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Int J Gynaecol Obstet ; 145(3): 361-366, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30932170

RESUMO

OBJECTIVE: To assess the effect of a 5-hydroxytryptamine-3 receptor antagonist (granisetron) on the use of sympathomimetic (cafedrine/theodrenaline) and uterotonic (oxytocin) agents after spinal anesthesia during cesarean delivery. METHODS: A retrospective observational analysis was conducted using intraoperative records (n=240) created at a single hospital in Germany between November 1, 2016, and July 31, 2017. The granisetron group (n=120) had received 3 mg of granisetron immediately before induction of spinal anesthesia. The control group (n=120) had not received granisetron. The primary endpoints were the intraoperative requirements for sympathomimetic and uterotonic agents. The secondary endpoints were parameters of intraprocedural maternal hemodynamic and clinical states. RESULTS: More patients in the granisetron group than in the control group received intraoperative cafedrine/theodrenaline (P=0.045), with the cumulative intraoperative dosage also increased in the granisetron group (P=0.016). By contrast, the cumulative intraoperative dose of oxytocin was lower in the granisetron group than in the control group (P<0.001). Decreases in heart rate and mean arterial blood pressure were lower in the granisetron group versus the control group (P=0.015 and P=0.002, respectively). CONCLUSION: Treatment with granisetron immediately before cesarean delivery did not reduce the perioperative requirement for sympathomimetics but did reduce the need for uterotonics. REGISTERED AT CLINICALTRIALS.GOV (NCT03318536).


Assuntos
Raquianestesia/efeitos adversos , Antieméticos/administração & dosagem , Cesárea/efeitos adversos , Granisetron/administração & dosagem , Adulto , Estudos de Casos e Controles , Combinação de Medicamentos , Feminino , Alemanha , Frequência Cardíaca , Hemodinâmica , Humanos , Ocitocina/administração & dosagem , Gravidez , Estudos Retrospectivos , Simpatomiméticos/administração & dosagem , Teofilina/administração & dosagem , Teofilina/análogos & derivados
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