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1.
Disabil Rehabil ; : 1-8, 2023 Jul 04.
Artigo em Inglês | MEDLINE | ID: mdl-37403374

RESUMO

PURPOSE: To evaluate the balance in patients with total knee arthroplasty (TKA) and knee osteoarthrosis (KOA), measured by postural stability computerized evaluation (PSCE), and to evaluate the effect of post-TKA patients' characteristics in their performance on PSCE. MATERIALS AND METHODS: An observational cross-sectional study was conducted in two sets of patients: (A) patients with KOA and primary TKA surgery scheduled and (B) patients who underwent primary TKA >9 months. Sociodemographic, radiographic, clinical and PSCE parameters (using the Biodex Balance System) were assessed. RESULTS: Post-TKA patients placed more load on the replaced knee than the contralateral osteoarthritic knee (p = 0.027). They had less imbalance on the balance tests performed with the eyes open, on stable (p = 0.032), and unstable platforms (p = 0.022). These patients also showed better postural stability in monopodalic stance, both standing on the TKA (p = 0.010) and contralateral knee (p = 0.017). Age, weight, pain on the operated knee, extension deficit on the operated knee, and Berg Balance Scale scores on post-TKA patients were significantly associated with their performance on PSCE tests. CONCLUSIONS: PSCE can be useful to quantify the balance of post-TKA and KOA patients.


Total knee arthroplasty is the definitive treatment for knee osteoarthrosis and it has several benefits, but its effect on balance is still unknown.Postural stability computerized evaluation is used to evaluate balance on vestibular diseases and it has been recently studied on musculoskeletal conditions.Postural stability computerized evaluation may be useful to evaluate patients' balance before and after total knee arthroplasty.

2.
PLoS One ; 18(5): e0285988, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37256883

RESUMO

Abdominal wall defects in calves are commonly diagnosed and treated via laparotomy. This technique has witnessed several advancements in the management of these disorders. This study aimed to create a study model and evaluate the feasibility of video-assisted percutaneous correction of abdominal wall defects in bovine fetuses (corpses) compared with the conventional technique. Sixteen bovine fetuses from pregnant cows slaughtered in slaughterhouses were included in this study. The fetuses were categorized into the control group (CG, n = 8), which was subjected to umbilical abdominorrhaphy via laparotomy, and the video-surgical group (VG, n = 8), which received video-assisted percutaneous sutures with two lateral accesses on the right flank. An abdominal wall defect was created in the VG group to generate a study model, which was corrected using the laparoscopic technique. The procedures were performed in two steps. The first step consisted of creating an abdominal wall defect in the umbilical region by laparoscopic approach in an iatrogenic manner (Step 1: E1). The second stage consisted of conventional abdominorrhaphy of the umbilical region wall defect in the CG group and video-assisted percutaneous suturing of the edges of the iatrogenic abdominal wall defect in the VG group, until reversal of the laparoscopic accesses (Step 2: E2). Step 1 showed no statistically significant difference between the two groups. However, a significant statistical difference (p < 0.0001) was observed between the two groups in step 2. The surgical time of step 2 was longer in the CG group (33.10 ± 0.43 minutes) than that in the VG group (10.13 ± 0.68 minutes, p < 0.0001), and the total surgical time was also longer in the CG group (38.48 ± 0.35 minutes) than that in the VG group (15.86 ± 0.67 minutes). The proposed laparoscopic technique allowed the creation of a study model for video-assisted percutaneous suturing with two portals and reduced the surgical time compared with the conventional technique. However, this method needs to be studied further in live animals.


