Like No Other? A Family-Specific Network Approach to Parenting Adolescents.

Numerous theories suggest that parents and adolescents influence each other in diverse ways; however, whether these influences differ between subgroups or are unique to each family remains uncertain. Therefore, this study explored whether data-driven subgroups of families emerged that exhibited a similar daily interplay between parenting and adolescent affective well-being. To do so, Subgrouping Group Iterative Multiple Model Estimation (S-GIMME) was used to estimate family-specific dynamic network models, containing same- and next-day associations among five parenting practices (i.e., warmth, autonomy support, psychological control, strictness, monitoring) and adolescent positive and negative affect. These family-specific networks were estimated for 129 adolescents (Mage = 13.3, SDage = 1.2, 64% female, 87% Dutch), who reported each day on parenting and their affect for 100 consecutive days. The findings of S-GIMME did not identify data-driven subgroups sharing similar parenting-affect associations. Instead, each family displayed a unique pattern of temporal associations between the different practices and adolescent affect. Thus, the ways in which parenting practices were related to adolescents' affect in everyday life were family specific.

The direction of effects between parenting and adolescent affective well-being in everyday life is family specific.

Numerous theories and empirical studies have suggested that parents and their adolescent children reciprocally influence each other. As most studies have focused on group-level patterns, however, it remained unclear whether this was true for every family. To investigate potential heterogeneity in directionality, we applied a novel idiographic approach to examine the effects between parenting and adolescent well-being in each family separately. For 100 days, 159 Dutch adolescents (Mage = 13.31, 62% female) reported on affective well-being and four parenting dimensions. The family-specific effects of pre-registered ( https://osf.io/7n2jx/ ) dynamic structural equation models indeed revealed that a reciprocal day-to-day association between parenting and adolescent affective well-being was present only in some families, with the proportion of families displaying a reciprocal association varying across the four parenting dimensions (11-55%). In other families, either parenting predicted the adolescent's affective well-being (8-43%) or vice versa (10-27%), or no day-to-day associations were found (16-60%). Adolescents with higher trait levels of environmental sensitivity and neuroticism were more strongly affected by parenting. Thus, findings suggest that the ways in which parents and adolescents influence each other in everyday life are unique, stressing the need to move towards an idiographic parenting science.

Quaranteens: Prepandemic relationship quality and changes in adolescent internalizing problems during the COVID-19 pandemic.

This preregistered longitudinal study examined changes in adolescents' depressive and anxiety symptoms before and during the COVID-19 pandemic using latent additive piece-wise growth models. It also assessed whether support from and conflict with mothers, fathers, siblings, and best friends explained heterogeneity in change patterns. One hundred and ninety-two Dutch adolescents (Mean age: 14.3 years; 68.8% female) completed online biweekly questionnaires for a year (November 2019-October 2020), consisting of a prepandemic, lockdown, and reopening phase. Depressive symptoms increased following the lockdown and decreased upon reopening. Anxiety symptoms showed an immediate decrease followed by a gradual increase in the reopening phase. Prepandemic family and best friend support and conflict did not explain heterogeneity in depressive and anxiety symptoms during the COVID-19 pandemic.

A moment of autonomy support brightens adolescents' mood: Autonomy support, psychological control and adolescent affect in everyday life.

This experience sampling study examined whether autonomy-supportive and psychologically controlling interactions with parents are intertwined with adolescents' momentary affect. For 7 days (in 2020), 143 adolescents (Mage = 15.82; SDage = 1.75; 64% girls; 95% European, 1% African, 3% unknown) reported 5 or 6 times a day how they felt and how interactions with parents were experienced. Preregistered dynamic structural equation models on 1439 (including 532 adjacent) parent-adolescent interactions revealed significant within-family associations: Adolescents experienced more positive affect during and following autonomy-supportive interactions, and vice versa. Adolescents felt more negative affect during and 3 h before psychologically controlling interactions. Between-family associations showed significant linkages between parenting and affect. These findings show that a moment of autonomy support can alter adolescents' everyday well-being.

Better, for worse, or both? Testing environmental sensitivity models with parenting at the level of individual families.

According to environmental sensitivity models, children vary in responsivity to parenting. However, different models propose different patterns, with responsivity to primarily: (1) adverse parenting (adverse sensitive); or (2) supportive parenting (vantage sensitive); or (3) to both (differentially susceptible). This preregistered study tested whether these three responsivity patterns coexist. We used intensive longitudinal data of Dutch adolescents (N = 256, Mage = 14.8, 72% female) who bi-weekly reported on adverse and supportive parenting and their psychological functioning (tmean = 17.7, tmax = 26). Dynamic Structural Equation Models (DSEM) indeed revealed differential parenting effects. As hypothesized, we found that all three responsivity patterns coexisted in our sample: 5% were adverse sensitive, 3% vantage sensitive, and 26% differentially susceptible. No adolescent appeared unsusceptible, however. Instead, we labeled 28% as unperceptive, because they did not perceive any changes in parenting and scored lower on trait environmental sensitivity than others. Furthermore, unexpected patterns emerged, with 37% responding contrary to parenting theories (e.g., decreased psychological functioning after more parental support). Sensitivity analyses with concurrent effects and parent-reported parenting were performed. Overall, findings indicate that theorized responsivity-to-parenting patterns might coexist in the population, and that there are other, previously undetected patterns that go beyond environmental sensitivity models.

