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3.
Respiration ; 47(3): 177-84, 1985.
Artigo em Inglês | MEDLINE | ID: mdl-3839089

RESUMO

The authors describe the ultrastructural alterations of the pulmonary parenchyma produced in dogs by endotoxic shock, and they examine the effects that a 'secretolytic' drug (bromexine) has in modifying those changes. In the animals under shock there is a complete breakdown of the normal structure of the pulmonary parenchyma. According to the authors, these lesions are caused by the damage of the lining layer and of the cells which produce the constituents of the surfactant system. In dogs under shock and treated with bromexine the authors have seen a better organization of the pulmonary parenchyma: the cellular limits of the pneumocytes of types I and II were more clearly defined and the osmiophilic bodies were increased both in number and volume. The authors conclude that the damage of the lining layer and of the pneumocytes of type II plays an important role in the development of the ARDS and they say that bromexine can improve clinical and morphological aspects of that syndrome.


Assuntos
Bromoexina/farmacologia , Pneumopatias/patologia , Pulmão/ultraestrutura , Choque Séptico/patologia , Animais , Bromoexina/uso terapêutico , Citidina Difosfato Colina/farmacologia , Citidina Difosfato Colina/uso terapêutico , Cães , Pulmão/efeitos dos fármacos , Pneumopatias/tratamento farmacológico , Surfactantes Pulmonares/análise , Choque Séptico/tratamento farmacológico
4.
Ital J Surg Sci ; 13(2): 133-7, 1983.
Artigo em Inglês | MEDLINE | ID: mdl-6195126

RESUMO

An immunologic study was undertaken on 89 lung cancer patients and on the basis of results obtained so far, a protocol of active, aspecific immunotherapy by living bacterial vaccines (BCG) and/or synthetic immunopotentiator (methisoprinol) was carried out. First results obtained in patients undergoing immunostimulation are reported together with the observation that while positive humoral effects seem present in stage I and II patients, in cases of spread of the disease results are substantially negative.


Assuntos
Adenocarcinoma/terapia , Vacina BCG/uso terapêutico , Carcinoma de Células Pequenas/terapia , Carcinoma de Células Escamosas/terapia , Inosina Pranobex/uso terapêutico , Inosina/análogos & derivados , Neoplasias Pulmonares/terapia , Adulto , Humanos , Imunoglobulinas/análise , Imunoterapia , Ativação Linfocitária , Masculino , Pessoa de Meia-Idade , Formação de Roseta
9.
Minerva Med ; 71(36): 2555-64, 1980 Sep 26.
Artigo em Italiano | MEDLINE | ID: mdl-7432677

RESUMO

The first case of human liver infestation due to liver fluke in Sicily is reported. After a clinical review of parasitosis, the autochthonous nature of the case is mentioned to highlight its epidemiological and prophylactic importance, especially in those regions where climatic conditions and living and working habits favour infestation. Finally, attention is called to diagnostic difficulties, treatment and appropriate hygiene and dietetic measures.


Assuntos
Colestase Extra-Hepática/parasitologia , Doenças do Ducto Colédoco/parasitologia , Fasciolíase/complicações , Doenças da Vesícula Biliar/complicações , Hepatopatias Parasitárias/complicações , Idoso , Colestase Extra-Hepática/etiologia , Doenças do Ducto Colédoco/etiologia , Fasciola hepatica , Fasciolíase/epidemiologia , Humanos , Masculino , Sicília
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