Assuntos
Parede Abdominal , Laparoscopia , Feminino , Gravidez , Bovinos , Animais , Parede Abdominal/cirurgia , Laparoscopia/métodos , Músculos Abdominais , Feto/cirurgia , Doença Iatrogênica
3.
Sensors (Basel) ; 23(7)2023 Mar 29.
Artigo em Inglês | MEDLINE | ID: mdl-37050630

RESUMO

The study of data quality in crowdsourcing campaigns is currently a prominent research topic, given the diverse range of participants involved. A potential solution to enhancing data quality processes in crowdsourcing is cognitive personalization, which involves appropriately adapting or assigning tasks based on a crowd worker's cognitive profile. There are two common methods for assessing a crowd worker's cognitive profile: administering online cognitive tests, and inferring behavior from task fingerprinting based on user interaction log events. This article presents the findings of a study that investigated the complementarity of both approaches in a microtask scenario, focusing on personalizing task design. The study involved 134 unique crowd workers recruited from a crowdsourcing marketplace. The main objective was to examine how the administration of cognitive ability tests can be used to allocate crowd workers to microtasks with varying levels of difficulty, including the development of a deep learning model. Another goal was to investigate if task fingerprinting can be used to allocate crowd workers to different microtasks in a personalized manner. The results indicated that both objectives were accomplished, validating the usage of cognitive tests and task fingerprinting as effective mechanisms for microtask personalization, including the development of a deep learning model with 95% accuracy in predicting the accuracy of the microtasks. While we achieved an accuracy of 95%, it is important to note that the small dataset size may have limited the model's performance.


Assuntos
Crowdsourcing , Humanos , Crowdsourcing/métodos , Confiabilidade dos Dados , Cognição
4.
Heliyon ; 9(4): e14694, 2023 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-37035361

RESUMO

Our study provides valuable insights into the relationship between artificial intelligence (AI) and Human Resource Management (HRM). We have minimised bias and ensured reliable findings by employing a systematic literature review and the PRISMA statement. Our comprehensive synthesis of the studies included in this research, along with a bibliometric analysis of articles, journals, indexes, authors' affiliations, citations, keyword co-occurrences, and co-authorship analysis, has produced robust results. The discussion of our findings focuses on critical areas of interest, such as AI and Talent, AI Bias, Ethics and Law, and their impact on Human Resource (HR) management. Our research highlights the recognition by organisations of the importance of talent management in achieving a competitive advantage as higher-level skills become increasingly necessary. Although some HR managers have adopted AI technology for talent acquisition, our study reveals that there is still room for improvement. Our study is in line with previous research that acknowledges the potential for AI to revolutionise HR management and the future of work. Our findings emphasise the need for HR managers to be proactive in embracing technology and bridging the technological, human, societal, and governmental gaps. Our study contributes to the growing body of AI and HR management knowledge, providing essential insights and recommendations for future research. The importance of our study lies in its focus on the role of HR in promoting the benefits of AI-based applications, thereby creating a larger body of knowledge from an organisational perspective.

5.
Acta Radiol ; 64(2): 666-674, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-35538854

RESUMO

BACKGROUND: Micro instability of the hip joint has been suggested to cause pain in patients with hip dysplasia. Recently, the Femoral-Epiphyseal Acetabular Roof (FEAR) index has been developed to evaluate hip instability in patients with dysplasia. PURPOSE: To investigate associations between the FEAR index and patient-reported outcomes before and six months after periacetabular osteotomy (PAO). MATERIAL AND METHODS: Radiographs of patients with hip dysplasia who underwent PAO between 2018 and 2020 were retrospectively assessed by a radiologist and an orthopedic surgeon. Radiographic measurements indicative of hip instability (Shenton's line, FEAR index, center-edge angle of Wiberg, acetabular index of Tönnis, and the femoral neck-shaft angle) were measured. Data on hip pain, function, and quality of life were collected prospectively using the Hip dysfunction and Osteoarthritis Outcome Score (HOOS). RESULTS: A total of 222 patients were included in the study. All radiographic measurements and patient-reported outcomes improved significantly from preoperative to six months postoperative (P < 0.001). There were no differences in the change score of patient-reported outcomes between patients with a FEAR index >2° (indicative of hip instability) and patients with a FEAR index ≤2°. CONCLUSION: The FEAR index was not associated with hip pain, function, and quality of life among patients with hip dysplasia. This study did not find evidence supporting that instability defined by the FEAR index caused pain in patients with hip dysplasia.


