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1.
Immunol Invest ; 37(5): 565-82, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-18716938

RESUMO

Establishment of the maternal-fetal interface is characterized by the influx of maternal NK cells, macrophages, and T cells into the decidua. Although a great deal has been learned about the function of NK cells in the decidua, comparatively little is known of decidual T cell function. NKT cells are an unusual T cell subset capable of producing both Th1-like and Th2-like cytokines. Unlike conventional alphabeta T cells that recognize peptides in the context of MHC molecules, NKT cells recognize glycolipids presented by the MHC class I-like molecule, CD1d. Recent reports have demonstrated that NKT cells and CD1d are present at the maternal-fetal interface. Moreover, activation of NKT cells can have dramatic effects on pregnancy. In this article, we will review basic aspects of NKT cell biology and summarize the recent literature on NKT cells at the maternal-fetal interface.


Assuntos
Aborto Espontâneo/imunologia , Células Matadoras Naturais/imunologia , Troca Materno-Fetal/imunologia , Placenta/imunologia , Circulação Placentária/imunologia , Subpopulações de Linfócitos T/imunologia , Aborto Espontâneo/sangue , Animais , Antígenos CD1/imunologia , Antígenos CD1/metabolismo , Feminino , Humanos , Imunidade Celular , Células Matadoras Naturais/metabolismo , Células Matadoras Naturais/patologia , Ativação Linfocitária , Placenta/patologia , Gravidez , Subpopulações de Linfócitos T/metabolismo , Subpopulações de Linfócitos T/patologia
2.
Phys Rev Lett ; 92(10): 102003, 2004 Mar 12.
Artigo em Inglês | MEDLINE | ID: mdl-15089200

RESUMO

We report on a new measurement of the parity-violating asymmetry in quasielastic electron scattering from the deuteron at backward angles at Q2=0.038 (GeV/c)2. This quantity provides a determination of the neutral weak axial vector form factor of the nucleon, which can potentially receive large electroweak corrections. The measured asymmetry A=-3.51+/-0.57 (stat)+/-0.58 (syst) ppm is consistent with theoretical predictions. We also report on updated results of the previous experiment at Q2=0.091 (GeV/c)2, which are also consistent with theoretical predictions.

3.
Phys Rev Lett ; 91(12): 122002, 2003 Sep 19.
Artigo em Inglês | MEDLINE | ID: mdl-14525355

RESUMO

We report new measurements of the ratio of the electric form factor to the magnetic form factor of the neutron, G(n)(E)/G(n)(M), obtained via recoil polarimetry from the quasielastic 2H(e-->,e(')n-->)1H reaction at Q2 values of 0.45, 1.13, and 1.45 (GeV/c)(2) with relative statistical uncertainties of 7.6% and 8.4% at the two higher Q2 points, which points have never been achieved in polarization measurements.

4.
Phys Rev Lett ; 86(14): 2963-6, 2001 Apr 02.
Artigo em Inglês | MEDLINE | ID: mdl-11290083

RESUMO

High-precision 1H(e,e'p)pi(0) measurements at Q2 = 0.126 (GeV/c)2 are reported, which allow the determination of quadrupole amplitudes in the gamma*N-->Delta transition; they simultaneously test the reliability of electroproduction models. The derived quadrupole-to-dipole ( I = 3/2) amplitude ratios, R(SM) = (-6.5+/-0.2(stat+sys)+/-2.5(mod))% and R(EM) = (-2.1+/-0.2(stat+sys)+/-2.0(mod))%, are dominated by model error. Previous R(SM) and R(EM) results should be reconsidered after the model uncertainties associated with the method of their extraction are taken into account.

5.
Phys Rev Lett ; 84(6): 1106-9, 2000 Feb 07.
Artigo em Inglês | MEDLINE | ID: mdl-11017455

RESUMO

We report a new measurement of the parity-violating asymmetry in elastic electron scattering from the proton at backward scattering angles. This asymmetry is sensitive to the strange magnetic form factor of the proton as well as electroweak axial radiative corrections. The new measurement of A = -4.92+/-0.61+/-0.73 ppm provides a significant constraint on these quantities. The implications for the strange magnetic form factor are discussed in the context of theoretical estimates for the axial corrections.

6.
Science ; 290(5499): 2117-9, 2000 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-11118140

RESUMO

The violation of mirror symmetry in the weak force provides a powerful tool to study the internal structure of the proton. Experimental results have been obtained that address the role of strange quarks in generating nuclear magnetism. The measurement reported here provides an unambiguous constraint on strange quark contributions to the proton's magnetic moment through the electron-proton weak interaction. We also report evidence for the existence of a parity-violating electromagnetic effect known as the anapole moment of the proton. The proton's anapole moment is not yet well understood theoretically, but it could have important implications for precision weak interaction studies in atomic systems such as cesium.

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