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1.
Glob Health Action ; 17(1): 2326253, 2024 Dec 31.
Artigo em Inglês | MEDLINE | ID: mdl-38683158

RESUMO

Effective and sustainable strategies are needed to address the burden of preventable deaths among children under-five in resource-constrained settings. The Tools for Integrated Management of Childhood Illness (TIMCI) project aims to support healthcare providers to identify and manage severe illness, whilst promoting resource stewardship, by introducing pulse oximetry and clinical decision support algorithms (CDSAs) to primary care facilities in India, Kenya, Senegal and Tanzania. Health impact is assessed through: a pragmatic parallel group, superiority cluster randomised controlled trial (RCT), with primary care facilities randomly allocated (1:1) in India to pulse oximetry or control, and (1:1:1) in Tanzania to pulse oximetry plus CDSA, pulse oximetry, or control; and through a quasi-experimental pre-post study in Kenya and Senegal. Devices are implemented with guidance and training, mentorship, and community engagement. Sociodemographic and clinical data are collected from caregivers and records of enrolled sick children aged 0-59 months at study facilities, with phone follow-up on Day 7 (and Day 28 in the RCT). The primary outcomes assessed for the RCT are severe complications (mortality and secondary hospitalisations) by Day 7 and primary hospitalisations (within 24 hours and with referral); and, for the pre-post study, referrals and antibiotic. Secondary outcomes on other aspects of health status, hypoxaemia, referral, follow-up and antimicrobial prescription are also evaluated. In all countries, embedded mixed-method studies further evaluate the effects of the intervention on care and care processes, implementation, cost and cost-effectiveness. Pilot and baseline studies started mid-2021, RCT and post-intervention mid-2022, with anticipated completion mid-2023 and first results late-2023. Study approval has been granted by all relevant institutional review boards, national and WHO ethical review committees. Findings will be shared with communities, healthcare providers, Ministries of Health and other local, national and international stakeholders to facilitate evidence-based decision-making on scale-up.Study registration: NCT04910750 and NCT05065320.


Pulse oximetry and clinical decision support algorithms show potential for supporting healthcare providers to identify and manage severe illness among children under-five attending primary care in resource-constrained settings, whilst promoting resource stewardship but scale-up has been hampered by evidence gaps.This study design article describes the largest scale evaluation of these interventions to date, the results of which will inform country- and global-level policy and planning .


Assuntos
Algoritmos , Sistemas de Apoio a Decisões Clínicas , Oximetria , Humanos , Lactente , Pré-Escolar , Recém-Nascido , Quênia , Atenção Primária à Saúde/organização & administração , Senegal , Índia , Tanzânia
2.
Contraception ; 99(2): 137-141, 2019 02.
Artigo em Inglês | MEDLINE | ID: mdl-30439358

RESUMO

OBJECTIVES: The primary objective of this study was to compare the 12-month continuation rate for women who self-injected subcutaneous depot-medroxyprogesterone acetate (DMPA-SC) with that for women receiving intramuscular depot-medroxyprogesterone acetate (DMPA-IM) from a provider. This research contributes to the broader goal of identifying solutions to support women to use contraception for their full desired duration. STUDY DESIGN: Participants were clients from 13 clinics in the Dakar and Thiés regions of Senegal who had decided to use injectable contraception prior to enrollment. They chose self-injection of DMPA-SC or provider administration of DMPA-IM. Self-injectors were trained and given three units of DMPA-SC. The provider-injected group received DMPA-IM and returned to the clinics for future injections. We interviewed participants at baseline and after the second, third and fourth injections (the equivalent of 12 months of contraceptive coverage). We employed Kaplan-Meier methods to estimate continuation probabilities, with a log-rank test to compare differences between groups. A multivariate Cox regression identified factors correlated with discontinuation. RESULTS: The 12-month continuation rate for 650 women self-injecting DMPA-SC was 80.2%, while that for 649 women receiving DMPA-IM from a provider was 70.4% (p<.01). The difference in continuation between self-injectors and those receiving DMPA from a provider remained significant in a multivariate Cox regression model. The primary reason for discontinuation in both groups (44.7% self-injected; 44.5% provider-injected) was forgetting to reinject or reinjecting late. Fewer women reported side effects in the self-injection group than in the provider-administered group. CONCLUSIONS: The higher 12-month continuation rate for women self-injecting DMPA-SC relative to provider-administered DMPA-IM suggests that self-injection may help prevent pregnancy more consistently and continuously. IMPLICATIONS: Discontinuation of injectable contraception among women wishing to avoid pregnancy may increase unmet need in francophone West Africa. This study showed higher 12-month continuation rates for women who self-injected DMPA-SC, suggesting that this delivery method may improve injectable continuation.


Assuntos
Contraceptivos Hormonais/administração & dosagem , Injeções/estatística & dados numéricos , Adesão à Medicação/estatística & dados numéricos , Acetato de Medroxiprogesterona/administração & dosagem , Adulto , Feminino , Humanos , Estudos Prospectivos , Autoadministração , Senegal , Adulto Jovem
3.
Soc Sci Med ; 188: 91-99, 2017 09.
Artigo em Inglês | MEDLINE | ID: mdl-28734964