Assuntos
Luxação Congênita de Quadril , Luxação do Quadril , Humanos , Luxação do Quadril/complicações , Luxação do Quadril/diagnóstico por imagem , Luxação do Quadril/cirurgia , Estudos Retrospectivos , Qualidade de Vida , Acetábulo/diagnóstico por imagem , Acetábulo/cirurgia , Articulação do Quadril/cirurgia , Dor , Resultado do Tratamento
6.
Arch Orthop Trauma Surg ; 143(7): 3743-3751, 2023 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35986746

RESUMO

INTRODUCTION: Outcomes for patients treated with PAO and subsequent total hip arthroplasty (THA) remain unclear. We evaluated patient-reported outcomes among patients treated with PAO and subsequent THA and investigated differences in the number of additional surgical procedures after PAO among patients treated with PAO and subsequent THA and patients treated with PAO only. MATERIALS AND METHODS: 1378 hips underwent PAO and subsequently 66 hips were treated with THA. We evaluated the Hip disability and Osteoarthritis Outcome Score (HOOS) and physical activity questions for the 66 hips. Additional surgery after PAO was identified through inquiry to the Danish National Patient Registry. RESULTS: 13% undergoing PAO and subsequent THA reported a HOOS pain score ≤ 50 indicating a clinical failure. The risk difference for hip arthroscopy after PAO within 2 and 4 years was 14% (CI 5-23%) and 26% (CI 15-38%) in favor of hips treated with PAO only. Similarly, the risk difference for screw removal within 2 and 4 years was 19% (CI 8-29%) and 23% (CI 12-34%). CONCLUSION: 87% of patients undergoing PAO and subsequent THA had little or no hip pain. However, these patients received a high number of additional surgeries after PAO. Surgeons and patients may consider if additional surgery after PAO may be the first choice in a series of actions leading to conversion to THA.


Assuntos
Artroplastia de Quadril , Luxação do Quadril , Humanos , Seguimentos , Acetábulo/cirurgia , Resultado do Tratamento , Estudos Retrospectivos , Osteotomia/métodos , Dor/etiologia , Articulação do Quadril/cirurgia , Luxação do Quadril/cirurgia
7.
BMC Vet Res ; 18(1): 378, 2022 Oct 25.
Artigo em Inglês | MEDLINE | ID: mdl-36284310

RESUMO

BACKGROUND: Due to the complexity of ruminant digestion, cannulation of organs of the digestive tract has been carried out in order to advance the understanding of digestive physiology, nutrient degradability, gastrointestinal diseases and biotechnological research. The abomasal cannulation is interesting for nutritional studies, especially in suckling calves, to obtain fluid and abomasal content, evaluation of abomasal flow and function, and infusion of nutrients and drugs when it is intended to reach high concentrations in the organ. Conventionally, access and cannulation of digestive organs of ruminants has been performed by laparotomy, a method often criticized and classified as cruel by some sectors related to ethics and animal welfare. The aim of this present study is to describe and standardize a minimally invasive by laparoscopy assisted abomasal cannulation in bovine fetuses (cadavers), which had been previously slaughtered by accident and would be discarded in local slaughterhouses. RESULTS: The abomasal cannulation technique was feasible, simple and did not present major difficulties. The surgical time for cannulation of the abomasum, from the insertion of the trocars to the completion of the technique with fixation of the organ to the abdominal wall, ranged from 9 to 27 min, with an average of 15.5 ± 6.62 min. CONCLUSIONS: The Laproscopic assisted abomasal cannulation in bovine fetuses was feasible and safe with minimal tissue injury to the abdominal wall and with short surgical time. More studies in the clinical routine related to minimally invasive abomasal content collection, abomasopexy and abomasotomy are required in order to demonstrate its impact and importance in bovine clinic.


