Understanding Parental Intentions for COVID-19 Child Vaccination: A Cross-Sectional Study From Jordan Using Theory of Planned Behavior.

Introduction: Using the Theory of Planned Behavior, this study addresses the factors that influence parental intentions to vaccinate their 12- to 17-year-old children against COVID-19. The study looked at how attitudes, subjective norms, perceived behavioral control, and fear of the COVID-19 vaccine impact these intentions. Methods: Between November and December 2021, 396 Jordanian parents completed an anonymous online survey. A multivariate logistic regression analysis was used for analyzing the relationships. Results: While 94.7% of children had received routine vaccinations, only 23.5% intended to vaccinate their children against COVID-19, indicating a vaccine acceptance gap. The analysis revealed that attitudes are the most significant positive predictor of vaccination intent, accounting for 75% of the variance. Subjective norms had a positive influence on parents' decisions, whereas fear of the COVID-19 vaccine was a significant barrier. Perceived behavioral control had a small but negative effect, indicating significant challenges to vaccination. Conclusion: The Theory of Planned Behavior (TPB) clarifies numerous factors that influence parents' decisions to immunize their children against COVID-19. Understanding these factors is critical for narrowing the gap between high rates of routine vaccinations and low rates of COVID-19 vaccinations, as well as developing effective strategies to increase vaccine acceptance among parents.

A rare case of methemoglobinemia in a preterm newborn with unclear etiology.

 Cyanosis is a bluish discoloration of the tissues due to increased levels of deoxygenated hemoglobin in capillaries. It is a common finding in newborn infants that can be caused by different diseases, including pulmonary, cardiac, infectious, and hematological disorders. Methemoglobinemia is a rare cause of cyanosis, in which hemoglobin is oxidized, changing its heme iron configuration from the ferrous (Fe2 +) to the ferric (Fe3 +) state, creating methemoglobin (Met-Hb), a form that does not bind oxygen, leading to decreased oxygen delivery to the tissues and cyanosis. We report a rare case of a preterm newborn, who developed cyanosis and worsening hypoxemia on day ten of life, she was found to have elevated Met-Hb percentage in blood gas analysis that required treatment with intravenous methylene blue. Her symptoms resolved after a period of maintenance treatment with oral methylene blue and ascorbic acid, and the etiology of her disease remains unclear.

Congenital Diaphragmatic Hernia at a Non-ECMO Center in Jordan.

OBJECTIVES: We studied the clinical characteristics and outcomes of neonates with congenital diaphragmatic hernia (CDH) admitted to a non-extracorporeal membrane oxygenation (ECMO) center. METHODS: A retrospective chart review of neonates with CDH admitted to a University Hospital, in Amman, Jordan, between 2005 and 2019. Demographic characteristics and their management details were extracted and factors associated with survival were analyzed. RESULTS: A total of 28 neonates born with CDH were included; their survival rate was 39.3%. Onset of respiratory distress, pre-operative ventilation, and length of hospitalization were significantly associated with mortality. Survival after surgery was significantly associated with a higher gestational age and a longer hospital stay. CONCLUSION: Our study showed a high mortality rate for CDH patients. Decreasing the health inequity and improved clinical interventions could improve outcomes.

Family planning interventions in Jordan: A scoping review.