RESUMO

Plan Sésame (PS) is a user fee exemption policy launched in 2006 to provide free access to health services to Senegalese citizens aged 60 and over. Analysis of a large household survey evaluating PS echoes findings of other studies showing that user fee removal can be highly inequitable. 34 semi-structured interviews and 19 focus group discussions with people aged 60 and over were conducted in four regions in Senegal (Dakar, Diourbel, Matam and Tambacounda) over a period of six months during 2012. They were analysed to identify underlying causes of exclusion from/inclusion in PS and triangulated with the household survey. The results point to three steps at which exclusion occurs: (i) not being informed about PS; (ii) not perceiving a need to use health services under PS; and (iii) inability to access health services under PS, despite having the information and perceived need. We identify lay explanations for exclusion at these different steps. Some lay explanations point to social exclusion, defined as unequal power relations. For example, poor access to PS was seen to be caused by corruption, patronage, poverty, lack of social support, internalised discrimination and adverse incorporation. Other lay explanations do not point to social exclusion, for example: poor implementation; inadequate funding; high population demand; incompetent bureaucracy; and PS as a favour or moral obligation to friends or family. Within a critical realist paradigm, we interpret these lay explanations as empirical evidence for the presence of the following hidden underlying causal mechanisms: lacking capabilities; mobilisation of institutional bias; and social closure. However, social constructionist perspectives lead us to critique this paradigm by drawing attention to contested health, wellbeing and corruption discourses. These differences in interpretation lead to subsequent differential policy recommendations. This demonstrates the need for the adoption of a "multi-epistemological" perspective in studies of health inequity and social exclusion.


Assuntos
Atenção à Saúde/economia , Gastos em Saúde/normas , Acessibilidade aos Serviços de Saúde/economia , Adulto , Atenção à Saúde/estatística & dados numéricos , Honorários e Preços/legislação & jurisprudência , Honorários e Preços/estatística & dados numéricos , Feminino , Grupos Focais , Gastos em Saúde/estatística & dados numéricos , Acessibilidade aos Serviços de Saúde/estatística & dados numéricos , Humanos , Conhecimento , Serviços de Saúde Materna/economia , Serviços de Saúde Materna/estatística & dados numéricos , Pessoa de Meia-Idade , Gravidez , Pesquisa Qualitativa , Senegal , Fatores Socioeconômicos , Inquéritos e Questionários
4.
Contraception ; 96(3): 203-210, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28673645

RESUMO

OBJECTIVES: Expanding contraceptive options through self-injection may improve access and confidentiality. There are few published studies on contraceptive self-injection in sub-Saharan Africa and none in West Africa, a region with high unmet need. This study was performed to assess feasibility of subcutaneous DMPA self-injection in Senegal; objectives were to (1) measure the proportion of participants who self-injected competently 3 months after training, (2) measure the proportion who self-injected on time (defined conservatively as within 7 days of reinjection date), and (3) assess acceptability of self-injection. STUDY DESIGN: In this prospective cohort study, 378 women aged 18-49 years were trained to self-inject by study nurses. Three months later, women returned unprompted to the clinic to self-inject, and technique and visit timing were evaluated. Women continuing with a third self-injection were followed up at home after their next scheduled injection date. At each interaction, participants were interviewed to learn about their experience; additional questions during the final home visit focused on storage and disposal practices, and acceptability. RESULTS: Among the 337 participants followed up 3 months post-training, 310 self-injected, and 87% did so competently. Factoring in women who declined to self-inject, electing to have the provider administer the injection instead, a total of 80% [95% confidence interval (CI)=75-84%] self-injected competently 3 months post-training, and 84% [95% CI=80-88%] reinjected on time, while 72% [95% CI=67-77%] were both on time and competent. The vast majority (93%) expressed a desire to continue. CONCLUSIONS: Self-injection is feasible and acceptable among most study participants in Senegal. IMPLICATIONS: These first research results on contraceptive self-injection in West Africa indicate initial feasibility and acceptability of the practice. Results underscore the importance of designing self-injection programs that empower and support women, including those with limited education.


Assuntos
Anticoncepcionais Femininos/administração & dosagem , Acetato de Medroxiprogesterona/administração & dosagem , Aceitação pelo Paciente de Cuidados de Saúde , Autoadministração , Adolescente , Adulto , Anticoncepcionais Femininos/uso terapêutico , Estudos de Viabilidade , Feminino , Humanos , Injeções Subcutâneas , Acetato de Medroxiprogesterona/uso terapêutico , Pessoa de Meia-Idade , Estudos Prospectivos , Senegal , Adulto Jovem
6.
Artigo em Francês | AIM (África) | ID: biblio-1256257

RESUMO

La plupart des politiques d'exemption en Afrique subsaharienne se dotent de facto de modalites dites passives d'allocation de ressources. Le Plan Sesame - mecanisme d'exemption adopte au Senegal en 2006 et ciblant les citoyens ages de 60 ans et plus - n'echappe pas a la regle : il se base sur le paiement a l'acte comme modalite d'achat de services. Ce texte a pour but d'explorer l'effet de cette modalite passive d'achat de services sur l'equite d'acces aux soins du Plan Sesame. Notre analyse se base sur une enquete menee au Senegal entre mai 2012 et juillet 2013. Une methodologie mixte incluant une revue de documents de politiques; une analyse des detenteurs d'enjeux et une enquete-menage a ete utilisee. Les resultats montrent que le Plan Sesame est caracterise par un financement hybride; lequel a favorise les personnes agees evoluant dans le secteur formel qui ont un meilleur acces aux hopitaux. Ceux-ci ont donc capte une grande partie des budgets alloues au Plan Sesame. En somme; les couches sociales les plus aisees et celles residant en milieu urbain ont plus de chance d'acceder aux ressources du Plan Sesame


Assuntos
Ajuda a Famílias com Filhos Dependentes , Organização do Financiamento , Assistência ao Paciente , Populações Vulneráveis
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