Antimicrobial peptides derived from microalgae for combating antibiotic resistance: Current status and prospects.

Microalgae are photosynthetic cell factories that produce a spectrum of bioactive compounds extensively used for various applications. Owing to the increase in antibiotic resistance among microbial pathogens, there is a significant thrust for identifying new treatment strategies, and antimicrobial peptides (AMPs) generation is one such method. These AMPs have multiple roles and are active against bacteria, fungi, and viruses. Such peptides synthesized in microalgae have a significant role in medical application, managing aquaculture-associated diseases, and the food industry. To increase their effectiveness and novel peptides, genetically modified microalgae are used as cell factories. With the advancement of new technologies like the CRISPR-Cas system, new avenues are opened for developing novel AMPs using microalgae. This review gives us insight into the various AMPs produced by microalgae and multiple technologies involved in creating such therapeutically essential molecules.

Diverse endophytic Streptomyces species with dynamic metabolites and their meritorious applications: a critical review.

The strains of actinobacteria are unique as they lie between true fungi and bacteria and several of them were reported as endophytic actinobacteria as they were isolated from the inner regions of various plant parts and will enhance uptake of nutrients and improve defense against pathogens. Literature and scientific communications reported the relationship between the endophytes and plants, most of them concluded the association as commensalism. Remarkably, bioactive compounds from endophytic Streptomyces sp. were confirmed with various applications. A retrospective consolidation on the endophytic Streptomyces sp. and their metabolite application in day to day life is presented here. It was deduced that this group of the organism are a source for a wide range of bioactive compounds including anticancer agents, immune suppressor, plant growth promoters, anti-inflammatory agents, anti-tumor agents, enzymes and antimicrobial substances. These antimicrobial metabolites show broad-spectrum activity and are effective against bacteria and fungi. The mechanism of action of secondary metabolites from endophytes and its positive influence on the host plants are noted as involvement in deterrence, antifeedant activity, toxicity against common pests, and as enhancers for physical mechanisms such as water uptake and sunlight absorption, thus supporting the growth of host plants.