BACKGROUND: Despite all efforts in Jordan to increase the demand and use of family planning services, many challenges have likely influenced fertility and contraceptive use outcomes. Improving accessibility and availability of family planning services and interventions to married women and their spouse is essential to improve pregnancy outcomes. OBJECTIVES: This study reviewed the gray and peer-reviewed literature published between January 2010 and June 2022 that described family planning interventions implemented in Jordan and highlighted the gaps identified in the literature. ELIGIBILITY CRITERIA: For inclusion, primary studies that included information regarding family planning interventions implemented in Jordan were retained. SOURCES OF EVIDENCE: PubMed database was searched between 2010 till June 2022, as well as bibliographies of the retrieved literature were screened for the relevant literature. CHARTING METHODS: Information extracted from the interventions included author, publication year, study design and purpose, intervention name, aim of the intervention, population descriptor and sample size of the intervention, and impact of the intervention. RESULTS: A total of 10 studies that met the inclusion criteria were reviewed. The studies described/assessed 10 different interventions including communication interventions, child preparation programs, evidence-based educational program, counseling interventions, pharmacist booklet on effective use of oral contraceptive pills and Village Health Center project. Five family planning interventions targeted women and five targeted health care providers. Three interventions targeted men, two targeted religious leaders, and two targeted community health committees. Many of the interventions suffered from a lack of a robust methodological framework. CONCLUSION: This scoping review showed that there is scarce information on the implementation of High Impact Practices in Family Planning in Jordan. The review identified a lack of robust evidence on the impact and effectiveness of family planning interventions on the access to and use of family planning services and methods. There is a need for developing, implementing, and evaluating family planning interventions that elicit a positive environment and encourage the use of family planning services.

Knowledge of Jordanian women of reproductive age who underwent bariatric surgery and its effect on birth outcomes: A cross-sectional study.

Objectives: This study aims at exploring the knowledge of women of reproductive age who underwent bariatric surgery in Jordan regarding its effect on birth outcomes. Methods: A cross-sectional study was conducted on 183 women (aged 15-49) who had undergone bariatric surgery at the Jordan University Hospital in Amman, Jordan, between 2016 and 2019, using telephone interviews with conveniently selected participants' samples. The survey tool obtained data on women's knowledge and other sociodemographic, obstetric health, and bariatric surgery information. Unfavorable birth outcomes include preterm delivery, small for gestational age, congenital abnormalities, low birth weight, and admission to the neonatal critical care unit. Results: More than half of the participants did not know about the possible unfavorable birth outcomes after bariatric surgery and related practice guidelines. This is shown in their median score of 3 (interquartile range: 2-4) out of a maximum possible score of 8. Women who had a good score (>4) had received counseling about unfavorable bariatric surgery outcomes from their surgeon (p < 0.013); those who had educational qualifications higher than secondary school (p < 0.001) as well as those who were employed (p < 0.008) and believed that the surgery would affect the newborn (p < 0.001). The median score was also unfavorably associated with the parity of the participants (p < 0.003). Conclusion: The extent of knowledge regarding the unfavorable birth outcome of bariatric surgery is low among women who underwent bariatric surgery at Jordan University Hospital in Jordan. Improving health literacy and information on bariatric surgery implications on pregnancy and birth outcomes amongst women of reproductive age is a recommendation from this study.

Machine learning techniques for predicting depression and anxiety in pregnant and postpartum women during the COVID-19 pandemic: a cross-sectional regional study.

Background: Maternal depression and anxiety are significant public health concerns that play an important role in the health and well-being of mothers and children. The COVID-19 pandemic, the consequential lockdowns and related safety restrictions worldwide negatively affected the mental health of pregnant and postpartum women. Methods: This regional study aimed to develop a machine learning (ML) model for the prediction of maternal depression and anxiety. The study used a dataset collected from five Arab countries during the COVID-19 pandemic between July to December 2020. The population sample included 3569 women (1939 pregnant and 1630 postpartum) from five countries (Jordan, Palestine, Lebanon, Saudi Arabia, and Bahrain). The performance of seven machine learning algorithms was assessed for the prediction of depression and anxiety symptoms. Results: The Gradient Boosting (GB) and Random Forest (RF) models outperformed other studied ML algorithms with accuracy values of 83.3% and 83.2% for depression, respectively, and values of 82.9% and 81.3% for anxiety, respectively. The Mathew's Correlation Coefficient was evaluated for the ML models; the Naïve Bayes (NB) and GB models presented the highest performance measures (0.63 and 0.59) for depression and (0.74 and 0.73) for anxiety, respectively. The features' importance ranking was evaluated, the results showed that stress during pregnancy, family support, financial issues, income, and social support were the most significant values in predicting anxiety and depression. Conclusion: Overall, the study evidenced the power of ML models in predicting maternal depression and anxiety and proved to be an efficient tool for identifying and predicting the associated risk factors that influence maternal mental health. The deployment of machine learning models for screening and early detection of depression and anxiety among pregnant and postpartum women might facilitate the development of health prevention and intervention programs that will enhance maternal and child health in low- and middle-income countries.

