Triglyceride to HDL Cholesterol Ratio for the Identification of MASLD in Obesity: A Liver Biopsy-Based Case-Control Study.

Associations between dyslipidemia and metabolic dysfunction-associated steatotic liver disease (MASLD) have been reported. Previous studies have shown that the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio may be a surrogate marker of MASLD, assessed by liver ultrasound. However, no studies have evaluated the utility of this ratio according to biopsy-proven MASLD and its stages. Therefore, our aim was to evaluate if the TG/HDL-C ratio allows for the identification of biopsy-proven MASLD in patients with obesity. We conducted a case-control study in 153 patients with obesity who underwent metabolic surgery and had a concomitant liver biopsy. Fifty-three patients were classified as no MASLD, 45 patients as metabolic dysfunction-associated steatotic liver-MASL, and 55 patients as metabolic dysfunction-associated steatohepatitis-MASH. A receiver operating characteristic (ROC) analysis was performed to assess the accuracy of the TG/HDL-C ratio to detect MASLD. We also compared the area under the curve (AUC) of the TG/HDL-C ratio, serum TG, and HDL-C. A higher TG/HDL-C ratio was observed among patients with MASLD, compared with patients without MASLD. No differences in the TG/HDL-C ratio were found between participants with MASL and MASH. The greatest AUC was observed for the TG/HDL-C ratio (AUC 0.747, p < 0.001) with a cut-off point of 3.7 for detecting MASLD (sensitivity = 70%; specificity = 74.5%). However, no statistically significant differences between the AUC of the TG/HDL-C ratio and TG or HDL-C were observed to detect MASLD. In conclusion, although an elevated TG/HDL-C ratio can be found in patients with MASLD, this marker did not improve the detection of MASLD in our study population, compared with either serum TG or HDL-C.

A propósito de un caso de síndrome de Fraser. Autopsia de un feto de 37 semanas de gestación con múltiples malformaciones / About a case of Fraser syndrome. Autopsy of a 37 weeks gestation fetus with multiple malformations

El síndrome de Fraser o síndrome criptoftalmos/sindactilia es una enfermedad genética rara, cuyo diagnóstico se basa en una serie de criterios clínicos mayores y menores, y que puede apoyarse en pruebas genéticas. En este artículo se presenta el caso de una autopsia fetal de 37 semanas de gestación con sospecha de síndrome de CHAOS (síndrome obstructivo congénito de las vías aéreas altas). (AU)

Fraser syndrome or cryptophthalmos-syndactyly syndrome is a rare genetic disease, the diagnosis of which is based on a series of major and minor clinical criteria and that can be supported by genetic tests. This article presents the case of a fetal autopsy at 37 weeks of gestation with suspicion of CHAOS syndrome (congenital obstructive syndrome of the upper airways). (AU)

A propósito de un caso de síndrome de Fraser. Autopsia de un feto de 37 semanas de gestación con múltiples malformaciones / About a case of Fraser syndrome. Autopsy of a 37 weeks gestation fetus with multiple malformations

El síndrome de Fraser o síndrome criptoftalmos/sindactilia es una enfermedad genética rara, cuyo diagnóstico se basa en una serie de criterios clínicos mayores y menores, y que puede apoyarse en pruebas genéticas. En este artículo se presenta el caso de una autopsia fetal de 37 semanas de gestación con sospecha de síndrome de CHAOS (síndrome obstructivo congénito de las vías aéreas altas). (AU)

Fraser syndrome or cryptophthalmos-syndactyly syndrome is a rare genetic disease, the diagnosis of which is based on a series of major and minor clinical criteria and that can be supported by genetic tests. This article presents the case of a fetal autopsy at 37 weeks of gestation with suspicion of CHAOS syndrome (congenital obstructive syndrome of the upper airways). (AU)

[About a case of Fraser syndrome. Autopsy of a 37 weeks gestation fetus with multiple malformations]. / A propósito de un caso de síndrome de Fraser. Autopsia de un feto de 37 semanas de gestación con múltiples malformaciones.

Fraser syndrome or cryptophthalmos-syndactyly syndrome is a rare genetic disease, the diagnosis of which is based on a series of major and minor clinical criteria and that can be supported by genetic tests. This article presents the case of a fetal autopsy at 37 weeks of gestation with suspicion of CHAOS syndrome (congenital obstructive syndrome of the upper airways).