Assuntos
Abomaso , Laparoscopia , Bovinos/cirurgia , Animais , Abomaso/cirurgia , Laparoscopia/veterinária , Laparoscopia/métodos , Cateterismo/veterinária , Feto/cirurgia , Cadáver
8.
Galicia clin ; 83(4): 18-24, oct.-dic. 2022. tab
Artigo em Inglês | IBECS | ID: ibc-214892

RESUMO

Objective: Ascertain healthcare-associated infection (HAI) prevalenceand identify risk factors associated with a higher incidence of infectionin a Rehabilitation Ward.Materials and Methods: Two-year retrospective cohort study conducted in a post-acute Rehabilitation Ward of a tertiary-care, public,university-affiliated hospital. Demographic and clinical data were collected from electronic medical record. The assessment of risk factorswas done by comparison of patients with or without HAI. Univariateand multivariate logistic regression analysis was used to identify riskfactors.Results: There were 262 admissions to the Rehabilitation Ward during the study period. One-hundred thirty-one HAIs were detected in95 (36.3%) of the 262 patients. The most common infections wereurinary tract infections (87.8% of all infections). An age-sex adjustedmultivariate logistic regression model showed that urinary catheter,surgery in the last 30 days and length of stay ≥ 30 days were independent risk factors for HAI. Length of stay was associated with anincreased odd of developing HAI (median length of 28 days for thosewithout HAI, 35 days for those with only one HAI and 55 days for patients having ≥ 2 HAI). Only one patient died of infection.Conclusions: HAI is a frequent complication in a post-acute Rehabilitation Ward. The logistic regression model identified patients withurinary catheter, surgery in the last 30 days and length of stay ≥ 30days as having an higher risk for HAI, thereby being the main targetsof surveillance and adoption of preventive measures. (AU)


Objetivo: Determinar la prevalencia y los factores de riesgo de infección nosocomial en pacientes ingresados en una Unidad de Rehabilitación.Material y Métodos: Estudio de cohorte retrospectivo de dos añosrealizado en una Unidad de Rehabilitación posaguda de un hospitalpúblico. La evaluación de los factores de riesgo se realizó mediante lacomparación de pacientes con o sin infección nosocomial. Se utilizóun análisis de regresión logística univariado y multivariado para identificar los factores de riesgo.Resultados: Hubo 262 ingresos a la Unidad de Rehabilitación duranteel período de estudio. Se detectaron 131 infecciones nosocomialesen 95 (36,3%) de los 262 pacientes. Las infecciones más frecuentes fueron las del tracto urinario (87,8%). Un modelo de regresiónlogística multivariado ajustado por edad y sexo mostró que el catéterurinario, la cirugía en los últimos 30 días y la duración de la estancia≥ 30 días fueron factores de riesgo independientes para infecciónnosocomial. La duración de la estancia se asoció con una mayor probabilidad de desarrollar una infección nosocomial (duración media de28 días para aquellos sin infecciones, 35 días para aquellos con solouna infección y 55 días para pacientes con ≥ 2 infecciones). Solo unpaciente murió de infección.Conclusiones: La infección nosocomial es una complicación frecuente en una Unidad de Rehabilitación. El modelo de regresión logísticaidentificó a los pacientes con catéter urinario, cirugía en los últimos30 días y estadía ≥ 30 días con mayor riesgo de infección, por lo queson los principales objetivos de la vigilancia y adopción de medidaspreventivas. (AU)


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Infecção Hospitalar/reabilitação , Fatores de Risco , Catéteres , Estudos Retrospectivos
9.
J Imaging ; 8(9)2022 Sep 09.
Artigo em Inglês | MEDLINE | ID: mdl-36135410

