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1.
Eur Arch Otorhinolaryngol ; 273(11): 3747-3752, 2016 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-27075685

RESUMO

Nasal septum deviation (NSD) can cause obstruction of the upper airway, which may lead to increased pulmonary artery pressure (PAP) and right ventricle dysfunction. The aim of the present study was to evaluate the effect of septoplasty on right ventricular function and mean PAP of patients with marked NSD. 25 patients with marked NSD (mean age = 31.8 ± 12.3 years) and 27 healthy volunteers (mean age = 34.5 ± 10.8 years) were enrolled. Echocardiography was performed for all subjects and right ventricular function and mean PAP were evaluated before and 3 months after septoplasty. Tricuspid annular plane systolic excursion (TAPSE) and tricuspid annulus early diastolic myocardial velocity (E') were significantly lower in patients with NSD than control subjects, while right ventricle myocardial performance index (RVMPI) and mean PAP were significantly higher (respectively, p = 0.006, 0.037, 0.049, 0.046). When preoperative and postoperative findings were compared, the mean PAP decreased whereas TAPSE increased significantly (respectively, p = 0.007, 0.03). The results of the present study demonstrated that mean PAP increased and right ventricular function worsened in patients with NSD. However, mean PAP decreased and right ventricular function tended to recover after septoplasty.


Assuntos
Pressão Arterial , Septo Nasal/anormalidades , Septo Nasal/cirurgia , Artéria Pulmonar/fisiologia , Rinoplastia , Função Ventricular Direita , Adulto , Estudos de Casos e Controles , Ecocardiografia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Septo Nasal/fisiopatologia , Rinoplastia/métodos , Resultado do Tratamento , Adulto Jovem
2.
Laryngoscope ; 125(5): 1175-82, 2015 May.
Artigo em Inglês | MEDLINE | ID: mdl-25583134

RESUMO

OBJECTIVES/HYPOTHESIS: The aim of this study was to investigate the potential protective effect of curcumin on paclitaxel-induced ototoxicity in rats by means of immunohistochemical and histopathological analysis and distortion product otoacoustic emissions (DPOAEs). STUDY DESIGN: Animal study. METHODS: Forty Sprague-Dawley rats were randomized into five groups. Group 1 was administered no paclitaxel and curcumin during the study. Groups 2, 3, 4 and 5 were administered 5 mg/kg paclitaxel; 200 mg/kg curcumin; 5 mg/kg paclitaxel, followed by 200 mg/kg curcumin; 200 mg/kg curcumin and a day later 5 mg/kg paclitaxel followed intraperitoneally by 200 mg/kg curcumin once a week for 4 consecutive weeks, respectively. After the final DPOAEs test, the animals were sacrificed and their cochlea were prepared for hematoxylin and eosin and caspase-3 staining. RESULTS: The DPOAEs thresholds and histopathological and immunohistochemical findings were substantially correlated in all groups. The histopathologic findings in the cochlea of the paclitaxel-treated animals showed not only changes in the organ of Corti, but also damage to the stria vascularis and spiral limbus, including nuclear degeneration, cytoplasmic vacuolization, and atrophy of intermediate cells. Additionally, cochlear changes in group 2, such as intense apoptosis, were confirmed by caspase-3 immunohistochemical staining. In group 4, coreceiving curcumin could not sufficiently prevent paclitaxel-induced ototoxicity, and the results in group 5 were similar to the control group. CONCLUSIONS: In our study, we have concluded that pre- and coreceiving curcumin can significantly protect the cochlear morphology and functions on paclitaxel-induced ototoxicity in rats. Curcumin might be considered as a potential natural product that, used as a dietary supplement, could be easily given to patients undergoing paclitaxel chemotherapy. LEVEL OF EVIDENCE: NA


Assuntos
Curcumina/uso terapêutico , Orelha Interna/efeitos dos fármacos , Perda Auditiva Neurossensorial/prevenção & controle , Emissões Otoacústicas Espontâneas/efeitos dos fármacos , Paclitaxel/toxicidade , Animais , Anti-Inflamatórios não Esteroides/uso terapêutico , Modelos Animais de Doenças , Perda Auditiva Neurossensorial/induzido quimicamente , Perda Auditiva Neurossensorial/fisiopatologia , Ratos , Ratos Sprague-Dawley , Resultado do Tratamento
3.
Kulak Burun Bogaz Ihtis Derg ; 24(5): 247-53, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25513866