Long-term outcomes of percutaneous tricuspid annuloplasty with Cardioband device.

AIMS: Severe tricuspid regurgitation (TR) has adverse effects on outcomes, with limited therapeutic options. We report the outcomes of patients undergoing percutaneous annuloplasty as a treatment of ≥severe functional TR in a single centre. METHODS AND RESULTS: Prospective, single-arm, single-centre study that enrolled 24 consecutive patients with at least severe functional TR undergoing percutaneous annuloplasty with Cardioband system between 2019 and 2021. Clinical and echocardiographic data were prospectively collected, with a mean follow-up of 279 ± 246 days. At baseline, 66.6% were in New York Heart Association (NYHA) Classes III and IV and 100% had significant oedema. Technical success was 91.6%. At the end of follow-up, there was one death. Echocardiography showed a significant reduction in septolateral annular diameter of 10.4 mm (P < 0.001) that remained stable at the end of follow-up. The severity of the TR was also reduced. About 81.8% of patients were in NYHA Classes I and II. The number of patients with significant oedema decreased to 46% (P = 0.01). Six-minute walk distance improved by 68.8 m (P = 0.12). CONCLUSION: Percutaneous annuloplasty with Cardioband system is an effective and safe treatment for patients with symptomatic, ≥severe functional TR. Annular reduction and TR severity reduction remained significant and sustained for 1 year. Patients experienced improvements in quality of life and exercise capacity.

A DNA damage repair gene-associated signature predicts responses of patients with advanced soft-tissue sarcoma to treatment with trabectedin.

Predictive biomarkers of trabectedin represent an unmet need in advanced soft-tissue sarcomas (STS). DNA damage repair (DDR) genes, involved in homologous recombination or nucleotide excision repair, had been previously described as biomarkers of trabectedin resistance or sensitivity, respectively. The majority of these studies only focused on specific factors (ERCC1, ERCC5, and BRCA1) and did not evaluate several other DDR-related genes that could have a relevant role for trabectedin efficacy. In this retrospective translational study, 118 genes involved in DDR were evaluated to determine, by transcriptomics, a predictive gene signature of trabectedin efficacy. A six-gene predictive signature of trabectedin efficacy was built in a series of 139 tumor samples from patients with advanced STS. Patients in the high-risk gene signature group showed a significantly worse progression-free survival compared with patients in the low-risk group (2.1 vs 6.0 months, respectively). Differential gene expression analysis defined new potential predictive biomarkers of trabectedin sensitivity (PARP3 and CCNH) or resistance (DNAJB11 and PARP1). Our study identified a new gene signature that significantly predicts patients with higher probability to respond to treatment with trabectedin. Targeting some genes of this signature emerges as a potential strategy to enhance trabectedin efficacy.

Marijuana, tobacco, alcohol and cocaine use during pregnancy in 2013 and 2016. A self-report study in Montevideo, Uruguay. / Autodeclaración del consumo de marihuana, tabaco, alcohol y derivados de cocaína en embarazadas en 2013 y 2016, Montevideo, Uruguay.

BACKGROUND: Uruguay passed Law 19.172 on December 20, 2013, thus enabling the State to regulate the production, distribution, sale, and consumption of cannabis. OBJECTIVES: to determine the change in maternal self-report of marijuana, tobacco, alcohol, and cocaine use during pregnancy between 2013 and 2016. METHODS: cross-sectional, descriptive, analytical study between 2013 and 2016. The sample consists of pregnant woman who delivered and received immediate postpartum care at the Centro Hospitalario Pereira Rossell in Montevideo, Uruguay. The instrument was a protocolized survey that assessed outcomes such as sociodemographic level, years of formal education, data on pregnancy, childbirth, newborn, and substance use before and during pregnancy. RESULTS: the sample consisted of 577 pregnant women, 319 corresponding to interviews conducted in 2013 and 258 in 2016. Regarding alcohol intake, 76 (23.82%) women reported drinking while pregnant in 2013, whereas in 2016, 91 (35.3%) (p=.003) did so. As for tobacco, 59 (43%) quit smoking when they found out about their pregnancy in 2013, and 69 (60%) quit in 2016 (p=.008). In 2013, 41 women (12.85%) smoked marijuana until they discovered their pregnancy, and 79 (30%) did so in 2016 (p < .001). The use of cocaine and its derivatives did not change significantly between 2013 and 2016. CONCLUSIONS: between 2013 and 2016, there was a significant increase in the self-report of marijuana and alcohol consumption before and during pregnancy. The consumption of cocaine and cocaine base paste remained stable during this period. Tobacco use decreased significantly in pregnant women.