RESUMO

The current technological advances have pushed the quantification of exercise intensity to new era of physical exercise sciences. Monitoring physical exercise is essential in the process of planning, applying, and controlling loads for performance optimization and health. A lot of research studies applied various statistical approaches to estimate various physiological indices, to our knowledge, no studies found to investigate the relationship of facial color changes and increased exercise intensity. The aim of this study was to develop a non-contact method based on computer vision to determine the heart rate and, ultimately, the exercise intensity. The method was based on analyzing facial color changes during exercise by using RGB, HSV, YCbCr, Lab, and YUV color models. Nine university students participated in the study (mean age = 26.88 ± 6.01 years, mean weight = 72.56 ± 14.27 kg, mean height = 172.88 ± 12.04 cm, six males and three females, and all white Caucasian). The data analyses were carried out separately for each participant (personalized model) as well as all the participants at a time (universal model). The multiple auto regressions, and a multiple polynomial regression model were designed to predict maximum heart rate percentage (maxHR%) from each color models. The results were analyzed and evaluated using Root Mean Square Error (RMSE), F-values, and R-square. The multiple polynomial regression using all participants exhibits the best accuracy with RMSE of 6.75 (R-square = 0.78). Exercise prescription and monitoring can benefit from the use of these methods, for example, to optimize the process of online monitoring, without having the need to use any other instrumentation.

10.
Arch Toxicol ; 96(11): 2865-2879, 2022 11.
Artigo em Inglês | MEDLINE | ID: mdl-35987941

RESUMO

Robust and efficient processes are needed to establish scientific confidence in new approach methodologies (NAMs) if they are to be considered for regulatory applications. NAMs need to be fit for purpose, reliable and, for the assessment of human health effects, provide information relevant to human biology. They must also be independently reviewed and transparently communicated. Ideally, NAM developers should communicate with stakeholders such as regulators and industry to identify the question(s), and specified purpose that the NAM is intended to address, and the context in which it will be used. Assessment of the biological relevance of the NAM should focus on its alignment with human biology, mechanistic understanding, and ability to provide information that leads to health protective decisions, rather than solely comparing NAM-based chemical testing results with those from traditional animal test methods. However, when NAM results are compared to historical animal test results, the variability observed within animal test method results should be used to inform performance benchmarks. Building on previous efforts, this paper proposes a framework comprising five essential elements to establish scientific confidence in NAMs for regulatory use: fitness for purpose, human biological relevance, technical characterization, data integrity and transparency, and independent review. Universal uptake of this framework would facilitate the timely development and use of NAMs by the international community. While this paper focuses on NAMs for assessing human health effects of pesticides and industrial chemicals, many of the suggested elements are expected to apply to other types of chemicals and to ecotoxicological effect assessments.


Assuntos
Ecotoxicologia , Praguicidas , Animais , Humanos , Projetos de Pesquisa , Medição de Risco
12.
BMC Vet Res ; 18(1): 41, 2022 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-35039024

RESUMO

BACKGROUND: Endosurgery is a surgical subspecialty that has been widely used in production animals, because it enables good visualization of abdominal organs and the diagnosis and treatment of several conditions in a minimally invasive manner, while preserving the animal's well-being and causing a lower impact on animal production. Rumenostomy is one of the most common surgical procedures in ruminants. This procedure is used to allow access to the rumen for various purposes, especially nutritional and therapeutic studies, and it can be performed either in a conventional way or in a minimally invasive video-assisted manner. Another possibility of access to ruminants is through the rumenoscopy technique. The objective of this study is to describe a minimally invasive technique for rumenostomy using an endoscope, working on a bovine fetal corpse as an experimental model. RESULTS: The execution of the endoscopy-guided rumenostomy technique was simple and did not present major difficulties. The endoscope, its lighting and air pump, and the decubitus used provided a good anatomical visualization of the rumen, and it was possible to evaluate several regions of the organ. The mean duration of the procedure was 11.15 min. CONCLUSIONS: The endoscopic rumenostomy technique using anatomical pieces of calves was shown to be feasible. It was performed in a simple and efficient way, particularly regarding the premise of preserving the animal's well-being, due to its minimally invasive nature.