RESUMO

OBJECTIVES: This study aims to investigate the effect of radiofrequency thermal ablation (RFTA) treatment on nasal mucociliary activity before and after treatment in inferior turbinate hypertrophy. PATIENTS AND METHODS: Thirty-nine patients (21 males, 18 females; mean age 36.3±13.9 years; range 16 to 67 years) admitted to our clinic with complaint of nasal obstruction and diagnosed with stromal inferior turbinate hypertrophy were included in this study. Effect of RFTA treatment on nasal mucociliary activity was investigated by saccharine test before treatment and two months after treatment. Grade of nasal obstruction was evaluated by visual analog scale (VAS) before treatment and two months after treatment. Results were compared with paired t-test. RESULTS: Mean mucociliary activity times were 9.8±4.4 minutes before treatment and 9.6±4.1 minutes two months after treatment, and the difference between two tests was not statistically significant (p=0.3). Mean VAS scores for nasal obstruction were 6.5±1.2 before treatment and 3.8±1.0 two months after treatment, and the difference between two results was statistically significant (p=0.001). Difference between sexes in terms of saccharine transit time and VAS values before and after treatment was not statistically significant (p>0.05). CONCLUSION: It was detected that RFTA has no adverse effect on mucociliary activity in the treatment of inferior turbinate hypertrophy, and this method is notably effective in relieving the nasal obstruction caused by inferior turbinate hypertrophy.


Assuntos
Hipertrofia/patologia , Conchas Nasais/patologia , Adolescente , Adulto , Idoso , Ablação por Cateter/métodos , Feminino , Humanos , Hipertrofia/complicações , Hipertrofia/cirurgia , Masculino , Pessoa de Meia-Idade , Depuração Mucociliar , Obstrução Nasal/etiologia , Sacarina , Resultado do Tratamento , Conchas Nasais/cirurgia , Adulto Jovem
4.
Kulak Burun Bogaz Ihtis Derg ; 24(2): 74-7, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24835901

RESUMO

OBJECTIVES: This study aims to assess possible wound complications of tympanoplasty and tympanomastoidectomy with or without postoperative mastoid dressing. PATIENTS AND METHODS: A total of 37 patients (22 females, 15 males; mean age: 23.88 years; range 9 to 64 years) who underwent middle ear or mastoid operations via postauricular incision were included in this prospective, randomized, controlled study. The patients were divided into two groups as having mastoid dressing (n=17) and nonmastoid dressing (n=20). Through a close follow-up, postoperative complications were noted and distance from mastoid scalp and auricular rim was measured. RESULTS: The mean mastoid-helix distance of non-mastoid dressing group was found 17.2 mm in operated and 16.9 mm in non-operated ears. The mean mastoid-helix distance of mastoid dressing group was 15.53 mm in operated ears and 16.47 mm in non-operated ears. Skin erythema was seen in a patient. There was no statistically significant increase in mastoid-helix distance (p>0.05). CONCLUSION: Tympanoplasty with or without mastoidectomy does not cause postoperative complication or protrusion of the ear, even if no mastoid dressing is used. Our study results suggest no benefit of mastoid dressing after tympanoplasty with or without mastoidectomy.


Assuntos
Bandagens , Processo Mastoide/cirurgia , Complicações Pós-Operatórias/etiologia , Timpanoplastia/métodos , Adolescente , Adulto , Idoso , Criança , Pavilhão Auricular/patologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Resultado do Tratamento , Adulto Jovem
5.
Case Rep Otolaryngol ; 2014: 703021, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24782937

RESUMO

Grisel's syndrome is a nontraumatic atlantoaxial subluxation which is usually secondary of an infection or an inflammation at the head and neck region. It can be observed after surgery of head and neck region. Etiopathogenesis has not been clearly described yet, but increased looseness of paraspinal ligament is thought to be responsible. Patients typically present with painful torticollis. Diagnosis of Grisel's syndrome is largely based on suspicion of the patient who has recently underwent surgery or history of infection in head and neck region. Physical examination and imaging techniques assist in diagnosis. Therefore, clinicians should be aware of acute nontraumatic torticollis after recently applied the head and neck surgery or undergone upper respiratory tract infection. In this paper, a case of an eight-year-old male patient who had Grisel's syndrome after adenotonsillectomy is discussed with review of the literature.

