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1.
Curr Res Transl Med ; 70(4): 103346, 2022 09.
Artigo em Inglês | MEDLINE | ID: mdl-35487168

RESUMO

It has been known as almost all the cells consists a lipid molecule which has a considerable impact in various biological processes. Lipids have been investigated with a potential role for the formation of cellular membrane and thereby maintaining the structural integrity. Omics has placed as a combined technologies utilized for an exploaration of mechanistic actions in several kinds of molecules that make up the cells of an organism. Lipidomics has been recognized as a newly emerged branch of omics technology. This technology has the captivating factors to classify and characterize almost all the cellular lipids with the help of various analytical techniques and computational biological plateform. In lipidomics studies, structural display of several lipid biomarkers could also be analyzed and considered for actual disease diagnosis procedures. This could also replace certain traditional diagnostics method at all over the globe. Our review focuses how important this lipidomics particularly in disease diagnosis and also covers various analytical techniques and computational methods or bioinformatics tools in for the diagnosis of disease. In addtion, we also pinponted the possible role of lipids in several kinds of cellular disorders including cancer, neurodegenerative diseases, cardiovascular diseases, diabetes and obesity in human population. .


Assuntos
Metabolismo dos Lipídeos , Lipidômica , Humanos , Lipídeos/química , Espectrometria de Massas/métodos , Doença Crônica
2.
Comput Biol Chem ; 93: 107538, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34246892

RESUMO

Nowadays, the purpose of human genomics is widely emerging in health-related problems and also to achieve time and cost-efficient healthcare. Due to advancement in genomics and its research, development in privacy concerns is needed regarding querying, accessing and, storage and computation of the genomic data. While the genomic data is widely accessible, the privacy issues may emerge due to the untrusted third party (adversaries/researchers), they may reveal the information or strategy plans regarding the genome data of an individual when it is requested for research purposes. To mitigate this problem many privacy-preserving techniques are used along with cryptographic methods are briefly discussed. Furthermore, efficiency and accuracy in a secure and private genomic data computation are needed to be researched in future.


Assuntos
Segurança Computacional , Bases de Dados Genéticas , Privacidade Genética , Genoma Humano/genética , Inquéritos e Questionários , Humanos
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