Dietary intake and lifestyle practices of eastern mediterranean postpartum women before and during COVID-19 pandemic: An internet-based cross-sectional survey.

Background: During the lockdown period, a substantial group of these women reported lifestyle changes. Aim: The aim of the study is to characterize the dietary patterns, intake and the adherence to the United States Department of Agriculture (USDA) pregnancy guidelines before and during the COVID-19 pandemic in Eastern Mediterranean postartum women. Methods: An internet-based cross-sectional survey was used to collect the data. The survey was carried out among 1,939 postpartum women from five countries from the Eastern Mediterranean region. Change in dietary intake from the five food groups and the adherence to USDA's daily recommendations were assessed. Findings: There was a significant increase in the mean (SD) consumption of all the food groups, including bread, rice, and other cereals, fruits, vegetables, milk and milk products, white and red meat, and nuts during the pandemic. Around 84% of participants reported no/low adherence (0-2) to USDA guidelines, whereas only 15% reported moderate or high adherence (3-5) to the guidelines before the pandemic. However, there was an increase in the proportion of subjects reporting moderate/high adherence (22%) during the pandemic. Discussion and conclusions: A substantial proportion of our study participants reported a lower dietary intake than the recommended amounts, and low adherence to the five food groups. Reasonable and applicable actions should be taken to protect postpartum women and their children from the effects of low dietary intake, particularly during pandemics and lockdowns. More researches are needed to identify the modifiable factors which could improve the nutritional status of the postpartum women during the pandemic.

Impact of COVID-19 Self-Isolation on Medical Students' Education and Adherence to Protective Measures.

This study aims to evaluate the impact of self-isolation on the level of adherence to health protective measures among medical students in Jordan and on their clinical education. Because of being suspected of having or testing positive for COVID-19, 336 students were self-isolated . A questionnaire was sent to study the clinical adherence of students to COVID-19 protective measures after their self-isolation period, the student's satisfaction about the policy followed during the pandemic, the impact of these measures on their clinical training, and the level of vaccine acceptance among them. The study included 283 participants, with a mean age of 22.5 (±1.50) years; 49.5% males and 50.5% females. We found that students' adherence to protective measures generally increased after their self-isolation. Gender, age, and having an infection from the hospital were the most important predictors for better adherence to health safety measures. Most students (83%) have registered to take the vaccine. 97.5% of self-isolated students reported that they are aware and satisfied of the School of Medicine instructions and policies. The findings suggest the need to ensure that medical students' clinical training should not be negatively affected by COVID-19 and COVID-19 self-isolation, as medical students are adherent to COVID-19 precautionary measures and willing to take the vaccine.

Children with type one diabetes who are migrants and refugees suffer from poor metabolic control and frequent acute complications, a study from Jordan, a limited resource country with high migrant/refugee population.

BACKGROUND: Data from developed countries show that pediatric patients with type one diabetes (T1D) who are migrants/refugees suffer from poor metabolic control and frequent complications. Their status in developing countries is underreported. AIM: To compare Jordanian and migrant/refugee children with T1D in terms of socio-demographic and metabolic characteristics. METHODS: This is a questionnaire-based, cross-sectional study. It was completed using Microsoft forms and patients/caregivers were asked to consent if they agreed to answer. RESULTS: A total of 146 children with T1D were enrolled in the study (42, 28.8% migrants/refugees). Jordanian and migrant/refugee children with T1D had poor metabolic control: average HbA1c was 8.9 ± 1.99% (74 ± 22 mmol/mol) and 9.0 ± 1.93% (75 ± 21 mmol/mol), respectively P = 0.81. Migrant children with T1D suffered from recurrent hypoglycemia more than the Jordanian group 33 (78.6%) and 56 (53.8%) respectively, p = 0.006. Although not statistically significant, recurrent attacks of DKA was reported more in the migrant/refugee group 13 (31.0%) and 18 (17.3%) respectively, p = 0.068. CONCLUSION: Both Jordanian children with T1D and those who are refugees/migrants had poor metabolic control. However, those who are of migrant/refugee background were more likely to develop acute complications related to diabetes.