6.
Eur Arch Otorhinolaryngol ; 271(10): 2681-6, 2014 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-24121821

RESUMO

Diabetes mellitus (DM) is a systemic inflammatory disease. Sensorineural hearing loss (SNHL) is seen more frequently in diabetic patients and it is believed that vascular complications of DM may be the cause of SNHL via inflammation. Neutrophil-to-lymphocyte ratio (NLR) was defined as a novel-potential marker to determine inflammation. We aimed to investigate the relationship between NLR levels and SNHL in diabetic patients using high-frequency audiometry (8­16 kHz) for the first time. The study included 58 patients diagnosed with DM. The control group was composed of 45 age­sex­BMI­matched healthy subjects. An automated blood cell counter was used for NLR measurements. The hearing assessments of the patients were carried out by Interacoustics Clinical Audiometer AC 40 device. The mean NLR values of the patients were significantly higher than the control group (p = 0.015). Speech recognition threshold values were higher and the speech discrimination values were lower in patients (p = 0.002, p < 0.001), respectively. Pure tone average of the patients at 500, 1,000, 2,000 Hz frequencies was divided into two groups (group 1 >25 dB and group 2 <25 dB). NLR levels of the diabetic patients with >25 dB were higher than the other diabetics (p = 0.007). In conclusion, while diabetic patients are evaluating, audiologic assessments of these patients should be performed because they are at more risk of SNHL and NLR may be considered as a predictive and prognostic marker of hearing loss or its beginning in these patients as a useful and reliable marker without any cost.


Assuntos
Biomarcadores/sangue , Diabetes Mellitus , Perda Auditiva Neurossensorial/sangue , Audição/fisiologia , Linfócitos/patologia , Neutrófilos/patologia , Feminino , Perda Auditiva Neurossensorial/etiologia , Perda Auditiva Neurossensorial/fisiopatologia , Humanos , Contagem de Leucócitos , Masculino , Pessoa de Meia-Idade , Prognóstico , Estudos Retrospectivos
7.
Laryngoscope ; 124(7): 1678-81, 2014 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-24307612

RESUMO

OBJECTIVES/HYPOTHESIS: Bell palsy can be defined as an idiopathic, acute, facial nerve palsy. Although the pathogenesis of Bell palsy is not fully understood, inflammation seems to play important role. Neutrophil-to-lymphocyte (NLR) ratio was defined as a novel potential marker to determine inflammation and it is routinely measured in peripheral blood. Our goal was to investigate the relationship between Bell palsy and inflammation by using NLR. STUDY DESIGN: Retrospective study. METHODS: The 54 patients who were followed up for Bell palsy for a period of 1 to 3 years, along with 45 age- and sex-matched controls, were included in the study. An automated blood cell counter was used for NLR measurements. All patients were treated with prednisone, 1 mg/kg per day with a progressive dose reduction. Patients were classified according to the House-Brackmann grading system at posttreatment period. Those with House-Brackmann grade I and grade II were regarded as satisfactory recovery; and those with House-Brackmann grade III to grade VI were regarded as nonsatisfactory recovery. RESULTS: The mean NLR and neutrophil values in patients with Bell palsy were significantly higher than in the control group (P=0.001 and P<0.001, respectively). In addition, NLR levels were higher in nonsatisfactory recovered patients compared with satisfactory recovered ones (P<0.001). CONCLUSION: This is the first study investigating the relationship between NLR levels and Bell palsy and its prognosis. Our result suggest that while evaluating Bell palsy patients, NLR might be taken into account as a novel potential marker to predict the patients' prognosis. LEVEL OF EVIDENCE: 3b.


Assuntos
Paralisia de Bell/sangue , Linfócitos/patologia , Neutrófilos/patologia , Adulto , Paralisia de Bell/diagnóstico , Feminino , Seguimentos , Humanos , Inflamação/sangue , Inflamação/patologia , Contagem de Leucócitos , Masculino , Pessoa de Meia-Idade , Prognóstico , Estudos Retrospectivos , Índice de Gravidade de Doença
8.
J Craniofac Surg ; 24(6): 1953-6, 2013 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-24220381