Introducción: Uruguay es el primer país en modificar la legislación sobre el consumo recreativo de cannabis, mediante la Ley 19.172 del 20 de diciembre de 2013, otorgando al Estado la potestad de regular su producción y comercialización. Objetivo: evaluar las prevalencias de la autodeclaración del consumo de marihuana, tabaco, alcohol, cocaína y derivados y su evolución temporal en embarazadas para los años 2013 y 2016. Metodología: estudio descriptivo, transversal y analítico, durante dos períodos de tiempo, en 2013 y 2016. Se incluyeron mujeres que tuvieron su parto y puerperio inmediato en el Centro Hospitalario Pereira Rossell (CHPR) de Montevideo, Uruguay. Se realizó una encuesta protocolizada sobre su nivel sociodemográfico, años de educación formal, datos del embarazo, parto, recién nacido y consumo de sustancias antes y durante la gestación. Resultados: en la investigación participaron 577 mujeres, 319 correspondientes a las entrevistas realizadas en el año 2013 y 258 en 2016. Respecto al alcohol, 76 (23,82%) mujeres declaran su consumo durante el embarazo en 2013, mientras que, en 2016, 91 (35,3%) (p=0,003). En cuanto al tabaco, 59 (43%) dejaron de fumar al enterarse del embarazo en 2013 y 69 (60%) en 2016 (p=0,008). En 2013, 41 mujeres (12,85%) fumaron marihuana hasta saber del embarazo y 79 (30%) en 2016 (p <0,001). Durante la gestación, en 2013 declararon fumar marihuana 5 mujeres (1,57%), mientras que en 2016 fueron 28 (10,85%) (p <0,001). El uso de cocaína y pasta base de cocaína (PBC) no cambió significativamente entre 2013 y 2016. Conclusiones: Entre los años 2013 y 2016 se observó un aumento significativo en la autodeclaración del consumo de marihuana y alcohol antes y durante el embarazo. El consumo de cocaína y pasta base de cocaína se mantuvo estable en ese periodo. El consumo de tabaco disminuyó significativamente en mujeres embarazadas.

Autodeclaración del consumo de marihuana, tabaco, alcohol y derivados de cocaína en embarazadas en 2013 y 2016, Montevideo, Uruguay / Marijuana, tobacco, alcohol and cocaine use during pregnancy in 2013 and 2016. A self-report study in Montevideo, Uruguay

INTRODUCCIÓN: Uruguay es el primer país en modificar la legislación sobre el consumo recreativo de cannabis, mediante la Ley 19.172 del 20 de diciembre de 2013, otorgando al Estado la potestad de regular su producción y comercialización. OBJETIVO: evaluar las prevalencias de la autodeclaración del consumo de marihuana, tabaco, alcohol, cocaína y derivados y su evolución temporal en embarazadas para los años 2013 y 2016. METODOLOGÍA: estudio descriptivo, transversal y analítico, durante dos períodos de tiempo, en 2013 y 2016. Se incluyeron mujeres que tuvieron su parto y puerperio inmediato en el Centro Hospitalario Pereira Rossell (CHPR) de Montevideo, Uruguay. Se realizó una encuesta protocolizada sobre su nivel sociodemográfico, años de educación formal, datos del embarazo, parto, recién nacido y consumo de sustancias antes y durante la gestación. RESULTADOS: en la investigación participaron 577 mujeres, 319 correspondientes a las entrevistas realizadas en el año 2013 y 258 en 2016. Respecto al alcohol, 76 (23,82%) mujeres declaran su consumo durante el embarazo en 2013, mientras que, en 2016, 91 (35,3%) (p = 0,003). En cuanto al tabaco, 59 (43%) dejaron de fumar al enterarse del embarazo en 2013 y 69 (60%) en 2016 (p = 0,008). En 2013, 41 mujeres (12,85%) fumaron marihuana hasta saber del embarazo y 79 (30%) en 2016 (p < 0,001). Durante la gestación, en 2013 declararon fumar marihuana 5 mujeres (1,57%), mientras que en 2016 fueron 28 (10,85%) (p < 0,001). El uso de cocaína y pasta base de cocaína (PBC) no cambió significativamente entre 2013 y 2016. CONCLUSIONES: Entre los años 2013 y 2016 se observó un aumento significativo en la autodeclaración del consumo de marihuana y alcohol antes y durante el embarazo. El consumo de cocaína y pasta base de cocaína se mantuvo estable en ese periodo. El consumo de tabaco disminuyó significativamente en mujeres embarazadas