Assuntos
Endoscopia , Feto , Rúmen , Animais , Bovinos , Endoscopia/veterinária , Rúmen/cirurgia
13.
Front Plant Sci ; 12: 729880, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34567041

RESUMO

"Persian" walnut (Juglans Regia L.) is one of the most consumed tree nuts in the world. It is rich in several bioactive compounds, with polyunsaturated and monounsaturated fatty acids (PUFA and MUFA) appearing at high concentrations. Walnut consumption protects against cardiovascular, carcinogenic, and neurological disorders. The fatty acid profile has usually been determined by gas chromatography, a reliable and robust tool, but also complex, polluting, and time consuming. In this study, near infrared hyperspectral imaging has been used for the screening of total fat, MUFA, PUFA, saturated, and individual fatty acids in walnuts. Five different walnuts varieties have been considered and modified partial least square (MPLS) regressions have been performed. The SEs of prediction (SEP) in external validation (ranged from 2.12% for PUFA to 13.08% for MUFA) suggest that hyperspectral imaging can be a reliable tool for controlling these parameters in a simple, non-destructive and environmentally friendly way.

14.
Sensors (Basel) ; 21(18)2021 Sep 07.
Artigo em Inglês | MEDLINE | ID: mdl-34577208

RESUMO

Currently, solutions based on the Internet of Things (IoT) concept are increasingly being adopted in several fields, namely, industry, agriculture, and home automation. The costs associated with this type of equipment is reasonably small, as IoT devices usually do not have output peripherals to display information about their status (e.g., a screen or a printer), although they may have informative LEDs, which is sometimes insufficient. For most IoT devices, the price of a minimalist display, to output and display the device's running status (i.e., what the device is doing), might cost much more than the actual IoT device. Occasionally, it might become necessary to visualize the IoT device output, making it necessary to find solutions to show the hardware output information in real time, without requiring extra equipment, only what the administrator usually has with them. In order to solve the above, a technological solution that allows for the visualization of IoT device information in actual time, using augmented reality and a simple smartphone, was developed and analyzed. In addition, the system created integrates a security layer, at the level of AR, to secure the shown data from unwanted eyes. The results of the tests carried out allowed us to validate the operation of the solution when accessing the information of the IoT devices, verify the operation of the security layer in AR, analyze the interaction between smartphones, the platform, and the devices, and check which AR markers are most optimized for this use case. This work results in a secure augmented reality solution, which can be used with a simple smartphone, to monitor/manage IoT devices in industrial, laboratory or research environments.


Assuntos
Realidade Aumentada , Internet das Coisas , Segurança Computacional , Confidencialidade , Atenção à Saúde
15.
Sensors (Basel) ; 21(18)2021 Sep 09.
Artigo em Inglês | MEDLINE | ID: mdl-34577256

RESUMO

The Portuguese population is aging at an increasing rate, which introduces new problems, particularly in rural areas, where the population is small and widely spread throughout the territory. These people, mostly elderly, have low income and are often isolated and socially excluded. This work researches and proposes an affordable Ambient Assisted Living (AAL)-based solution to monitor the activities of elderly individuals, inside their homes, in a pervasive and non-intrusive way, while preserving their privacy. The solution uses a set of low-cost IoT sensor devices, computer vision algorithms and reasoning rules, to acquire data and recognize the activities performed by a subject inside a home. A conceptual architecture and a functional prototype were developed, the prototype being successfully tested in an environment similar to a real case scenario. The system and the underlying concept can be used as a building block for remote and distributed elderly care services, in which the elderly live autonomously in their homes, but have the attention of a caregiver when needed.


