Assuntos
Vinho , Antioxidantes/química , Antioxidantes/farmacologia , Doenças Cardiovasculares/epidemiologia , Doenças Cardiovasculares/prevenção & controle , Humanos , Doenças Neurodegenerativas/epidemiologia , Doenças Neurodegenerativas/prevenção & controle , Resveratrol , Sirtuína 1 , Sirtuínas/genética , Estilbenos/química , Estilbenos/farmacologia , Vinho/análiseRESUMO
Samples of blood and marrow from children with leukemia were assayed for telomerase activity and expression on the day of diagnosis and during the course of chemotherapy. A strong correlation between either variables and clinical response was observed in most patients. A unique case was observed in which telomerase activity was only moderately increased on diagnosis; it gradually increased in the course of therapy, and a subsequent decrease occurred only after application of intensified therapy. This patient did not respond to therapy, his disease progressed, and he finally died during intensified therapy. In another patient, analysis of telomere lengths using dideoxy-PRINS revealed a single telomere expansion on a long arm of chromosome 4, suggesting involvement of a telomerase-independent mechanism of telomere elongation.
Assuntos
Leucemia Mieloide/enzimologia , Leucemia-Linfoma Linfoblástico de Células Precursoras/enzimologia , Telomerase/genética , Telômero/genética , Doença Aguda , Domínio Catalítico , Criança , Regulação Enzimológica da Expressão Gênica , Regulação Neoplásica da Expressão Gênica , Humanos , Hibridização in Situ Fluorescente , Leucemia Mieloide/genética , Leucemia Mieloide/terapia , Leucemia-Linfoma Linfoblástico de Células Precursoras/genética , Leucemia-Linfoma Linfoblástico de Células Precursoras/terapia , RNA Neoplásico/genética , RNA Neoplásico/metabolismo , Telomerase/metabolismoRESUMO
Various possibility of computerized analysis of radiographic image of bone and joint are presented. The principle of digital image recording and processing are described. Practical application of computer programs of bone structure analysis and measurement of joint width using image analysis procedure are presented.
Assuntos
Artrografia/métodos , Osso e Ossos/diagnóstico por imagem , Intensificação de Imagem Radiográfica/métodos , Algoritmos , Humanos , Gravação em VídeoRESUMO
The authors analyze seven cases of thrombocytopenia and three cases of thrombocytopathies in neonates and infants who were hospitalized within a short period of time at the First Paediatric Clinic in Brno. The results support the view that thrombocytopenia and thrombocytopathies in neonates and infants are fairly frequent. Because they are not manifested by clinical symptoms, their frequency escapes attention.
Assuntos
Transtornos Plaquetários , Trombocitopenia , Transtornos Plaquetários/sangue , Transtornos Plaquetários/patologia , Transtornos Plaquetários/terapia , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Trombocitopenia/sangue , Trombocitopenia/patologia , Trombocitopenia/terapiaRESUMO
The paper is the result of five years paediatric, neurological and neurosurgical care of 102 infants with inborn and acquired damage of the central nervous system. Early diagnosis, a suitably indicated neurosurgical operation, comprehensive paediatric and neurosurgical care ensure along with rehabilitation and psychic stimulation, optimum therapeutic results. So far only few reports on results of long-term studies of thus treated child patients were published. The paper is an example of interdisciplinary cooperation.