Secondary Hemophagocytic Lymphohistiocytosis in a Neonate with SARS-CoV-2 Infection.

BACKGROUND Infants born to mothers with Coronavirus disease (COVID-19) are susceptible to infection, either vertically or horizontally. The mechanism is not completely understood. Regardless, it is rare that an infant with COVID-19 suffers from serious, life-threatening complications. We speculate that one of these complications can be hemophagocytic lymphohistiocytosis (HLH), a dysregulated hyperinflammatory response that leads to multi-organ failure. CASE REPORT We describe a case of a female newborn, born to a SARS-CoV-2-positive mother via cesarean section delivery at 35 weeks of gestation, that tested positive for SARS-CoV-2 on the first day after birth. The patient presented with progressive respiratory distress, intermittent fever, splenomegaly, and cytopenia. Hemophagocytic lymphohistiocytosis (HLH) work-up was done, which showed hyperferritinemia, hypofibrinogenemia, and hypertriglyceridemia. Bone marrow aspirate showed hemophagocytic activity of both red blood cells and platelets. We suspect that the virus triggered HLH, which led to the patient's death at 51 days of age due to severe respiratory failure. CONCLUSIONS Infants and children suffer from milder symptoms than adults when infected with SARS-CoV-2, for reasons not well understood, although multiple hypotheses have been proposed, which are discussed in this paper. However, there is a possibility that the severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) virus can cause HLH and multi-system inflammatory syndrome in children (MIS-C).

Adverse pregnancy outcomes during the COVID-19 lockdown. A descriptive study.

BACKGROUND: The ongoing spread coronavirus disease worldwide has caused major disruptions and led to lockdowns. Everyday lifestyle changes and antenatal care inaccessibility during the coronavirus disease 2019 (COVID-19) pandemic have variable results that affect pregnancy outcomes. This study aimed to assess the alterations in stillbirth, neonatal-perinatal mortality, preterm birth, and birth weight during the COVID-19 national lockdown. METHODS: We used the data from the Jordan stillbirths and neonatal death surveillance system to compare pregnancy outcomes (gestational age, birth weight, small for gestational age, stillbirth, neonatal death, and perinatal death) between two studied periods (11 months before the pandemic (May 2019 to March 2020) vs. 9 months during the pandemic (April 2020 to March 1st 2020). Separate multinomial logistic and binary logistic regression models were used to compare the studied outcomes between the two studied periods after adjusting for the effects of mother's age, income, education, occupation, nationality, health sector, and multiplicity. RESULTS: There were 31106 registered babies during the study period; among them, 15311 (49.2%) and 15795 (50.8%) births occurred before and during the COVID-19 lockdown, respectively. We found no significant differences in preterm birth and stillbirth rates, neonatal mortality, or perinatal mortality before and during the COVID-19 lockdown. Our findings report a significantly lower incidence of extreme low birth weight (ELBW) infants (<1kg) during the COVID-19 lockdown period than that before the lockdown (adjusted OR 0.39, 95% CI 0.3-0.5: P value <0.001) CONCLUSIONS: During the COVID-19 lockdown period, the number of infants born with extreme low birth weight (ELBW) decreased significantly. More research is needed to determine the impact of cumulative socio-environmental and maternal behavioral changes that occurred during the pandemic on the factors that contribute to ELBW infants.

