Distinctive skeletal dysplasia in Cockayne syndrome.

Cockayne syndrome is a well-known autosomal recessive form of dwarfism with senile-like appearance. Skeletal changes such as flattening of vertebral bodies, ivory epiphyses and thickening of cranial vault, have been observed in some patients with this condition. We describe here a 5.5-year-old girl with the typical clinical signs of Cockayne syndrome and a distinctive form of bone dysplasia with major involvement of the spine.

[The age of menarche]. / L'epoca del menarca.

PIP: A review of the literature concerning age at menarche is presented, and the various methods for measuring age at menarche are described. Factors considered include genetic and ethnic factors, family characteristics, physique, geographic factors, morbidity, and socioeconomic factors. The results of a wide range of studies from historical times to the present are summarized. The geographic focus is worldwide. (summary in ENG)^ieng