BACKGROUND: Uruguay passed Law 19.172 on December 20, 2013, thus enabling the State to regulate the production, distribution, sale, and consumption of cannabis. OBJECTIVES: to determine the change in maternal self-report of marijuana, tobacco, alcohol, and cocaine use during pregnancy between 2013 and 2016. METHODS: cross-sectional, descriptive, analytical study between 2013 and 2016. The sample consists of pregnant woman who delivered and received immediate postpartum care at the Centro Hospitalario Pereira Rossell in Montevideo, Uruguay. The instrument was a protocolized survey that assessed outcomes such as sociodemographic level, years of formal education, data on pregnancy, childbirth, newborn, and substance use before and during pregnancy. RESULTS: the sample consisted of 577 pregnant women, 319 corresponding to interviews conducted in 2013 and 258 in 2016. Regarding alcohol intake, 76 (23.82%) women reported drinking while pregnant in 2013, whereas in 2016, 91 (35,3%) (p =.003) did so. As for tobacco, 59 (43%) quit smoking when they found out about their pregnancy in 2013, and 69 (60%) quit in 2016 (p = 0,008). In 2013, 41 women (12.85%) smoked marijuana until they discovered their pregnancy, and 79 (30%) did so in 2016 (p < .001). The use of cocaine and its derivatives did not change significantly between 2013 and 2016. CONCLUSIONS: between 2013 and 2016, there was a significant increase in the self-report of marijuana and alcohol consumption before and during pregnancy. The consumption of cocaine and cocaine base paste remained stable during this period. Tobacco use decreased significantly in pregnant women

Consumo de tabaco, alcohol y marihuana según autodeclaración en mujeres que tuvieron su parto en el Centro Hospitalario Pereira Rosell (mayo 2013-abril 2014) / Smoking, alcohol and marijuana consumption in a self-report by women who delivered their babies at the Pereira Rossell Hospital Center (May 2013- April 2014)

Introducción: la prevalencia del consumo de drogas entre las mujeres que quedan embarazadas es probable que sea similar al de la población general, lo que puede resultar en una alta exposición fetal durante el primer trimestre, etapa más vulnerable con respecto al neurodesarrollo y organogénesis(¹).Objetivo: conocer la prevalencia de consumo de tabaco, alcohol, marihuana y derivados de cocaína durante el embarazo, según el autorreporte en mujeres que tuvieron su parto en el Centro Hospitalario Pereira Rossell.Material y método: se realizó un estudio descriptivo de tipo transversal, analítico, durante el período de un año. Los datos fueron recabados a partir de una encuesta protocolizada realizada a mujeres durante el puerperio inmediato y se recolectaron datos de la historia clínica.Resultados: se entrevistaron 319 mujeres. La mayoría eran mayores de 18 años (83,65%) con una media de 24,67 años; el embarazo no había sido planificado en 182 casos (57%). Declararon haber fumado tabaco alguna vez durante el embarazo 136 mujeres (42,63%), la mayor parte de las que abandonaron el hábito lo hicieron en el primer trimestre. Declararon consumo de alcohol en el embarazo 76 mujeres (23,82%), 5 (1,5%) reportaron consumo de marihuana durante el embarazo. Declararon consumir cocaína y pasta base de cocaína 3 (0,94%) y 3 (0,94%), respectivamente.Conclusiones: la sustancia que se consume con mayor frecuencia en el embarazo es el tabaco seguido en frecuencia por el alcohol. Un elevado porcentaje de embarazos no planificados puede determinar una mayor exposición a hábitos previos durante el primer trimestre de gestación, período de máxima vulnerabilidad para el desarrollo fetal.

