Expression and correlation of cyclooxygenase-2 and vascular endothelial growth factor in nasopharyngeal carcinoma- / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To evaluate the Expression and correlation of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor receptor (VEGF) in nasopharyngeal carcinoma.@*METHOD@#In this study, expression levels of COX-2, VEGF were examined in 58 patients with nasopharyngeal carcinoma and 38 patients with inflammation in nasopharyngeal mucosa by immunohistochemistry method.@*RESULT@#The expression of COX-2, VEGF were higher in nasopharyngeal carcinoma than those in nasopharyngeal mucosa (P < 0.05), and they had some correlation with the invasion and lymphatic metastasis and with the clinical stage of nasopharyngeal carcinoma (P < 0.05). The expression of COX-2 was positively correlated with that of VEGF (P < 0.05).@*CONCLUSION@#The coexpression of COX-2 and VEGF may play animportant role in the carcinogenesis and development of nasopharyngeal carcinoma, and they may prom (see text) lymph node metastasis of nasopharyngeal carcinoma.

Clinical Study on the Staging of Colorectal Carcinoma using Fat-dense Contrast Medium and Enhanced Multislice Spiral CT / 实用放射学杂志

Objective To assess the value of enhanced multislice spiral CT (MSCT) scan using fat-dense enema for the staging of colorectal carcinoma.Methods 33 cases with colorectal carcinoma confirmed by colonoscopy were examined by enhanced MSCT scan ,from the dome of the diaphragm to symphysis pubica,after bowel cleaning,administration of smooth muscle relaxant, and rectal fat-dense contrast agent insuffation .Carcinomas were staged with TNM by axial,multiplannar reconstruction(MPR) and CT virtual endoscopy (CTVE) images. The staging results on CT were compared with that of postoperative pathological examination in all cases.Results All the 33 colorectal carcinoma were demonstrated clearly by MSCT ,the total accurate rate in staging with the TNM classification was 78.78%.The sensitivity and positive accurate values for T staging were 100%and 87.88%(29/33),respectively. The sensitivity and positive accurate values for in detecting lymph node involvement were 86.36%(19/22)and 68.18%(15/22), respectively. Five cases in M stage were all diagnosed correctly. Conclusion Using fat-dense contrast medium and enhanced multislice spiral CT is of very important value in staging of colorectal carcinoma.

The Study of the Cochlear Implantation Surgery and the Clinical Characteristics in Otospongiosis Patients with Profound Sensory Hearing Loss / 听力学及言语疾病杂志

Objective To summarize 5 otospongiosis cases with profound sensory hearing loss who received cochlear implante(CI) in routine way.To analyze their characteristics in audiology and temporal CT,and the effects after CI.Methods 5 cases of profound sensorineural hearing loss with otospongiosis received pure tone test,otoacoustic emission,auditory brainstem evoked potential and temporal CT before operation.One of the patients received binaural CIs.Mapping was done one month after operation.Follow-up tests were provided 6 months after operation to assess the effects.Results 5 cases showed clinical characteristics of gradual binaural hearing reduction,PTA greater than 90 dB HL,mixed or sensorineural deafness,normal tympanic membranes,reduced peaks in acoustic impedance,and typical CT findings.5 patients(6 ears) were implanted in routine manner.It was difficult to open the cochlea scala tympani.The scala tympani was filled with loose bony tissues.It was about 7～9 mm between the round window and the normal scala tympani.All patients showed the standard wave from in nerves reaction remote monitoring.The patients were followed up from 8 months to 3.1years.The average PTA was 20～37dB HL.The speech discrimination score was 95%～99% for open Chinese audiometry.Conclusion CI was an effective way to help patients with profound sensory hearing loss and otospongiosis.