RESUMO

Cervical necrotizing fasciitis (CNF) is a rare, rapidly advancing infection that involves the skin, the subcutaneous fibrofatty tissue, as well as the superficial and deep fascia and can cause life-threatening complications. The most frequent initiating factors in the head and neck region are a primary odontogenic infection, a peritonsillar infection, as well as posttraumatic or iatrogenic skin and mucosal injuries. Necrotizing fasciitis (NF) can expand within hours, and the reported mortality rate is up to 75% with delay interference. If the patients have any risk factors, poor prognosis can be seen. In this study, 1 patient with CNF with a history of peritonsillar infection and 2 patients with CNF who had a history of odontogenic infection with spreading to the temporal region and the mediastinum were described, with information of the literature and a clinical experience that was gained from 5 patients with NF who were seen at our clinic in the recent year, despite the fact that CNF was not seen up to last year. None of the patients had any risk factors. One of them had a worse clinical state with ascending infection to the temporal region, cranial nerve paralysis, and descending necrotizing mediastinitis, but he recovered from NF. After the oral intake began, dyspnea due to aspiration was seen and he died because of sepsis and multiorgan dysfunction. We aimed to attract attention to the importance of dental pathologies and increased mortality in a healthy patient.


Assuntos
Paralisia Facial/etiologia , Fasciite Necrosante/microbiologia , Infecção Focal Dentária/microbiologia , Mediastinite/etiologia , Infecções por Acinetobacter/diagnóstico , Acinetobacter baumannii/fisiologia , Adulto , Idoso de 80 Anos ou mais , Infecções por Bacteroidaceae/diagnóstico , Candidíase/diagnóstico , Doenças dos Nervos Cranianos/etiologia , Feminino , Humanos , Masculino , Pescoço/patologia , Paralisia/etiologia , Prevotella/fisiologia , Prognóstico , Infecções Estreptocócicas/diagnóstico , Estreptococos Viridans/fisiologia
9.
Otol Neurotol ; 34(8): 1400-4, 2013 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-23988996

RESUMO

INTRODUCTION: Idiopathic Sudden sensorineural hearing loss (ISSNHL) is a common otologic emergency. Recently, the cause of ISSNHL, which is still unclear, has been focused on chronic inflammation. Neutrophil-to-lymphocyte ratio (NLR) is a new and quick inflammatory marker, which is being measured routinely in CBC tests without any cost. We aimed to investigate the relationship between ISSNHL and inflammation by using NLR. MATERIALS AND METHOD: Forty-seven patients diagnosed with ISSNHL and 45 age- and sex-matched healthy subjects were enrolled in the study. An automated blood cell counter was used for NLR measurements. The hearing assessments of the patients were carried out by an audiometer, and audiometric patterns were assessed initially and after 1 month of the treatment. All the patients were treated with prednisone in the dose of 1 mg/kg per day, with a progressive dose reduction maintained for at least 2 weeks. Then, the patients were divided into 2 groups as " recovered" and "unrecovered" according to their response to the treatment. RESULTS: The mean NLR, neutrophil, and lymphocyte values in patients with ISSNHL were significantly higher than the control group (p < 0.001, p < 0.001, and p = 0.004, respectively). In addition, NLR levels were higher in unrecovered patients compared with the recovered ones (p < 0.001). CONCLUSION: This is the first study investigating the relationship between NLR levels and ISSNHL and its prognosis. While evaluating ISSNHL, determining NLR should not be overlooked as a quick and reliable indicator for predicting the diagnosis and the prognosis of the disease.


Assuntos
Perda Auditiva Neurossensorial/diagnóstico , Perda Auditiva Súbita/diagnóstico , Linfócitos/efeitos dos fármacos , Neutrófilos/efeitos dos fármacos , Adulto , Idoso , Anti-Inflamatórios/farmacologia , Anti-Inflamatórios/uso terapêutico , Contagem de Células , Feminino , Perda Auditiva Neurossensorial/sangue , Perda Auditiva Neurossensorial/tratamento farmacológico , Perda Auditiva Súbita/sangue , Perda Auditiva Súbita/tratamento farmacológico , Humanos , Masculino , Pessoa de Meia-Idade , Prednisona/farmacologia , Prednisona/uso terapêutico , Prognóstico , Estudos Retrospectivos , Resultado do Tratamento
10.
J Craniofac Surg ; 24(4): 1153-5, 2013 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-23851760