Abstract Introduction: prevalence of drug use in women who get pregnant is likely to be similar to that of the general population, what may result in a high exposure of fetus during the first trimester, the most vulnerable stage with regards to neurodevelopment and organogenesis. Objective: to learn about the prevalence of smoking, alcohol, marijuana and cocaine derivatives during pregnancy, according to a self report by women who delivered their babies at the Pereira Rossell Hospital Center. Methods: we conducted a descriptive study,The data transversal and analytical during one year. The data were collected by means of a protocolized survey to women during the immediate puerperium and data was taken from the medical record. Results: 319 women were surveyed. Most women were older than 18 years old (83.65%) with an average of 24.67 years old; pregnancy had not been planned in 182 cases (57%). 136 women declared to have smoked during pregnancy (42.63%), most of those who quit the habit did it in the first trimester. 76 women declared to have drunk alcohol during pregnancy (23.825), 5 (1.5%) reported marijuana consumption during pregnancy. Three women declared they had consumed cocaine and 3 to have consumed coca paste (0.94 and 0.94 respectively). Conclusions: the substance that is more widely used during pregnancy is tobacco, followed by alcohol. A high percentage of unwanted pregnancies may determine a higher exposure to previous habit during the first trimester of pregnancy, when fetus are most vulnerable.

Resumo Introdução: a prevalência do consumo de drogas entre as mulheres que ficam grávidas provavelmente é similar ao da população em geral, o que pode causar uma alta exposição fetal durante o primer trimestre, etapa em que o feto é mais vulnerável com relação ao neurodesenvolvimento e a organogênese(¹). Objetivo: conhecer a prevalência do consumo de tabaco, álcool, maconha e derivados da cocaína durante a gravidez, de acordo com a auto declaração de mulheres cujos partos foram realizados no Centro Hospitalario Pereira Rossell. Material e método: foi realizado um estudo descritivo de tipo transversal, analítico, durante o período de um ano. Os dados foram coletados em entrevistas protocolizadas realizadas a mulheres durante o puerpério imediato e também foram coletados dados do prontuário das pacientes. Resultados: foram entrevistadas 319 mulheres. A maioria tinha mais de 18 anos (83,65%) com una media de 24,67 anos; a gravidez não havia sido planejada em 182 casos (57%). Declararam haver fumado tabaco alguma vez durante a gestação 136 mulheres (42,63%) sendo que a maior parte das que abandonaram o hábito o fez durante o primeiro trimestre. 76 mulheres (23,82%) declararam consumo de álcool durante a gravidez e 5 (1,5%) de maconha. 3 (0,94%) informaram consumir cocaína e 3 (0,94%) seus derivados (crack). Conclusões: a substância consumida com maior frequência durante a gravidez é o tabaco seguido pelo álcool. Uma porcentagem alta de gestações não planejadas pode determinar uma maior exposição a hábitos prévios durante o primeiro trimestre de gestação, período de máxima vulnerabilidade para o desenvolvimento fetal.

Ablación con alcohol en miocardiopatía hipertrófica: localización y cuantificación con ecocardiografía 3D del miocardio dependiente de la septal diana / Alcohol ablation in hypertrophic cardiomyopathy: localization and quantification of target septal artery-dependent myocardium with 3-dimensional echocardiography

No disponible

Características de la población expuesta a cocaína y pasta base de cocaína durante la gestación en el Centro Hospitalario Pereira Rossell / Characteristics of the population exposed to cocaine and cocaine base paste during gestation in the Centro Hospitalario Pereira Rossell

