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Objective In this study, we aimed to assess cytological changes and p53 expression in oral mucosa among waterpipe users in the Kingdom of Saudi Arabia (KSA). Methodology A case-control study was conducted in KSA from January to October 2022. Two cytologic oral smear samples each were taken from 500 volunteers; 300 were waterpipe users (case) while 200 did not use a waterpipe (control). They were then stained using the Papanicolaou staining procedure and immunocytochemical method to show the expression of P53. Results The interpretation of the Papanicolaou staining outcomes showed the presence of four results with different proportions: inflammation, infection, atypia, and keratinization. Cytological inflammation was identified among 77/300 (25.6%) waterpipe smokers, which was higher than that among non-users (12/200, 6%). The reverse cytological infection and atypia were also higher in waterpipe smokers compared with controls (9% vs. 4.5% and 4.3% vs. 0.5%, respectively), and keratinization was detected only in waterpipe users (3.6%) compared with controls. Waterpipe users had higher p53 protein expression than non-users. Conclusion Using a waterpipe is an effective way to change the oral mucosa. In atypia and keratinization, there was high p53 expression. These results could indicate that p53 is involved in both the change from normal to cancerous cells and the growth of new cells, but the presence or absence of p53 staining could not be used to predict the outcome of potentially cancerous oral mucosal lesions.
RESUMO
Background Exposure to social media gives individuals more significant body image concerns, and many studies have emphasized that people with a negative body image are more interested in cosmetic surgery. So, increased exposure to celebrities with aesthetic images and exposure to cosmetic Surgery information and advertisements lead to negative body image in the exposed populations. Aim This study aimed to determine the impact of social media on self-image inclination toward cosmetic procedures. Subjects and methods This is a cross-sectional study conducted among an adult population in the Kingdom of Saudi Arabia. A self-administered questionnaire was distributed among participants using social media platforms. the questionnaire was sought information on socio-demographic characteristics (age, gender, education, etc.), the influence of social media on the decision to undergo cosmetic surgery, and the Acceptance of Cosmetic Surgery Scale (ACSS). Results Among the 1064 participants recruited, 41.4% were aged less than 25 with females outnumbering men substantially (82.1). Twenty-seven of the respondents increased their desire to undergo a cosmetic procedure due to advertisements or publications posted on social media. The total mean ACSS score was 3.36 (SD 1.69) out of 10 points, indicating lower acceptance. The socio-demographic variables associated with increased ACSS scores were being older, female, educated, having been married, and previous history of cosmetic surgery. Conclusion Despite the influence of Snapchat on body image, there was a low inclination to undergo cosmetic surgery among the general population in Saudi Arabia. The tendency to undergo cosmetic surgery tends to increase due to the influence of increased social media following, social media influencers, and advertisements and publications posted on social media platforms. More research is warranted to determine the perspectives of the general public regarding the influence of social media platforms on the inclination to undergo cosmetic surgery procedures for the enhancement of body appearance.
