Brain MR image simulation for deep learning based medical image analysis networks.

BACKGROUND AND OBJECTIVE: As large sets of annotated MRI data are needed for training and validating deep learning based medical image analysis algorithms, the lack of sufficient annotated data is a critical problem. A possible solution is the generation of artificial data by means of physics-based simulations. Existing brain simulation data is limited in terms of anatomical models, tissue classes, fixed tissue characteristics, MR sequences and overall realism. METHODS: We propose a realistic simulation framework by incorporating patient-specific phantoms and Bloch equations-based analytical solutions for fast and accurate MRI simulations. A large number of labels are derived from open-source high-resolution T1w MRI data using a fully automated brain classification tool. The brain labels are taken as ground truth (GT) on which MR images are simulated using our framework. Moreover, we demonstrate that the T1w MR images generated from our framework along with GT annotations can be utilized directly to train a 3D brain segmentation network. To evaluate our model further on larger set of real multi-source MRI data without GT, we compared our model to existing brain segmentation tools, FSL-FAST and SynthSeg. RESULTS: Our framework generates 3D brain MRI for variable anatomy, sequence, contrast, SNR and resolution. The brain segmentation network for WM/GM/CSF trained only on T1w simulated data shows promising results on real MRI data from MRBrainS18 challenge dataset with a Dice scores of 0.818/0.832/0.828. On OASIS data, our model exhibits a close performance to FSL, both qualitatively and quantitatively with a Dice scores of 0.901/0.939/0.937. CONCLUSIONS: Our proposed simulation framework is the initial step towards achieving truly physics-based MRI image generation, providing flexibility to generate large sets of variable MRI data for desired anatomy, sequence, contrast, SNR, and resolution. Furthermore, the generated images can effectively train 3D brain segmentation networks, mitigating the reliance on real 3D annotated data.

Multi-modal brain tumor segmentation via conditional synthesis with Fourier domain adaptation.

Accurate brain tumor segmentation is critical for diagnosis and treatment planning, whereby multi-modal magnetic resonance imaging (MRI) is typically used for analysis. However, obtaining all required sequences and expertly labeled data for training is challenging and can result in decreased quality of segmentation models developed through automated algorithms. In this work, we examine the possibility of employing a conditional generative adversarial network (GAN) approach for synthesizing multi-modal images to train deep learning-based neural networks aimed at high-grade glioma (HGG) segmentation. The proposed GAN is conditioned on auxiliary brain tissue and tumor segmentation masks, allowing us to attain better accuracy and control of tissue appearance during synthesis. To reduce the domain shift between synthetic and real MR images, we additionally adapt the low-frequency Fourier space components of synthetic data, reflecting the style of the image, to those of real data. We demonstrate the impact of Fourier domain adaptation (FDA) on the training of 3D segmentation networks and attain significant improvements in both the segmentation performance and prediction confidence. Similar outcomes are seen when such data is used as a training augmentation alongside the available real images. In fact, experiments on the BraTS2020 dataset reveal that models trained solely with synthetic data exhibit an improvement of up to 4% in Dice score when using FDA, while training with both real and FDA-processed synthetic data through augmentation results in an improvement of up to 5% in Dice compared to using real data alone. This study highlights the importance of considering image frequency in generative approaches for medical image synthesis and offers a promising approach to address data scarcity in medical imaging segmentation.

MRI based automated diagnosis of Alzheimer's: Fusing 3D wavelet-features with clinical data.

This paper presents a novel algorithm for classification of patients with Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) from the healthy controls (HC) using structural MRI. Feature extraction is based on discrete 3D wavelet transform followed by PCA for transforming the feature space into linearly uncorrelated variables. Linear SVM is used for classification purposes with clinical dementia rating used as the target vector. Proposed methodology is fully automated and independent of the annotation of region of interest. The importance of MRI, demographical data, neuro-psychiatric test scores and statistics calculated over the wavelet coefficients for the classification is studied. Proposed methodology is applied on 197 subjects from a public database. A classification accuracy of 95% was achieved for the case of HC vs AD. For the case of HC vs MCI, and MCI vs AD the classification accuracy of 78% and 81% were achieved. The results are compared with an existing state of the art technique.