The Association of Preoperative Trail Making Tests With Postoperative Delirium.

Aims The aim of the present study was to investigate the preoperative Trail Making Test (TMT) and its association with postoperative delirium. Materials and methods This cross-sectional, observational study consisted of 51 patients admitted to the surgical ward for any planned operative procedure. Consenting patients provided their sociodemographic information, and the Hospital Anxiety and Depression Scale (HADS), Montreal Cognitive Assessment (MoCA) test, and Trail Making Test (TMT) were applied. Results A total of 51 patients (66.7% male and 33.3% female) were categorized as the "normal" group (n=34), completing TMT in time, and the "slow" group (n=17). The mean age was 45.05 ± 13.69 for the normal group and 44.29 ± 10.95 for the slow group. The HADS score mean was 15.02 ± 9.52 and 11.64 ± 5.73, respectively, for these two groups (t = -1.577; degrees of freedom {df} = 47.11; p = 0.121). However, the "normal" group scored significantly higher MoCA scores in comparison to the slow group (26.35 ± 1.06 and 24.29 ± 1.10, respectively) (t = -6.410; df = 49; p = 0.000). Conclusions The study shows that the TMT can indicate effectively the cognitive decline in preoperative patients, which predicts postoperative delirium.

Stigma Scale Adaptation and Validation for Measuring COVID-19 Stigma.

BACKGROUND: The current coronavirus disease 2019 (COVID-19) pandemic has been found to be associated with increased psychosocial problems such as depression, anxiety, stress, and stigma. Many health-related stigma instruments that have been developed are condition-specific; these should be adapted and validated for generic use, across different health conditions. This study was conducted to measure stigma, stress, anxiety, and depression using the COVID-19 Stigma Scale-Modified (CSS-M), a modified version of the HIV Stigma Scale, among the Indian population. METHODS: A weblink-based online survey was conducted using the adapted CSS-M, along with the Depression, Anxiety, and Stress Scale-21. Collected data were analyzed with correlation analysis, reliability analysis, exploratory factor analysis, and convergent and divergent validity. RESULTS: With a sample size of 375, the modified scale for COVID-19 stigma showed internal consistency and a good inter-item correlation (Cronbach's alpha 0.821). Principal axis factoring with varimax rotation along with alternative parallel analysis established the two factorial structure and had valid composite reliability, discriminate validity, and partial convergent validity. CONCLUSION: We found that COVID-19 Stigma Scale-Modified is a valid measure to assess COVID-19-related stigma. The scale was found to be internally consistent with a good inter-item correlation, composite reliability, valid discriminate validity, and partial convergent validity. Specific COVID-related validated scales for stigma should be developed in the future.

Prevalence of depression in visually impaired children and adolescents: A systematic review and meta-analysis.

The prevalence of depression among visually impaired or blind children and adolescents has not been systematically reviewed. This study aims to provide the prevalence of depression among visually impaired or blind children and adolescents. This systematic review and meta-analysis were conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines (PRISMA) (2020) and Meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines. A systematic search of various online databases was done to identify and include studies reporting the prevalence of depression among visually impaired or blind children and adolescents (aged up to 20 years). A random-effects meta-analysis was used to estimate the pooled prevalence of depression. Heterogeneity was assessed using I2 to explain heterogeneity meta-regressive analysis and subgroup analyses were done. With the finally selected 13 studies consisting of 822 participants, the overall pooled prevalence of depression or dysthymia among visually impaired children or adolescents was 14% (137/822 individuals, 95% CI = 9% to 20%), with high heterogeneity between studies (I2 = 80.11%; P < 0.001). Five studies that expressed gender distribution showed a cumulative prevalence of diagnosed depressive disorders was 6.85% and 18.96%, respectively, for male (n = 219, I2 = 47.52) and female (n = 116, I2 = 60.6%) participants. In this systematic review and meta-analysis, we selected and analyzed 13 studies and estimated pooled prevalence of depression was 14% (95% CI = 9% to 20%), among visually impaired or blind children and adolescents.

Indian Psychiatric Society multicentre study: Diagnostic patterns, comorbidity and prescription practices for patients with Dementia.

