[The effect of alimentary hypercholesterolemia on the level of lipids and essential fatty acids in rabbit enterohepatic circulation]. / Vliianie alimentarnoi giperkholesterinemii na urovni lipidov i éssentsial'nykh zhirnykh kislot v énterogepaticheskoi tsirkuliatsiu krolikov.

Patterns of lipid metabolism were estimated in biological fluids and tissues involved in enterohepatic circulation of bile lipid complexes in female rabbits with alimentary hypercholesterolemia. Cholesterol gallstones were not found in gallbladder of rabbits with alimentary hypercholesterolemia. A number of reasons was responsible for the phenomenon, including specific ratio of four lipid components, which contributed to maintaining bile cholesterol in soluble form: concentration of bile acids was unaltered simultaneously with high contents of cholesterol and a decrease in phospholipids level, while content of free fatty acids was increased and the content of arachidonic acid was elevated in majority of lipid fractions.

[The effect of a diet enriched with food fibers and polyunsaturated fatty acids on the composition of the lipid components in the enterohepatic circulation system in rabbits with cholestasis]. / Vliianie ratsiona, obogashchennogo pishchevymi voloknami i polinenasyshchennymi zhirnymi kislotami, na sostav lipidnykh komponentov v sisteme pechenochno-kishechnoi tsirkuliatsii u krolikov pri kholestaze.

In experiments on rabbits that had undergone partial constriction of the choledochus, the development of calculous hepatocholecystitis was observed in a half of the operated on animals. No biliary calculi were detected in the animals that received the ration enriched with food vegetable fibres, beta-sitosterol and linoleic polyunsaturated fatty acids after similar operations.

[Lipids, bile and fatty acids of the bile in rabbits with hypercholesterolemia]. / Lipidy, zhelchnye i zhirnye kisloty zhelchi krolikov pri giperkholesterinemia.

Fractions of bile acids, neutral lipids, phospholipids as well as their fatty acid composition were studied in bile of 7 rabbits with alimentary hypercholesterolemia. Distinct alterations were observed in content of lipid fractions involved in cholesterol metabolism; the spectrum of fatty acids were transformed mainly towards increase in content of polyunsaturated acids, the bile acid spectrum was also altered. These alterations in metabolism of bile lipids appear to serve for neutralization of the unfavourable effect of cholesterol excess.

[Effect of alimentary hypercholesterolemia on the lipid composition of the chyme and of the blood flowing from the intestines]. / Vliianie alimentarnoi giperkholesterinemii na sostav lipidov khimusa i ottekaiushchei ot kishechnika krovi.

The wall of the rabbit small intestine was found to take part in regulation of the balance of general lipids, fatty and bile acids of arterio-venous blood both in intact animals and in those with hypercholesterolemia. Excessive amount of cholesterol in food reconstructs the lipid composition of enterocytes which loose important bile and fatty acids, accumulating nonequivalent intermediary products of lipid metabolism which affects the membrane permeability, readjusts the lipid exchange in enterocytes and their control over lipid complexes circulating in the blood.