Relative validity and reproducibility of a food frequency questionnaire to evaluate food group intakes among Jordanian children and adolescents / Validez relativa y reproducibilidad de un cuestionario de frecuencia alimentaria para evaluar la ingesta de grupos de alimentos entre niños y adolescentes jordanos

Introduction: studies of the impact of diet on the prevention and occurrence of diseases in all life stages require a reliable and valid dietary assessment tool for assessing dietary intake. Objectives: this study aimed to develop and evaluate the relative validity and reproducibility of a culturally sensitive quantitative food frequency questionnaire (FFQ) to assess food group intake among Jordanian children and adolescents. Methods: the validation study was carried out on 136 children and adolescents aged between 6 and 18 years who enrolled from selected public and private schools. Fifty of these children and adolescents participated in the reproducibility phase. Food group intake from a quantitative FFQ was compared with food group intake from 24-hour dietary recalls (24h-DRs). Four 24-HRs were collected weekly for one month. Results: intraclass correlation coefficients between the two FFQs ranged from 0.18 for nuts to 0.98 for tea. De-attenuated and energy-adjusted correlations ranged from 0.08 for nuts to 0.95 for vegetable oils. On average, 46.6 % and 43.6 % of participants were ranked by the FFQ-1 and the 24h-DRs into the same quartile based on their crude and energy-adjusted food group intake, respectively. Bland-Altman plots showed a satisfactory agreement between the two methods for milk and milk products and vegetables. Conclusions: the findings of this study suggested that the developed FFQ has excellent reproducibility and good relative validity for most food groups. (AU)

Introducción: los estudios sobre el impacto de la dieta en la prevención y aparición de enfermedades en todas las etapas de la vida requieren una herramienta de evaluación dietética confiable y válida para evaluar la ingesta dietética. Objetivos: este estudio tuvo como objetivo desarrollar y evaluar la validez relativa y la reproducibilidad de un cuestionario cuantitativo de frecuencia alimentaria (CFC) culturalmente sensible para evaluar la ingesta de grupos de alimentos entre niños y adolescentes jordanos. Métodos: el estudio de validación se realizó en 136 niños y adolescentes de entre 6 y 18 años matriculados en escuelas públicas y privadas seleccionadas. Cincuenta de estos niños y adolescentes participaron en la fase de reproducibilidad. La ingesta del grupo de alimentos de un CFC cuantitativo se comparó con la ingesta del grupo de alimentos de los recordatorios dietéticos de 24 horas. Se recogieron cuatro recordatorios de 024 horas semanales durante un mes. Resultados: los coeficientes de correlación intraclase entre los dos CFC variaron de 0,18 para las nueces a 0,98 para el té. Las correlaciones atenuadas y ajustadas por energía variaron de 0,08 para las nueces a 0,95 para los aceites vegetales. En promedio, el 46,6 % y el 43,6 % de los participantes fueron clasificados por el CFC-1 y el 24h-DR en el mismo cuartil en función de la ingesta de grupo de alimentos crudos y ajustados por energía, respectivamente. Los gráficos de Bland-Altman mostraron una concordancia satisfactoria entre los dos métodos para la leche y los productos lácteos y las hortalizas. Conclusiones: los hallazgos de este estudio sugirieron que el CFC desarrollado tiene una excelente reproducibilidad y una buena validez relativa para la mayoría de los grupos de alimentos. (AU)

Assessment of Perceived Compliance and Barriers to Personal Protective Equipment Use Among Healthcare Workers During the COVID-19 Pandemic's Second Wave Surge: "Walk to Talk" Cross-Sectional Correlational Study.

OBJECTIVE: This study aimed at investigating HCWs' perceptions of PPE compliance and barriers, as well as influencing factors, in order to develop methods to combat the rise in their infection rates. METHODS: During the 'second wave' surge, a cross-sectional correlational analysis was conducted over a 1-month period. It consists of HCWs from various hospital sectors that admit COVID-19 patients using an online self-administered predesigned tool. RESULTS: Out of the 285 recruited participants, 36.1% had previously been diagnosed with COVID-19. Around 71% received training on PPE use. The perceived compliance was good for (PPE) usage (mean 2.60 ± 1.10). A significant higher compliance level was correlated with previous diagnosis with COVID-19, working with patients diagnosed with COVID-19, and having a direct contact with a family member older than 45 years old (P < 0.01). The main perceived barriers to the use of PPEs were unavailability of full PPEs (35%), interference with their ability to provide patient care (29%), not enough time to comply with the rigors of PPEs (23.2%) and working in emergency situations (22.5%). With regards to perceived barriers, those working with patients diagnosed with COVID-19 and those who reported having a direct contact with a family member older than 45 years old showed significantly higher level of barriers. CONCLUSION: A series of measures, including prioritization of PPE acquisition, training, and monitoring to guarantee appropriate resources for IPC, are necessary to reduce transmission.