Background: There are more than 5 million people with dementia in India. Multicentre studies looking at details of treatment for people with dementia In India are lacking. Clinical audit is a quality improvement process which aims to systematically assess, evaluate, and improve patient care. Evaluating current practice is the key to a clinical audit cycle. Aim: This study aimed to assess the diagnostic patterns and prescribing practices of psychiatrists for patients with dementia in India. Method: A retrospective case file study was conducted across several centers in India. Results: Information from the case records of 586 patients with dementia was obtained. Mean age of the patients was 71.14 years (standard deviation = 9.42). Three hundred twenty one (54.8%) were men. Alzheimer's disease (349; 59.6%) was the most frequent diagnosis followed by vascular dementia (117; 20%). Three hundred fifty five (60.6%) patients had medical disorders and 47.4% patients were taking medications for their medical conditions. Eighty one (69.2%) patients with vascular dementia had cardiovascular problems. Majority of the patients (524; 89.4%) were on medications for dementia. Most frequently prescribed treatment was Donepezil (230; 39.2%) followed by Donepezil-Memantine combination (225; 38.4%). Overall, 380 (64.8%) patients were on antipsychotics. Quetiapine (213, 36.3%) was the most frequently used antipsychotic. Overall, 113 (19.3%) patients were on antidepressants, 80 (13.7%) patients were on sedatives/hypnotics, and 16 (2.7%) patients were on mood stabilizers. Three hundred nineteen (55.4%) patients and caregivers of 374 (65%) patients were receiving psychosocial interventions. Conclusions: Diagnostic and prescription patterns in dementia which emerged from this study are comparable to other studies both nationally and internationally. Comparing current practices at individual and national levels against accepted guidelines, obtaining feedback, identifying gaps and instituting remedial measures help to improve the standard of care provided.

Excessive and Unreliable Health Information and Its Predictability for Anxiety: A Cross-Sectional Observational Study.

INTRODUCTION: Being ignorant or unaware is not expected in a situation like the pandemic of COVID-19 with modern internet connectivity and the era of social media. However, information overload may itself lead to health anxiety. AIMS AND OBJECTIVES: This study investigated the predictability of health anxiety with information overload and sociodemographic profiles during the COVID-19 pandemic. MATERIALS AND METHODS: A cross-sectional study was done among 400 caretakers of non-covid patients in a tertiary healthcare medical college. The consenting participants provided their sociodemographic details and responded to the short health anxiety inventory (SHAI), Beck anxiety inventory (BAI) and Information overload scale (IOS) for COVID-19. RESULTS: A total number of 400 participants aged 35.58 ± 10.57 years participated and out of which 88.2% acknowledged health-related anxiety and 56.8% for excessive use of social media. BAI measured anxiety was mild for 19.8%, moderate for 3.5% and severe for 3%. The linear regression analysis predicted health anxiety by three variables only: total anxiety as measured by the Beck anxiety inventory [ß = 0.416, t = 9.318, p = 0.000], information overload (rejection of information) [ß = 0.171, t = 3.126, p = 0.002], and excessive use of social media [ß = 0.124, t = 2.888, p = 0.004]. CONCLUSION: Information overload, its rejection and excessive use of social media were found to be predictive of health-related anxiety.

A multicentric exploratory study of behavioral and psychological symptom characteristics of dementia.

Background: Behavioral and psychological symptoms (BPS) are usually the expected consequences of dementia. BPS increases morbidity and burden, affects the quality of life, and impacts care costs. However, the symptom characteristics, clinical correlations, and symptom-specific clusters aiding the diagnosis are less well studied, especially in the Indian population. Materials and Methods: The present study examined the BPS clusters based on various cognitive and neuropsychiatric profiles in patients with dementia under a multicentric study in India. We did a cross-sectional assessment using the Neuropsychiatric Inventory Questionnaire (NPI-Q) and cognitive functions by Montreal Cognitive Assessment (MoCA), and the severity of dementia using the Clinical Dementia Rating (CDR) scale. In addition, all of the participants were evaluated on a structured Clinical Interview for DSM-5 Research Version for past or current psychiatric disorder(s). Results: We describe the various BPS clusters uniquely associated with the severity of dementia. Further, on linear regression analysis, we predicted three symptom clusters (anxiety, irritability, aberrant motor) in mild, two symptom clusters (disinhibition, agitation/aggression) in moderate and three symptom clusters (delusion, euphoria/elation, disinhibition) in severe dementia. Conclusion: The study provides insights into the various symptom characteristics and inter-relationship of BPS, which may benefit the clinician while assessing patients with dementia.

Memory changes following adjuvant temporo-parietal repetitive transcranial magnetic stimulation in schizophrenia.