RESUMO

We aimed to examine the prevalence of cerebellar tonsil ectopia and Chiari 1 malformation in sensorineural hearing loss (SHL) that has, to the best of our knowledge, not been studied previously. Magnetic resonance imaging records of 166 subjects with SHL and 50 controls without known otologic disturbances were included in the study. A tonsils descent more than 2 mm was assumed as cerebellar ectopia, and a descent equal to or more than 5 mm was assumed as Chiari 1 malformation. A tonsil descent group was also formed by summation of both groups. Transverse diameters of bilateral intracranial vertebral arteries and transverse sinuses were also measured, and all parameters were analyzed using appropriate statistics. A significant difference of frequencies of Chiari 1, ectopia, and tonsil descent was detected between patients and controls. In comparison of cerebellar ectopia and Chiari 1 groups, SHL did not show any significant difference. The left lateral sinus diameter showed positive correlation with tonsil descent. There was no significant correlation for the diameters of other vessels. A powerful correlation was detected between SHL and age. In addition, right and vertebral artery diameters showed positive correlations with age. Chiari 1 malformation and cerebellar ectopia showed an association with SHL. These patients should also be evaluated for otologic disturbances. Further high-resolution magnetic resonance imaging studies to explain the exact cause of this currently unknown association seems required.


Assuntos
Malformação de Arnold-Chiari/complicações , Doenças Cerebelares/complicações , Perda Auditiva Neurossensorial/etiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Malformação de Arnold-Chiari/epidemiologia , Malformação de Arnold-Chiari/patologia , Estudos de Casos e Controles , Doenças Cerebelares/epidemiologia , Doenças Cerebelares/patologia , Criança , Feminino , Perda Auditiva Neurossensorial/patologia , Humanos , Imageamento por Ressonância Magnética/métodos , Masculino , Pessoa de Meia-Idade , Prevalência , Adulto Jovem
11.
Ulus Travma Acil Cerrahi Derg ; 19(1): 73-6, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23588985

RESUMO

Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by anterior and lateral ossification of the vertebral body. We present a case report of central cord syndrome in a patient with DISH after minor trauma. The patient was treated surgically. We also discuss symptomatology and the common mechanism of cord injury in DISH.


Assuntos
Síndrome Medular Central/etiologia , Vértebras Cervicais/lesões , Hiperostose Esquelética Difusa Idiopática/etiologia , Idoso , Humanos , Masculino
12.
Eur Arch Otorhinolaryngol ; 270(11): 2875-8, 2013 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-23341093

RESUMO

Mean platelet volume (MPV) is one of the platelet function indices which reflects the platelet production rate and functions. While vascular occlusion, acute or chronic syndromes and vasculitis are increasing the MPV levels, infections, autoimmune diseases, and inflammatory situations reduce it. The indicator for idiopathic sudden sensorineural hearing loss (ISHL) etiology remains a matter of debate because it is associated with many different disorders. We evaluated MPV levels in ISHL patients. Forty patients with ISHL and 40 healthy, age and sex matched subjects were enrolled to the study. Audiometer and laboratory results were recorded. Comparative multivariate analyses between indicator factors and hearing outcomes were conducted. MPV and platelet distribution width is significantly higher in ISHL. Platelet count is lower in the ISHL than control group (p < 0.001), (p < 0.001), (p = 0.003), respectively. Our findings indicate that, ISHL appears to be characterized by ischaemic or thrombotic events. Considering the increased MPV levels; MPV may be used to evaluate ISHL as an hepler indicator.


Assuntos
Perda Auditiva Súbita/sangue , Volume Plaquetário Médio , Adulto , Audiometria , Estudos de Casos e Controles , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Contagem de Plaquetas
13.
Eur Arch Otorhinolaryngol ; 270(1): 239-42, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-22923168

RESUMO

The leading cause of vocal fold lesions such as nodules and polyps is phonotrauma, which causes microhematoma formation in the vocal fold cover that can initiate an inflammatory process. Vitamin A (Vit A) is essential for immunity, cellular differentiation and maintenance of respiratory epithelium. The aim of this study is to investigate the effect of Vit A (retinyl palmitate) on healing of vocal fold lesions, including vocal polyps and nodules. Eighteen patients with vocal fold lesions were included in the study. Of the patients, 13 had vocal polyps and 5 had vocal nodules. Patients received 90,000 IU oral Vit A in palmitate form daily for 2 months. In addition to Vit A treatment, only vocal hygiene recommendations were given to the patients, without any other medication or specific voice therapy. Pre- and post-treatment acoustic analysis [jitter % (jitt %), shimmer % (shim %), normalized noise energy (NNE), maximum phonation time (MPT), etc.] were performed. Lesion dimensions and stroboscopic findings were evaluated. Voice handicap index (VHI) was applied. Statistical analysis was performed between pre- and post-treatment measurements. Of the 18 patients, 8 had immature lesions (6 polyp-like lesions and 2 immature nodules) and 10 had mature lesion (7 polyps and 3 nodules). None of the patients showed complete healing. Partial response was seen in four patients with immature lesions. There were minimal changes in lesion dimensions, but this difference did not reach statistical significance. MPT of patients with immature lesions were close to significance level but overall MPT revealed no significant improvement (p = 0.051). Jitt %, shim % and NNE did not change significantly. In this study, the only statistically significant finding was VHI of the patients with immature lesions. Three of the patients complained of weight gain. Our data showed that Vit A at a given level of dose and duration seems to be ineffective in the treatment of benign vocal fold lesions. On the other hand, whether Vit A is effective on mature and immature lesions of vocal folds at higher doses and/or longer duration of treatment or not requires further studies.