Parents' Experience of Having an Infant in the Neonatal Intensive Care Unit: A Qualitative Study.

INTRODUCTION: Admission to the neonatal intensive care unit (NICU) is usually unexpected and can be stressful to the parents causing strenuous psychosocial effects. Parents of these infants are subject to suffering stress, depression, and feelings of powerlessness. This study aimed at describing parents' experience of having their infant in the neonatal intensive care unit. METHOD:  A qualitative descriptive design was used. Parents (six couples and four mothers) of infants hospitalized for at least ten days regardless of gestational age, gender, or medical diagnosis were selected from a teaching hospital in Amman, Jordan. Semi-structured interviews were conducted between June 2019 and November 2019. RESULTS:  Thematic analysis of the data revealed four emerging themes: (1) Living the ambiguities of the admission to the NICU, (2) Living the burdens of their infants' hospitalization, (3) Coping with the stresses of a hospitalized infant, and (4) Reflecting on interactions with healthcare staff and the environment. DISCUSSION AND CONCLUSION:  The study findings demonstrated parents' worries and needs and highlighted the use of spirituality/religiosity as a coping mechanism. The findings will guide healthcare providers and policymakers to develop caring strategies that enhance care delivered to parents of infants in intensive care units.

Perinatal Transmission and Clinical Outcomes of Neonates Born to SARS-CoV-2-Positive Mothers.

BACKGROUND: The aim of the study was to investigate the clinical outcomes and rate of virus detection in neonates born to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive mothers. METHODS: This prospective study included neonates born to SARS-CoV-2-positive mothers, documenting their viral polymerase chain reaction results and clinical outcomes. RESULTS: Of the 130 neonates born to 122 SARS-CoV-2-positive mothers, 12% tested positive. Most (62%) neonates were delivered via cesarean section at an average gestational age of 36 weeks, with a birth weight of 2,900 g. Only 38% neonates required admission. SARS-CoV-2-positive infants were born at a significantly lower gestational age; had a significantly lower birth weight; and had significantly higher admission rates, surfactant therapy, and bradycardia than SARS-CoV-2-negative infants. There was no significant difference in mortality rates. CONCLUSION: This study documents perinatal transmission of SARS-CoV-2. It reports for the first time the occurrence of neonatal bradycardia as a complication of maternal SARS-CoV-2 infection. Despite that, neonates born to SARS-CoV-2-positive mothers had relatively good short-term outcomes.

Relative validity and reproducibility of a food frequency questionnaire to evaluate food group intakes among Jordanian children and adolescents.

INTRODUCTION: Introduction: studies of the impact of diet on the prevention and occurrence of diseases in all life stages require a reliable and valid dietary assessment tool for assessing dietary intake. Objectives: this study aimed to develop and evaluate the relative validity and reproducibility of a culturally sensitive quantitative food frequency questionnaire (FFQ) to assess food group intake among Jordanian children and adolescents. Methods: the validation study was carried out on 136 children and adolescents aged between 6 and 18 years who enrolled from selected public and private schools. Fifty of these children and adolescents participated in the reproducibility phase. Food group intake from a quantitative FFQ was compared with food group intake from 24-hour dietary recalls (24h-DRs). Four 24-HRs were collected weekly for one month. Results: intraclass correlation coefficients between the two FFQs ranged from 0.18 for nuts to 0.98 for tea. De-attenuated and energy-adjusted correlations ranged from 0.08 for nuts to 0.95 for vegetable oils. On average, 46.6 % and 43.6 % of participants were ranked by the FFQ-1 and the 24h-DRs into the same quartile based on their crude and energy-adjusted food group intake, respectively. Bland-Altman plots showed a satisfactory agreement between the two methods for milk and milk products and vegetables. Conclusions: the findings of this study suggested that the developed FFQ has excellent reproducibility and good relative validity for most food groups.