Assuntos
Envelhecimento , Computadores , Idoso , Humanos , Processamento de Imagem Assistida por Computador , Monitorização Fisiológica , Privacidade
16.
J Vet Med Sci ; 83(8): 1315-1320, 2021 Aug 26.
Artigo em Inglês | MEDLINE | ID: mdl-34162781

RESUMO

This study aimed to describe the anatomical topography of the abdominal cavity of buffaloes in the quadruped position to establish the best endosurgical access and vantage points and identify possible limitations. Laparoscopies were performed on 10 healthy female buffaloes obtained from the Universidade Federal Rural da Amazônia to explore possible access points to the abdomen. Techniques for assessing and possibly observing certain organs and structures through the left and right flanks of 10 animals have been described. In five animals, access was created through the right side of the last intercostal space to allow more cranial access to the abdominal cavity. Despite the presence of the rumen, access through the left flank allowed the visualization of the structures of the gastrointestinal tract and the genitourinary system. With access through the right flank, however, imaging was hampered by the presence of the greater omentum and its deep and superficial walls, which prevented the progression of the endoscope. Access through the last right intercostal space allowed the visualization of the cranial structures of the abdominal cavity, such as the caudate process, right lobe of the liver, right kidney, and pancreas. Laparoscopic access through the left flank and the last intercostal space in healthy buffaloes in the quadruped position is feasible, and it is promising for the exploration, diagnosis, and treatment of various disorders in buffaloes.


Assuntos
Búfalos , Laparoscopia , Abdome/diagnóstico por imagem , Animais , Brasil , Feminino , Laparoscopia/veterinária
17.
Cutan Ocul Toxicol ; 40(2): 145-167, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33830843

RESUMO

There are multiple in vitro and ex vivo eye irritation and corrosion test methods that are available as internationally harmonized test guidelines for regulatory use. Despite their demonstrated usefulness to a broad range of substances through inter-laboratory validation studies, they have not been widely adopted for testing agrochemical formulations due to a lack of concordance with parallel results from the traditional regulatory test method for this endpoint, the rabbit eye test. The inherent variability of the rabbit test, differences in the anatomy of the rabbit and human eyes, and differences in modelling exposures in rabbit eyes relative to human eyes contribute to this lack of concordance. Ultimately, the regulatory purpose for these tests is protection of human health, and, thus, there is a need for a testing approach based on human biology. This paper reviews the available in vivo, in vitro and ex vivo test methods with respect to their relevance to human ocular anatomy, anticipated exposure scenarios, and the mechanisms of eye irritation/corrosion in humans. Each of the in vitro and ex vivo methods described is generally appropriate for identifying non-irritants. To discriminate among eye irritants, the human three-dimensional epithelial and full thickness corneal models provide the most detailed information about the severity of irritation. Consideration of the mechanisms of eye irritation, and the strengths and limitations of the in vivo, in vitro and ex vivo test methods, show that the in vitro/ex vivo methods are as or more reflective of human biology and less variable than the currently used rabbit approach. Suggestions are made for further optimizing the most promising methods to distinguish between severe (corrosive), moderate, mild and non-irritants and provide information about the reversibility of effects. Also considered is the utility of including additional information (e.g. physical chemical properties), consistent with the Organization for Economic Cooperation and Development's guidance document on an integrated approach to testing and assessment of potential eye irritation. Combining structural and functional information about a test substance with test results from human-relevant methods will ensure the best protection of humans following accidental eye exposure to agrochemicals.


Assuntos
Agroquímicos/toxicidade , Cáusticos/toxicidade , Olho/efeitos dos fármacos , Irritantes/toxicidade , Testes de Toxicidade/métodos , Animais , Traumatismos Oculares/induzido quimicamente , Humanos
18.
Sensors (Basel) ; 21(4)2021 Feb 19.
Artigo em Inglês | MEDLINE | ID: mdl-33669733