OBJECTIVE: The use of repetitive transcranial magnetic stimulation (rTMS) in schizophrenia has shown improvement as well as deficits in memory. Though most studies had focused on dorsolateral prefrontal cortex only, but impact of rTMS on cognitive functions remain inconclusive. The need of the study is to assess the impact of rTMS on memory in schizophrenia. MATERIALS AND METHODS: Forty right-handed male patients with schizophrenia were included by purposive sampling and rated on Positive and Negative Syndrome Scale (PANSS) before starting the rTMS treatment with the experimental group. Low frequency 1 Hz rTMS including 1200 stimulations were given over temporo-parietal cortex for 20 min as add on to medications. At the end of 10 session treatment (5 days a week for 2 weeks), the patients were re-evaluated. RESULTS: A total of 39 patients (20 for experimental group and 19 for control group) with mean age of 29.70 ± 9.05 and 31.26 ± 7.78 years, respectively, shows significant difference to pre- and post-treatment mean PANSS score in positive, negative and general psychopathology domains. The pre- and post-treatment mean Postgraduate Institute Memory Scale Scores with multivariate repeated measures analysis of variance revealed significant improvements in all memory domains (P < 0.01) except remote memory in both experimental and control groups. CONCLUSION: RTMS in combination with antipsychotics has shown improvement in psychopathology in patients of schizophrenia without any deterioration of memory.

Factor structure and internal consistency of Oriya version of Edinburgh Postnatal Depression Scale.

BACKGROUND: "Edinburgh Postnatal Depression Scale" (EPDS) is a widely used screening instrument for assessing peripartal depression. To utilize it for Oriya-speaking population, we translated the scale and studied its internal consistency and factor structure. MATERIALS AND METHODS: Consenting Oriya-speaking pregnant women attending antenatal checkup during second or third trimester were administered the translated EPDS. Internal consistency analysis (Cronbach's alpha and item-total correlation) and exploratory factor analysis (principal component analysis) with varimax rotation were carried out to identify factor structure. RESULTS: The Cronbach's alpha coefficient for the scale was found to be 0.81, whereas principal component analysis revealed a three-factor solution that accounted for 87.61% of the total variance. The factors included "cognitive depression," "somatic depression," and "anxiety factor," with a percentage of variance being 41.18%, 28.09%, and 18.33%, respectively. CONCLUSION: The translated Oriya EPDS is a reliable scale with adequate internal consistency and three-dimensional factor structures.

Psychosocial morbidity among children with type-1 diabetes mellitus.

BACKGROUND: Although the psychosocial impact of type-1 diabetes mellitus (T1DM) patients is well recognized, data about its prevalence in India is scant. Hence, this study was undertaken to determine the prevalence and spectrum of psychosocial morbidities among pediatric T1DM patients and factors associated with psychosocial distress. METHODS: Among 39 pediatric T1DM patients, a cross-sectional questionnaire-based study was carried out. Psychological distress was measured by applying a childhood psychopathological measurement schedule (CPMS) questionnaire. Psychosocial distress was analyzed across various sociodemographic factors and disease-specific variables by applying the Chi-square test using the statistical package for social sciences (SPSS) version 16. RESULTS: The mean age of the study sample was 11.59 + 2.65 years (range: 6-16 years). Out of a total 39 patients, 21 (53.85%) were found to be psychologically distressed. The mean CPMS score was 12.74 + 9.54. Mean scores among psychologically distressed and nondistressed patient groups were 19.19 + 8.5 and 5.22 + 2.74, respectively. Anxiety, conduct disorder, and depression were the most common problems identified. Psychosocial distress was more prevalent among those who were postpubertal, males, Muslims, residing in rural areas, living in a nuclear family, having no sibling, and from the upper-lower socioeconomic background. Psychosocial distress was significantly associated with an increased number of insulin injections per day (P = 0.041) and dietary and drug regimen noncompliance (P = 0.001). CONCLUSION: The present study revealed a very high prevalence (53.85%) of psychosocial morbidity among T1DM patients. Psychosocial distress was significantly more among patients taking an increased number of insulin injections per day and patients who were noncompliant with the dietary and drug regimen.

Information overload regarding COVID-19: Adaptation and validation of the cancer information overload scale.

