Assuntos
Acetilcolina/fisiologia , Asma/enzimologia , Bulbo/enzimologia , Neurônios/enzimologia , Óxido Nítrico Sintase/metabolismo , Nervo Vago/enzimologia , Acetilcolina/administração & dosagem , Administração por Inalação , Vias Aferentes/citologia , Vias Aferentes/enzimologia , Animais , Asma/fisiopatologia , Modelos Animais de Doenças , Masculino , Bulbo/citologia , NADPH Desidrogenase/metabolismo , Óxido Nítrico Sintase Tipo II , Gânglio Nodoso/citologia , Gânglio Nodoso/enzimologia , Ratos , Nervo Vago/citologiaRESUMO
The expression NADPH-diaphorase and inducible NO-synthase (NOS) was studied in vagal nucleus dorsalis and ganglion nodosum neurons following acethylcholine inhalation in healthy rats and rats with ovalbumin-induced experimental bronchial asthma (BA). It was found that NOS activity regulation is mediated by cholinoreceptors; functioning of this mechanism is disturbed in hypoxic state. It is shown that both in conditions of physiological norm and in experimental BA, changes in NOS activity are determined by its constitutive, neuronal isoform.
Assuntos
Acetilcolina/farmacologia , Asma/enzimologia , Óxido Nítrico Sintase/metabolismo , Núcleo Olivar/enzimologia , Nervo Vago/enzimologia , Acetilcolina/administração & dosagem , Administração por Inalação , Animais , Asma/patologia , Imuno-Histoquímica , Masculino , NADPH Desidrogenase/metabolismo , Neurônios/enzimologia , Óxido Nítrico Sintase Tipo II , Gânglio Nodoso/enzimologia , Gânglio Nodoso/patologia , Núcleo Olivar/patologia , Ratos , Nervo Vago/patologiaRESUMO
Mediastinal pleura was studied in pregnancy second part abortive human fetuses using histological and histochemical technique. It was found to have a well-developed monoaminergic apparatus that includes adrenergic axons and mast cells. Electron microscope study confirmed monoaminergic and single peptidergic vesicles presence in axons. Luminescent method revealed that mast cells of nerve plexuses and blood vessels contain catecholamines and indolalkylamines. Monoaminergic axons and mast cells were shown to constitute a functionally integrative apparatus that regulates local hemodynamics and trophics.