Assuntos
Antioxidantes/uso terapêutico , Vitamina A/análogos & derivados , Prega Vocal/patologia , Distúrbios da Voz/diagnóstico , Cicatrização/efeitos dos fármacos , Administração Oral , Adulto , Idoso , Antioxidantes/administração & dosagem , Diterpenos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Ésteres de Retinil , Estroboscopia , Resultado do Tratamento , Vitamina A/administração & dosagem , Vitamina A/uso terapêutico
14.
J Craniofac Surg ; 23(6): 1812-4, 2012 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-23147345

RESUMO

Necrotizing soft-tissue infection (NSTI) is a bacterial infection with necrosis of the cutaneous, subcutaneous tissue and fascia with sparing of the underlying muscle. The most frequent initiating factor reported, for necrotizing fasciitis, in the head and neck region is a primary odontogenic infection or postextraction infection, abrasion, and laceration of the face or scalp. Necrotizing fasciitis can progress rapidly to systemic toxicity and even death if not promptly diagnosed and treated. If the patient has any risk factors, this can worsen the prognosis. In this study, 2 cases of NSTI with dental pathology history (one with the spreading to mediastinum and the other spreading to suprahyoid) were discussed with a review of the literature. One of the cases had diabetes mellitus, but interestingly, she had a better prognosis, and she was discharged asymptomatic. In addition, the other case had no any risk factors, but he had a worse clinical cranial nerve paralysis (a rare complication of NSTI) and died. As a conclusion, despite the intensive therapy, large debridement, and antibiotics with large spectrum, the delay in the patient's diagnosis and treatment increased mortality. We aimed to attract attention to the importance of dental pathologies and early diagnosis.


Assuntos
Doenças dos Nervos Cranianos/terapia , Fasciite Necrosante/terapia , Pescoço/cirurgia , Infecções dos Tecidos Moles/terapia , Doenças dos Nervos Cranianos/diagnóstico , Desbridamento , Diagnóstico Diferencial , Fasciite Necrosante/diagnóstico , Evolução Fatal , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , Infecções dos Tecidos Moles/diagnóstico , Tomografia Computadorizada por Raios X , Traqueotomia
15.
Gen Thorac Cardiovasc Surg ; 60(12): 843-6, 2012 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-22729848

RESUMO

Pleomorphic adenoma in the trachea is very rare. We report the case of a 46-year-old woman who had been treated for asthma for 12 months before the diagnosis of pleomorphic adenoma of the trachea was made. The tumour was defined by fiberoptic bronchoscopy in the mid 1/3 of the trachea obstructing nearly 90 % of the lumen. Through a collar incision and partial sternotomy, 3 cm segment of the trachea was resected and end-to-end anastomosis was performed.


Assuntos
Adenoma Pleomorfo/patologia , Dispneia/etiologia , Doenças Raras/patologia , Neoplasias da Traqueia/patologia , Adenoma Pleomorfo/cirurgia , Asma/tratamento farmacológico , Broncoscopia , Feminino , Humanos , Pessoa de Meia-Idade , Doenças Raras/cirurgia , Neoplasias da Traqueia/cirurgia
16.
Int J Pediatr Otorhinolaryngol ; 76(8): 1087-90, 2012 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-22552023