BACKGROUND: Access to excessive information from multiple sources relating to COVID-19 in a short span of time can have detrimental effects on individuals. AIM: The study aims to validate Corona Information Overload Scale (CoIOS) by adaptation of Cancer Information Overload scale (CIOS) on English speaking Indian citizens. MATERIALS AND METHODS: An online survey was carried out using Google Form on 300 individuals out of whom 183 responded. The CoIOS was to be filled up. It was an 8 item Likert type scale with responses ranging from "strongly agree" to "strongly disagree." RESULTS: Principal components analysis showed two components with an initial eigenvalue > unity (3.38 and 1.09), with 42.33% and 13.64% of variance, respectively, making a total of 55.97% variance. The composite reliability value was also found to be 0.789 and 0.815 for factors I and II, respectively, convergent validity and discriminant validity calculation also affirmed good construct reliability. CONCLUSION: CoIOS appears to be a valid and reliable scale for measuring health information overload in relation to COVID-19. However, it has a two factor component, namely "excessiveness of information" and "rejection of information."

Auditory sensation with affective agnosia: A prevalence of alexithymia among tinnitus patients.

OBJECTIVES: The aim of the present study was to determine the prevalence and association of alexithymia, depression, and anxiety in patients affected by tinnitus. METHODS: The study was conducted among the patients referred for audiometric evaluation for tinnitus. They were further evaluated with the Hospital Anxiety and Depression Scale, the Tinnitus Handicap Inventory, and the Toronto Alexithymia Scale. Analysis was done for prevalence and the sample was categorized as high and low tinnitus handicap subgroups, and mean scores of alexithymia, anxiety, and depression were compared. RESULTS: A total of 70 patients (55.7% - male and 44.3% - female) with a mean age of 33.17 ± 12.24 years were finally analyzed. The severity of tinnitus was most severe (34.3%), followed by moderate (20%), catastrophic (18.6%), mild (17.1%), and slight (10%). The prevalence of alexithymia, anxiety, and depression among patients of tinnitus was found to be 65.7%, 37.1%, and 20%, respectively. The high tinnitus handicap group showed higher scoring on total alexithymia score, anxiety, and depression and higher scoring with describing emotion and identification of emotion, but there was no difference for the subscale of externally oriented thinking. CONCLUSIONS: The study found a prevalence of alexithymia, anxiety, and depression as 65.7%, 37.1%, and 20%, respectively, among patients of tinnitus, and problem of describing and identification of emotion are associated with higher tinnitus handicap.

Escitalopram-induced severe akathisia leading to suicide attempt.

Akathisia, a distressing adverse reaction, is usually underdiagnosed or misdiagnosed in patients, who are treated with selective serotonin reuptake inhibitors (SSRIs). Escitalopram-induced akathisia is rarely reported in the literature. We report a case of severe akathisia leading to a suicide attempt in a 25-year-old male induced by 5 mg of escitalopram, that remitted completely after discontinuation of escitalopram and did not reappear later. Patient and their caretakers should be warned of symptoms of akathisia even when a very low dose of SSRI is prescribed.

Ranchi Institute of Neuro-Psychiatry and Allied Sciences: A pioneer in the field of psychiatry in India.

Ranchi Institute of Neuro-Psychiatry and Allied Sciences (RINPAS; Ranchi Indian Mental Hospital; Ranchi Manasik Aryogyashala) traces its origin from a lunatic asylum for Indian soldiers established at Munghyr in Bihar in 1795 and thus is the first mental hospital in India established by the British purely for Indian patients as well as the second oldest functioning mental hospital in India. The hospital made great strides in improving patients care and using modern methods of assessment and treatment as well as education and research during the tenure of Dr J E Dhunjibhoy the first Indian medical superintendent. As a result the mortality rate was the lowest among the mental hospitals in Indian. There was a shift from custodial care to curative treatment. Since 1930s psychiatric training was given to undergraduate medical students of Patna Medical College and subsequently from Darbhanga and Cuttack. The Institute was affiliated to Universities of London and Edinburgh for Diploma in Psychological Medicine in 1936. The thesis work of the first Indian MD (Psychiatry) was done at this institute. Subsequently many psychiatrists completed their MD (Psychiatry) under the guidance of Dr L.P. Verma at this institute. A number of staff and alumini of the institute held the post of President and office bearers of Indian Psychiatric Society (IPS), starting with Dr J.E. Dhunjibhoy, the first president of the IPS. The Institute declined in the 1980s but after intervention of the Supreme Court it was transformed into an autonomous institute. Under the new dispensation the institution is regaining its vitality. Care and facilities for inpatients has greatly improved. Laboratory and imaging services have been updated. Modern facilities for eye and dental surgery are available. Attendance in outpatient department and especially in satellite clinics is increasing. Postgraduate training in psychiatry, clinical psychology, psychiatric social work and psychiatric nursing has started and research is once again a priority.

Depression and Anxiety following Coronary Artery Bypass Graft: Current Indian Scenario.

