Neuroendocrine tumours of rare location.

Neuroendocrine tumours (NETs) arising from dispersed endocrine system may originate from almost every location, although they are most commonly found in the gastrointestinal tract and respiratory system. NETs are considered as particularly rare if they constitute less than 1% of all neuroendocrine tumours. The aim of the paper is to present ten rare NETs from the database of the Endocrinology Department of the Jagiellonian University, Medical College: 4 NETs of the ampulla of Vater, 2 of the gallbladder, and 1 of the ovary, sphenoid sinus, Meckel's diverticulum, and epiglottis. The clinical presentation of such tumours and their management are discussed.

[Quantitative analysis of heart scintigraphy (99mTc-MIBI GSPECT) with regional myocardial wall motion and systolic thickening of left ventricle assessment for detecting myocardial damage in ethanol withdrawal patients]. / Zastosowanie analizy ilosciowej badania 99mTc-MIBI GSPECT z ocena odcinkowej ruchomosci scian i grubienia skurczowego miesnia lewej komory w aspekcie oceny stopnia uszkodzenia miesnia sercowego w zespole odstawiennym u chorych uzaleznionych od alkoholu--doniesienie wstepne.

Severe ethanol withdrawal syndrome, with psychosomatic symptoms, is life-threatening condition and if not treated can be fatal (in approximately 15% of cases). The purpose of this investigation was to assess cardiac muscle function using 99mTc-MIBI GSPECT in acute alcohol withdrawal. The group examined consisted of 10 males aged from 33 to 45 (45.7 +/- 8.82) because of alcohol withdrawal syndrome. The control group for quantitative analysis of the heart scintigraphy (GSPECT) consisted of 20 people referred for examination to the Laboratory of Nuclear Medicine, Jagiellonian University, which results of cardiac perfusion scintigraphy were assessed as normal. In acute withdrawal syndrome quantitative analysis of the heart scintigraphy (99mTc-MIBI GSPECT) revealed impaired regional wall motion and wall thickening related mainly to the lower wall segments. The abnormalities in myocardial perfusion (99mTc-MIBI GSPECT) was found in varying degrees of severity in all patients.

[Current opinions on pathogenesis, diagnostic procedures and management of gastric neuroendocrine tumors]. / Wspólczesne poglady na patogeneze, diagnostyke i leczenie guzów neuroendokrynnych zoladka.

Gastric neuroendocrine tumors (NET ventriculi) are rare neoplasms of the gastrointestinal tract, increasing in incidence over last fifty years, what partly could be explained by the common use of upper gastrointestinal tract endoscopy. Pathogenesis of the NET ventriculi is not fully understood, however it is well known, that in all NET ventriculi types there is a hyperplasia of enterochromaffine-like cells (ECL) related to different stimuli. NET ventriculi type 1 is related to autoimmunological atrophic gastritis and hypergastrinaemia, NET ventriculi type 2 with hypergastrinemia in the course of Zollinger-Ellison syndrome associated with multiple endocrine neoplasia (MEN 1) syndrome, NET ventriculi type 3 are sporadic tumors not related to hypergastrinaemia, usually with poor prognosis. Localization of tumors and possible metastases, histo-pathological confirmation of the neoplasm type and defining the source of hypergastrinaemia is essential in diagnostic of NET ventriculi. Treatment dependent on the NET ventriculi type is based on endoscopic or surgical tumor excision in type 1 and 2 and surgical radical treatment in type 3. There is an increased interest in the use of somatostatin analogues (SSA) both in type 1 and in cases with dissemination of the disease. Advances in understanding of the pathogenesis and recent development of medical techniques leads to the improvement of diagnostic and therapy in these group of neoplasms.