INTRODUCCIÓN: Introducción: los estudios sobre el impacto de la dieta en la prevención y aparición de enfermedades en todas las etapas de la vida requieren una herramienta de evaluación dietética confiable y válida para evaluar la ingesta dietética. Objetivos: este estudio tuvo como objetivo desarrollar y evaluar la validez relativa y la reproducibilidad de un cuestionario cuantitativo de frecuencia alimentaria (CFC) culturalmente sensible para evaluar la ingesta de grupos de alimentos entre niños y adolescentes jordanos. Métodos: el estudio de validación se realizó en 136 niños y adolescentes de entre 6 y 18 años matriculados en escuelas públicas y privadas seleccionadas. Cincuenta de estos niños y adolescentes participaron en la fase de reproducibilidad. La ingesta del grupo de alimentos de un CFC cuantitativo se comparó con la ingesta del grupo de alimentos de los recordatorios dietéticos de 24 horas. Se recogieron cuatro recordatorios de 024 horas semanales durante un mes. Resultados: los coeficientes de correlación intraclase entre los dos CFC variaron de 0,18 para las nueces a 0,98 para el té. Las correlaciones atenuadas y ajustadas por energía variaron de 0,08 para las nueces a 0,95 para los aceites vegetales. En promedio, el 46,6 % y el 43,6 % de los participantes fueron clasificados por el CFC-1 y el 24h-DR en el mismo cuartil en función de la ingesta de grupo de alimentos crudos y ajustados por energía, respectivamente. Los gráficos de Bland-Altman mostraron una concordancia satisfactoria entre los dos métodos para la leche y los productos lácteos y las hortalizas. Conclusiones: los hallazgos de este estudio sugirieron que el CFC desarrollado tiene una excelente reproducibilidad y una buena validez relativa para la mayoría de los grupos de alimentos.

Coronavirus disease 2019 (COVID-19): a brief overview of features and current treatment.

Since the report of the first cases of pneumonia caused by SARS-CoV-2 in December 2019, COVID-19 has become a pandemic and is globally overwhelming healthcare systems. The symptoms of COVID-19 vary from asymptomatic infection to severe complicated pneumonia with acute respiratory distress syndrome (ARDS) and multiple organ failure leading to death. The estimated case-fatality rate among infected patients in Wuhan, the city where the first case appeared, was 1.4%, with 5.1 times increase in the death rate among those aged above 59 years than those aged 30-59 years. In the absence of a proven effective and licensed treatment, many agents that showed activity against previous coronavirus outbreaks such as SARS and MERS have been used to treat SARS-CoV-2 infection. The SARS-CoV-2 is reported to be 80% homologous with SARS-CoV, and some enzymes are almost 90% homologous. Antiviral drugs are urgently required to reduce case fatality-rate and hospitalizations to relieve the burden on healthcare systems worldwide. Randomized controlled trials are ongoing to assess the efficacy and safety of several treatment regimens.

Coronaviruses in children: A review of potential mechanisms of childhood protection.

AIM: The 2019 coronavirus disease (COVID-19) has spread worldwide and the number of cases continues to rise exponentially. Epidemiologic reports indicate that severity of illness increases with age. However, the reasons behind the relative protection of children and infants are unclear. Whether the rationale is host-related or virus dependent is important to determine since the latter could change with viral mutations. We review factors that could affect the susceptibility of children to the novel coronavirus. METHODS: We search publications indexed on PUBMED. RESULTS: Descriptions of the pathophysiology of current and previous coronavirus infections suggest several viral targets and immunomodulatory pathways affecting the severity of illness. There is limited evidence to suggest age-variability of viral cell receptors and transmembrane co-factors required for coronavirus entry and replication. However, the ensuing cytokine storm and the effect of higher melatonin in children are age-dependent and could explain decreased disease variability in children. CONCLUSION: We believe that current evidence suggests host factors can play a role in disease severity in children and thus may remain protective despite potential virus mutation in the future. However, we recognise and discuss avenues of future research that can further illuminate the reasons children are protected from severe COVID-19 illness.

