RESUMO
The prevalence of the different types of thalassaemia and that of iron deficiency anaemia was investigated in 1020 schoolchildren (age range: 6-15 years) from the north-eastern Badia region of Jordan. beta-thalassaemia minor was the most prevalent (3.04%), followed by alpha 2-thalassaemia (2.06%). Only three cases of alpha 1-thalassaemia and one case of beta-thalassaemia major were found. Iron deficiency anaemia was diagnosed in 54 children (5.3%) (33 males, 21 females). The mean values of the blood characteristics of the normal, haemoglobinopathic and iron-deficient children were examined and compared.
Assuntos
Anemia Ferropriva/epidemiologia , Estudantes/estatística & dados numéricos , Talassemia alfa/epidemiologia , Talassemia beta/epidemiologia , Adolescente , Distribuição por Idade , Anemia Ferropriva/sangue , Anemia Ferropriva/diagnóstico , Criança , Testes Genéticos , Humanos , Incidência , Jordânia/epidemiologia , Vigilância da População , Prevalência , Distribuição por Sexo , Talassemia alfa/sangue , Talassemia alfa/diagnóstico , Talassemia beta/sangue , Talassemia beta/diagnósticoRESUMO
The prevalence of the different types of thalassaemia and that of iron deficiency anaemia was investigated in 1020 schoolchildren [age range: 6-15 years] from the north-eastern Badia region of Jordan. beta-thalassaemia minor was the most prevalent [3.04%], followed by alpha 2-thalassaemia [2.06%]. Only three cases of alpha 1-thalassaemia and one case of beta-thalassaemia major were found. Iron deficiency anaemia was diagnosed in 54 children [5.3%] [33 males, 21 females]. The mean values of the blood characteristics of the normal, haemoglobinopathic and iron-deficient children were examined and compared
Assuntos
Anemia Ferropriva , Testes Genéticos , Talassemia alfa , Distribuição por Sexo , Estudantes , Talassemia beta , TalassemiaRESUMO
Binding of [51Cr]EDTA to human plasma proteins was investigated using chemical and chromatographic techniques of separation of the proteins and protein fractions. Total plasma proteins isolated with ethanol retained 12.95 +/- 0.46% of the initial plasma activity. Proteins separated by other precipitants retained about 16% of the initial radioactivity. Globulins exhibited the highest binding capacity for [51Cr]EDTA and retained about 11.7% of the initial plasma activity following chromatographic separation. This value represents about 70% of the radioactivity bound by the total proteins of the plasma. gamma-Globulins contributed most of the binding attributed to the globulins and retained about 8.7% of the initial [51Cr]EDTA activity. The repeatedly reported underestimation of the renal glomerular filtration rate when estimated as the clearance of [51Cr]EDTA could be adequately accounted for by the extent of binding of this marker to the plasma proteins.
Assuntos
Proteínas Sanguíneas/metabolismo , Ácido Edético/metabolismo , Fibrinogênio/metabolismo , Humanos , Pré-Albumina/metabolismo , Albumina Sérica/metabolismo , Soroglobulinas/metabolismo , gama-Globulinas/metabolismoAssuntos
Pressão Sanguínea/efeitos dos fármacos , Rim/fisiologia , Hormônios Neuro-Hipofisários/farmacologia , Animais , Aorta , Diurese/efeitos dos fármacos , Relação Dose-Resposta a Droga , Eletrólitos/sangue , Eletrólitos/urina , Peixes , Rim/efeitos dos fármacos , Ocitocina/farmacologia , Ureia/urina , Vasotocina/farmacologiaRESUMO
Low doses of arginine-vasotocin (AVT), isotocin and oxytocin (1 pg-1 ng/kg body weight) were antidiuretic in eels adapted to fresh water but not in those adapted to sea-water. High doses (more than 10 ng/kg) were always diuretic. No effects on tubular water reabsorption were observed and the glomerular filtration rate (GFR) was proportional to the maximum reabsorptive rate for glucose (Tm(glucose)) in eels adapted to sea-water. Increases in urinary flow appeared therefore to result from glomerular recruitment. Infusion of AVT or isotocin at low rates reduced the GFR and urinary flow of freshwater eels to the levels found in seawater eels. Vasopressin (lysine or arginine) had no direct effect on kidney function in freshwater eels but blocked both the diuretic and antidiuretic actions of the other hormones. When infused into seawater eels it was diuretic. This effect could have been due to blockade of the actions of endogenous AVT and/or isotocin.