1.
Org Lett
; 25(28): 5185-5190, 2023 Jul 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37439552
RESUMO
Cp*Rh(III)-catalyzed nitro-directed C-H alkylation/alkenylation of nitroarenes has been reported for the first time. This protocol is associated with the features of high efficiency, broad substrate scope, and good functional group compatibility. Additionally, gram-scale experiments and synthetic applications proved the practicability of the method. Moreover, preliminary mechanistic investigations consistently revealed C-H bond cleavage as the rate-limiting step.