Development and validation of a food frequency questionnaire for assessing nutrient intake during childhood in Jordan / Desarrollo y validación de un cuestionario de frecuencia alimentaria para evaluar la ingesta de nutrientes durante la infancia en Jordania

INTRODUCTION: assessing the relationship between childhood diseases and nutrient intake is a crucial issue that requires valid and reliable dietary assessment tools in this period of physical and physiological development. OBJECTIVE: the present study aimed to develop and validate a food frequency questionnaire (FFQ) to assess nutrient intake in Jordanian children. METHODS: in this validation study, nutrient intake as obtained from a culturally sensitive quantitative FFQ was compared to nutrient intake as assessed by four 24-hour dietary recalls (24-HRs) between September 2017 and May 2018. One hundred and thirty-six children aged 6-18 years were enrolled from selected schools in Amman, Jordan. Children or their caregivers were asked to complete the FFQ during an initial face-to-face interview. Four 24-HRs were collected weekly over one month. Of these children, 50 also took part in the reproducibility phase, which involved a repeat completion of the FFQ within 1 month. RESULTS: the intraclass correlation coefficients between the two FFQs ranged from 0.5 for trans-fats to 0.96 for calcium. Correlation coefficients between dietary intake estimates derived from the FFQ and 24-HRs were significant at p < 0.05. The highest correlation was detected for energy (0.8) while the lowest was identified for trans-fatty acids (0.04). For all nutrients, over 60 % of participants were classified into the same or adjacent quartile of crude and adjusted intake. Bland-Altman plots showed a satisfactory agreement between the two methods for energy and proteins. CONCLUSION: the FFQ showed a good reproducibility and a reasonable relative validity for most nutrients

INTRODUCCIÓN: evaluar la relación entre las enfermedades infantiles y la ingesta de nutrientes es un tema crucial que requiere herramientas de evaluación dietética válidas y confiables en este período de desarrollo físico y fisiológico. OBJETIVO: el presente estudio tuvo como objetivo desarrollar y validar un cuestionario de frecuencia de alimentos (FFQ) para evaluar la ingesta de nutrientes de los niños jordanos. MÉTODOS: en este estudio de validación, la ingesta de nutrientes de un FFQ cuantitativo culturalmente sensible se comparó con la ingesta de nutrientes de cuatro recordatorios dietéticos de 24 horas (24-HR) entre septiembre de 2017 y mayo de 2018. Se reclutaron ciento treinta y seis niños y adolescentes de 6 a 18 años en escuelas seleccionadas de Amán, Jordania. Se pidió a los niños o sus cuidadores que completaran el FFQ en una entrevista inicial presencial. Se recogieron cuatro 24-HR semanalmente durante un mes. De estos niños, 50 también participaron en la fase de reproducibilidad, que involucró la repetición del FFQ en un plazo de 1 mes. RESULTADOS: los coeficientes de correlación intraclase entre los dos FFQ oscilaron entre 0,5 para las grasas trans y 0,96 para el calcio. Los coeficientes de correlación entre las estimaciones de la ingesta alimentaria derivadas del FFQ y los 24-HR fueron significativas, con un valor p < 0,05. La correlación más alta se detectó para la energía (0,8) mientras que la más baja fue para los ácidos grasos trans (0,04). Para todos los nutrientes, más del 60 % de los participantes se clasificaron en el mismo cuartil o el adyacente de ingesta cruda y ajustada. Las gráficas de Bland-Altman mostraron un acuerdo satisfactorio entre los dos métodos en términos de energía y proteínas. CONCLUSIÓN: el FFQ mostró una buena reproducibilidad y una validez relativa razonable para la mayoría de los nutrientes