Daily affect intensity and variability of adolescents and their parents before and during a COVID-19 lockdown.

INTRODUCTION: The corona virus (COVID-19) pandemic may have a prolonged impact on people's lives, with multiple waves of infections and lockdowns, but how a lockdown may alter emotional functioning is still hardly understood. METHODS: In this 100-daily diaries study, we examined how to affect intensity and variability of adolescents (N = 159, Mage = 13.3, 61.6% female) and parents (N = 159, Mage = 45.3, 79.9% female) changed after the onset and during (>50 days) the second COVID-19 lockdown in the Netherlands, using preregistered piecewise growth models. RESULTS: We found only an unexpected increase in parents' positive affect intensity after the lockdown onset, but no immediate changes in negative affect intensity or variability. However, both adolescents and parents reported gradual increases in negative affect intensity and variability as the lockdown prolonged. Lockdown effects did not differ between adolescents and parents. However, within groups, individuals differed. The individual differences in the effects were partly explained by life satisfaction, depressive symptoms, and self-reported lockdown impact. CONCLUSIONS: Overall, these findings suggests that a lockdown triggers changes in daily affective well-being especially as the lockdown prolongs. Individual differences in the effects indicate heterogeneity in the impact of the lockdown on daily affect that was partly explained by baseline life satisfaction and depressive symptoms. However, more knowledge on the causes of this heterogeneity is needed to be able to increase resilience to lockdown effects in the population.

Evaluating Covariate Effects on ESM Measurement Model Changes with Latent Markov Factor Analysis: A Three-Step Approach.

Invariance of the measurement model (MM) between subjects and within subjects over time is a prerequisite for drawing valid inferences when studying dynamics of psychological factors in intensive longitudinal data. To conveniently evaluate this invariance, latent Markov factor analysis (LMFA) was proposed. LMFA combines a latent Markov model with mixture factor analysis: The Markov model captures changes in MMs over time by clustering subjects' observations into a few states and state-specific factor analyses reveal what the MMs look like. However, to estimate the model, Vogelsmeier, Vermunt, van Roekel, and De Roover (2019) introduced a one-step (full information maximum likelihood; FIML) approach that is counterintuitive for applied researchers and entails cumbersome model selection procedures in the presence of many covariates. In this paper, we simplify the complex LMFA estimation and facilitate the exploration of covariate effects on state memberships by splitting the estimation in three intuitive steps: (1) obtain states with mixture factor analysis while treating repeated measures as independent, (2) assign observations to the states, and (3) use these states in a discrete- or continuous-time latent Markov model taking into account classification errors. A real data example demonstrates the empirical value.

Testing transactional processes between parental support and adolescent depressive symptoms: From a daily to a biennial timescale.

Transactional processes between parental support and adolescents' depressive symptoms might differ in the short term versus long term. Therefore, this multi-sample study tested bidirectional within-family associations between perceived parental support and depressive symptoms in adolescents with datasets with varying measurement intervals: Daily (N = 244, Mage = 13.8 years, 38% male), bi-weekly (N = 256, Mage = 14.4 years, 29% male), three-monthly (N = 245, Mage = 13.9 years, 38% male), annual (N = 1,664, Mage = 11.1 years, 51% male), and biennial (N = 502, Mage = 13.8 years, 48% male). Preregistered random-intercept cross-lagged panel models (RI-CLPMs) showed negative between- and within-family correlations. Moreover, although the preregistered models showed no within-family lagged effect from perceived parental support to adolescent depressive symptoms at any timescale, an exploratory model demonstrated a negative lagged effect at a biennial timescale with the annual dataset. Concerning the reverse within-family lagged effect, increases in adolescent depressive symptoms predicted decreases in perceived parental support 2 weeks and 3 months later (relationship erosion effect). Most cross-lagged effects were not moderated by adolescent sex or neuroticism trait level. Thus, the findings mostly support adolescent-driven effects at understudied timescales and illustrate that within-family lagged effects do not generalize across timescales.

Universal ingredients to parenting teens: parental warmth and autonomy support promote adolescent well-being in most families.

