Effectiveness of dental implants in patients undergoing radiotherapy for head and neck cancer: An umbrella review.

OBJECTIVE: The objective of this overview is to evaluate the effectiveness of dental implants placed in patients who underwent radiotherapy for the treatment of head and neck cancer, as well as to assess the methodological quality of the included systematic reviews. METHODS: The study was conducted in four PubMed, Lilacs, Dare Cochrane and Google Scholar databases until July 2022, using the descriptors "Radiotherapy," "Dental implants," and "Head and Neck Cancer." RESULTS: 958 studies were found in the initial search and after applying the inclusion and exclusion criteria, fifteen systematic reviews were selected to compose this overview and had their methodological quality evaluated by the AMSTAR 2 tool. RESULTS: 24,996 implants in 5487 patients were evaluated with a rate of success rate of 86.2% in patients who underwent radiotherapy and 95.2% in patients who did not undergo radiotherapy. Only one of the systematic reviews was of high quality according to AMSTAR 2. CONCLUSION: Oral rehabilitation with dental implants in patients with a history of head and neck cancer undergoing radiotherapy is a valid therapy. However, given the level of evidence found, further studies with better design are necessary to provide greater confidence in the clinical decision.

Is HIV positive a risk factor or contraindication in dental implant therapy?

HIV pathogenesis affects TCD4+ lymphocytes, causing impairment of the immune system. Thus, the consequent immunological fragility of individuals with the disease and the absence of studies that serve as a guide for clinicians' decision-making make many healthcare professionals recognize it as a synonym of contraindication for oral rehabilitation treatments with dental implants.

Is Down syndrome a risk factor or contraindication for dental implants? A systematic review.

STATEMENT OF PROBLEM: Whether oral rehabilitation with dental implants in patients with Down syndrome leads to an increased complication rate is unclear. PURPOSE: The purpose of this systematic review was to determine the effectiveness of dental implants placed in patients with Down syndrome and whether the condition is a risk factor or contraindication for dental implant placement. MATERIAL AND METHODS: Searches were conducted in 6 databases, including the non-peer-reviewed literature, up to February 2021 by 2 independent reviewers according to established inclusion and exclusion criteria to answer this question: Is Down syndrome a risk factor or contraindication for oral rehabilitation with dental implants? RESULTS: A total of 655 studies were initially found in the databases. Five were included in this systematic review, all of which were observational studies. A total of 50 patients with 186 implants were evaluated, with a reported effectiveness of 79.1%. The risk of bias assessment determined that 3 of the 5 studies had a high risk of bias. CONCLUSIONS: Treatment with dental implants in patients with Down syndrome is a suitable option, but more complications are to be expected than with patients without this condition. Controlled studies with better methodological design and less risk of bias should be developed to improve the scientific evidence for the treatment of these patients.

Do zirconia dental implants present better clinical results than titanium dental implants? A systematic review and meta-analysis.

INTRODUCTION: The purpose of this systematic review is to determine if the zirconia implants present better clinical results when compared to titanium implants. METHODS: Searches were conducted in 5 databases including, until March 2022, by 2 independent reviewers, according to the inclusion and exclusion criteria established in the study and according whit this question: Do zirconia dental implants present better clinical results than titanium dental implants? RESULTS: 3235 studies were initially found in the researched databases. 03 randomized clinical trials were included in this systematic review and meta-analysis. A total of 71 patients with 192 implants (87 titanium and 105 zirconia) were evaluated, showing an effectiveness of 87,4% and 78,1% respectively and there was no statistically significant difference in terms of survival rate in the meta-analysis (P = 0.70; I2 = 0%). Still in the meta-analysis, there was no statistically significant difference between titanium and zirconia implants in relation to the pink esthetich score or bleeding on probing, however, a favorable difference was observed for titanium in relation to marginal bone loss (P = 0.001; I2 = 0%). None of the studies evaluated had a low risk of bias. CONCLUSION: Oral rehabilitation with zirconia implants showed no advantages over titanium in this systematic review. However, the small number of studies included and the uncertain risk of bias may raise doubts in this interpretation and the results should be analyzed with caution. New studies with greater methodological rigor, follow-up time and number of interventions should be performed in order to safely determine the indication for the use of zirconia implants.

Is low-level laser therapy effective in the treatment of herpes labialis? Systematic review and meta-analysis.

The objective of this systematic review is to evaluate the effectiveness of low-level laser therapy in the treatment of herpes labialis. The searches were carried out independently by 2 researchers and the articles were selected through the electronic databases according to the inclusion and exclusion criteria previously established. Initially, 480 articles were found, of which 7 randomized clinical trials and 1 clinical trial were selected. In total, 928 patients were included. In the meta-analysis, the mean healing time for laser use was significant, showing a mean reduction of 1.37 [CI 95% = 0.92 to 1.82] days for tissue healing (p < 0.0001). In the meta-analysis to evaluate the time for crust formation, there was no significant difference between the groups and no significant reduction in the mean time for crust formation (p = 0.150). Only one of the selected studies had a low risk of bias. The use of low-level laser proved to be effective in the treatment of herpes labialis. However, due to the high risk of bias in the included studies, there is a need to carry out new standardized studies to prove the effectiveness of this therapy.

Is the Er: YAG Laser Effective in Reducing Pain, Edema, and Trismus After Removal of Impacted Mandibular Third Molars? A Meta-Analysis.