Epidemiological studies have shown a high prevalence of coronary artery disease among the Indian Population. Due to increasing availability and affordability of tertiary care in many parts of India, carefully selected patients undergo coronary artery bypass surgery to improve cardiac function. However, the procedure is commonly associated with depression and anxiety which can adversely affect overall prognosis. The objective of this review is to highlight early identifiable symptoms of depression and anxiety following coronary artery bypass graft (CABG) in Indian context so as to facilitate prompt intervention for better outcome. The current review was able to establish firm evidence in support of screening for depression and anxiety following CABG. Management of depression and anxiety following CABG is briefly reviewed.

Etiologic and Cognitive Differences in Hyperactive and Hypoactive Delirium.

OBJECTIVE: To assess the differing patterns of cognitive impairment in the hyperactive and hypoactive subtypes of delirium and test the hypothesis that cognitive disturbances are high in patients with hypoactive delirium. METHOD: The study was conducted in a general hospital in Pune, India from 2007 to 2009 and included 80 patients with delirium (DSM-IV-TR criteria). A detailed sociodemographic profile was obtained for each patient, and their cognitive function was assessed with the Mini-Mental State Examination (MMSE) and Memorial Delirium Assessment Scale (MDAS). Patients were classified as hyperactive or hypoactive using the MDAS. RESULTS: Of the 80 patients, 70% (n = 56) were identified as hyperactive, with a mean ± SD age of 33.42 ± 7.37 years, and 30% (n = 24) as hypoactive, with a mean ± SD age of 34.62 ± 6.64 years. Alcohol and other substance use disorders were the most frequent diagnosis associated with the hyperactive subtype, whereas other psychiatric disorders such as schizophrenia and mood disorders, infection, and chronic medical conditions were associated with the hypoactive subtype. Cognitive impairments were significantly high in the hypoactive subtype, as found in various cognitive domains of the MMSE and MDAS (P = .000). CONCLUSIONS: The hyperactive and hypoactive subtypes of delirium appear to be etiologically associated with a different diagnostic group. Severe cognitive impairment was associated with the hypoactive subtype.

A suspected case of olanzapine induced hyponatremia.

Here we report a case of a 63-year-old male diagnosed with recurrent depressive disorder and current episode of severe depression with psychotic symptoms, developed hyponatremia soon after addition of olanzapine and increasing the dose of escitalopram. A possible causality association was established with olanzapine, and the possible etiological reasons of this clinically significant risk were discussed.

Factor Structure of CIWA-Ar in Alcohol Withdrawal.

Objective. To identify the underlying factor structure of alcohol withdrawal syndrome, as measured with CIWA-Ar. Methods. Exploratory factor analysis was conducted on the items of CIWA-Ar. On 201 alcohol-dependent male patients seeking treatment for alcohol withdrawal at 36 hours of abstinence. Results. A three-factor solution was obtained that accounted for 68.74% of total variance. First factor had loading from four items (34.34% variance), second factor also had four items (24.25% variance), and the third had two items (10.04% variance). Conclusions. Factor analysis reveals the existence of multidimensionality of alcohol withdrawal as measured with CIWA-Ar and we found three factors that can be named as delirious, autonomic and nonspecific factors.

Seasonal obsessive-compulsive disorder.

A case of obsessive-compulsive disorder (OCD) with seasonal variation in symptoms of 10-years duration is reported because of its rarity. The phenomenology of the observed disorder was obsessions related to dirt and contamination resulting in washing compulsions with onset in October and complete resolution in April-May every year. The patient responded to phototherapy along with exposure and response prevention therapy and pharmacotherapy.

Internal consistency and factor structure of 12-item general health questionnaire in visually impaired students.

BACKGROUND: As there are no instruments to measure psychological wellness or distress in visually impaired students, we studied internal consistency and factor structure of GHQ-12 in visually impaired children. MATERIALS AND METHODS: Internal consistency analysis (Cronbach's alpha and item total correlation) and exploratory factor analysis (principal component analysis) were carried out to identify factor structure of 12-item general health questionnaire (GHQ-12). RESULTS: All items of GHQ-12 were significantly associated with each other and the Cronbach's alpha coefficient for the scale was 0.7. On analysis of principal component, three-factor solution was found that accounted for 47.92% of the total variance. The factors included, 'general well-being', 'depression' and 'cognitive', with Cronbach's alpha coefficients being 0.70, 0.59, and 0.34, respectively. CONCLUSION: Our study findings suggest GHQ-12 is a reliable with adequate internal consistency scale and multidimensional factor structure in visually impaired students.