Even though each adolescent is unique, some ingredients for development may still be universal. According to Self-Determination Theory, every adolescent's well-being should benefit when parents provide warmth and autonomy. To rigorously test this idea that each family has similar mechanisms, we followed 159 Dutch parent-adolescent dyads (parent: Mage = 45.34, 79% mothers; adolescent: Mage = 13.31, 62% female) for more than three months, and collected 100 consecutive daily reports of parental warmth, autonomy support, positive and negative affect. Positive effects of parental warmth and autonomy support upon well-being were found in 91-98% of the families. Preregistered analysis of 14,546 daily reports confirmed that effects of parenting differed in strength (i.e., some adolescents benefited more than others), but were universal in their direction (i.e., in fewer than 1% of families effects were in an unexpected direction). Albeit stronger with child-reported parenting, similar patterns were found with parent-reports. Adolescents who benefited most from need-supportive parenting in daily life were characterized by higher overall sensitivity to environmental influences. Whereas recent work suggests that each child and each family have unique developmental mechanisms, this study suggests that need-supportive parenting promotes adolescent well-being in most families.

Parent-adolescent interaction quality and adolescent affect-An experience sampling study on effect heterogeneity.

Person-environment interactions might ultimately drive longer term development. This experience sampling study (Data collection: 2019/20 the Netherlands) assessed short-term linkages between parent-adolescent interaction quality and affect during 2281 interactions of 124 adolescents (Mage  = 15.80, SDage  = 1.69, 59% girls, 92% Dutch, Education: 25% low, 31% middle, 35% high, 9% other). Adolescents reported on parent-adolescent interaction quality (i.e., warmth and conflict) and momentary positive and negative affect five to six times a day, for 14 days. Preregistered dynamic structural equation models (DSEM) revealed within-family associations between parent-adolescent interaction quality and adolescent affect (concurrently: r = -.22 to .39; lagged effects: ß = -.17 to .15). These effects varied significantly between families. These findings stress the need for more person-specific research on parenting processes.

Measuring parent-adolescent interactions in natural habitats. The potential, status, and challenges of ecological momentary assessment.

Few people are as important for an adolescent's development as their parents. However, most research on parent-adolescent relationships describes long-term population-wide effects. Therefore, little is known about everyday interactions between adolescents and parents in individual families. Ecological momentary assessment (EMA) measures families several times a day as they go through daily life. This approach provides ecologically valid insights into which interactions took place and how they were experienced. State-of-the-art EMA studies suggest that within-family fluctuations in parenting may trigger changes in an adolescent's well-being and behaviors. In practice, moreover, EMA may strengthen family support and intervention research. This article reviews recent empirical work, highlights the (un)used theoretical and practical promise of EMA and identifies key-challenges to unlock this full potential.

Parenting adolescents in times of a pandemic: Changes in relationship quality, autonomy support, and parental control?

This Dutch multi-informant study examined effects of the first COVID-19 lockdown (LD; e.g., school closure and social restrictions) on parent-adolescent relationships. Four biweekly measurements before and 4 biweekly measurements during the LD were collected among adolescents (N = 179, Mage = 14.26 years, 69% girls) and their parents (N = 144, Mage = 47.01 years, 81% female). Parents' educational level was relatively diverse: 12% low (high school or lower), 33% medium (vocational training), and 55% high (college or university). Adolescents and parents reported on parental support, parent-adolescent conflict, autonomy support, psychological control, behavioral control, and time spent on various activities. Adolescents spent more time with their parents during LD (before M = 8.6 hr, during M = 12.7 hr), but less time with friends (before M = 8.1 hr, during M = 2.1 hr), and reported on average 13 COVID-19-related rules. Preregistered piecewise growth models confirmed that autonomy support decreased immediately during the LD, but no mean level changes were observed in the other relationship dimensions. During the first 2 months of the LD, parents reported gradual increases in autonomy support and decreases in behavioral control. Moreover, significant differences between families were found in sudden and more gradual relationship changes, which correlated strongly with pre-LD characteristics of the relationship, and in some models with adolescent oppositional defiance and legitimacy beliefs. In sum, findings suggest resilience in most families, but also heterogeneity: Some families were negatively affected, and others were positively affected. A tailored approach is therefore needed to mitigate the impact of COVID-19 on family functioning. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Tracking Infant Development With a Smartphone: A Practical Guide to the Experience Sampling Method.

The COVID-19 pandemic has forced developmental researchers to rethink their traditional research practices. The growing need to study infant development at a distance has shifted our research paradigm to online and digital monitoring of infants and families, using electronic devices, such as smartphones. In this practical guide, we introduce the Experience Sampling Method (ESM) - a research method to collect data, in the moment, on multiple occasions over time - for examining infant development at a distance. ESM is highly suited for assessing dynamic processes of infant development and family dynamics, such as parent-infant interactions and parenting practices. It can also be used to track highly fluctuating family dynamics (e.g., infant and parental mood or behavior) and routines (e.g., activity levels and feeding practices). The aim of the current paper was to provide an overview by explaining what ESM is and for what types of research ESM is best suited. Next, we provide a brief step-by-step guide on how to start and run an ESM study, including preregistration, development of a questionnaire, using wearables and other hardware, planning and design considerations, and examples of possible analysis techniques. Finally, we discuss common pitfalls of ESM research and how to avoid them.