Introducción: para identificar el consumo de cocaína durante la gestación se utiliza frecuentemente el autorreporte; dado que esta conducta puede generar procesos judiciales y comprometer la tenencia de su hijo hay un porcentaje significativo de negación de consumo. El meconio del recién nacido puede identificar el consumo de sustancia desde la semana 20 de gestación.Objetivos: determinar la prevalencia del consumo de cocaína y pasta base de cocaína durante la gestación,describir sus características y evaluar el valor del autorreporte en referencia a la determinación en meconio.Metodología: se realizó un estudio observacional analítico de corte transversal en el Centro Hospitalario Pereira Rossell entre noviembre de 2010 y marzo del 2011. Se realizó una encuesta protocolizada sobre los hábitos de consumo y se obtuvo una muestra de meconio para su análisis por ELISA con una sensibilidad de 5 ng/g. Resultados: se obtuvieron 227 muestras de meconio,fueron positivos para el consumo de clorhidrato de cocaína y PBC con un corte de 5 ng/g el 9,25%. Se destaca que en las consumidoras de cocaína/PBC se observa una diferencia estadísticamente significativa(p=0,006) en la edad con una media de 28,04 años(DE=5,99) con respecto a la ausencia de consumo con una media de 24.66 (DE=5,42). Se observó una diferencia significativa en la población consumidora en la presencia de cuadros infecciosos(vulvovaginitis/sífilis) p=0,001. Los ingresos declarados en el núcleo familiar en la población consumidora de PBC estuvieron por debajo de la línea de pobreza. Se encontró una asociación importante entre el consumo de cocaína-PBC y marihuana. La especificidad de la autodeclaración fue muy alta pero la sensibilidad fue de 14,3...

Introduction: consumption of cocaine base pulp (PBC) in Uruguay was identified as a Public Health problem from the economic crisis that hit the country in 2002. To identify consumption of this substance in pregnant women in clinical practice is frequently used the self-report. Since the maternal cocaine consumption can generate law suits and may jeopardize the custody of the child there is a significant percentage of under reporting. Newborn`s meconium can identify cocain-PBC use from the 20th week of gestation. Objectives: determine the prevalence during pregnancy in a hospital population, describe their characteristics and assess the value of self-report in reference to the determination in meconium. Methodology: the methodology used in this ptoject was a observational analytic cross-sectional study of the population assisted in the Hospital Center Pereira Rossell between November 2010 and March 2011. A protocolized survey about consumption habits was conducted after an informed agreeing consent and a meconium sample obtained for analysis. By ELISA screening of NEOGEN brand the presence of cocaine and its metabolites in meconium was determined with a sensitivity of 5 ng/gy 20 ng/g.Results: 227 Meconium valid samples were obtained for analysis. 9,5% were positive for the consumption of cocaine hydrochloride and PBC with a cutoff of 5 ng/g. It is emphasized that in cocaine users / PBC a statistically significant difference (p = 0,006) was observed in the average age 28,04 years (SD = 5,99) compared to the absence of consumption with an average of 24,66 (SD 5,42). Pregnant women consumers Cocaine / PBC during pregnancy are over 19 years. A significant difference was observed in the consumer population regarding to the presence of infectious types (vulvovaginitis / syphilis) p = 0,001. Reported income in the household in the PBC consuming population was below the poverty line. Also was found a significant association between cocaine consumes and ...

Pancreatitis del surco. Presentación de dos casos en piezas de duodenopancreatectomía / Groove pancreatitis: two cases in surgical pancreatoduodenectomy specimens

La pancreatitis del surco representa una forma segmentaria de pancreatitis crónica que afecta la región periduodenal, entre la pared duodenal y el páncreas. Esta entidad es poco frecuente y posee ciertas características clínico patológicas que permiten identificarla preoperatoriamente. Esta condición ha recibido varios nombres entre estos: distrofia quística del páncreas heterotópico, hamartoma pancreático del duodeno, quiste paraduodenal y mioadenomatosis del páncreas. Presentamos dos casos de pancreatitis del surco en piezas de duodenopancreatectomía en hombres de 39 y 50 años, ambos bebedores de alcohol. Los estudios de imagen mostraron en ambos lesiones quísticas intrapancreáticas. Histológicamente se observó engrosamiento de la mucosa duodenal, hiperplasia severa de las glándulas de Brunner, proliferación miofibroblástica con formaciones quísticas, entremezclada con tejido pancreático e inflamación crónica. Esta entidad entra en el diagnóstico diferencial de las lesiones pseudotumorales pancreáticas que pueden simular carcinoma(AU)

Groove pancreatitis is a form of chronic segmental pancreatitis affecting the periduodenal region between the duodenum and the head of the páncreas. This uncommon entity has distinct clinicopathological features which facilitate its preoperative diagnosis. It is also been known as cystic dystrophy in heterotopic páncreas, pancreatic hamartoma of the duodenum, paraduodenal cyst and adenomyomatosis of the páncreas. We present two cases of groove pancreatitis in adult males aged 39 and 50, both alcohol drinkers, who had undergone pancreatoduodenectomy. Imaging studies showed cystic intrapancreatic lesions. Histologically, a large duodenal wall with prominent myofibroblastic proliferation and cysts admixed with pancreatic tissue and cronic inflammation was seen. Groove pancreatitis may be confused with carcinoma(AU)

Fibrocartilaginous mesenchymoma of the spine in a child: a case report.

