUSION: In comparison to bovine xenograft and demineralized dentin block graft, the demineralized particulate tooth grafting material is a promising bone grafting substitute as it proved to be osteoconductive, biocompatible, and bioresorbable. CLINICAL SIGNIFICANCE: Demineralized tooth grafting material can aid in the regeneration of large bone defects, leading to improvement in the filling of the bone defects which can help in oral and maxillofacial reconstruction.

Prediction of neurosensory disorders after impacted third molar extraction based on cone beam CT Maglione's classification: A pilot study.

BACKGROUND: Surgical difficulty assessment in the extraction of impacted mandibular third molars is a constant challenge for oral surgeons. AIM: The first aim was to apply Maglione's new classification on patients that needed surgical extraction of impacted mandibular third molars, and the second aim was to study the correlation of the classification classes with the occurrence of postoperative neurosensory disorders. MATERIALS & METHODS: The present prospective clinical trial pilot study was conducted on patients attending oral and maxillofacial surgery clinics from February 2017 until January 2018 for the surgical extraction of impacted lower third molars. RESULTS: Fifty-one out of sixty-nine patients made the surgical removal of one impacted mandibular third molar. The most common subclass was 1B (24.6%), followed by subclass 3B (23.2%). Subclass 3A and 4B showed an equal distribution of (11.6%) each, and then subclass 2B (10%). The most significant subclass was 4B with (5.9%) neurosensory disturbance. None of the patients had a permanent disturbance. CONCLUSION: Maglione's classification offers unique detailed description of the buccolingual relationship of MTM with IAC that could be used as a future reliable radiographic guide to reduce the risk of post-operative neurosensory disturbances after MTM surgical removal.

Accuracy of panoramic radiographic predictor signs in the assessment of proximity of impacted third molars with the mandibular canal.

OBJECTIVES: This study aimed to validate the accuracy of panoramic radiographic risk signs through detection of presence or absence of corticalization between an impacted mandibular third molar and the inferior alveolar canal on cone beam computed tomography (CBCT). METHODS: This retrospective study analyzed 210 impacted mandibular third molars from 135 patients (aged 17-51 years) who showed one or more of the seven previously established panoramic radiographic risk signs of inferior alveolar nerve exposure. These patients were referred for CBCT examination. Three-dimensional images were used to assess the canal position relative to the third molar, the proximity between the canal and third molar, and third molar angulation. The correlation of panoramic findings and CBCT was evaluated using a Chi-square test. RESULTS: Panoramic findings of interruption of inferior alveolar canal wall, isolated or combined with one of these signs (darkening of third molar roots, narrowing of canal, and diversion of canal); darkening of the roots; and narrowing of canal were significantly correlated with direct contact between the inferior alveolar canal and impacted third molars on CBCT (P < 0.001). CONCLUSION: Preoperative CBCT is recommended for cases showing interruption of canal wall; darkening of the roots or narrowing of the canal; or association between interruption and narrowing, diversion, or darkening of roots in a panoramic view. This study evaluated the risk relationship between the inferior alveolar nerve and impacted mandibular third molars, with the aim of reducing the occurrence of postoperative injury to the inferior alveolar nerve.

Nanostructural analysis by atomic force microscopy followed by light microscopy on the same archival slide.

Integrated information on ultrastructural surface texture and chemistry increasingly plays a role in the biomedical sciences. Light microscopy provides access to biochemical data by the application of dyes. Ultrastructural representation of the surface structure of tissues, cells, or macromolecules can be obtained by scanning electron microscopy (SEM). However, SEM often requires gold or coal coating of biological samples, which makes a combined examination by light microscopy and SEM difficult. Conventional histochemical staining methods are not easily applicable to biological material subsequent to such treatment. Atomic force microscopy (AFM) gives access to surface textures down to ultrastructural dimensions without previous coating of the sample. A combination of AFM with conventional histochemical staining protocols for light microscopy on a single slide is therefore presented. Unstained cores were examined using AFM (tapping mode) and subsequently stained histochemically. The images obtained by AFM were compared with the results of histochemistry. AFM technology did not interfere with any of the histochemical staining protocols. Ultrastructurally analyzed regions could be identified in light microscopy and histochemical properties of ultrastructurally determined regions could be seen. AFM-generated ultrastructural information with subsequent staining gives way to novel findings in the biomedical sciences.

The significance of Epstein Barr virus (EBV) & DNA topoisomerase II alpha (DNA-Topo II alpha) immunoreactivity in normal oral mucosa, oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC).

BACKGROUND: Head and neck cancer including oral cancer is considered to develop by accumulated genetic alterations and the major pathway is cancerization from lesions such as intraepithelial dysplasia in oral leukoplakia and erythroplakia. The relationship of proliferation markers with the grading of dysplasia is uncertain. The involvement of EBV in oral carcinogenesis is not fully understood. AIM: The present study was designed to investigate the role of EBV and DNA Topoisomerase II proportional (DNA-Topo II proportional) during oral carcinogenesis and to examine the prognostic significance of these protein expressions in OSCCs. METHODS: Using specific antibodies for EBV and DNA-Topo II proportional, we examined protein expressions in archival lesion tissues from 16 patients with oral epithelial dysplasia, 22 oral squamous cell carcinoma and 20 normal oral mucosa by immunohistochemistry. Clinical information was obtained through the computerized retrospective database from the tumor registry. RESULTS: DNA-Topo II proportional was expressed in all examined specimens. Analysis of Variance ANOVA revealed highly significant difference (P < 0.01) in young aged labial tissues and significant (P < or = 0.05) in gingival and not significant (P > 0.05) in inferior surface of tongue and in hard palatal tissues. Significant differences were observed between OEDs and NSE (P < 0.001) and SCCs and controls (P < 0.001), also, significant differences could be observed between SCCs and OEDs. DNA-Topo II proportional expression was significantly higher in tumors of low differentiation versus tumors of moderate and high differentiation (P < 0.001), DNA-Topo II proportional expression was correlated with age, tumor size, tumor stage, node metastasis and tumor differentiation, but not with gender and tumor site. None of normal squamous epithelium (NSE) expressed EBV. Heterogeneous reactivity for EBV was observed through the series of dysplasia and squamous cell carcinoma. Its expression increased progressively with lymph node metastasis and low tumor differentiation, but no significant association could be observed with other clinicopathological parameters. EBV protein expression was increased with elevated Topo II-proportional LI in OEDs and OSCCs. A tendency to positive correlation between EBV and Topo II proportional, variant expression was observed in OEDs but not in OSCCs. CONCLUSION: EBV and DNA Topo II-alphaLI expression are possible indicators in oral carcinogenesis and may be valuable diagnostic and prognostic indices in oral carcinoma.