RESUMO

OBJECTIVES: To investigate whether Helicobacter pylori causes inflammation in the normal middle ear and in the middle ear with effusion. METHODS: Sixteen adult New Zealand white rabbits were divided into two gropus equally. Group I was representing histamine-induced middle ear inflammation and Group II was representing normal middle ear. While H. pylori was inoculated in the right ears, physiologic saline was inoculated in the left ears of the rabbits in both groups. Results were evaluated clinically, histopathologically and microbiologically. Fisher's exact test was used for statistical analysis. RESULTS: In Group I, clinical scores of the inflammation in the right ears were higher than the left ears scores at the 7th day. Histopathological scores of the inflammation in the right ears were higher than the left ears scores at the 7th day. Also, H. pylori was isolated in 6 of the 8 right ears of the rabbits. In Group II, while clinical scores of the inflammation in the right ears scores were higher than the left ears scores at the 7th day, histopathological scores were not significantly different between both ears. Also, no H. pylori was isolated in right ears of the rabbits. CONCLUSIONS: Effusion in the middle ear induced by histamine is an appropriate medium for H. pylori reproduction and it also aggravates the inflammation process. In contrary, H. pylori did not cause inflammation in the normal middle ear. We suggest that H. pylori does not play a role in the etiology of otitis media with effusion alone, but it contributes to the inflammation process in the presence of an effusion.


Assuntos
Orelha Média/microbiologia , Helicobacter pylori , Otite Média com Derrame/microbiologia , Animais , Orelha Média/patologia , Histamina , Otite Média com Derrame/induzido quimicamente , Otite Média com Derrame/patologia , Coelhos
17.
Artigo em Inglês | MEDLINE | ID: mdl-22433786

RESUMO

OBJECTIVE: The aim of the present study was to evaluate the outcomes of combined oral steroid, nasal steroid and surgical therapy in patients with impaired olfaction due to nasal polyposis. PATIENTS AND METHODS: This prospective observational study was undertaken in the otolaryngology department of a university hospital. During the study, 19 nasal polyposis patients were evaluated three times, i.e. before oral steroid therapy, before surgery (after steroid therapy) and after surgery, with smell identification tests, acoustic rhinometry, subjective smell score, endoscopic grading and a visual analog scale for nasal obstruction. RESULTS: All subjective and objective measures were significantly improved after medical and surgical therapy (p < 0.01). The median smell identification score improved from 2 (interquartile range 0-4) to 5 (interquartile range 4-7) after combined therapy. Smell identification scores were found to be modestly correlated with all other examination findings. CONCLUSION: Combined therapy seems efficient in improving smell identification scores of nasal polyposis patients.


Assuntos
Pólipos Nasais/tratamento farmacológico , Pólipos Nasais/cirurgia , Transtornos do Olfato/tratamento farmacológico , Transtornos do Olfato/cirurgia , Olfato/fisiologia , Esteroides/uso terapêutico , Administração Oral , Adulto , Idoso , Terapia Combinada , Endoscopia/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Transtornos do Olfato/diagnóstico , Cuidados Pré-Operatórios , Estudos Prospectivos , Recuperação de Função Fisiológica/efeitos dos fármacos , Recuperação de Função Fisiológica/fisiologia , Rinometria Acústica , Olfato/efeitos dos fármacos , Adulto Jovem
18.
Artigo em Inglês | MEDLINE | ID: mdl-21822030

RESUMO

AIM: Injuries due to traffic accidents are frequent in childhood, and they have high mortality and morbidity. Laryngeal injury due to a traffic accident is a rare pathology and might be missed if not suspected. Here we present a laryngeal fracture in a child after a blunt chest trauma during a traffic accident that presented with pneumomediastinum and pneumothorax. CASE: A 14-year-old girl was referred for pneumomediastinum. Her physical examination was normal except subcutaneous emphysema, edema and tenderness in the cervical area, hoarseness, facial and extremity abrasions and ecchymoses. Chest tomography revealed pneumothorax and pneumomediastinum, and cranial tomography revealed maxillofacial fractures. Upper airway damage was suspected, flexible endoscopy revealed right vocal cord paralysis and cervical tomography revealed thyroid cartilage fracture. The fracture was repaired and tracheotomy was performed. She was discharged on postoperative day 6. Facial fractures were repaired in another center. Tracheotomy was removed on postoperative day 20. Her hoarseness, although decreased, still persists. CONCLUSION: Pneumomediastinum is a rare result of a laryngeal fracture and if not suspected, the fracture can easily be missed. It should be kept in mind after blunt cervical trauma with pneumomediastinum and/or pneumothorax. Direct endoscopy and cervical tomography may be necessary for the differential diagnosis.