BACKGROUND: Originally described by Dahlin et al. in 1984, fibrocartilaginous mesenchymoma (FCM) constitutes a rare bone tumor of children and adolescents that mainly affects the long bones. A spinal location of this tumor is exceptional. Only two previous instances of vertebral FCM have been reported in the current literature, and both occurred in young adults. REPORT OF THE CASE: We report the case of a 9-year-old boy with backache caused by a neoplasm that involved the Th12 vertebra treated with tumor excision. Histopathological diagnosis was confirmatory of FCM. During a follow-up period of 2 years, there was no evidence of disease progression. Our patient, thus, represents the first case of FCM occurring in a child. CONCLUSIONS: Given the rarity of spinal FCM, there are no guidelines about its management. However, treatment of this neoplasm seems to be mainly surgical aiming at total removal of the lesion, if feasible, as FCM may recur locally.

Carcinoma intraductal de glándula salival menor. Descripción de un caso en paladar blando / Intraductal carcinoma in minor salivary gland. A case report in soft palate

El carcinoma intraductal de glándula salival mayor es un tumor agresivo tanto clínica como citológicamente. En glándula salival menor, son muy raros y a pesar de tener una citología agresiva son tumores con buen comportamiento clínico. Presentamos un caso en paladar blando, fácilmente diagnosticable por la presencia de abundantes células mioepiteliales que rodean conductos con células epiteliales grandes, atípicas, con mitosis y necrosis. Un año después de la extirpación permanece asintomático

Intraductal carcinoma of major salivary gland is a very agressive neoplasm in clinical and cytological grounds. In minor salivary gland it´s very rare and have a good clinical evolution irrespective of the cytological agressivity. We report a case in soft palate, without diagnostics problems by the easy demonstration of myoepithelial cells around all epithelial units.The epithelial cells are large, atypical with mitosis and necrosis.A year later the patient is well

Long-term survival associated with complete resection after induction chemotherapy in stage IIIA (N2) and IIIB (T4N0-1) non small-cell lung cancer patients: the Spanish Lung Cancer Group Trial 9901.

PURPOSE: To assess the activity of induction chemotherapy followed by surgery in stage IIIA and selected stage IIIB non-small-cell lung cancer patients. PATIENTS AND METHODS: Mediastinoscopy proof of either positive N2 (IIIA) or T4N0-1 (IIIB) disease was required. Induction therapy was three cycles of cisplatin/gemcitabine/docetaxel, followed by surgery. RESULTS: From December 1999 to March 2003, 136 patients were entered onto the study; the clinical response rate in 129 assessable patients was 56%. The overall complete resection rate was 68.9% of patients eligible for surgery (72% of stage IIIA patients and 66% of stage IIIB patients) and 48% of all assessable patients. Eight (12.9%) of 62 completely resected patients had a pathologic complete response. Seven patients (7.8%) died during the postoperative period. The median overall survival time was 15.9 months, 3-year survival rate was 36.8%, and 5-year survival rate was 21.1%, with no significant differences in survival between stage IIIA and stage IIIB patients. Median survival time was 48.5 months for 62 completely resected patients, 12.9 months for 13 incompletely resected patients, and 16.8 months for 15 nonresected patients (P = .005). Three- and 5-year survival rates were 60.1% and 41.4% for completely resected patients, 23.1% and 11.5% for incompletely resected patients, and 31.1% and 0% for nonresected patients, respectively. In the multivariate analysis, complete resection (hazard ratio [HR] = 0.35; P < .0001), clinical response (HR = 0.32; P < .0001), and age younger than 60 years (HR = 0.64; P = .027) were the most powerful prognostic factors. CONCLUSION: Induction chemotherapy followed by surgery is effective in stage IIIA and in selected stage IIIB patients attaining complete resection.