RESUMO
Alzheimer's Disease (AD) is the sixth leading cause of death in the US. AD causes significant disability due to the devastating impact on the patients' day-to-day living activities and their loss of independence. One such day-to-day activity is driving, a complex task that requires attention, concentration, the ability to follow particular steps, react to stimuli promptly, and the ability to perceive and interpret visual-spatial information, all of which can be impaired in AD. Therefore, to ensure the safety of AD patients and other drivers, it is important to develop accurate and low-cost diagnostic tools to assess patients' fitness-to-drive. In this study, we develop machine learning (ML) models to predict fitness-to-drive using the electroencephalogram (EEG) technique of event-related potential (ERP). Specifically, we develop random forest (RF) models using EEG signals in early-stage AD patients and age-matched controls and conduct numerical experiments to predict fitness-to-drive and other driving performance metrics, collected from driving simulator data. Our results show that RF models predict patients' fitness-to-drive with AUC=0.83 and provide accurate measures of other driving performance metrics. Therefore, ML and ERP offer a valuable approach to assess driving safety for patients with early AD symptoms in the laboratory setting.