Assuntos
Doenças da Laringe/etiologia , Laringe/lesões , Enfisema Mediastínico/etiologia , Pneumotórax/etiologia , Traumatismos Torácicos/complicações , Cartilagem Tireóidea/lesões , Ferimentos não Penetrantes/complicações , Acidentes de Trânsito , Adolescente , Diagnóstico Diferencial , Drenagem , Endoscopia , Feminino , Seguimentos , Humanos , Doenças da Laringe/diagnóstico , Doenças da Laringe/cirurgia , Enfisema Mediastínico/diagnóstico , Enfisema Mediastínico/cirurgia , Procedimentos Cirúrgicos Otorrinolaringológicos/métodos , Pneumotórax/diagnóstico , Pneumotórax/cirurgia , Traumatismos Torácicos/diagnóstico , Tomografia Computadorizada por Raios X , Ferimentos não Penetrantes/diagnóstico
19.
Kulak Burun Bogaz Ihtis Derg ; 21(3): 117-21, 2011.
Artigo em Turco | MEDLINE | ID: mdl-21595614

RESUMO

OBJECTIVES: In this study, we assessed the hearing aid usage ratios and durations, patient satisfaction and the probable causes of disuse if they are not used. PATIENTS AND METHODS: A questionnaire with 16 questions was applied to the patients who were prescribed hearing aids in our clinic between January 2007 and December 2009. A total of 517 patients were called by phone. Hundred and seventy-nine of the patients (75 females, 104 males; mean age 60±23 years; range 17 to 94 years) participated in the trial. Hearing aid usage ratios and patients' satisfaction were determined and the factors influencing usage were statistically investigated. RESULTS: Hundred and forty-two of the patients used their hearing aids regularly and 37 of the patients either used their aids rarely or never used them. The most common cause reported for disuse was the frequent noise coming from the hearing aid. CONCLUSION: Failure to explain the usage of the hearing aids to the patients and age over 70 years have a statistically significant negative effect on the duration of hearing aid use and patient satisfaction.


Assuntos
Auxiliares de Audição/estatística & dados numéricos , Satisfação do Paciente/estatística & dados numéricos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Inquéritos e Questionários , Turquia , Adulto Jovem
20.
Intern Med ; 50(8): 833-8, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-21498930

RESUMO

OBJECTIVE: Obstructive Sleep Apnea Syndrome (OSAS) is a common sleep-related breathing disorder. Associations among Apnea-Hypopnea Index (AHI), Resting Metabolic Rate (RMR), body habitus differences, and otorhinolaryngologic abnormality may clarify the characteristics of patients with OSAS. In order to test this hypothesis, we aimed to compare the RMR, Modified Mallampati Scores (MMS), anthropometric measurements and body composition of male OSAS patients with simple snorers and to investigate the association among these parameters. METHODS: MMS were calculated, overnight polysomnography was performed, body mass index, neck, shoulder, chest, waist, hip and abdomen circumferences, body fat amount and ratio, lean body weight, body water amount and RMR were measured for all of the patients. PATIENTS: Ninety-eight male patients with suspected OSAS were included in the study. RESULTS: Fifty-one patients were diagnosed as OSAS and 47 patients were diagnosed as simple snorers. RMR, total body water, neck, shoulder and chest circumferences were significantly higher in OSAS patients than the simple snorers. The majority of the simple snorers was seen to have a MMS of stage 2 whereas OSAS patients had MMS of stages 3 and 4. AHI was significantly correlated with neck, shoulder, chest circumferences, total body water amount, MMS and RMR. Chest girth was found as the most important single predictor of sleep apnea in multivariate analysis. CONCLUSION: We suggest that the increased RMR and chest circumference might have occurred due to the condition resulting from the elevated AHI in patients with OSAS. Mallampati score should be routinely evaluated in OSAS patients.


Assuntos
Metabolismo Basal , Apneia Obstrutiva do Sono/metabolismo , Apneia Obstrutiva do Sono/patologia , Adulto , Antropometria , Composição Corporal , Diagnóstico Diferencial , Humanos , Masculino , Pessoa de Meia-Idade , Otolaringologia/métodos , Polissonografia , Apneia Obstrutiva do Sono/diagnóstico , Apneia Obstrutiva do Sono/fisiopatologia , Ronco/diagnóstico , Ronco/metabolismo , Ronco/patologia , Ronco/fisiopatologia
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