RESUMO

Data and services are available anywhere at any time thanks to the Internet and mobile devices. Nowadays, there are new ways of representing data through trendy technologies such as augmented reality (AR), which extends our perception of reality through the addition of a virtual layer on top of real-time images. The great potential of unmanned aerial vehicles (UAVs) for carrying out routine and professional tasks has encouraged their use in the creation of several services, such as package delivery or industrial maintenance. Unfortunately, drone piloting is difficult to learn and requires specific training. Since regular training is performed with virtual simulations, we decided to propose a multiplatform cloud-hosted solution based in Web AR for drone training and usability testing. This solution defines a configurable trajectory through virtual elements represented over barcode markers placed on a real environment. The main goal is to provide an inclusive and accessible training solution which could be used by anyone who wants to learn how to pilot or test research related to UAV control. For this paper, we reviewed drones, AR, and human-drone interaction (HDI) to propose an architecture and implement a prototype, which was built using a Raspberry Pi 3, a camera, and barcode markers. The validation was conducted using several test scenarios. The results show that a real-time AR experience for drone pilot training and usability testing is achievable through web technologies. Some of the advantages of this approach, compared to traditional methods, are its high availability by using the web and other ubiquitous devices; the minimization of technophobia related to crashes; and the development of cost-effective alternatives to train pilots and make the testing phase easier for drone researchers and developers through trendy technologies.

19.
Sci Rep ; 11(1): 5328, 2021 03 05.
Artigo em Inglês | MEDLINE | ID: mdl-33674673

RESUMO

Surgical intervention for umbilical diseases in calves, when indicated, is a complementary and indispensable therapeutic resource for the treatment of umbilical conditions and is commonly performed using celiotomy. However, laparoscopy has demonstrated feasibility in many diagnostic and therapeutic procedures. The aim of this study was to assess the feasibility of the techniques and the surgical time of laparoscopy and celiotomy used in intra-abdominal resection of the umbilical vein and urachus of bovine fetuses (cadavers). Resection of the umbilical vein and urachus using laparoscopy and celiotomy was performed in 26 anatomical specimens (bovine fetuses obtained from an official slaughterhouse). Resection of umbilical structures was feasible with both techniques, but shorter surgical time and minimal tissue damage were achieved using laparoscopy. Laparoscopy requires specialized training and appropriate instruments and is an important tool for diagnostic and therapeutic exploration of the umbilical structures, liver, bladder, and associated/adjacent structures.


Assuntos
Feto/cirurgia , Laparoscopia/métodos , Veias Umbilicais/cirurgia , Úraco/cirurgia , Animais , Cadáver , Bovinos
20.
Sensors (Basel) ; 21(4)2021 Feb 20.
Artigo em Inglês | MEDLINE | ID: mdl-33672605

RESUMO

The demand for online services is increasing. Services that would require a long time to understand, use and master are becoming as transparent as possible to the users, that tend to focus only on the final goals. Combined with the advantages of the unmanned vehicles (UV), from the unmanned factor to the reduced size and costs, we found an opportunity to bring to users a wide variety of services supported by UV, through the Internet of Unmanned Vehicles (IoUV). Current solutions were analyzed and we discussed scalability and genericity as the principal concerns. Then, we proposed a solution that combines several services and UVs, available from anywhere at any time, from a cloud platform. The solution considers a cloud distributed architecture, composed by users, services, vehicles and a platform, interconnected through the Internet. Each vehicle provides to the platform an abstract and generic interface for the essential commands. Therefore, this modular design makes easier the creation of new services and the reuse of the different vehicles. To confirm the feasibility of the solution we implemented a prototype considering a cloud-hosted platform and the integration of custom-built small-sized cars, a custom-built quadcopter, and a commercial Vertical Take-Off and Landing (VTOL) aircraft. To validate the prototype and the vehicles' remote control, we created several services accessible via a web browser and controlled through a computer keyboard. We tested the solution in a local network, remote networks and mobile networks (i.e., 3G and Long-Term Evolution (LTE)) and proved the benefits of decentralizing the communications into multiple point-to-point links for the remote control. Consequently, the solution can provide scalable UV-based services, with low technical effort, for anyone at anytime and anywhere.

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