PURPOSE: Removal of impacted third molars can be associated with complications such as pain, edema, and trismus that can increase the morbidity of the procedure. The purpose of this study is to determine whether the Erbium: yttrium aluminum garnet (Er: YAG) laser is effective in reducing pain, swelling and trismus compared to rotary instruments in removing impacted lower third molars (3Ms). METHODS: For this systematic review, the searches were carried out independently by 2 researchers and the articles were selected according to the inclusion and exclusion criteria previously established. The predictor variable was the study group (Er: YAG laser versus rotary instruments). The main outcome was the analysis of post-operative pain, edema, and trismus after third molar extractions. Data analysis included the risk of bias evaluation (RoB 2 Cochrane) and meta-analysis with random effects I2 based heterogeneity and 95% confidence. RESULTS: In the initial results, 1,371 articles were found and 6 randomized controlled trials (RCT) were selected to compose this study. A total of 299 lower 3Ms were removed, 126 with the Er: YAG laser, 142 with a drill and 31 with a piezoelectric instrument. The results of this meta-analysis showed that in the laser group there was a significant reduction in edema (1.82 [CI95% = -3.06 to -0.57] cm (P = .004)) and complications (P = .0004), a slight reduction in pain after 2 days (P = .030) and there was no variation in trismus (P = .200) when compared to the drill group. The surgery and/or osteotomy time was shorter in the drill group. Only 1 study presented low risk of bias. CONCLUSIONS: The Er: YAG laser has been shown to be effective in reducing edema, pain and complications in impacted lower 3M surgeries. However due to the lack of standardization in Er: YAG laser therapy, new controlled and standardized studies should be performed with the aim of proving the efficacy of this therapeutic modality.

Is Sjogren's syndrome a risk factor/contraindication for dental implants? An umbrella review.

INTRODUCTION: There have been concerns that longstanding oral dryness secondary to Sjogren's syndrome may increase the risk of failure of dental implants. AIMS: The aim of the present study was to determine the level of methodological quality of systematic reviews that evaluated the effectiveness of dental implants in patients diagnosed with Sjogren's syndrome. METHODS AND RESULTS: Databases of PubMed/Medline, LILACS, Science Direct and Dare Cochrane to October 2020 were evaluated. A total of 833 articles were initially identified but following use of appropriate inclusion and exclusion criteria 4 papers were identified for detailed analysis. An eventual study sample comprised 722 implants placed in 189 patients with a 95.22% success rate, the minimum follow-up time was 45.2 ± 23.8 months and the maximum 125.5 months. The studies were assessed for their methodological quality by the AMSTAR 2 tool, in which 3 had critically low quality and one low quality. CONCLUSION: Oral rehabilitation with dental implants in patients with Sjogren's syndrome seems to have a high success rate; however, the low quality of relevant reports highlights the need for primary and secondary studies with better methodological design in order to reduce bias and provide reassurance for this treatment option.

Steps for biomodel acquisition through addtive manufacturing for health / Passos para a obtenção de biomodelos em manufatura aditiva para a saúde

ABSTRACT The use of rapid prototyping in medical and dental fields consists of three-dimensional models using Computer Aided Design systems and Computer Aided Manufacturing systems. Such systems focus specifically on enhanced 3D visualization tools that provide a precise preoperative planning opportunity through three-dimensional printing, to the professional. The objective of this study was to describe the main steps in the biomodel manufacturing using an Objet 3D printer (CONNEX 350), whose raw material is a light-curing resin. The steps are adopted by researchers from three-dimensional technologies laboratory (LT3D), of the Center for Strategic Technologies in Health (NUTES), from the State University of Paraíba (UEPB), Brazil. It begins with the acquisition of tomographic images that are processed through specific software and exported to the digital Stereo lithography (STL) format. The additive manufacturing technique is Stereo lithography, which consists in the construction of biomodel by photopolymerization of a liquid epoxy resin using ultraviolet radiation. The biomodel that comes from this process was brought to a pressurizing machine to remove the resin support, washing it with water jets. After this step, this biomodel was sent to the health professional in charge. The use of biomodels constitutes a major breakthrough in the area of Dentistry, allowing more precise diagnosis by professionals, simulation and surgical planning, previous adaptation of biomaterials and orthoses, as well as interaction between the surgeon and the patient, thus obtaining more satisfactory aesthetic results and decreased surgical time.

RESUMO A utilização da prototipagem rápida na área médico-odontológica consiste na obtenção de modelos tridimensionais através de sistemas Computer Aided Design (CAD) e Computer Aided Manufacturing (CAM). Tais sistemas incidem especificamente sobre ferramentas de visualização aprimoradas 3D, que fornecem ao profissional a oportunidade de planejamento pré-operatório preciso através da impressão tridimensional. O objetivo deste trabalho é descrever as principais etapas na fabricação de biomodelos utilizando uma impressora 3D Objet (CONNEX 350), cuja matéria prima é uma resina fotopolimerizável. As etapas descritas são adotadas pelos pesquisadores do Laboratório de Tecnologias Tridimensionais (LT3D) do Núcleo de Tecnologias Estratégicas em Saúde, da Universidade Estadual da Paraíba, e iniciam-se com a aquisição das imagens tomográficas que são processadas por meio do softwares específicos e exportadas para o formato Stereolitography (STL). A técnica de manufatura aditiva utilizada é a estereolitografia, que consiste na construção do biomodelo por fotopolimerização de uma resina epoxy líquida usando radiação ultravioleta. O biomodelo resultante deste processo é levado à máquina pressurizadora para remoção da resina de suporte através de lavagem por jatos de água. Após esta etapa o mesmo é enviado ao profissional de saúde responsável. O uso de biomodelos constitui um grande avanço para a área da Odontologia, permitindo a realização de diagnósticos mais precisos por parte do profissional; simulação e planejamento cirúrgico; adaptação prévia de biomateriais e órteses; bem como a comunicação entre o cirurgião e o paciente, obtendo assim, resultados estéticos mais satisfatórios e diminuição do tempo cirúrgico.