Quantity and quality of empathic responding by autistic and non-autistic adolescent girls and boys.

LAY ABSTRACT: Empathy is an important feature to feel for another person, evoking social support for the person in distress, and thus strengthening social cohesion. The question is to what extent empathic reactions can also be observed in autistic adolescents and autistic girls in particular, since their often mentioned good social skills might prevent their direct social environment from recognizing their autism. We examined 194 adolescents (autistic and non-autistic boys and girls) during an in vivo task in which the experimenter pretended to hurt herself while closing a binder. All responses by the participants were videotaped and coded by two independent coders. In line with our predictions, no group or gender differences appeared related to their attention for the event; yet autistic girls and boys showed less visible emotional arousal, which could indicate less affective empathy (feeling for someone), or which could indicate that autistic adolescents know less well how to show empathy. Autistic girls and boys reacted by comforting the experimenter equally often as their non-autistic peers, but autistic boys addressed the problem more often than any other group, while girls (autistic and non-autistic) more often addressed the emotion of the person in need. Our findings highlight that empathic behaviour is remarkably similar between autistic and non-autistic boys and girls. Indeed, only subtle differences exist, in terms of expressed emotional arousal and gender-specific comforting styles. Autistic girls' higher levels of emotion-focused comforting could be explained by well-developed social skills, camouflaging, or emotional investment in relationships with others.

Synthesis and evaluation of dibenzothiazepines: a novel class of selective cannabinoid-1 receptor inverse agonists.

A novel class of CB1 inverse agonists was discovered. To efficiently establish structure-activity relationships (SARs), new synthetic methodologies amenable for parallel synthesis were developed. The compounds were evaluated in a mammalian cell-based functional assay and in radioligand binding assays expressing recombinant human cannabinoid receptors (CB1 and CB2). In general, all of the compounds exhibited high binding selectivity at CB1 vs CB2 and the general SAR revealed a lead compound 11-(4-chlorophenyl)dibenzo[b,f][1,4]thiazepine-8-carboxylic acid butylamide (12e) which showed excellent in vivo activity in pharmacodynamic models related to CB1 receptor activity. The low solubility that hampered the development of 12e was solved leading to a potential preclinical candidate 11-(3-chloro-4-fluorophenyl)dibenzo[b,f][1,4]thiazepine-8-carboxylic acid butylamide (12h).

Combinatorial synthesis of benztropine libraries and their evaluation as monoamine transporter inhibitors.

A combinatorial synthesis of benztropine analogues is presented. Radical azidonation of 3-benzyloxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester 3 to 3-(1-azidobenzyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester 4 was used as a key step in the synthesis. This step was optimized by adding 10% DMF to the reaction. Reaction of 4 with phenyl magnesium bromide followed by Boc removal and N-methylation gave benztropine 1. Reaction of five-component Grignard reagents with 4 was used to create a two-dimensional library of 25 N-normethylbenztropine analogues. Further reaction of this library with five alkyl bromides was carried out to create a three-dimensional library containing 125 compounds. Screening of the libraries towards binding and inhibition of uptake of the human dopamine (hDAT), serotonin (hSERT) and norepinephrine transporters (hNET) was carried out. None of the synthesized compounds were found to be stronger than benztropine, and none were selective for inhibition of binding over monoamine uptake.

Two- and three dimensional combinatorial chemistry from multicomponent Grignard reagents.

The conjugate addition of five component Grignard reagents to methyl ecgonidine was used to create libraries of 3-substituted tropanes. By variation in the reagent combination in 10 such 5-membered sublibraries, a library of 25 compounds was made in a two-dimensional format. Screening of this library led to identification of two new potent monoamine transporter ligands that were subsequently synthesized. The most potent compound in this library was (1R,2S,3S,5S)-3-(3,4-dimethylphenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid methyl ester, which inhibited dopamine transporter (hDAT) binding and reuptake with a K(i) of 26 and 20 nM, respectively. The conjugate addition to a 5-membered library of methyl ecgonidine analogues with variation of nitrogen substituent was also carried out and used to create 15 sublibraries of 25 compounds, which displayed 125 compounds in a three-dimensional format. From this 3D library, several potent dopamine transport inhibitors were likewise identified and synthesized. The most potent hDAT inhibitor discovered was (1R,2S,3S,5S)-3-(3,4-dimethylphenyl)-8-pentyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid methyl ester. The study also showed that 3-alkyltropanes were poor inhibitors of monoamine transporters.